• To describe the genetic basis of the Rhodococcus oleaginous metabolism, we sequenced and performed comparative analysis of the 9.27 Mb R. opacus PD630 genome. (prolekare.cz)
  • A genetic understanding of the oleaginous metabolism of chemoheterotrophic species like Rhodococcus provides critical insight for biofuels development. (prolekare.cz)
  • Our preclinical efficacy testing services offer scientific expertise and an array of target-based and phenotype-based outcome measures, both in vivo and at endpoint, for flexible study designs and assay development in mouse models of muscular dystrophy. (jax.org)
  • To test whether the newly identified barren stalk plants have a different problem, the researchers performed genetic crosses, known as a complementation test, and concluded that the phenotype they observed in their plant was caused by a mutation in a totally different gene. (phys.org)
  • OVERVIEW - Genetic and environmental contributions interact to determine phenotype. (coursehero.com)
  • We set out to predict and experimentally test the functions of such proteins. (biomedcentral.com)
  • Previously the human nucleotide excision repair gene ERCC3 was shown to be responsible for a rare combination of the autosomal recessive DNA repair disorders xeroderma pigmentosum (complementation group B) and Cockayne's syndrome (complementation group C). The human and mouse ERCC3 proteins contain several sequence motifs suggesting that it is a nucleic acid or chromatin binding helicase. (eur.nl)
  • In this study, we tested the hypothesis that bacterial stress-responses are activated within biofilms. (frontiersin.org)
  • To test this possibility, transgenic mice were generated with 145- and 207-kb bacterial artificial chromosomes (BACs) that contained the human apoB gene and more extensive 5'- and 3'-flanking sequences. (caltech.edu)
  • Together, we propose that Lrp6 is one of the key genetic components for the pathogenesis of vertebral segmentation defects and of osteoporosis in humans. (biologists.org)
  • The big (and still somewhat controversial) conclusion from this study is that for species evolving in relatively small Ne (for example, trees and humans), genetic drift is too strong and natural selection is too weak to keep deleterious genomic features (such as transposons and other forms of 'extra genome space') out of the genome. (oregonstate.edu)
  • These include: autonomy of the rate of the mitotic division in some Minutes (Morata and Ripoll, 1975), induction of non-disjunction in the X-chromosome (Miklos, 1970), cell autonomy of some Minutes in chaetae differentiation, and cell lethality in genetic mosaics (Stern and Tokunaga, 1971), and their high rate of induction by ethylmethanesulfonate (Huang and Baker, 1976). (springer.com)
  • After identification of the underlying genetic defect in several disorders of cholesterol biosynthesis, we have shifted our research focus primarily to pathogenetic aspects of the inflammatory metabolic disorder mevalonate kinase deficiency (MKD), which is characterized by recurring episodes of inflammation and high fever. (amc.nl)
  • To test whether a methylation-sensitive restriction system contributes to poor B. burgdorferi transformability, shuttle plasmids were treated with the CpG methylase M.SssI prior to the electroporation of a variety of strains harboring different putative R-M systems. (umassmed.edu)
  • I have used this collection of plasmids to generate a physical-genetic map of the PR4 genome. (illinois.edu)
  • We show that rs is a hypomorphic Lrp6 allele by a genetic complementation test with Lrp6 -null mice, and that the mutated protein cannot efficiently transduce signals through the Wnt/β-catenin pathway. (biologists.org)
  • This temporal pattern of gene expression during sporulation in S. cerevisiae provides a simple model for studying the mechanisms by which morphological and genetic changes might control gene expression during development. (asm.org)
  • RNase protection, in situ hybridization, immunohistochemical, and genetic complementation studies revealed that the BAC transgenic mice manifested appropriate apoB gene expression in both the intestine and the liver, indicating that both BACs contained the distant intestinal element. (caltech.edu)
  • backcross A genetic crossing of a heterozygous organism and one of its homozygous parents. (kumc.edu)
  • Twenty-one predicted functions have been experimentally tested or are currently under investigation by our group in at least one prokaryotic organism (nine of them have been validated, four invalidated, and eight are in progress). (biomedcentral.com)
  • Crosses, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • A/J inbred mice are widely used to model cancer and for carcinogen testing given their high susceptibility to carcinogen-induced tumors. (jax.org)
  • While the pace of discovery of human genetic variants in tumors, patients, and diverse populations has rapidly accelerated, deciphering their functional consequence has become rate-limiting. (genetics.org)
  • Database of human genetic variants associated with longevity. (ageing-map.org)
  • Genetic complementation test also proved that Mo-01947_9 protein induces avirulence response in the pathogen in presence of Pi54 gene. (frontiersin.org)
  • To test whether CG12120 possesses these predicted activities, we produced recombinant CG12120 protein using a baculovirus expression system in insect cell culture (Figure 4). (nih.gov)
  • We spent time discussing one molecular test for the effects of natural selection on protein-coding sequences: the Ka/Ks test. (oregonstate.edu)
  • This is at its core a very simple test that is also very broadly applicable - all you need is two homologous protein-coding sequences to compare to each other. (oregonstate.edu)
  • This graph shows the total number of publications written about "Crosses, Genetic" by people in Harvard Catalyst Profiles by year, and whether "Crosses, Genetic" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Crosses, Genetic" by people in Profiles. (harvard.edu)