AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Transcription FactorsGene Expression Regulation, DevelopmentalHomeodomain ProteinsMSX1 Transcription FactorTranscription, GeneticIn Situ HybridizationDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTranscriptional ActivationBinding SitesTrans-ActivatorsSignal TransductionRNA, MessengerProtein BindingBasic Helix-Loop-Helix Transcription FactorsNuclear ProteinsTranscription Factor AP-1Cell LineRepressor ProteinsForkhead Transcription FactorsAmino Acid SequenceDNAMutationBasic-Leucine Zipper Transcription FactorsCell DifferentiationTranscription Factor AP-2TransfectionCell NucleusKruppel-Like Transcription FactorsCells, CulturedGenes, ReporterTranscription Factors, TFIIChromatin ImmunoprecipitationHeLa CellsYY1 Transcription FactorSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDNFATC Transcription FactorsReverse Transcriptase Polymerase Chain ReactionPaired Box Transcription FactorsNF-kappa BActivating Transcription Factor 3Sp3 Transcription FactorTranscription Initiation SiteElectrophoretic Mobility Shift AssayZinc FingersActivating Transcription Factor 2Enhancer Elements, GeneticGene Expression ProfilingTranscription Factor TFIIBRecombinant Fusion ProteinsGene ExpressionPhosphorylationRegulatory Sequences, Nucleic AcidCloning, MolecularE2F1 Transcription FactorRNA Polymerase IIPlasmidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsGATA3 Transcription FactorProtein Structure, TertiaryGene Expression Regulation, FungalModels, BiologicalGATA1 Transcription FactorGATA2 Transcription FactorGATA Transcription FactorsLuciferasesTCF Transcription FactorsCell Line, TumorMicrophthalmia-Associated Transcription FactorSTAT1 Transcription FactorActivating Transcription FactorsMice, KnockoutSaccharomyces cerevisiaeTranscription Factor RelASaccharomyces cerevisiae ProteinsProto-Oncogene ProteinsOligonucleotide Array Sequence AnalysisSequence Homology, Amino AcidBlotting, WesternE2F Transcription FactorsChromatinHelix-Loop-Helix MotifsGene Expression Regulation, PlantCyclic AMP Response Element-Binding ProteinDown-RegulationMice, TransgenicActivating Transcription Factor 1GATA6 Transcription FactorTumor Cells, CulturedActivating Transcription Factor 4Transcription Factor 7-Like 1 ProteinUp-RegulationMice, Inbred C57BL
Neural crestDevelopmentalFibroblast GrowthGeneEmbryoCoordinateCharacteristicsExpressionDiseaseHomeoboxInteractionsGenesRegulatoryPathwaysMolecularOrganizerTargetsLeadCellNetworkShownShowSpecificResultsCellsMuscle
Neural crest4
  • Underlying the development of neural crest is a gene regulatory network, described as a set of interacting signals, transcription factors, and downstream effector genes that confer cell characteristics such as multipotency and migratory capabilities. (wikipedia.org)
  • A molecular cascade of events is involved in establishing the migratory and multipotent characteristics of neural crest cells. (wikipedia.org)
  • In coherence with this observation, the promoter region of slug (a neural crest specific gene) contains a binding site for transcription factors involved in the activation of Wnt-dependent target genes, suggestive of a direct role of Wnt signaling in neural crest specification. (wikipedia.org)
  • Morphorgens such as Wnt, fibroblast growth factor (FGF), retinoic acid (RA) and bone morphogenetic protein (BMP) secreted from the paraxial mesoderm and epidermis regulates the expression of a group of transcription factors ( Pax3, Zic1, Msx1 ) whereby defines the boarder of neural crest. (biomedcentral.com)
Developmental2
  • The nested and interrelated signaling pathways that bring about a specific developmental process are known as developmental cascades. (medscape.com)
  • My goal is translate an improved molecular genetic and developmental understanding of congenital heart disease from the laboratory into clinically actionable models, diagnostics, and ultimately therapeutic interventions. (stanford.edu)
Fibroblast Growth1
  • Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
Gene1
  • Many molecules and some gene cascades have been identified in the initial phases of tooth development: bud, cap, bell, and to a lesser degree, root formation 4-10 . (bvsalud.org)
Embryo1
  • In the embryo, zygotic transcription of Eph is confined to the nervous system. (sdbonline.org)
Coordinate1
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
Characteristics2
  • However, the clinical characteristics and genetic etiology underlying TGA remain largely unexplored. (stanford.edu)
  • Objective: We sought to systematically examine the clinical characteristics and genetic etiology for isolated nonsyndromic TGA. (stanford.edu)
Expression2
  • Signaling events that establish the neural plate border lead to the expression of a set of transcription factors delineated here as neural plate border specifiers. (wikipedia.org)
  • We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit. (molcells.org)
Disease1
  • With my combined research training in genomics and clinical training in pediatric cardiology I endeavor to close this gap with investigation into the genetic basis of congenital heart malformations and developing new models of disease. (stanford.edu)
Homeobox1
  • 6. The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb. (nih.gov)
Interactions2
  • So far, there is a small set of curated known interactions between transcription factors and their downstream genes. (hindawi.com)
  • Here, we built a transcription factor network for human monocytic THP-1 myeloid cells based on the experimentally curated FANTOM4 database where nodes are genes and the experimental interactions correspond to links. (hindawi.com)
Genes5
  • Our aim was to study a large number of genes encoding either transcription factors or key components in signaling pathways shown to be involved in tooth odontogenesis. (nih.gov)
  • We selected 8 genes-MSX1, PAX9, AXIN2, EDA, SPRY2, TGFA, SPRY4, and WNT10A-and performed one of the largest case-control studies taking into account the number of genes and variants assessed, aiming at the identification of MLIA susceptibility factors. (nih.gov)
  • Genes like ZHX2, ADNP, or SMAD6 seem to be highly regulated to avoid an avalanche transcription event. (hindawi.com)
  • On the other hand, a reduced set of genes, called transcription factors (TFs), has the role of regulating the transcriptional program of the cells. (hindawi.com)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Regulatory2
  • 9. A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis. (nih.gov)
  • For understanding the whole program in the embryonic blood cell differentiation, it is important to elucidate the molecular mechanisms underlying the tissue-tissue interaction, in addition to the analysis of the regulatory cascade that takes place in the mesodermal cells. (bioone.org)
Pathways3
  • This suggests that the same transcription factors and signaling pathways could activate cell-type-specific responses in multiple components of the musculoskeletal complex that may help coordinate the development of this intricate system. (elifesciences.org)
  • The nested and interrelated signaling pathways that bring about a specific developmental process are known as developmental cascades. (medscape.com)
  • At the molecular level, the organizer's inductive properties are mediated by factors that inhibit the BMP, Wnt, and Nodal signaling pathways. (biomedcentral.com)
Molecular3
  • A molecular cascade of events is involved in establishing the migratory and multipotent characteristics of neural crest cells. (wikipedia.org)
  • During the last five years, enormous progress has been made in understanding the molecular basis of circadian systems, mainly by molecular genetic studies using the mouse and fly. (bioone.org)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Organizer1
Targets1
  • The lack of experimental information regarding the regulation of the whole set of transcription factors and their targets in different cell types is one of the main reasons to this incompleteness. (hindawi.com)
Lead1
  • Disturbances in these signaling cascades can lead to abnormalities in odontogenesis, resulting in alterations in the formation of the normal teeth number. (nih.gov)
Cell2
  • The modification of proteins by s mall u biquitin-related mo difier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes, such as chromosome organization, DNA replication and repair, transcription, nuclear transport, and cell signaling transduction. (mdpi.com)
  • The down-stream target molecules of the BMP-4 signaling, such as vent-1/2 and msx-1/2 are the positive regulators for muscle tissue differentiation, whereas these factors do not promote blood cell formation. (bioone.org)
Network1
  • We present the topological parameters which define the network as well as some global structural features and introduce a relative inuence parameter to quantify the relevance of a transcription factor in the context of induction of a phenotype. (hindawi.com)
Shown1
  • We believe that an approach, such as the one shown here, could help to understand the one regulation of transcription in eukaryotic cells. (hindawi.com)
Show1
  • We show that compound genetic inactivation of Sfrp1 and Sfrp2 prevents Wnt/β-catenin signalling activation in this structure, which fails to be specified and acquires neural retina characteristics. (biologists.com)
Specific1
  • Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
Results1
  • This large study results in a better understanding of the genetic components and mechanisms underlying this trait. (nih.gov)
Cells1
  • It has not yet been elucidated how the BMP-4 signaling promotes the differentiation of blood cells, but it is likely that transcription factors such as GATA-2, SCL, LMO-2, biklf and GATA-1 are at least involved in the initial blood program. (bioone.org)
Muscle1
  • 11. Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors. (nih.gov)