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  • Genetics
  • He also has a strong interest in the role of genetics in cardiovascular disease and holds a PhD degree which is related to that. (schweitzer-online.de)
  • No currently plubished text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. (oup.com)
  • Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. (semanticscholar.org)
  • METHODS: Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. (ox.ac.uk)
  • A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. (coursera.org)
  • International Inflammatory Bowel Disease Genetics Consortium , Parkes M 25 , Vermeire S 31 , Rioux JD 2 , Mansfield J 32 , Silverberg MS 33 , Radford-Smith G 34 , McGovern DP 35 , Barrett JC 36 , Lees CW 37 . (nih.gov)
  • Umicevic Mirkov M, Verstockt B, Cleynen I. Genetics of inflammatory bowel disease: beyond NOD2. (springer.com)
  • These results indicate a substantial, but by no means total, contribution of genetics underlying susceptibility to both early-onset and late-onset PD, suggesting that, despite the novel associations discovered here and elsewhere, the majority of the genetic component for Parkinson's disease remains to be discovered. (plos.org)
  • Our study thus illustrates the ability of web-based methods for enrollment and data collection to yield new scientific insights into the etiology of disease, and it demonstrates the power and reliability of self-reported data for studying the genetics of Parkinson's disease. (plos.org)
  • As one of the first of its kind in South America, the Urugenomes Project is aimed at discovering the genetic basis of different diseases in Uruguay and laying the vital foundation for future growth of genetics in Uruguay through development of human resources and investment on infrastructures. (technologynetworks.com)
  • We hope that through this collaboration, the Uruguayan scientists will gain valuable insight into genetics and bioinformatics to lay the solid foundation for future Uruguayan genetic research. (technologynetworks.com)
  • polymorphism
  • Our analysis revealed that FSE cases did not encode an identifiable disease-associated PrP polymorphism. (bibsys.no)
  • Methods -DNA samples isolated from 61 patients with alcoholic liver disease, 46 patients with hepatocellular carcinoma, and 375 healthy controls were subjected to polymerase chain reaction amplification followed by digestion with the endonucleases Rsa I, Dra I, or Taq I. Meta-analysis was performed using data from previous studies of Rsa I polymorphism and the risk of alcoholic liver disease. (bmj.com)
  • Meta-analysis of this data and previous data concerning Rsa I polymorphism and alcoholic liver disease risk failed to demonstrate any significant association between the two. (bmj.com)
  • 3, 6- 13 Rsa I/Pst I polymorphism was investigated in all nine studies, most of which were unable to demonstrate any significant association between the polymorphism and the risk of developing alcoholic liver disease. (bmj.com)
  • 8 The Dra I polymorphism of the CYP2E1 gene is considerably more prevalent in white populations than the Rsa I/Pst I polymorphism 9, 11 and, therefore, could conceivably play a more important role in inherited susceptibility for alcoholic liver disease. (bmj.com)
  • allele
  • Conclusions -Possession of the less common Taq I cytochrome p4502E1 allele is associated with reduced susceptibility to alcoholic liver disease. (bmj.com)
  • 3, 6- 12 This conclusion has, however, not gained universal acceptance, particularly because one UK study reported a strong link between carriage of the less common Rsa I allele (c2) and an increased risk of developing alcoholic liver disease. (bmj.com)
  • pathogenesis
  • These findings clarify the pathogenesis and genetic architecture of PSP. (springer.com)
  • A deeper understanding of the genetic factors driving fibrogenesis might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapies. (springer.com)
  • Rieder F, Kessler S, Sans M, Fiocchi C. Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease. (springer.com)
  • 3- 13 Some of these discrepancies might relate to CYP2E1 having different putative roles in the pathogenesis of alcoholic liver disease in different ethnic groups. (bmj.com)
  • patterns
  • The researchers will be looking for particular DNA patterns that only appear in people who have the disease. (biotechlearn.org.nz)
  • An essential component of incorporating the X and Y into studies of human disease, with their unique inheritance patterns, and response to population history and selection, is to understand their evolutionary history. (labroots.com)
  • cardiovascular diseases
  • The striking thing about this book was that, despite the fact that it was written by different authors, they adopted similar framework and flow when addressing different aspects of cardiovascular diseases. (frontiersin.org)
  • Although largely preventable, cardiovascular diseases (CVDs) are the biggest cause of death worldwide. (frontiersin.org)
  • Despite the fact that cardiovascular diseases (CVDs) are largely preventable they are the biggest cause of death worldwide, responsible for almost one-third of all global deaths ( 1 ). (frontiersin.org)
  • novel
  • S. Haglund, S. Almer, C. Peterson, and J. Söderman, "Gene expression and thiopurine metabolite profiling in inflammatory bowel disease-novel clues to drug targets and disease mechanisms? (hindawi.com)
  • We also replicated 20 previously discovered genetic associations (including LRRK2 , GBA , SNCA , MAPT , GAK , and the HLA region), providing support for our novel study design. (plos.org)
  • We report two novel genetic associations and replicate a total of twenty previously described associations, showing that there are now many solid genetic factors underlying PD. (plos.org)
  • epidemiological
  • The theory of direct-indirect genetic effects and epidemiological concepts were combined to develop methodologies. (wur.nl)
  • Screening for antifungal susceptibilities during epidemiological surveillance programs could help to uncover putative multidrug resistant Sporothrix strains, and improve our ability to adjust therapeutic regimens and reduce relapse. (springer.com)
  • differences
  • The PAGE2 projects are aimed at unraveling subtle variations in the genetic makeup among racial and ethnic groups that may account for differences in underlying risks for conditions such as high blood pressure and high blood lipids, as well as common diseases such as cancer and heart disease. (healthcanal.com)
  • However, all canid PrPs contained aspartic acid or glutamic acid at codon 163 which we propose provides a genetic basis for observed susceptibility differences between canids and felids. (bibsys.no)
  • This situation allows differences in the genetic basis of disease to build naturally via genetic drift. (plos.org)
  • Alzheimer's
  • In a study looking at the association between apolipoprotein E gene variants and Alzheimer's disease, Farrer and colleagues* found that there was a strong association between the genetic variant epsilon4 ( APOE4 ), and the development of Alzheimer's disease. (phgfoundation.org)
  • The first consisted of reanalysing all their existing data based on common criteria, a total of more than 17,000 cases of Alzheimer's disease collected in Europe and North America, comparing them to some 37,000 non-diseased controls. (inserm.fr)
  • Firstly, this observation provides a better understanding of the physiopathology of Alzheimer's disease, an essential step to discovering new treatments. (inserm.fr)
  • Furthermore, this genome analysis better identifies the genetic profile of patients with a risk of developing Alzheimer's disease. (inserm.fr)
  • study
  • First the researchers need to study the DNA from a huge number of people who have a disease, and those who don't. (biotechlearn.org.nz)
  • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study," Journal of Hepatology , vol. 47, no. 5, pp. 711-717, 2007. (hindawi.com)
  • Study selection Randomised and quasi-randomised controlled trials involving adults in which one group received personalised DNA based estimates of disease risk for conditions where risk could be reduced by behaviour change. (bmj.com)
  • onset
  • It allows preventive measures to be taken to prevent the disease, or at least to delay its onset. (gene-decode.com)
  • Exposure to other causes of the disease (e.g. smoking) may also result in the onset of the disease. (gene-decode.com)
  • Autoantibodies directed against islet antigens are often detected at the onset of disease in affected individuals and are a distinctive signature of the autoimmune process that takes place at the initiation of the disease. (diabetesjournals.org)
  • Parkinson's
  • We analyzed the genetic correlation with multiple neurodegenerative diseases, and found that PSP had shared polygenic heritability with Parkinson's disease and amyotrophic lateral sclerosis. (springer.com)
  • In addition, this same regions is also found associated with two other neuro-degenerative diseases, multiple sclerosis and Parkinson's disease. (inserm.fr)