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  • Phenotypes
  • Genetic heterogeneity occurs through the production of single of similar phenotypes through different genetic mechanisms. (wikipedia.org)
  • Increased understanding of the role of genetic heterogeneity and the mechanisms through which it produces common disease phenotypes will facilitate the development of effective prevention and treatment methods for these diseases. (wikipedia.org)
  • Although the phenotypes are identical for each gene, the linkage distance was eventually worked out. (wikipedia.org)
  • It considers neural characteristics as phenotypes (i.e. manifestations, measurable or not, of the genetic make-up of an individual), and is mainly based on the observation that the nervous systems of individuals, even of those belonging to the same species, may not be identical. (wikipedia.org)
  • molecular
  • PL analyzed the molecular and phenotypic data, constructed the genetic and QTL map, and drafted the manuscript. (springer.com)
  • Deoxyribonucleic acid (DNA) was shown to be the molecular repository of genetic information by experiments in the 1940s to 1950s. (wikipedia.org)
  • A necessary step for improving space radiation cancer risk assessment is to perform studies on the molecular pathways that can cause cancer initiation and progression, and to extend these studies to learn how such pathways can be disrupted by HZE ions, including both genetic and epigenetic modifications that are noted as the hallmarks of cancer (Figure 4-8). (wikipedia.org)
  • genetics
  • Autism has a strong genetic basis, although the genetics of autism is complex and it is unclear whether autism spectrum disorder (ASD) is explained more by multigene interactions or by rare mutations with major effects. (wikipedia.org)
  • While the genetic basis of simple diseases and disorders has been accurately pinpointed, the genetics behind more complex, neurological disorders is still a source of ongoing research. (wikipedia.org)
  • recombination
  • This process is known as genetic recombination. (wikipedia.org)
  • If linkage is complete, there should be no recombination events that separate the two alleles, and therefore only parental combinations of alleles should be observed in offspring. (wikipedia.org)
  • Through recombination, daughter cells have the greatest amount of genetic diversity. (wikipedia.org)
  • Studies
  • Significant linkage has subsequently been established for the linkage group comprised of DXS304, DXS15, DXS52, and F8C in several studies. (mysciencework.com)
  • To date, published linkage studies have provided no evidence of genetic heterogeneity in severe neonatal myotubular myopathy (XLMTM). (mysciencework.com)
  • The phylogenetic position of corals also suggests important applications for a coral genetic map in studies of ancestral metazoan genome architecture. (utexas.edu)
  • phenotypic
  • Alzheimer's disease is a complicated neurodegenerative disorder with multiple phenotypic subtypes, including clinical and preclinical, that result from different genetic origins. (wikipedia.org)
  • He argued that the effects of competition and genetic drift on populations, limited in genetic diversity, would overwhelm weak selection pressure acting on modifier alleles with nominal phenotypic consequences. (wikipedia.org)
  • evidence of genetic
  • The commentary discusses the use of publicly available data from online resources, methods for evaluating evidence of genetic versus environmental influences in a disease or disease‐related endophenotype, and use of e‐forms to capture data electronically. (currentprotocols.com)
  • allele
  • This method incorporates genetic map information but not allele frequency information and requires a strict genetic model (recessive and fully penetrant) and sampling scheme (exomes of two or more affected siblings must be sequenced). (biomedcentral.com)
  • We inferred genotypes at the location of HapMap Phase II SNPs, [ 34 ] as this resource provides comprehensive annotation, including the population allele frequencies and genetic map positions required for linkage analysis. (biomedcentral.com)
  • Data
  • We adapted our existing software [ 35 ] to extract HapMap Phase II SNP genotypes from WES data and format them for linkage analysis. (biomedcentral.com)
  • This may be an overestimate: new twin data and models with structural genetic variation are needed. (wikipedia.org)
  • Click Here for a video tutorial explaining genetic recombnation) One powerful tool for interpreting and graphing linkage data sets is called Hierarchical Clustering. (wikipedia.org)
  • In complete-linkage Hierarchical Clustering, this process of combining data points into clusters of increasing size is repeated until all date as part of a single cluster. (wikipedia.org)
  • Thomas Hunt M
  • The understanding of linkage was expanded by the work of Thomas Hunt Morgan. (wikipedia.org)
  • Thomas Hunt Morgan expanded the idea of linkage after noticing that in some instances the observed rate of crossing-over events differed from the expected rate of crossing-over events. (wikipedia.org)
  • statistical
  • Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer. (google.com)