• Puppies can be predisposed to develop joint disease if they are asked to do more than they should, such as jumping high or running long distances. (1800petmeds.com)
  • With the aid of genetic markers, researchers were able to provide conclusive evidence that the cancerous tumor cell evolved into a transmissible parasite. (wikipedia.org)
  • Researchers from Washington University School of Medicine in St. Louis have identified genetic mutations that can influence the accumulation of Tau proteins, according to Medical Daily. (foxnews.com)
  • Dr. Wolpin says as well as helping to develop a screening test for pancreatic cancer, another reason the discovery of the markers is important is that it will help researchers looking for molecular explanations of why some people are more susceptible to pancreatic cancer. (medicalnewstoday.com)
  • Researchers at the company are also analyzing data they hope will lead to better understanding of genetic factors that cause the disease. (deseretnews.com)
  • Researchers found a genetic risk score combining the top 10 variants was statistically associated with parents being centenarians. (eurekalert.org)
  • Researchers have identified 16 genetic markers associated with a decreased lifespan, including 14 new to science. (news-medical.net)
  • Researchers have long searched for molecular markers that track the rate of physical deterioration that accumulates with age. (sciencenews.org)
  • Northwestern University researchers have found a genetic marker associated with aggressive forms of prostate cancer . (slashdot.org)
  • Scientists have uncovered two related cytokines and associated genetic markers that may explain why some people develop progressive multiple sclerosis, or MS. The study, led by researchers at OHSU in Portland, Oregon, and Yale University, point the way toward developing the first-ever treatment to prevent progressive forms of the disease. (eurekalert.org)
  • Researchers also identified two genetic markers that enhance expression of MIF, and D-DT, that occurred more frequently in MS patients with progressive disease, particularly in men. (eurekalert.org)
  • Researchers believe that environmental factors may interact with genetic mutations to cause FSGS, at least in some patients. (clinicaltrials.gov)
  • University of Chicago researchers said they have identified a genetic marker that will help identify children most likely to develop asthma after they catch a cold. (sun-sentinel.com)
  • The researchers found that 90 percent of children under age 3 who wheezed after catching a cold and had the genetic marker, which is a DNA sequence associated with a particular gene, developed asthma by the time they turned 6. (sun-sentinel.com)
  • Those children who had two copies of the genetic marker were almost four times as likely to develop asthma as children who did not wheeze when they caught a cold and do not have the genetic marker, the researchers said. (sun-sentinel.com)
  • An international project involving Canadian scientists has identified scores of new genetic markers associated with the risk of breast cancer, a discovery that researchers believe will allow them to more precisely identify who is most at risk. (theglobeandmail.com)
  • We have developed a set of 400,000 markers with which we can study the genetics of the malaria vector mosquito Anopheles gambiae ," said Muskavitch, the DeLuca Professor of Biology at Boston College, who co-authored the paper with an international team of researchers. (scienceblog.com)
  • Researchers have linked genetic markers on eight chromosomes in the tissue surrounding breast tumors to the grade of the cancer and the spread of the disease to the lymph nodes. (emaxhealth.com)
  • In their work, the researchers tested the hypothesis that genetic alterations in stroma, or tissue surrounding breast tumors, significantly altered tumor behavior, as reflected in clinicopathological features at the time of diagnosis. (emaxhealth.com)
  • The researchers completed a cross-sectional analysis of DNA from the epithelium and stroma of 220 primary sporadic invasive breast cancer tumors to identify genetic alterations. (emaxhealth.com)
  • The researchers found eight significant genetic markers that correlated with variances in clinicopathological features. (emaxhealth.com)
  • Researchers conducting a meta-analysis of a large pool of genetic information relating to Type 1 diabetes have discovered new genes believed to be related to the disease, adding to the knowledge of the complex genetic interactions which cause diabetes as reported by DiabeticLive.com. (fiercebiotech.com)
  • WEDNESDAY, March 12 (HealthDay News) -- Certain genetic alterations in tumors and tissue from patients with early-stage lung cancer may identify those at greatest risk for cancer recurrence, say researchers at the Johns Hopkins Kimmel Cancer Center. (bio-medicine.org)
  • Fox Chase Cancer Center researchers have identified a genetic marker that is associated with an earlier onset of prostate cancer in Caucasian men who have a family history of prostate cancer. (biologynews.net)
  • The marker, while associated with drug resistance, likely does not play a functional role in enabling parasites to resist piperaquine, according to the researchers. (nih.gov)
  • The researchers analyzed the PNPLA3 gene, the most important genetic factor for both alcoholic liver disease and nonalcoholic fatty liver disease, according to Dunn, and specifically focused on the rs738409 polymorphism, a variation in a single base pair of DNA in the PNPLA3 gene. (healio.com)
  • Researchers found that only four of nearly 630 patients without either marker died as a result of papillary thyroid cancer. (southlakeoncology.com)
  • The researchers looked in rats' brains for the genetic instructions needed to make a key "pleasure receptor", called D2, that allows brain cells to receive signals sent by the brain chemical dopamine - or cocaine. (technologynetworks.com)
  • Identification of a causative mutation or marker will help researchers develop a genetic screening test to reduce disease prevalence in Newfoundlands and other at-risk breeds. (morrisanimalfoundation.org)
  • For one, there just weren't enough patients: In order to unearth a statistically significant genetic marker, researchers would need groups of patients much larger than what they had been able to assemble so far. (mit.edu)
  • By combining information on gene-disease associations with maps of chemical modifications known as epigenomic marks, which control what genes are turned on, the researchers were able to identify additional genetic contributors to a heritable cardiac disorder that makes people more susceptible to heart failure. (mit.edu)
  • Even before the development of the science of genetics, however, similarities of the language, skeleton, and teeth were being understood as crude genetic markers. (encyclopedia.com)
  • M. J. Iqbal, O. U. K. Reddy, K. M. El-Zik, and A. E. Pepper, "A genetic bottleneck in the 'evolution under domestication' of upland cotton Gossypium hirsutum L. examined using DNA fingerprinting," Theoretical and Applied Genetics , vol. 103, no. 4, pp. 547-554, 2001. (hindawi.com)
  • One of the most important findings in the study is that now we have a genetic marker that helps us identify those children with the highest risk of developing asthma,' said co-senior author Carole Ober, a professor of human genetics at the U. of C. 'In the first three years of life, one-third of children who get sick and wheeze go on to develop asthma. (sun-sentinel.com)
  • One justification for molecular genetics research on livestock and crop species is the expectation that information at the DNA level will lead to faster genetic gain than that achieved based on phenotypic data only. (genetics.org)
  • Rapid developments in cancer genetics have exposed a knowledge vacuum about genetic testing for susceptibility to cancer. (dtic.mil)
  • By studying the genetics of the tumours, they discovered that instead of one cancer, the tumours have three sub-types featuring distinct genetic abnormalities and leading to different outcomes for patients. (healthcanal.com)
  • Our world-class genetics research is focused on helping pet owners and veterinarians improve the health of pets with tools that define their genetic predispositions for health and disease. (medindia.net)
  • The identification of novel germline genetic loci involved in UM susceptibility in our study provides the first evidence of a link between the inherited genetics of pigmentation and UM risk. (eyecancer.com)
  • the U.S. Food and Drug Administration (FDA) , and academic institutions plans to identify and validate genetic markers that may help predict which individuals are at risk for serious adverse drug events. (highlighthealth.com)
  • It is rather remarkable that genetic alterations in seven chromosomal regions that predict for poor outcome, such as spread of tumor to the lymph glands and aggressive appearance of the tumor, reside in the stroma," said Dr. Eng. (emaxhealth.com)
  • Genetic Markers May Predict Lung Cancer R... ( DNA evidence in lymph nodes could alt. (bio-medicine.org)
  • CHICAGO - A research team identified genetic markers that predict which patients with hepatitis C and cirrhosis will most likely improve with direct-acting antiviral agent and those who will fail to improve or possibly worsen, according to a presentation at Digestive Disease Week. (healio.com)
  • working under the March of Dimes Prematurity Research Grants have identified genetic markers that help predict the risk of premature birth. (biotech-weblog.com)
  • In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. (google.com)
  • The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. (google.com)
  • In 2004, he and his students at the University of North Carolina at Chapel Hill used genetic analyses to identify red snapper, finding out that a significant number of the fish sold in markets were not what were advertised. (bio-medicine.org)
  • Seeking new pain markers continues to be very important in the field of nociception, which analyses the subjective experience of pain, and a need that has not yet been met," adds Torres P rez. (medindia.net)
  • Testing the associations in this study in the context of UM risk and the presence of ocular nevi will also be important in future analyses… Importantly, these genetic observations are also in clear alignment with previous epidemiological studies demonstrating that light eye color is indeed a UM risk factor. (eyecancer.com)
  • This new study brings to nine the total number of significant genetic markers that the scientists have discovered for pancreatic cancer. (medicalnewstoday.com)
  • But scientists at The University of Nottingham in the U.K. have identified genetic markers that they think will lead to vital new diagnostics for the condition. (fiercebiotech.com)
  • By identifying new genetic markers associated with breast-cancer risk, scientists envision a future in which a simple genetic test applied to the general population could determine which individuals need earlier and more frequent screening. (theglobeandmail.com)
  • The project, which involved some 550 scientists around the world and was carried out by the OncoArray Consortium, exemplifies the kind of collaborative research involved in pursuing personalized medicine, where treatment and interventions can be tailored to individuals based on their genetic profiles. (theglobeandmail.com)
  • A new genetic marker associated with ovarian cancer risk was recently discovered by an international research group, led by scientists from the Cancer Research Genetic Epidemiology Unit in the United Kingdom. (innovations-report.com)
  • Drs. Marc Goodman, Galina Lurie, Michael Carney, and Keith Terada of the University of Hawai'i at Mânoa's Cancer Research Center of Hawai'i participated in the validation of the discovered genetic marker as a part of the Ovarian Cancer Association Consortium, a worldwide forum of scientists performing ovarian cancer research. (innovations-report.com)
  • An international group of investigators led by scientists at Memorial Sloan Kettering Cancer Center (MSKCC) and the National Cancer Institute has identified a new genetic marker of risk for breast cancer . (mskcc.org)
  • A complete sequence would allow scientists to gain a clearer picture of the genetic processes that cause Type 1 diabetes. (fiercebiotech.com)
  • Since the human genome project was completed, scientists have compared the genetic make-up of thousands of people, in search of genetic differences associated with particular diseases. (mit.edu)
  • These studies, known as genome-wide association studies (GWAS), have revealed genetic markers linked with type 2 diabetes, Parkinson's disease, obesity, and Crohn's disease, among others. (mit.edu)
  • Background: Genetic factors that are associated with pancreatic cancer survival have previously been examined in Genome-Wide Association Studies (GWAS), but the results are inconsistent due to limited sample size. (aacrjournals.org)
  • Genetic and serological markers (antibodies) may have a role in identifying unclassified colitis. (edu.mt)
  • Serological and biochemical genetic markers in congenital cleft lip and cleft palate anomalies. (biomedsearch.com)
  • Serological and biochemical genetic markers in 76 patients with cleft lip with or without cleft palate [CL(P)] and 24 patients with isolated cleft palate (CP) were studied and compared with healthy control subjects. (biomedsearch.com)
  • 1e: To collect serum samples at the time of recruitment in a subset cohort (n=50 HD only, n=50 HD + HAEC) for serological immune markers known for inflammatory bowel disease (IBD) including ANCA, ASCA, OMPC, I2, and CBir1 and any newly identified markers. (centerwatch.com)
  • We aimed to identify genetic markers associated with breast cancer-specific survival. (harvard.edu)
  • Technically, the team in which the Spanish expert works has demonstrated in mice that a population of superficial neurons in the spinal cord controls an epigenetic marker known as pS10H3. (medindia.net)
  • It's also the first demonstration that a DNA tag called an epigenetic marker can predispose an individual to addiction and relapse. (technologynetworks.com)
  • A genetic marker is a trait transmitted from parent to child, thus potentially permitting the reconstruction of patterns of descent on the basis of its distribution among population members. (encyclopedia.com)
  • The method of tracking genetic inbreeding in a population through surname distribution is called isonymy. (encyclopedia.com)
  • About 10% of the population carries some configurations of these markers that shorten their life by over a year compared with the population average. (news-medical.net)
  • Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel," Human Mutation , vol. 31, no. 2, pp. 184-190, 2010. (hindawi.com)
  • In addition, our findings illustrate the complex genetic background of Cartagena population and reinforce the need to encompass more geographic regions to generate more robust data for anthropological and forensic applications. (scirp.org)
  • Conclusions Genetic diversities of ungenotyped regions of the genome (i.e. between markers) estimated by IBD-based methods and heterozygosity give similar results for the simulated population with a high marker density. (wur.nl)
  • Genetic maps of Vitis (2n=38) have been constructed from an interspecific hybrid population of 58 seedlings of the cross 'Horizon' ('Seyval' x 'Schuyler') x Illinois 547-1 ( V. cinerea B9 x V. rupestris B38). (cornell.edu)
  • Genetic tests can detect which animals might be carriers for specific diseases, so breeders can avoid mating them with another carrier. (medindia.net)
  • Thus, well-designed, multi-disciplinary investigations of genetic, immune and microbial etiologies of HAEC, with sufficient power to detect differences in disease phenotype are critically needed. (centerwatch.com)
  • W. Okello-Anyanga, K. Hansel-Hohl, A. Burg, S. Gaubitzer, P. R. Rubaihayo, J. Vollmann, P. T. Gibson, S. Fluch, E. M. Sehr (2017) Towards the selection of superior sesame lines based on genetic and phenotypic characterization for Uganda. (ait.ac.at)
  • These findings suggest that a simple genetic test could be used to identify MS patients at risk of developing the more severe form of the disease. (eurekalert.org)
  • In the long run, studies that demonstrate a genetic basis for FSGS may help us identify patients earlier and may lead to improved therapies. (clinicaltrials.gov)
  • But knowing individuals' genetic risk could allow clinicians to identify high-risk patients and screen them at a younger age and more frequently, while those with lower risk may need less-frequent screening, Simard says. (theglobeandmail.com)
  • The work of Dr. Eng and her colleagues indicates that genetic alterations within breast cancer tumors are likely the prime reason for the variability among patients. (emaxhealth.com)
  • Soon, we may be able to better care for patients by using a risk-adapted strategy based on a combination model of clinical, radiographic, laboratory, and genetic risk factors. (sciencemag.org)
  • Now, by comparing the complete genomes of 297 parasites isolated from Cambodian malaria patients to a reference malaria parasite genome, the team has identified two genetic markers that are strongly associated with the parasites' ability to resist piperaquine. (nih.gov)
  • The challenge became how to find a way to exploit this genetic deficiency to better treat these patients. (mcgill.ca)
  • Identifying this genetic marker continues to move toward precision medicine that we are seeing today, where health care providers can develop specific treatment plans based on the individual needs of patients," Dunn said in the press program. (healio.com)
  • The number of patients who died was also slight in cases where one or the other marker was found. (southlakeoncology.com)
  • When patients presented with both markers, however, the mortality rate rose to nearly 23 percent. (southlakeoncology.com)
  • Now it is possible to perform rigorous studies of the genetic, immune, and microbial differences in HD patients who develop HAEC compared with those children with HD that have not developed HAEC. (centerwatch.com)
  • The Xpert Carba-R Assay tests specimens directly taken from patients, which are usually obtained by rectal swabs, for the presence of five different genetic markers that are associated with carbapenemase, the enzyme produced by CRE. (infectioncontroltoday.com)
  • Blood group A phenotype and homozygous plasma haptoglobin (2-2) were found associated with CL(P). The findings suggest that the individuals possessing these markers are more likely to develop congenital CL(P). (biomedsearch.com)
  • Ethnicity has been associated with the incidence of diseases and consequently it is a cornerstone in medical genetic studies. (scirp.org)
  • A new strategy for controlling Marek's disease in poultry is to develop a line of chickens which are genetically resistant to the effects of the virus, and genetic markers may be a tool in controlling the virus, according to research completed by the U.S. Poultry & Egg Association and the U.S. Department of Agriculture's Agricultural Research Service Avian Disease and Oncology Laboratory . (wattagnet.com)
  • The SHCS investigators noted that certain genetic markers they analyzed are more common in nonwhites and that most of the nonwhites in this group were women. (natap.org)
  • WEDNESDAY March 12 (HealthDay News) -- Certain genetic alterations in. (bio-medicine.org)
  • A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in association studies. (nih.gov)
  • This is a critical time in the development of genetic testing for pets, which we believe is poised to expand dramatically as breeders, veterinarians and pet owners increasingly understand its benefits, exactly as it is currently happening for humans. (medindia.net)
  • They occur in less than 1 per cent of women, Simard says, whereas some of the newly identified genetic markers are much more common. (theglobeandmail.com)
  • Retrotransposons are also an ideal target for developing molecular marker techniques because of their amplification mechanism and sequence characteristics. (doaj.org)