• His group has pioneered the analysis of non-coding regulatory variants in the human genome and their effect on gene expression regulation, chromatin patterns and regulatory interactions and 3D genome interactions in cis and trans regulatory variants and how they are impacting cellular function as well as disease susceptibility and cancer. (wikipedia.org)
  • Genetic samples were obtained from several ongoing studies, including many funded by NIA: the Health and Retirement Study, the Age, Gene/Environment Susceptibility Reykjavic Study, and the SardiNIA Study of Aging, as well as dozens of other cohorts. (nih.gov)
  • Our approach builds on findings from large sample genome wide association studies to inform formation of polygenic scores that represent genetic risk for SUD and differential susceptibility to both risky and promotive family relationship dynamics. (hhs.gov)
  • The interactions of genetic susceptibility, immunity, and environmental factors are important in the pathogenesis of CD. (hindawi.com)
  • In recent years, increasing evidence has shown that autophagy-related genetic susceptibility is also closely related to the pathogenesis of CD [ 4 , 5 ]. (hindawi.com)
  • Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests that there is a genetic basis for this variability. (biomedcentral.com)
  • A variety of research findings suggest that there is a genetic basis for human susceptibility to S. aureus . (biomedcentral.com)
  • Priya Duggal, PhD, Associate Professor, Johns Hopkins Bloomberg School of Public Health, will discuss her research on host genetic susceptibility to infectious disease, focusing on AFM. (cdc.gov)
  • Scots pine ( Pinus sylvestris L.) is one of the most important tree species in European forests, characterized by high genetic variability and complex population structure. (seefor.eu)
  • Higher genetic variability makes the species more resilient and better adapted for survival in changing environmental conditions and in stress conditions (Villani and Eriksson 2006). (seefor.eu)
  • 2004), characterized by high genetic variability and complex population structure (Omanović 2008, Stefanović et al. (seefor.eu)
  • Estimates of effects of the dam's genotype, influencing the growth of her calf, were less sensitive to year-to-year variability. (usda.gov)
  • To learn more about prevalence and genetic variability of P. malariae in Africa, we examined blood samples from 663 asymptomatic and 245 symptomatic persons from western Kenya during June-August of 2014 and 2015. (cdc.gov)
  • Three-way ANOVA revealed a significant effect of treatments and years on growth of plants, accounting for more than 80% of the total variability. (frontiersin.org)
  • We examined the hypothesis that genetic variability (heterozygosity) within an individual plant would affect its dependent community, which adds a new dimension to the importance of genetic diversity. (mdpi.com)
  • Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. (cdc.gov)
  • I. Some effects of pyridine and their prevention by methionine [Abstract]. (cdc.gov)
  • Abstract Our overarching goal is to use new quantitative methods of capturing dynamic family interactions in early childhood to identify key mechanisms underlying genetic and family intervention effects on substance use and dependence (SUD) and mental health problems across adolescence. (hhs.gov)
  • article{b018f50c-e478-4679-80e3-a9de13827c99, abstract = {{Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. (lu.se)
  • In this study, we explore the regulatory role of mutations occurring in distal regulatory elements related to gene expression and phenotypic variations with adapted long-read ChIA-PET, and construct high-resolution chromatin interaction maps of maize promoter proximal regions and distal regulatory elements associated with RNA polymerase II occupancy and histone mark H3K4me3. (nature.com)
  • Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
  • This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. (elifesciences.org)
  • Conversely, phenotypic variation in genetically diverse populations is a result of both genetic and epigenetic factors operating in tandem. (elifesciences.org)
  • Understanding the scope and landscape of these interactions on a genome-wide scale is a vital step towards deciphering the genetic regulation of gene expression and, in turn, the mechanisms of non-coding variation on phenotypic outcomes. (elifesciences.org)
  • That genotype by environment interaction potentially influences genetic evaluation of beef cattle has long been recognized. (usda.gov)
  • The presence of genotype by environment interaction was examined using reaction norms wherein year effects on preweaning gain were hypothesized to linearly influence the EBV. (usda.gov)
  • Thus, changing systems of national cattle evaluation to more fully account for potential genotype by environment interaction would improve the assessment of breeding stock, particularly for direct effects. (usda.gov)
  • Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
  • Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
  • Change in genetic variation across environments is one of the many forms of genotype by environment interaction (G×E). G×E can be interpreted equivalently either as variable genetic architecture across environments or as variable environmental plasticity across genotypes, depending on what factor is chosen as the context. (nature.com)
  • By integrating expression quantitative trait locus (eQTL) and genome-wide association study (GWAS) data, we demonstrate that long-range chromatin interactions between variant regulatory elements and their target genes contribute to variations in gene expression, metabolic phenotypes, and agronomic traits. (nature.com)
  • Genetic interactions, obtained from genome-wide double-mutant screens, provide a key for interpreting the functional information contained in chemical-genetic interaction profiles. (nih.gov)
  • Although this study identified no common variant of large effect size to have genome-wide significance for association with either the risk of acquiring SAB or severity of SAB, the variant (rs2043436) most significantly associated with severity of infection is located in a biologically plausible candidate gene ( CDON , a member of the immunoglobulin family) and may warrant further study. (biomedcentral.com)
  • It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. (lu.se)
  • With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. (elifesciences.org)
  • Yet the interacting effects that genetic and epigenetic factors produce on gene transcription are rarely studied at a genome-wide scale, leaving us without global information on a key step between the genetic code and the phenotype. (elifesciences.org)
  • The traditional genome-wide association studies (GWAS) only consider one genetic factor at a time and then repeat the testing procedure to analyze all genetic factors, ignoring the joint effects. (ukbiobank.ac.uk)
  • We leveraged the genetically diverse Collaborative Cross (CC) mouse panel in conjunction with a library of Mtb mutants to create a resource for associating bacterial genetic requirements with host genetics and immunity. (elifesciences.org)
  • In a population of genetically diverse individuals, the extent of genetic variation of a phenotype measures the overall sensitivity of individuals to mutations segregating in the population. (nature.com)
  • Here we undertake a genome-scale analysis of these interactions in a genetically diverse population to systematically identify global genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure. (elifesciences.org)
  • In this article, we will discuss what schizophrenia is and what its potential causes are, and then introduce some of our recent research to investigate the combined genetic and environmental influences that can lead to this devastating condition. (scienceinschool.org)
  • NIH-funded study examines genetic influences on behavior. (nih.gov)
  • Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively. (bvsalud.org)
  • For this research, heights and root collar diameters of Scots pine plants on two provenance tests in Bosnia and Herzegovina were measured and the interaction between the effects of provenance genetic structure and habitat conditions for these two traits was estimated based on regression. (seefor.eu)
  • Both immunological and bacterial traits can be associated with genetic variants distributed across the mouse genome, making the CC a unique population for identifying specific host-pathogen genetic interactions that influence pathogenesis. (elifesciences.org)
  • Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
  • Opposing effects of plant traits on diversification. (sb-roscoff.fr)
  • We estimated the genetic parameters for two approximated (not entirely based on individual data) feed efficiency traits (lactation feed conversion ratio (LFCR) and residual energy intake (REI)) and daily milk yield (DMY) at different stages of lactation and throughout lactation. (bvsalud.org)
  • High genetic correlations were observed between the two efficiency traits and milk production traits, with a genetic correlation between LFCR and DMY of 0.74 ± 0.04 and between REI and DMY of -0.79 ± 0.04. (bvsalud.org)
  • A strong influence of environmental factors such as farm, year of milk production and lactation stage affected the genetic link between REI and milk production traits. (bvsalud.org)
  • In paper III we investigated whether genetic variants which were previously reported to be associated with lipid traits will exert different effects on obesity and blood lipid traits based on their parental origin. (lu.se)
  • Moreover, our results indicate possible sex-specific parental effects on some blood lipid traits. (lu.se)
  • As a result, we explored parent-of-origin effects on cardiometabolic and anthropometric traits in a birth cohort which was followed up from delivery until 18 years. (lu.se)
  • Our results indicate that the parental specific effects of cardiometabolic and anthropometric traits and associated genetic variants manifested in early life. (lu.se)
  • To systematically identify these interactions, an array of mutants is challenged with a compound and monitored for fitness defects, generating a chemical-genetic interaction profile that provides a quantitative, unbiased description of the cellular function(s) perturbed by the compound. (nih.gov)
  • To shed light on the underlying factors, this study investigated possible genetic and environmental factors that are common to negative career-goal appraisals and depressive symptoms among young adults. (cambridge.org)
  • Previous research has shown that genetic factors account for about 20 percent of variation in educational attainment. (nih.gov)
  • The initiation and severity of S. aureus infections is complex and influenced by at least 3 characteristics: bacterial virulence factors, host genetic factors, and the environment in which the host and pathogen interact. (biomedcentral.com)
  • In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
  • Importantly, the state of plasticity or homeostasis, with respect to either genetic or environmental variation, is not necessarily static and can be modified by both genetic and environmental factors. (nature.com)
  • We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. (isciii.es)
  • Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. (isciii.es)
  • The precise causes of asthma, although largely unknown, are multifactorial and involve a complex interaction of genetic and environmental factors. (ersjournals.com)
  • Researchers reviewed existing data on the genetic factors and the gene-diet interactions that could alter dietary management of type 2 diabetes. (news-medical.net)
  • Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. (lu.se)
  • In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. (lu.se)
  • These findings provide evidence that genetic and epigenetic factors operate within the context of three-dimensional chromatin structure. (elifesciences.org)
  • In addition to genetic factors, environmental factors such as parental education level, length of physical activity per week, and being a smoker or non-smoker are also relevant. (ukbiobank.ac.uk)
  • Importantly, the interactions between genetic factors and environmental factors, termed as Gene-Environment Interactions or GxE, are believed to have effects on BMI. (ukbiobank.ac.uk)
  • We propose to develop a novel approach that can simultaneously predict, identify important risk factors, and study the joint effects of GxE and genetic factors. (ukbiobank.ac.uk)
  • The dimension of genetic factors can be over hundreds of thousands, which is often much higher than the number of subjects in a study. (ukbiobank.ac.uk)
  • Including GxE interactions could increase the dimension of possible risk factors to millions. (ukbiobank.ac.uk)
  • Our research aims to identify possible risk factors including new GxE interactions for BMI and new genetic factors associated with BMI. (ukbiobank.ac.uk)
  • The aetiopathogenesis of RAS appears to be a complex interaction of genetic, nutritional and hematologic factors 11,12 . (bvsalud.org)
  • The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
  • Both genetic and environmental factors and their interaction play a pivotal role in the risk and development of the disease. (lu.se)
  • In this thesis we aim to better understand the effect of genetic and environmental factors by investigating parental effects manifesting from early life until adulthood. (lu.se)
  • We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
  • In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
  • On the other hand, no previous experimental study focused on the synergistic effects of edgetic mutations. (researchgate.net)
  • In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
  • There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
  • Some genetic conditions are caused by variants (also known as mutations) in a single gene. (medlineplus.gov)
  • In a recent publication, we applied CG-TARGET to a screen of nearly 14,000 chemical compounds in Saccharomyces cerevisiae, integrating this dataset with the global S. cerevisiae genetic interaction network to prioritize over 1500 compounds with high-confidence biological process predictions for further study. (nih.gov)
  • In a simulation study, estimates of the effect of a genetic variant were substantially higher when both an endophenotype and an environmental exposure modifying the variant effect were taken into account, particularly under transition models, compared to the alternative of ignoring the endophenotype. (ulaval.ca)
  • In order to further understand why depressive symptoms are associated with negative goal appraisals, the present study examined the genetic and environmental correlations and interactions between depressive symptoms and career-related goal appraisals. (cambridge.org)
  • These study results will enable us to ask more refined questions about the genetic and environmental underpinnings of educational attainment and their health consequences," said Jonathan W. King, Ph.D., program director in NIA's Division of Behavioral and Social Research, which supports the SSGAC. (nih.gov)
  • With that information and a DNA sample, investigators can conduct additional GWAS of other racial and ethnic groups, which could allow identification of new variants and genetic pathways associated with educational attainment and further validate the contribution of loci from the study reported today. (nih.gov)
  • If the methods used in this study were implemented in genetic evaluations that are conducted by breed associations, then seedstock producers could tailor their choice of animals for breeding to the environment found on their farm or ranch, or that of their commercial customers. (usda.gov)
  • The proposed study involves secondary analysis of existing videotaped observations of racially/ethnically diverse children and families from the Early Steps Multisite Trial, applying dynamic structural equation modeling and multivariate multilevel survival analysis to understand the effects of polygenic risk and family intervention on downstream adolescent SUD and mental health problems. (hhs.gov)
  • To study those interactions, I use isotopic and genetic tracers. (uwyo.edu)
  • Thus, our study indicates that direct interaction between chromatin and SWCNTs may contribute to genetic changes in somatic cells. (cdc.gov)
  • 4 The study was designed to understand the long-term effects of early childhood trauma-whether such trauma is one of the first dominoes in a long line that eventually leads to poor health outcomes in adulthood ( Figure 1 ). (psychiatrictimes.com)
  • A temporal and spatial study of genetic structure in four species of bladed Bangiales (Rhodophyta) from the southeastern Pacific coast of Chile. (sb-roscoff.fr)
  • Genetic analyses are a powerful approach that allow the study of these interactions. (elifesciences.org)
  • A study by Hull et al found that initiation of therapy within 8 hours of surgery had the greatest effect. (medscape.com)
  • This study measures the effect of emissions from an airport on the air quality of surrounding neighborhoods. (who.int)
  • Our study objectives were to assess the evidence for genetic involvement in the rate of lung function decline in a population of firefighters. (cdc.gov)
  • Thus, this study focused on the characterisation and genetic selection potential of feed efficiency in the Lacaune breed. (bvsalud.org)
  • Global celebrities' effect on health awareness among Jordanians: A study using the case of Angelina Jolie. (cdc.gov)
  • Comprehensive evaluation of a prospective Australian patient cohort with suspected genetic kidney disease undergoing clinical genomic testing: a study protocol. (cdc.gov)
  • The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)
  • Inconsistencies might be caused by differences in study design, study populations (geographic and ethnic background), statistical methods and power, allele frequencies, and gene-environment interactions. (cdc.gov)
  • However, little is known about the effect of gas cooking on bronchial responsiveness and on how this relationship may be modified by variants in the genes GSTM1 , GSTT1 and GSTP1 , which influence antioxidant defences. (bmj.com)
  • Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
  • This important work substantially advances our understanding of the interplay between genetic variation, chromatin, and genes within topologically associated domains and how this interplay regulates gene expression. (elifesciences.org)
  • Con la llegada de la técnica CRISPR, la posibilidad de corregir, cambiar y eliminar genes de una secuencia de ADN se ha convertido en una posibilidad de la ciencia. (bvsalud.org)
  • A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 families. (lu.se)
  • Neuronal control of behavior arises from the activity of underlying neural circuits, which in turn are specified by the interaction of various signaling pathways. (jneurosci.org)
  • Genotyping was done through an exome array enriched with genetic markers in specific pathways. (isciii.es)
  • Evidence links these drugs to severe adverse effects leading to life-shortening chronic diseases with little evidence of a therapeutic benefit. (ahrp.org)
  • In the case of mental patients, the issue is patients' legitimate refusal to take drugs with intolerable adverse-effects. (ahrp.org)
  • In the case of antipsychotics, the serious adverse effects are these drugs' primary effects, they are not rare side-effects. (ahrp.org)
  • This work demonstrates the successful translation and deployment of molecular genetic knowledge into specific MAS tools that can be easily applied in a selection or breeding program to efficiently screen MGR against WPBR in Alberta limber pine populations. (frontiersin.org)
  • Because educational attainment is a complex phenomenon, there are many additional sources of molecular genetic variation to be discovered. (nih.gov)
  • We employ a variety of surgical, molecular genetic approaches (e.g. (psu.edu)
  • Additionally, we evaluated the joint effect of the host and pathogen genomes in association with severity of SAB infection via logistic regression, including an interaction of host SNP with bacterial genotype, and adjusting for age (by decade), sex, the 6 significant principal components, and dialysis status. (biomedcentral.com)
  • We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP x physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. (lu.se)
  • Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). (cdc.gov)
  • Our results highlight the significance of 3D organization of regulatory elements and suggest that the topology of long-range genetic variations may affect gene expression as well as phenotype variation. (nature.com)
  • We classify the obtained interactions according to their class of epistasis, dependence on the chosen initial conditions and phenotype. (researchgate.net)
  • Structural equation modeling was used to evaluate the genetic and environmental correlations and gene-environment interactions between the career-goal appraisals and depressive symptoms. (cambridge.org)
  • Rank correlations of direct and maternal EBV appropriate to the 5th and 95th percentiles of the year effects were 0.67 and 0.92, respectively. (usda.gov)
  • Here, we have addressed these questions by altering intracellular Ca 2+ signals in flight-deficient itpr mutants through genetic means. (jneurosci.org)
  • Despite the utility of this approach, integrative analyses of genetic and chemical-genetic interaction networks have not been systematically evaluated. (nih.gov)
  • Analyses of P. malariae circumsporozoite protein gene sequences revealed high genetic diversity among P. malariae in Africa, but no clear differentiation among geographic populations was observed. (cdc.gov)
  • This thesis work combines analyses of long-term monitoring in a holm oak forest exposed to a rainfall exclusion experiment*, experimental manipulations of source-sink interactions involved in the resource allocation to reproduction, and modelling. (cnrs.fr)
  • I would like to summarize our analyses after genome project of E. coli and will report the present situation in Systems approaches, focusing on genetic interaction. (cam.ac.uk)
  • Analyses of these interactions has previously been limited, obscuring their regulatory context, and the extent to which they occur throughout the genome. (elifesciences.org)
  • This seminar will provide an introduction to Big Data and machine learning and potential public health applications, including examples from large scale analyses using National Health and Nutrition Examination Survey data to look at gene-environment interactions. (cdc.gov)
  • Both alleles influence the genetic trait or determine the characteristics of the genetic condition. (medlineplus.gov)
  • We revealed a saturating dose-dependent relationship but also allele-specific idiosyncratic interactions, including between alleles driving a step change in fruit size during domestication. (bvsalud.org)
  • We developed a method, called CG-TARGET (Chemical Genetic Translation via A Reference Genetic nETwork), that integrates large-scale chemical-genetic interaction screening data with a genetic interaction network to predict the biological processes perturbed by compounds. (nih.gov)
  • Additional investigation of the compatibility of chemical-genetic and genetic interaction profiles revealed that one-third of observed chemical-genetic interactions contributed to the highest-confidence biological process predictions and that negative chemical-genetic interactions overwhelmingly formed the basis of these predictions. (nih.gov)
  • Our approach successfully demonstrates the use of genetic interaction networks in the high-throughput functional annotation of compounds to biological processes. (nih.gov)
  • Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
  • Tomato (Solanum lycopersicum) is a rich source of lycopene, a carotenoid that confers various positive biological effects such as improved lipid metabolism. (researchgate.net)
  • various positive biological effects such as improved l ipid metabolism. (researchgate.net)
  • Although many new biological agents have been used for CD [ 3 ], they can cause certain side effects and drug resistance, and patients undergoing biological agent treatment are prone to relapse, which has a great impact on their daily life and work. (hindawi.com)
  • It is impossible to fully understand biological systems without understanding the 3D structure of their constituting parts and their interactions. (iscb.org)
  • To make this possible in Eshcrichia coli, which is one of the best organisms to understand cellular systems comprehensively based on the vast amount of accumulation of biological knowledge, we setup an easy and reliable system for construction double knockout strains by conjugation and for analysis of their growth effects. (cam.ac.uk)
  • Exposure to 2-nitrotoluene has also been associated with non-cancer effects in experimental animals, including developmental and reproductive effects as well as effects in the lungs, liver, spleen, bone marrow and the hematopoietic system. (gc.ca)
  • Margins of exposure were not calculated for non-cancer effects in this assessment since non-cancer effects occurred at a dose at which tumours were observed and because the information available indicates that exposures of the general Canadian population to 2-nitrotoluene from either environmental media or consumer products are expected to be negligible. (gc.ca)
  • BRIC-26 measures the effect of exposure to microgravity on three fundamental genetic processes and their interactions in the bacteria Bacillus subtilis . (nasa.gov)
  • Future studies in firefighters have been proposed to evaluate the interaction between exposure to products of combustion and genetic polymorphisms in relation to decline in lung function. (cdc.gov)
  • While the mode of induction of tumours has not been fully elucidated, based on the genotoxicity of 2-nitrotoluene, the tumours observed in the experimental animals are considered to have resulted from direct interaction with genetic material. (gc.ca)
  • Bacterial genetic characteristics also influence disease type and severity. (biomedcentral.com)
  • In a review article published in the journal Signal Transduction and Targeted Therapy, scientists have discussed host metabolic alteration triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect on disease severity. (news-medical.net)
  • We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
  • Here, we characterize epigenetic features of active promoter proximal regions and candidate distal regulatory elements to construct high-resolution chromatin interaction maps for maize via long-read chromatin interaction analysis by paired-end tag sequencing (ChIA-PET). (nature.com)
  • The recent expansion of repeated HERV sequences has offered a framework for genetic and epigenetic innovation. (mdpi.com)
  • Many have used a 100 to 500 kb flanking window around a gene to encapsulate the landscape of local epigenetic effects 3 - 5 . (elifesciences.org)
  • Chemical-genetic interactions-observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes-contain rich functional information linking compounds to their cellular modes of action. (nih.gov)
  • Many genetic variations outside protein-coding regions are associated with maize phenotypes. (nature.com)
  • Alternatively, organisms may develop homeostatic mechanisms to cushion the effect of environmental fluctuations without changing their phenotypes. (nature.com)
  • Our approach and findings expose an underexplored dimension of epistasis, in which cis-regulatory allelic diversity within gene regulatory networks elicits nonlinear, unpredictable interactions that shape phenotypes. (bvsalud.org)
  • This has drawn attention to possible benefits of studying populations where genetic heterogeneity might be reduced. (lu.se)
  • Estimates of environmental sensitivity parameters could also facilitate identification of genetic limitations to production. (usda.gov)
  • The most commonly used aggregate scores that define the family interaction may simply miss pathogenic dynamics. (hhs.gov)
  • My main interest revolves around the interaction between animal behavioral ecology, population dynamics, and ecosystem function. (uwyo.edu)
  • The dynamics of genetic variation (variance across different genotypes) and environmental variation (variance across different environments) may be controlled by different mechanisms. (nature.com)
  • Investigating the complex interactions that occur between the capsid protein of primate lentiviruses (including HIV) and human proteins, to understand the consequences of host evolution on viral replication. (uidaho.edu)
  • Although genetic diversity within stands of trees is known to have community-level consequences, whether such effects are present at an even finer genetic scale is unknown. (mdpi.com)
  • We establish the extent and structure of genotype-by-epigenotype interaction using embryonic stem cells derived from Diversity Outbred mice. (elifesciences.org)
  • Here, we present a method drawing on previous theoretical advances in population genetics [1] to interpret not only the functional effects of single genetic variants but also the epistasis effects from DMS data. (aps.org)
  • With extensive tests, our analysis reveals more consistent inference of mutational effects across experimental replicates compared to current methods. (aps.org)
  • Family interventions are central to evidence-based approaches to preventing and treating SUD, and direct observation of family interactions is the most rigorous way of measuring family interactions. (hhs.gov)
  • My research program uses molecular, proteomic, and physiological approaches to investigate insect-plant interactions. (psu.edu)
  • Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. (elifesciences.org)
  • Evidence about the effects of air pollutants on the occurrence of serious asthma is also unclear [ 2 ]. (ersjournals.com)
  • This has led to the concept of a "local area" in which most regulatory interactions take place. (elifesciences.org)
  • Further, we explored whether the relative contribution of genetic and environmental effects in career-goal appraisals differ as a function of depression. (cambridge.org)
  • Developmental theory on gene-environment interplay has highlighted the need to move away from focusing only on simple main effect models, thus, we examine genetic association in the context of dynamic social interactions and random assignment to a family-based intervention. (hhs.gov)
  • To examine the potential of nanotube s to induce genetic damage in normal lung cells, primary and immortalized human small airway epithelial cells were cultured and then exposed to single walled carbon nanotube s (SWCNTs) or a positive control vanadium pentoxide. (cdc.gov)
  • Knowledge of genetic variation among isolates from these geographic areas is still lacking. (cdc.gov)
  • To assess genetic variation among racial and ethnic groups in the U.S. population, we need genetic information from a large, well-designed, and population-based U.S. survey, such as the Third National Health and Nutrition Examination Survey (NHANES III) that includes the three major race/ethnic groups. (cdc.gov)
  • Estimates of heritability for direct and maternal effects, given the average environment, were 10 ± 2% and 26 ± 3% respectively. (usda.gov)
  • In the average environment, the genetic trends were 255 ± 1 g/yr for direct effects and 557 ± 3 g/yr for maternal effects. (usda.gov)
  • In summary, in this thesis we investigate paternal and maternal effects as a function of fetal programming and parentof- origin effects to better understand their influence on type 2 diabetes and insulin secretion. (lu.se)
  • Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions. (ulaval.ca)
  • For example, I investigate the effects of trade-off between nutritional requirements and risk of infanticide on consumption of salmon by female brown bears, and how female decisions made based on this trade-off influence the transfer of salmon-derived nutrients to terrestrial vegetation. (uwyo.edu)
  • The resulting maps are analyzed to identify and assess the roles of promoter proximal-proximal interaction (PPI) and proximal-distal interaction (PDI). (nature.com)
  • Local regulatory mechanisms within the genome and their interaction with chromatin structure give rise to subtle variations in gene expression. (elifesciences.org)
  • Effects may be manifest as alterations in DNA replication. (erowid.org)
  • Concomitant Genetic Alterations are Associated with Worse Clinical Outcome in EGFR Mutant NSCLC Patients Treated with Tyrosine Kinase Inhibitors. (cdc.gov)
  • We have developed a computational modeling framework for studying this process, where the combined effects of mechanical and genetic interactions are analyzed within the context of proliferating cells. (lu.se)
  • He continued his research career in Switzerland, as Professor of Genetics in the Department of Genetic Medicine and Development at the University of Geneva and in research centres including Frontiers in Genetics and the Swiss Institute of Bioinformatics in Geneva. (wikipedia.org)
  • This is an interesting development in behavior genetics," said NIA Director Richard J. Hodes, M.D. "It extends our understanding of the connection between the genetic components of cognition and years of formal education. (nih.gov)
  • It depends on genetic contributions to cognitive ability and other characteristics that motivate individuals to continue education, as well as substantial environmental contributions to educational success. (nih.gov)
  • Results could provide insight into how the interaction of DNA and environment affects gene expression and, ultimately, the observable characteristics in an organism. (nasa.gov)
  • It extends our understanding of the connection between the genetic components of cognition and years of formal education. (nih.gov)
  • Effects of genetic variants on the risk of complex diseases estimated from association studies are typically small. (ulaval.ca)
  • Interactions of associated loci were identified for MGR selection in trees with complex genetic backgrounds. (frontiersin.org)
  • The genetic architecture underlying SAB is likely to be complex. (biomedcentral.com)
  • Nonetheless, variants may have important effects in presence of specific levels of environmental exposures, and when a trait related to the disease (endophenotype) is either normal or impaired. (ulaval.ca)
  • Understanding the mutational effects of genetic variants is an important subject in evolutionary biology. (aps.org)
  • Other genetic and environmental effects and their interactions are important topics for future research. (nih.gov)
  • The maintenance of homeostasis is important for organismal fitness as it protects organisms from detrimental effects. (nature.com)
  • We further propose to develop a new model to identify important GxE and estimate their effects for varying quantiles of BMI. (ukbiobank.ac.uk)
  • For genetic counselling it would seem important to resolve the mode of genetic interaction. (lu.se)