• SBV, a member of the Simbu serogroup within the genus Orthobunyavirus , is closely related to Akabane virus (AKAV) and Aino virus (AINOV) among others. (biomedcentral.com)
  • The Orthobunyavirus genus of the Peribunyaviridae family contains numerous viruses, usually transmitted by mosquitoes ( 1 ). (cdc.gov)
  • We used it to discover a previously unknown member of the Orthobunyavirus genus of the Peribunyaviridae family, Cristoli virus, in a patient with fatal encephalitis. (cdc.gov)
  • Orthobunyavirus is a genus of the Peribunyaviridae family in the order Bunyavirales. (wikipedia.org)
  • Orthobunyavirus infection in arthropod cells is not fully understood, but is generally non-cytopathological and deleterious effects are minimal. (wikipedia.org)
  • Bartonella melophagi in blood of domestic sheep (Ovis aries) and sheep keds (Melophagus ovinus) from the southwestern US: Cultures, genetic characterization, and ecological connections. (utmb.edu)
  • In mosquitoes, replication of orthobunyaviruses is enhanced by immune modulation that occurs as a result of blood protein digestion producing GABA and the activation of GABAergic signalling. (wikipedia.org)
  • This family is composed of RNA viruses grouped into five genera Orthobunyavirus, Hantavirus, Nairovirus, Phlebovirus and Tospovirus characterized by their antigenic, genetic and ecological properties. (hal.science)
  • 400 million poultry have been culled since 2003 as a result of efforts to control highly pathogenic H5N1 avian influenza ( http://www.fao.org/avianflu/en/index.html ), and there are increasing biological and ecological consequences. (nationalacademies.org)
  • The L RNA encodes the viral RNA dependent RNA Polymerase or L Protein The primary vectors of Orthobunyaviruses are hematophagous insects of the Culicidae family, including members from a number of mosquito genera (including Aedes, Coquillettidia, Culex, Culiseta, and Anopheles) and biting midges (such as Culicoides paraensis). (wikipedia.org)
  • Although, Heparan sulfate and DC-SIGN (CD209 or Dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin) have been identified as viral entry components in some orthobunyaviruses. (wikipedia.org)
  • Like all negative-sense RNA viruses, orthobunyaviruses require ongoing, concurrent translation by the host cell to produce full-length viral mRNAs, consequently the 3' end of orthobunyavirus mRNAs lack polyadenylation. (wikipedia.org)
  • Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. (lookformedical.com)
  • Like all negative-sense RNA viruses, orthobunyaviruses require ongoing, concurrent translation by the host cell to produce full-length viral mRNAs, consequently the 3' end of orthobunyavirus mRNAs lack polyadenylation. (wikipedia.org)
  • Our findings also suggest genome reassortment within the Wyeomyia group, identifying Macaua and Tucunduba viruses as M-segment reassortants that, in the case of Tucunduba virus, may have altered pathogenicity, stressing the need for whole-genome sequence information to facilitate characterization of orthobunyaviruses and their phylogenetic relationships. (microbiologyresearch.org)
  • As the arboviruses are virtually all RNA viruses lacking proofreading functions, genetic mutations would certainly be a possible reason for changes in virulence, epidemiology or vector competence. (medscape.com)
  • Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus. (lookformedical.com)
  • Virus A Rna 0 domande Viruses whose genetic material is RNA. (lookformedical.com)
  • The name Orthobunyavirus derives from Bunyamwera, Uganda, where the original type species Bunyamwera orthobunyavirus was first discovered, along with the prefix orthos (ορθοϛ) meaning 'straight. (wikipedia.org)
  • In this Review, I describe the recent genetic and structural advances that have revealed important insights into the composition of orthobunyavirus virions, viral transcription and replication and viral interactions with the host innate immune response. (nih.gov)
  • In mosquitoes, replication of orthobunyaviruses is enhanced by immune modulation that occurs as a result of blood protein digestion producing GABA and the activation of GABAergic signalling. (wikipedia.org)
  • Two orthobunyaviruses reported on in this issue of Emerging Infectious Diseases are Inkoo virus and Chatanga virus (named for the towns of Inkoo, Finland, and Khatanga, Russia, respectively, where they were first isolated). (cdc.gov)
  • Efficient rescue of a newly classified Ebinur lake orthobunyavirus with GFP reporter and its application in rapid antiviral screening. (cdc.gov)
  • The L RNA encodes the viral RNA dependent RNA Polymerase or L Protein The primary vectors of Orthobunyaviruses are hematophagous insects of the Culicidae family, including members from a number of mosquito genera (including Aedes, Coquillettidia, Culex, Culiseta, and Anopheles) and biting midges (such as Culicoides paraensis). (wikipedia.org)
  • Orthobunyaviruses: From Virus Binding to Penetration into Mammalian Host Cells. (nih.gov)
  • We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. (cdc.gov)
  • This segmented, negative-sense RNA virus evolves predominately by genetic drift punctuated by infrequent episodes of genetic reassortment among novel strains. (bvsalud.org)
  • Brandi has studied multiple organisms and vectors through her career including Borrelia hermsii, Ornithodoros hermsi, Colorado Tick fever virus, Dermacentor andersoni, orthobunyaviruses, and hantaviruses. (nih.gov)