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  • descent
  • A genetic marker is a trait transmitted from parent to child, thus potentially permitting the reconstruction of patterns of descent on the basis of its distribution among population members. (encyclopedia.com)
  • A common genetic marker is less valuable than a rare one, for the simple reason that a match between two samples is more likely to be due to chance, rather than to familial descent, if the genetic marker is a common one. (encyclopedia.com)
  • Dr. Jerome F. Strauss III, dean of the Virginia Commonwealth University's School of Medicine, found that African American babies are three times more likely than babies of European descent to have genetic variation of the SERPINH1 gene which results to the production of less collagen, and therefore weakened fetal membranes which contributes to an increased chance of premature rupture of the membranes and premature birth. (biotech-weblog.com)
  • likelihood
  • Although the predictive accuracy of the genetic-only model (positive likelihood ratio of 2.0) was comparable with that of the clinical-only model (positive likelihood ratio of 2.1), the combination of the two models generated a statistically significant increase in predictive power (positive likelihood ratio of 3.4). (sciencemag.org)
  • genome
  • The study used a genome-wide association design in which the frequencies of hundreds of thousands of genetic variations across the genome are compared between large numbers of cases and unaffected controls. (innovations-report.com)
  • indicate
  • People have increasing opportunities to participate in genetic testing that can indicate their range of risk for developing a disease. (highlighthealth.com)
  • In another step toward the dream of personalized medicine, Genaissance Pharmaceuticals Inc. said it has identified some genetic markers in people that indicate they will benefit most from cholesterol-lowering drugs. (wsj.com)
  • identify
  • A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species . (wikipedia.org)
  • One of the most important findings in the study is that now we have a genetic marker that helps us identify those children with the highest risk of developing asthma,' said co-senior author Carole Ober, a professor of human genetics at the U. of C. 'In the first three years of life, one-third of children who get sick and wheeze go on to develop asthma. (sun-sentinel.com)
  • This study will attempt to identify genetic factors associated with the development of FSGS. (clinicaltrials.gov)
  • In the long run, studies that demonstrate a genetic basis for FSGS may help us identify patients earlier and may lead to improved therapies. (clinicaltrials.gov)
  • Pulmonologists and geneticists in the Lung Center at Brigham and Women's Hospital are developing a novel study incorporating genetic testing to identify patients at risk for pulmonary fibrosis with the goal of detecting and treating the disease at earlier stages. (brighamandwomens.org)
  • We aimed to identify genetic markers associated with breast cancer-specific survival. (harvard.edu)
  • We present evidence that specific genetic markers have good statistical properties to identify the impacts of ADHD, depression and obesity. (repec.org)
  • Consortium
  • Drs. Marc Goodman, Galina Lurie, Michael Carney, and Keith Terada of the University of Hawai'i at Mânoa's Cancer Research Center of Hawai'i participated in the validation of the discovered genetic marker as a part of the Ovarian Cancer Association Consortium, a worldwide forum of scientists performing ovarian cancer research. (innovations-report.com)
  • Through the Ovarian Cancer Association Consortium, the most promising markers were subsequently investigated among an additional 7,922 women with ovarian cancer and 10,577 women without disease. (innovations-report.com)
  • In the future, the Consortium hopes that several more genetic markers will be identified, facilitating the establishment of a genetic screening test for ovarian cancer. (innovations-report.com)
  • help reveal
  • These markers help reveal a new dynamism from poor health to lower academic achievement with substantial heterogeneity in their impacts across genders. (repec.org)
  • study
  • Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a particular mutation of a gene that results in a defective protein ). (wikipedia.org)
  • To address this problem, the team is embarking on a novel research study involving both the clinical assessment and genetic testing of patients with established pulmonary fibrosis, and then testing their first-degree relatives for genetic risk factors. (brighamandwomens.org)
  • Testing of first-degree relatives (siblings and children) in this study will include CT scanning, pulmonary function testing, and genetic testing. (brighamandwomens.org)
  • In addition to exploring whether genetic testing can help in the earlier diagnosis of pulmonary fibrosis, an important part of this study is to understand whether or not providing otherwise- healthy family members with the results of their genetic tests causes more harm than good," said Dr. Raby. (brighamandwomens.org)
  • Pharmacogenetic markers that purportedly signal antiretroviral side effects predicted discontinuation of atazanavir, efavirenz, and tenofovir (but paradoxically not abacavir) within the first year of treatment in the Swiss HIV Cohort Study (SHCS) . (natap.org)
  • But they plan a randomized study to see if monitoring patients for toxicity-related genetic shifts can improve antiretroviral care. (natap.org)
  • The HCP5 genetic marker was not a good predictor of quitting abacavir, perhaps because the study considered stopping abacavir for any reason, not just the hypersensitivity reaction, and because people in Switzerland started getting HLA-B*5701 screening before beginning abacavir during this period. (natap.org)
  • The road to answering these questions may have a lot to do with specific genetic factors that vary from individual to individual, a new study in rats suggests. (technologynetworks.com)
  • premature
  • 1. Colombo S, Lubomirov R, di Iulio J, Martinez R, Gunthard HF, Telenti A. Association of pharmacogenetic markers with premature discontinuation of first-line ART. (natap.org)
  • patients
  • Evidence of linkage disequilibrium among these markers will be sought between patients with and without FSGS. (clinicaltrials.gov)
  • Soon, we may be able to better care for patients by using a risk-adapted strategy based on a combination model of clinical, radiographic, laboratory, and genetic risk factors. (sciencemag.org)
  • tissues
  • The new marker was found on chromosome 9, close to the BNC2 (basonuclin 2) gene that encodes a protein which plays a role in regulation of DNA transcription and is highly expressed in reproductive tissues. (innovations-report.com)
  • contributes
  • This marker is present among 32% of women and contributes an estimated 0.7% to ovarian cancer risk.The association of this marker with risk was stronger for serous carcinoma, the most common (and most lethal) ovarian cancer subtype. (innovations-report.com)
  • onset
  • You are thinking of the marker responsible for the onset of sudden eye distress, which often causes the gene at location 09f9 to switch on and offer some relief. (slashdot.org)
  • Markers such as this one are useful because they may help clinicians distinguish between men who are at risk for earlier onset of disease where intensive screening approaches can be discussed. (biologynews.net)
  • nucleotide
  • A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change ( single nucleotide polymorphism , SNP), or a long one, like minisatellites . (wikipedia.org)
  • relatives
  • The goal is to determine if genetic testing in these at-risk relatives helps to improve the rate of subclinical idiopathic pulmonary fibrosis (IPF) diagnosis. (brighamandwomens.org)
  • Genetic counseling will be provided, and results of the genetic testing will be communicated to those first-degree relatives who are tested. (brighamandwomens.org)
  • People
  • About 1 in 10 people carry some configurations of these markers that shorten their life by over a year compared with the population average. (news-medical.net)
  • depression
  • APOE ε4 might be a marker for identifying older persons at risk to develop depression or dementia , which could be important for prevention and early detection of these common disorders. (wired.co.uk)
  • Certain
  • At this point, though, it is not clear which markers have a negative predictive value high enough to reliably warn physicians away from using a certain drug. (natap.org)
  • gender
  • Gender had a big impact on genetic risk for efavirenz-related central nervous system toxicity. (natap.org)
  • Health
  • The impact of poor health on academic performance: New evidence using genetic markers ," Journal of Health Economics , Elsevier, vol. 28(3), pages 578-597, May. (repec.org)
  • data
  • The HardyWeinberg package o ers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. (upc.edu)
  • Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. (upc.edu)