Animal Use AlternativesMutationDisease Models, AnimalDNA AdductsModels, AnimalMutagensPoint MutationMutation, MissenseDNA DamageFrameshift MutationPedigreeGerm-Line MutationDNA Mutational AnalysisHeterozygoteBase SequenceExonsMolecular Sequence DataPhenotypePolymerase Chain ReactionAllelesAmino Acid SubstitutionGenotypeMutation RatePolymorphism, Single-Stranded ConformationalSequence Analysis, DNAGenetic TestingHomozygoteCodon, NonsenseAmino Acid SequenceGenetic Predisposition to DiseaseGenes, RecessiveMutagenesis, Site-DirectedDNA PrimersMutagenesisCell LineChromosome MappingModels, GeneticProtein Structure, TertiaryMice, TransgenicGenes, p53Genetic LinkageSignal TransductionGene DeletionMice, Inbred C57BLDNA-Binding ProteinsFamily HealthMutant ProteinsTranscription FactorsSequence DeletionSyndromeMembrane ProteinsGenes, DominantModels, BiologicalProto-Oncogene Proteins B-rafNuclear ProteinsDNAProtein BindingEscherichia coliGenetic VariationSuppression, GeneticModels, MolecularTransfectionMice, KnockoutCodonMice, Mutant StrainsBinding SitesRNA, MessengerPolymorphism, Single NucleotidePolymorphism, GeneticCells, CulturedSequence Homology, Amino AcidFructose-1,6-Diphosphatase DeficiencyGenetic Complementation TestGenetic MarkersPromoter Regions, GeneticDeafnessAge of OnsetDNA, NeoplasmFounder EffectGene FrequencyTranscription, GeneticEye ProteinsGene Expression RegulationCloning, MolecularReverse Transcriptase Polymerase Chain ReactionCarrier ProteinsParkinson DiseaseSequence AlignmentGene ExpressionZebrafishNerve Tissue ProteinsBrainSaccharomyces cerevisiaeConsanguinityImmunohistochemistryBacterial ProteinsPlasmidsCell Transformation, NeoplasticEthylnitrosoureaCell Line, Tumor