Genetic microsatellite repeats. Medical search. Frequent questions

Search for the polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and copy number variation (CNV). (hinv.jp)
Microsatellites, or simple sequence repeats (SSRs), have long played a major role in genetic studies due to their typically high polymorphism. (pacb.com)
The pooled odds ratios with 95% confidence intervals were calculated to estimate the effects of MIF-173G/C polymorphism on psoriasis risk under different genetic models. (bvsalud.org)

Multiple different experiments have used genetic manipulation to induce null allele mutants in mice populations in order to observe the consequences of different allele combinations at specific loci. (wikipedia.org)
We also review the variety of techniques currently used for identifying microsatellite loci and developing primers, with a particular focus on those that make use of next-generation sequencing (NGS). (pacb.com)
Loci were isolated from a genomic library enriched for AC repeats. (researchgate.net)
We designed seven novel microsatellite markers and used four cross-amplified loci to determine the basic genetic structure of T. recurvata . (researchsquare.com)
Of the ten SSR loci used, seven are highly recommended for alfalfa genetic diversity analysis, as high genetic variation was detected at these loci. (slu.se)

Microsatellites (Short sequence repeats, SSRs, Short tandem repeats): are short (1-6bp) repeating sequences in genetic code. (flashcardmachine.com)
The SSRs were categorized for the numbers of repeats present, their overall length and were allocated to their linkage group. (researchgate.net)
We compare SSRs and newer methods, such as genotyping by sequencing (GBS) and restriction site associated DNA sequencing (RAD-Seq), and offer recommendations for researchers considering which genetic markers to use. (pacb.com)
Molecular markers such as single nucleotide polymorphisms (SNPs), simple sequence repeats (SSRs) or microsatellites are used to genotype segregating populations. (bioline.com)
They are also known as short tandem repeats (STRs) or simple sequence repeats (SSRs). (vajiramandravi.com)
To facilitate this integration of maps, we screened 3290 microsatellites (SSRs) identified from BAC end sequences of clones comprising the 'Williams 82' physical map. (arizona.edu)

It was through the study of plant breeding that Mendel identified the genotype-phenotype connection and described the fundamental laws of inheritance, often described as the founding of genetic science. (bioline.com)

A total of 35 microsatellites were identified from the ESTs, with 18 having sufficient flanking sequences for primer design. (nih.gov)
Microsatellite regions are usually characterized by short, repeated sequences of nucleotides. (wikipedia.org)
Divergence from the reference sequences (from genetic mutations) results in poor annealing of the primers so that the marker cannot be used, representative of a null allele. (wikipedia.org)
a decrease was noted in incidence of deleterious phys- of unique long terminal repeat and envelope sequences. (cdc.gov)
FeLV envelope ( env ) and the long (LTR4) was designed by using panther FeLV (FeLV-Pco) terminal repeat (LTR) sequences have been suggested as envelope sequence additionally. (cdc.gov)
Sequences repeated in tandems (microsatellites) are used for parentage testing. (genomia.cz)
These microsatellites contain sequences repeated in tandems from two to seven base pairs. (genomia.cz)
The length of these repeating sequences , at one time dismissed as mere junk DNA, in the gene that codes for a key hormone receptor determined male-female relations and parenting behaviors in a species of voles. (news-medical.net)
Hammock and Young were particularly intrigued with microsatellites, repeating sequences of letters in the genetic code peppered throughout these regulatory areas of the vasopressin receptor gene. (news-medical.net)
for example, the repeating letter sequences are much longer in monogamous than in polygamous vole species, and even within a species, there are differences in the number of letters in the sequence among individuals. (news-medical.net)
With a growing understanding of the genetic sequences and make-up of selected species, a more targeted approach looks at total genomics - linking complex phenotypic traits to the genetic architecture and underlying molecular mechanisms to better instruct cross-breeding and back-breeding efforts. (bioline.com)
Microsatellites are small DNA sequences made up of repeating units. (vajiramandravi.com)
Polymerase chain reaction (PCR) primers were designed from flanking sequences in 102 of the SSR clones, of which 50 primer pairs (for 10 AC-repeat microsatellites and 40 AG-repeat microsatellites) produced robust amplification products. (psu.edu)

Fragile X syndrome: genetic localisation by linkage mapping of two microsatellite repeats FRAXAC1 and FRAXAC2 which immediately flank the fragile site. (cnrs.fr)
These genome resources provide the material basis for future microarray development, marker validation, and genetic linkage and QTL analysis. (nih.gov)
Construction of dense genetic linkage maps of apple cultivars Kaşel-41" by ELMIRA ZIYA MOTALEBIPOUR, SALİH KAFKAS et al. (tubitak.gov.tr)
We performed a genome-wide linkage scan using highly polymorphic microsatellite markers. (duke.edu)

Microsatellite DNA is utilised in genetic analysis, more specifically in molecular genetics and genomics. (vajiramandravi.com)
In the realm of public health genomics, knowing your family history and use of appropriate genetic testing can also reduce morbidity and mortality from chronic diseases such as BRCA1/2 associated hereditary breast/ovarian cancer, Lynch syndrome and familial hypercholesterolemia. (cdc.gov)

Microsatellite markers are used for individual identification and, for paternity analysis in humans and animals. (genomia.cz)
The Emory researchers have found that the bonobo, an ape noted for its empathic traits, unlike its relative the chimpanzee, has a microsatellite with a sequence similar to that of humans. (news-medical.net)

A genetic null or amorphic allele has the same phenotype when homozygous as when heterozygous with a deficiency that disrupts the locus in question. (wikipedia.org)
A microsatellite null allele is an allele at a microsatellite locus that does not amplify to detectable levels in a polymerase chain reaction test. (wikipedia.org)
Primers that are specific to a particular locus are used in PCR amplification to bind to these nucleotide sequence repeats and are used as genetic markers. (wikipedia.org)
The objective of this study was to identify single locus microsatellite or simple sequence repeat (SSR) markers that are useful for genetic diversity assessment in four important Vaccinium species from the southeastern US including V. elliottii, V. darrowii, V. fuscatum and V. myrsinites. (usda.gov)
The number of repeats at a certain microsatellite locus might vary greatly between people in a population because microsatellite DNA is highly variable. (vajiramandravi.com)
Validation of a male-specific, 12-locus fluorescent short tandem repeat (STR) multiplex" [Forensic Sci. (unthsc.edu)

The genetic map for QTL analysis was created from SSR and RAPD markers covering all 11 chromosomes of the common bean genome. (edu.au)
Genetic mapping: Microsatellite DNA can be used to map the location of genes in the genome. (vajiramandravi.com)
A strategy is introduced by which physical and genetic map inconsistencies can be resolved using the preliminary 4x assembly of the whole genome sequence of soybean. (arizona.edu)

The objective of this study was to identify DNA-based molecular markers that can be used to evaluate genetic diversity in individuals from these southeastern US expeditions. (usda.gov)
This field of genetics emerged from the availability of several studies with classical molecular markers, such as isozymes, RAPD, AFLP, and microsatellites. (intechopen.com)
Morphological descriptors and ISSR molecular markers in the evaluation of genetic variability of Tectona grandis genotypes. (geneticsmr.com)
This study aimed to evaluate the genetic variability of the teak germplasm bank, using morphological traits and inter-simple sequence repeat molecular markers. (geneticsmr.com)
The aim of this Master thesis was to study the genetic diversity of alfalfa grown in Kyrgyzstan and in other countries and determine the genetic relationship using simple sequence repeat (SSR, microsatellite) molecular markers as well as to contribute to the development of synthetic alfalfa varieties for use as forage in Kyrgyzstan. (slu.se)

In 1995, faced with the compounding ef- netic analysis of panther FeLV, designated FeLV-Pco, de- fects of reduced genetic variation, probable depression of termined that the outbreak likely came from 1 cross-spe- numbers from inbreeding, and evidence of compromised cies transmission from a domestic cat. (cdc.gov)
The FeLV-Pco virus health, wildlife managers released 8 female Texas pumas was closely related to the domestic cat exogenous FeLV-A into southern Florida to increase genetic variation and ame- subgroup in lacking recombinant segments derived from liorate the physiologic effects of inbreeding. (cdc.gov)
Population genetic studies deal with allele frequencies and processes that shape their variation within and among populations. (intechopen.com)
Iranian sheep have a low level of genetic differentiation, as indicated by the analysis of molecular variance, which allocated a very small proportion (1.67%) of total variation to the between-population component, and by the small fixation index (FST = 0.02). (unicatt.it)
The analysis of alfalfa genetic diversity helps to assess the future risk of genetic erosion and helps in the development of sustainable conservation strategies and wise use of the genetic variation in breeding programs. (slu.se)
The Jaccard similarity coefficient and cluster analysis revealed a significant genetic variation between Kyrgyz alfalfa genotypes, which is significant enough for alfalfa improvement, including the development of synthetic varieties. (slu.se)
The introduction of new alfalfa genetic material from countries such as Argentina, Oman, Australia, Iran, Iraq and Norway into Kyrgyzstan is a great opportunity to increase genetic variation in the alfalfa gene pool in the country. (slu.se)

The researchers suggest that variability in vasopressin receptor microsatellite length could help account for differences in normal human personality traits, such as shyness, and perhaps influence disorders of sociability like autism and social anxiety disorders. (news-medical.net)
Unlike conventional breeding, genetic modification (GM) can occur between completely unrelated species, thus opening access to a broader range of traits. (bioline.com)
When it comes to conformation aptitudes for Dressage, the genetic values for 37 different conformation traits and the Global Genetic Index (GGI) were also published. (usprea.com)
hence, it allows selection and choice of the parental genetic divergence, which have the agronomic traits desired by the breeder. (geneticsmr.com)
Genetic diversity of Desmanthus sp accessions using ISSR markers and morphological traits. (geneticsmr.com)

Abstract Ten polymorphic microsatellite markers are described for the Mediterranean bath sponge Spongia officinalis. (researchgate.net)
The DNA fingerprinting methodologies, random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR), were used to estimate genetic diversity and relationships among 20 black gram (Vigna mungo L. Hepper) varieties. (korea.ac.kr)

Not of sperm abnormalities, and increased incidence of heart associated with FeLV outcome were the genetic heritage defects relative to other puma populations and felids in of the panthers (pure Florida vs. Texas/Florida crosses) general ( and co-infection with feline immunodefi ciency virus. (cdc.gov)
Bear researchers were at the forefront of using microsatellites to study the demographics and diversity of populations, such that 3 species have complete sampling and 3 others are represented across their range breadth. (bioone.org)
We extracted microsatellite summary statistics from 104 papers that sampled 284 populations of any species within Ursidae, then yardstick-transformed the data for direct comparison. (bioone.org)
Further, by comparing allelic richness to heterozygosity across the range of a species, managers may identify populations in need of genetic management. (bioone.org)
To assess if the behavioral difference between the family and kenneled dogs could be due to genetic divergence of these two populations and/or to lower genetic diversity of the kenneled dogs, we analyzed their genetic structure using 11 microsatellite markers. (frontiersin.org)
We found no significant difference between the populations in their genetic diversity (i.e., heterozygosity, level of inbreeding), nor any evidence that the family and kenneled populations originated from different genetic pools. (frontiersin.org)
Population genetic studies enabled the detection of population structure with those markers, but a more comprehensive analysis of natural populations was only possible with the development of statistical methods that combined both molecular data and environmental variables. (intechopen.com)
In a species whose populations in the eastern Mediterranean basin have been substantially declined due to recurring mass mortality incidents and intensive harvesting, these markers are expected to assist studies of genetic structure and differentiation between populations. (researchgate.net)
Population genetics: Microsatellite DNA can be used to study the genetic diversity of populations. (vajiramandravi.com)
All populations showed high global spatial genetic structure (SGS) and population differentiation. (researchsquare.com)
The high SGS of T. recurvata indicated low connectivity between urban populations, with strong evidence to suggest that this was the result of small population size and genetic drift. (researchsquare.com)
Although within-species genetic differences among AMF have been shown to differentially affect plant growth, very little is actually known about the degree of genetic diversity in AMF populations. (elsevierpure.com)

To minimize genetic heterogeneity, we focused on sibpairs meeting the strict diagnosis of autism. (duke.edu)
The results were obtained by allowing for genetic heterogeneity among these extended pedigrees, and ≈50% of families were linked to this region with the highest single-pedigree lod score being 3.6. (elsevierpure.com)

We describe ied extensively by monitoring a large proportion of adults the molecular genetic characterization of circulating FeLV by radio telemetry ( 2 - 5 ). (cdc.gov)

Each offspring has to correspond with a parent in 50% of each microsatellite marker. (genomia.cz)
Size of a marker (number of base pair in a microsatellite) is detected by polymerase chain reaction (PCR) and subsequent fragment analysis. (genomia.cz)
Pseudomolecules as well as unmapped scaffolds were used for the bulk mining of SSR markers and for the construction of the first globe artichoke microsatellite marker database. (researchgate.net)
Genomic assisted breeding programs greatly enhance selection efficiency through the construction of comprehensive genetic maps and establishment of marker-trait associations, directing molecular breeding programs for more precise outcomes. (bioline.com)
This laboratory is one of the few in Spain that has Quality Certification based on UNE-EN ISO 9001:2015 Standards, and with ENAC accreditation based on UNE-EN ISO/IEC 17025:2017 standards for the "Genetic profile identification, identity and parentage verification using microsatellite analysis (Short tandem repeats or STRs) and AME marker by means of PCR and capillary electrophoresis" for equines. (usprea.com)
Microsatellite marker-based genetic diversity analysis and developing synthetic varieties in Alfalfa (Medicago sativa L. (slu.se)

Moreover, exploring the genetic background of their higher resilience could also help to better understand the genetics behind stress- and fear-related behaviors. (frontiersin.org)
Microsatellite markers are very valuable in population genetics, conservation genetics, and phylogenetic research. (vajiramandravi.com)
The ANCCE Molecular Genetics Laboratory has the latest in equipment and performs genetic parentage analyses on all PRE horses seeking registration, wherever they are located in the world. (usprea.com)

A null allele is a nonfunctional allele (a variant of a gene) caused by a genetic mutation. (wikipedia.org)
A genetic null allele may be both a protein null and an RNA null, but may also express normal levels of a gene product that is nonfunctional due to mutation. (wikipedia.org)
HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. (bvsalud.org)

scolymus) has been used to catalog the genome's content of simple sequence repeat (SSR) markers. (researchgate.net)
Franco) and several other conifer tree species among di-, tri-, and tetra-nucleotide simple sequence repeats (SSR). (psu.edu)
A population of the arbuscular mycorrhizal fungus Glomus intraradices growing in an in vitro cultivation system was studied using newly developed simple sequence repeat (SSR), nuclear gene intron and mitochondrial ribosomal gene intron markers. (elsevierpure.com)
Therefore, 162 papaya accessions were evaluated using 23 simple sequence repeat (SSR) markers. (urosario.edu.co)

On the other hand, dogs bred and kept solely for breeding or research purposes ("kenneled dogs") are kept and handled under standardized conditions, and are usually of the same breed, thus the effects of environmental and breed-specific genetic variability on their individual behavioral variability is small. (frontiersin.org)

Genetic diversity analyses are an important aspect of conservation of plant genetic resources. (urosario.edu.co)

The markers generated by RAPD and ISSR assays can provide practical information for the management of genetic resources and these results will also provide useful information for the molecular classification and breeding of new black gram varieties. (korea.ac.kr)

Both experiments used the process of mutageneis, whereby the genetic content of the organism is changed, to produce individuals with different combinations of null mutations. (wikipedia.org)
The multihit model postulates that several unique genetic mutations combine to cause cancer. (medscape.com)
These diseases are all caused by microsatellite mutations, where a microsatellite either has three bases, four bases, five bases, or six bases, and these mutations result in excess numbers of copy of these particular units. (hstalks.com)

The objectives of this study were to construct a normalized cDNA library for efficient EST analysis, to generate thousands of ESTs, and to analyze the ESTs for microsatellites and potential single nucleotide polymorphisms (SNPs). (nih.gov)
Other useful motifs include the dinucleotide repeats AG, AT, and AG, with frequency of length polymorphisms ranging from 11.2% to 18.4% (AT), 12.4% to 20.6% (AG), and 11.3% to 16.4% (GT). (arizona.edu)
However, studies have not highlighted the importance of other genetic polymorphisms in dapsone-induced severe cutaneous adverse reactions (SCAR). (bvsalud.org)

In this investigation, the genetic diversity and differentiation of 10 Iranian indigenous fat-tailed sheep breeds were investigated using 18 microsatellite markers. (unicatt.it)

The microsatellite motifs AG, AC, and ATG were found to be the most abundant in Douglas-fir (Pseudotsuga menziesii (Mirb. (psu.edu)

The establishment of a genetic profile means identification of a set of markers that are characteristic and unmistakable for a given individual (for example as a fingerprint). (genomia.cz)
DNA fingerprinting: Microsatellite DNA can be used to create a unique DNA fingerprint for an individual. (vajiramandravi.com)

Also, no isolation by distance was observed through comparison of genetic and geographical distances. (unicatt.it)

Many of the 8 extant bear species have large ranges, yet range-wide studies of genetic diversity are often impractical because of logistic challenges or focus on local questions. (bioone.org)
Yet there has not been a synthesis of these data within or among species because of difficulties comparing microsatellites. (bioone.org)
We end by summarizing what is known about within-species lineages and genetic diversity and identify priority areas for future studies. (bioone.org)
Then they bred two strains of a monogamous species, the prairie vole, one with a long version of the microsatellites and the other with a short version. (news-medical.net)
Researchers can analyse the genetic structure, population dynamics, and evolutionary relationships among various species of animals by analysing microsatellite DNA. (vajiramandravi.com)
However, the connectivity and genetic structure of species that survive in these urban landscapes has received little attention, especially with regard to epiphytic plants. (researchsquare.com)

The United States Department of Agriculture (USDA)-Agricultural Research Service (ARS)-National Clonal Germplasm Repository (NCGR) in Corvallis Oregon preserves genetic resources of many temperate fruit crops. (usda.gov)

The disease is caused by a gain-of-function mutation that leads to the expression of higher levels of a genetic element called an expanded microsatellite CUG repeat. (medindia.net)
For instance, if you've got a mutation caused by triplet repeat expansion, for instance in the Huntington's gene, where the trinucleotide repeats a CAG, you might have 17 CAGs in a normal chromosome. (hstalks.com)
Because of the number of diseases in this slide, I've chosen to focus on those in boxes for the most part, and I've chosen to focus on them because I think they illustrate the key genetic principles underlying this class of mutation. (hstalks.com)

2013 ). As such, low connectivity would be expected in urban landscapes, as well as high spatial genetic structure (SGS) (Chaves et al. (researchsquare.com)

The researchers first demonstrated in cell cultures that the vole vasopressin receptor microsatellites could modify gene expression. (news-medical.net)
The researchers used mice genetically engineered to carry the same defect and treated some of them with an antisense oligonucleotide, which is essentially a strand of genetic material that sticks to RNA to repair specific gene defects. (medindia.net)
Researchers achieved a significant milestone in uncovering the genetic basis of dilated cardiomyopathy in Dobermanns. (medindia.net)
The report of my death was an exaggeration: A review for researchers using microsatellites in the 21st century. (pacb.com)
Finally, we discuss the future of microsatellites and make recommendations for researchers preparing to use microsatellites. (pacb.com)

This assessment provides an extensive record of the genetic diversity of papaya in Puerto Rico which can contribute to breeding strategies and to the conservation of papaya genetic resources in the Caribbean. (urosario.edu.co)

Microsatellites are inherited in Mendelian manner. (genomia.cz)

Evaluation of genetic diversity among soybean (Glycine max) genotypes using univariate and multivariate analysis. (geneticsmr.com)
Both Bayesian clustering and principal coordinates analysis revealed the absence of a detectable genetic structure. (unicatt.it)
Genetic analysis of 62 Chinese families with Duchenne muscular dystrophy and strategies of prenatal diagnosis in a single center. (cdc.gov)
Using microsatellite analysis for loss of heterozygosity (LOH) at 11q13 and DNA sequencing of coding exons, the MEN1 gene was studied in 49 parathyroid lesions of patients with divergent symptoms, operative findings, histopathological diagnosis, and biochemical signs of nonfamilial pHPT. (lu.se)

Microsatellites are causative agents in a variety of diseases. (flashcardmachine.com)
Today I'm going to tell you about microsatellites, and trinucleotide repeat expansions diseases. (hstalks.com)
Targeted broad-based genetic testing by next-generation sequencing informs diagnosis and facilitates management in patients with kidney diseases. (cdc.gov)

From the standpoint of genetic selectin, the LG PRE ANCCE Stud Book published the genetic values and indexes for all horses that were genetically assessed throughout 2022. (usprea.com)

In breeds burdened with a specific recessive genetic disease the selected parents are tested for presence of this disease. (genomia.cz)

Early clonal genetic events in benign hyperplastic lesions show losses at chromosomes 9p21 and 3p. (medscape.com)

Such preferences may partly explain within-population patterns of genetic diversity. (elsevierpure.com)

What is the clinical significance of microsatellites? (flashcardmachine.com)
Biochemical signs and severity of symptoms of primary hyperparathyroidism (pHPT) differ among patients, and little is known of any coupling of clinical characteristics of nonfamilial pHPT to genetic abnormalities in the parathyroid tumors. (lu.se)

The genetic profile is needed for testing the relationship of individuals, particularly for the paternity verification. (genomia.cz)
The genetic profile identifies the sperm and can be used for verification of the paternity. (genomia.cz)
This can be proven either by direct testing for the genetic disease in question or by paternity proof - proving that the kitten is an offspring of the parents declared free of this genetic disease. (genomia.cz)

Anatomy1

Organisms1

Diseases4

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes41

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Polymorphism3

Loci5

SSRs6

Genotype1

Sequences13

Linkage4

Genomics2

Humans2

Locus6

Genome3

Molecular markers5

Variation7

Traits5

Polymorphic2

Populations12

Heterogeneity2

Characterization1

Marker6

Genetics3

Allele3

Sequence4

Variability1

Analyses1

ISSR1

Mutations3

Polymorphisms3

Differentiation1

Motifs1

Fingerprint2

Isolation1

Species6

Agriculture1

Mutation3

Spatial genetic1

Researchers5

Conservation1

Mendelian1

Analysis4

Diseases3

Genetically1

Breeds1

Lesions1

Patterns of genetic diversity1

Clinical2

Paternity3