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  • researchers
  • Researchers at North Carolina State University have discovered that the placentas of women who suffer preeclampsia during pregnancy have an overabundance of a gene associated with the regulation of the body's immune system. (medicalnewstoday.com)
  • The researchers were excited by this finding because SIAE has recently been linked to autoimmune diseases like rheumatoid arthritis and type I diabetes . (medicalnewstoday.com)
  • A study of the human genome led by Cedars-Sinai researchers has now identified genes linked to ulcerative colitis, offering clues as to what causes the condition and potential avenues for new therapies to treat the disease. (medicalnewstoday.com)
  • Researchers think some genes contribute to how we control our appetites, and others to learning and memory around food. (healthcentral.com)
  • Since its creation in 2006, researchers have used the Cardiochip to pinpoint gene variants in dozens of studies. (sify.com)
  • For the new study, the researchers identified the top nine genetic variants that have been associated with Alzheimer's disease risk, not including the APOe4 gene that has long been linked to increased risk for several characteristics of Alzheimer's disease. (psychcentral.com)
  • Now, researchers at the University of Illinois at Chicago have discovered a gene linked to alcohol dependency. (innovations-report.com)
  • The gene the researchers investigated manufactures a protein called CREB, or cyclic AMP responsive element binding protein, which is known to regulate brain function during development and learning. (innovations-report.com)
  • The researchers found that 7 out 315 infertile men tested possessed a mutated form of the gene. (www.nhs.uk)
  • The researchers say that mutations in the NR5A1 gene have previously been associated with significant genital abnormalities and more severe developmental abnormalities of the testes and ovaries. (www.nhs.uk)
  • The researchers then assessed the genetic sequence of the NR5A1 gene in both these sets of men. (www.nhs.uk)
  • To test the effects of any mutations identified in this gene, the researchers genetically modified cells in the laboratory to contain the mutated form of the gene. (www.nhs.uk)
  • When the researchers engineered cells to carry the mutated gene, they found that the protein produced by mutant NR5A1 was in the appropriate location of the cell (the nucleus), but its function (controlling the activation of genes) was impaired. (www.nhs.uk)
  • The researchers say that their experiments using cell culture show that mutations in this gene may lead to a "functional disturbance of the NR5A1 protein", which may affect the subsequent regulation of genes that is normally seen during the development and functioning of the testes and ovaries. (www.nhs.uk)
  • The two genes were, by the researchers' admission, "relatively very small" contributors to an individual's overall vulnerability to developing PTSD. (latimes.com)
  • The existence of a study population with clear genetic links, common family histories, and exposure to a single trauma allowed researchers an unusual opportunity to distill information about genes' role in PTSD, said UCLA psychiatrist Armen K. Goenjian, who led the study. (latimes.com)
  • An international team of researchers led by a Fred Hutchinson Cancer Research Center geneticist has discovered two genes linked to a disabling form of arthritis called ankylosing spondylitis , a painful and progressive disease in which some or all of the spine's vertebrae fuse together. (emaxhealth.com)
  • The researchers also validated the association of two genes implicated in Graves' disease, an autoimmune condition that causes overactivity of the thyroid gland. (emaxhealth.com)
  • The discovery of both genes, as well as the validation of two prime genetic suspects in Graves' disease -- genes known as TSHR and FCRL3 -- arose from a comprehensive scan of the human genome in which dozens of researchers used genotyping technology to analyze DNA samples from thousands of patients suffering from a variety of common diseases and compared them to DNA from a similar number of healthy control subjects. (emaxhealth.com)
  • With these new clues in hand, researchers next will study the genes in model organisms to work out the pathways by which they cause disease. (emaxhealth.com)
  • The first MS susceptibility gene was discovered in the mid-1970s, when researchers found that immune system proteins known as human leukocyte antigens (HLA) account for some of the genetic basis of MS. Still, scientists have long realized that other genes also play a role. (nih.gov)
  • Researchers have discovered new genes linked to schizophrenia, it has been revealed. (science20.com)
  • Researchers have tied two genes to a deadly ovarian cancer that is generally resistant to chemotherapy. (emaxhealth.com)
  • researchers have concluded that a complex variant of the C4 gene is a major risk factor for schizophrenia . (metafilter.com)
  • The gene was hidden in the dauntingly complex and variable area of the genome which controls much of the immune system, which had made it invisible to previous genome-wide association studies and led some previous researchers to propose that schizophrenia might be an auto-immune disorder. (metafilter.com)
  • Although a higher "dose" of these genes carried by these patients predicted better response to the anti-VEGF drug ( P ≤0.0001), it didn't predict the effect of photodynamic therapy or sham treatment, the researchers reported here at the American Academy of Ophthalmology meeting. (medpagetoday.com)
  • The researchers used next-generation DNA sequencing to analyze genes linked to dementia. (innovations-report.com)
  • SAN FRANCISCO -- The gene thought most likely to be responsible for a poor response to clopidogrel (Plavix) may raise cardiovascular risk for homozygous carriers even when they aren't on the antiplatelet drug, researchers said. (medpagetoday.com)
  • For the study, the researchers analyzed the entire human genome to identify links between genetic variations and hot flashes and night sweats. (drugs.com)
  • The researchers said their finding could lead to new treatments that might help ease symptoms of menopause, but more research is needed to understand how other rare gene variants could affect hot flashes. (drugs.com)
  • Researchers have found a major piece of genetic evidence that confirms the role of a group of virus-fighting genes in cancer development. (biologynews.net)
  • But although researchers know that the number of repeats is broadly linked to how early someone will develop Huntington's - the more you have, the earlier you'll get it - it's still highly variable, so there must be other factors involved. (thenakedscientists.com)
  • A new gene linked to both depression and bipolar disorder has been identified by UCL (University College London) and Danish researchers. (innovations-report.com)
  • For the first time, researchers at the Translational Genomics Research Institute (TGen) and Barrow Neurological Institute have identified genetic risk factors that are linked to stress-induced cardiomyopathy (SIC), a rare type of heart disease. (medindia.net)
  • Using ultra-high resolution cameras and supercomputers, researchers identified the suspect genes by next generation DNA sequencing, essentially by spelling out the billions of bits of information in the genomes of seven women who exhibited SIC following a brain aneurysm. (medindia.net)
  • Researchers pin down two genes that may be responsible for abnormal neural development in Down's mice embryos. (scientificamerican.com)
  • The researchers conclude in their paper that these genes may be useful as 'biomarkers for the rational development of early interventional therapies of the cognitive impairments in DS. (scientificamerican.com)
  • Researchers linked the problems to a specific region of the mutated proteins whose normal function was unclear. (redorbit.com)
  • In a study published online June 30 in Science Express, the Johns Hopkins researchers say they have identified two genes that, when defective, may cause these telomere elongations. (redorbit.com)
  • By identifying genes important for atrial fibrillation, researchers constructed a risk score to help identify high-risk individuals and monitor them accordingly, which 'may have important implications for precision health and prevention of cardiovascular disease', Willer said. (mid-day.com)
  • Using data from 25,000 people, researchers from the Faculty of Medicine and University College London's Institute of Neurology discovered that a rare genetic mutation in the TREM2 gene - which helps trigger immune system responses - is also associated with increased risk of Alzheimer's. (utoronto.ca)
  • Michigan Technological University researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig's disease. (innovations-report.com)
  • Their findings will need to be confirmed by other researchers, but I think this will be very useful for the investigators who are trying to find genes underlying complex diseases such as ALS," said Zhu. (innovations-report.com)
  • Their method, a two-locus interaction analysis approach, allows the researchers to identify multiple genes associated with a complex illness. (innovations-report.com)
  • The researchers analysed 156 melanoma tissue samples from 129 individuals for expression of the protein p63 - the protein encoded by the gene TP63. (innovations-report.com)
  • The researchers suggest that the TP63 gene, and the subsequent production of the protein p63 in some melanoma, is inhibiting the apoptotic function of the protein p53. (innovations-report.com)
  • WEDNESDAY, Oct. 22 -- Researchers have identified 26 genes associated with the most common type of lung cancer, adenocarcinoma -- more than doubling the number of genes known to play a role in the deadly disease. (drugs.com)
  • The researchers determined the DNA sequence of 623 genes in 188 lung adenocarcinomas. (drugs.com)
  • Scientists
  • Scientists have identified genes involved in Obsessive Compulsive Disorder (OCD) in dogs. (biomedcentral.com)
  • The scientists from institutions including the Broad Institute and Uppsala University used a range of techniques to narrow down the regions of the genome involved in OCD to pinpoint four genes which were consistently linked to the disease in a range of dog breeds that are particularly susceptible to OCD - Doberman pinschers, bull terriers, Shetland sheepdogs and German shepherds. (biomedcentral.com)
  • The overlapping teams of scientists used different gene-hunting strategies. (nih.gov)
  • The genome-wide scan also identified nearly a dozen other genes that could represent risk factors for MS. These results give scientists new ways of looking at the biology of MS and suggest potential new strategies for developing treatments. (nih.gov)
  • In two papers published in Nature today (July 30), scientists identify four mutated gene regions that may hold the key to producing new tailor-made drugs to treat the devastating mental illness. (science20.com)
  • The Scottish scientists were previously instrumental in the discovery of the first schizophrenia gene, DISC1, which was eventually cloned in 2000. (science20.com)
  • Clear cell ovarian cancer - the most resistant to treatment - has been found by Johns Hopkins scientists to be linked to two genetic mutations. (emaxhealth.com)
  • She says it's likely they carry mutations in genes that scientists don't yet know about. (innovations-report.com)
  • A team of scientists from the University of California, Los Angeles says it identified gene variants that affect a brain receptor that regulates the release of estrogen. (drugs.com)
  • Scientists at the University of Leeds, working in collaboration with experts from other centres around the world, identified the gene, which is essential to photoreceptors in the eye, the cells that "see" light. (news-medical.net)
  • Scientists at Moorfields Eye Hospital, London, recently announced the start of clinical trials for a gene therapy involving injecting genes into the eye of patients with LCA to restore their sight. (news-medical.net)
  • Now, a collaborative team of scientists working with a mouse model of DS has discovered that just two genes are responsible for the majority of the brain abnormalities present in their animals. (scientificamerican.com)
  • In the new study led by Tarik Haydar, then at the Children's National Medical Center in Washington, D.C., the scientists sought to determine which of the extra genes in the DS mice are responsible for brain defects. (scientificamerican.com)
  • An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease. (utoronto.ca)
  • St George-Hyslop, renowned for identifying five genes associated with Alzheimer's disease, said the breakthrough is, "another win for U of T scientists who are building on a worldwide legacy of expertise in neurodegenerative research. (utoronto.ca)
  • Scientists at Queen Mary, University of London have identified a gene present in some melanoma which appears to make the tumour cells more resistant to treatment, according to research published today in the Journal of Experimental Medicine. (innovations-report.com)
  • The scientists discovered that the gene TP63 is unexpectedly expressed in some melanoma and correlates significantly with a worse prognosis. (innovations-report.com)
  • abnormalities
  • These are exciting new findings because the chromosomal abnormalities that have been described will be signposts to other genes involved in illness and hopefully lead on to new drug discoveries and novel treatment approaches. (science20.com)
  • The increased frequency of this common cancer signature in breast cancer patients with APOBEC gene abnormalities supports our theory that these enzymes play a role in generating this mutational signature," says Dr Serena Nik-Zainal, first author from the Wellcome Trust Sanger Institute. (biologynews.net)
  • Professor Hugh Gurling, UCL Department of Mental Health Sciences, says: "The next step is to determine the role of the Slynar gene in the brain and how abnormalities in this gene may cause bipolar disorder. (innovations-report.com)
  • role
  • But the role of other genes in obesity is not yet understood. (healthcentral.com)
  • The variants linked to PTSD were on genes that had some key things in common: Both have a role in governing the quantity and action in the brain of the neurotransmitter serotonin. (latimes.com)
  • Siân Jones, Ph.D., research associate at the Johns Hopkins Kimmel Cancer Center says, "This gene may play a significant role in this type of cancer. (emaxhealth.com)
  • Importantly, all of these genes were previously known to play a role in other cardiac diseases, but not in SIC. (medindia.net)
  • The results 'very much expand our understanding of just how these imbalances come to be in the first place, and demonstrates the specific role of [these genes] in this imbalance,' Reeves says. (scientificamerican.com)
  • In an accompanying editorial, Anthony L. Cunningham, MD, and David Booth, MD, of the Centre for Virus Research and the Institute of Immunology and Allergy Research at Westmead Millennium Institute and the University of Sydney in Australia, note that if the findings regarding the C21orf91 gene are confirmed, additional research may then begin to determine possible therapeutic applications and whether the same gene also plays a role in recurring genital herpes. (scienceblog.com)
  • Following a hunch, Meeker and his colleagues took a closer look at the two genes and their specific role in telomere lengthening. (redorbit.com)
  • It is important to study the role of the mutated genes in the growth and survival of lung cancer cells, which will help us work toward new treatments. (drugs.com)
  • disrupt
  • Without telomeres, the cell division-related shortening could snip off a cell's genes and disrupt key cell functions. (redorbit.com)
  • colleagues
  • Patients with a combination of three genes related to wound repair had a gain of 24 letters of visual acuity whereas those without any of the three actually lost 7.6 letters during ranibizumab treatment, Jason S. Ehrlich, MD, PhD, of Genentech in South San Francisco, and colleagues found. (medpagetoday.com)
  • Using data sets provided by University of Cambridge, Zhang, Sha and their colleagues have also identified 11 genes linked to type 2 diabetes, which has reached epidemic proportions in the U.S. (innovations-report.com)
  • biomarkers
  • According to Nickolas Papadopoulos, Ph.D., an associate professor of oncology and director of Translational Genetics at the Ludwig Center for Cancer Genetics & Therapeutics at the Johns Hopkins Kimmel Cancer Center, the new findings "may provide opportunities for developing new biomarkers and therapies that target those genes. (emaxhealth.com)
  • study
  • This proof of concept study shows that dogs with OCD can be a good model for human OCD, but more study is needed to elucidate whether these genes are involved in human OCD, and to identify ways that these findings can be used to improve treatments. (biomedcentral.com)
  • An international consortium carried out the largest-ever genetic study of cholesterol and other blood lipids and identified 21 new gene variants associated with risks of heart disease and metabolic disorders. (sify.com)
  • To date, this is the largest number of DNA samples ever used in a study for lipid traits, it clearly shows the value of using broad-ranging global scientific collaborations to yield new gene signals," Keating said. (sify.com)
  • The study is believed to be the first to directly link common variants of the genes - ABCA7 and MA4A6A - to atrophy in cortical and hippocampal regions of the brain, which are associated with memory and other key functions, according to the researcher. (psychcentral.com)
  • In the present study, mice that had only one copy of the CREB gene -- healthy mice have two copies -- produced lower-than-normal levels of the CREB protein, neuropeptide Y and another compound in the brain linked with alcohol drinking (called brain derived neurotrophic factor). (innovations-report.com)
  • This case-control study tested whether men seeking infertility treatment for unexplained reduced sperm counts had genetic mutations in a gene called NR5A1. (www.nhs.uk)
  • This small case-control study found that mutations of the NR5A1 gene were present in 4% of 315 men with otherwise unexplained reduced sperm counts. (www.nhs.uk)
  • The study revealed two genes linked to ankylosing spondylitis: ARTS1 and IL23R, both of which influence immune function. (emaxhealth.com)
  • The number of known gene regions influencing height has been roughly doubled to 400 in the largest genome-wide association study (GWAS) to date. (medindia.net)
  • The study, from the international Genetic Investigation of Anthropometric Traits (GIANT) Consortium, provides a better glimpse at the biology of height and offers a model for investigating traits and diseases caused by many common gene changes acting together. (medindia.net)
  • SAN FRANCISCO -- Genes may predict response to ranibizumab (Lucentis) for patients with neovascular age-related macular degeneration, according to a genome-wide association study. (medpagetoday.com)
  • One reason we didn't do this study until now is that 15 to 20 years ago when these genes were first identified, it would have taken years to sequence each gene individually. (innovations-report.com)
  • But the study did not prove the gene variants caused hot flashes. (drugs.com)
  • After investigating more than 11 million gene variants, the study authors found that 14 of the variants were associated with hot flashes. (drugs.com)
  • This is an extremely elegant set of experiments, which are very difficult to do,' says Roger Reeves , professor of physiology at Johns Hopkins University School of Medicine who studies mechanisms of gene action in Down's syndrome and was not involved in the study. (scientificamerican.com)
  • A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases. (redorbit.com)
  • To identify which of six possible genes in this region were associated with the frequency of outbreaks, this latest study used single nucleotide polymorphism genotyping in genome-wide, family-based linkage studies of 618 people from 43 large families. (scienceblog.com)
  • The types of early-childhood-onset epilepsy caused by potassium ion channel mutations comprise a field of study all their own within epileptic encephalopathy, the severe epilepsies which start early in life and which are linked with various degrees of developmental disruptions, reduced intelligence and other neuropsychiatric symptoms such as autism and disruptions to voluntary muscle coordination (ataxia). (innovations-report.com)
  • Although similar, smaller cancer gene sequencing projects have been reported, our study is the largest to date and provides the statistical power to detect significantly mutated genes," study co-author Richard Wilson, director of Washington University's Genome Sequencing Center in St. Louis, said during a Tuesday teleconference. (drugs.com)
  • Before the new research, 10 genes linked to adenocarcinoma had been identified, including six of the 26 reported in this study. (drugs.com)
  • pinpointed gene regions
  • They found that 33 newly pinpointed gene regions were linked to body fat distribution--which helps explain why some people are pear-shaped and others gain weight around their stomachs--and that 60 genetic locations influence body mass index or BMI, including some with links to the nervous system. (healthcentral.com)
  • common
  • Previous large-scale genome-wide association studies (GWAS) have indicated that a large number of genes influence height, and suggested that the majority of heritability comes from common genetic variants, not rare ones. (medindia.net)
  • In 2007 we published the first paper that identified the first common height gene, and we have now identified nearly 700 genetic variants that are involved in determining height," says co-senior investigator Timothy Frayling, PhD, of the University of Exeter, U.K. "We believe that large genetic studies could yield similarly rich lists in a variety of other traits. (medindia.net)
  • ARID1 and PPP2R1A were the most common genes mutated in the deadly form of ovarian cancer. (emaxhealth.com)
  • An international research team has discovered a gene that, when mutated, causes one of the most common forms of inherited blindness in babies. (news-medical.net)
  • suggests
  • The results, published in the journal Genome Biology , identify four genes strongly linked with canine OCD, and suggests that using dogs as a simplified model of the human condition might open up new avenues for research into the more complex human OCD. (biomedcentral.com)
  • But the appearance of an effect in patients not on the drug, although not significant, suggests that the single nucleotide polymorphism (SNP) could have a direct link to cardiovascular risk or to some other factor, Bhatt said. (medpagetoday.com)
  • However this is not explained by mutations in the TP53 gene, which encodes for the p53 protein, as evidence suggests this is mutated in less than 10 per cent of melanoma. (innovations-report.com)
  • findings
  • Together with the previously known gene HLA-B27, the new findings increase to three the number of genes known to be involved in the disease. (emaxhealth.com)
  • A pair of large-scale genetic studies has revealed 2 genes that influence the risk of getting multiple sclerosis (MS). The findings could shed new light on what causes MS and point the way toward potential treatments. (nih.gov)
  • metabolism
  • Other genes confirmed as important include genes involved in metabolism of collagen (a component of bone) and chondroitin sulfate (a component of cartilage), as well as networks of genes active in growth plates, the area of growing tissue near the ends of the long bones. (medindia.net)
  • tissue
  • Then they compared the DNA sequence of these genes with the same genes in normal tissue from the same patients. (drugs.com)
  • dozen
  • We already know of a dozen genes which, when mutated, cause LCA," says Professor Chris Inglehearn from the Leeds Institute of Molecular Medicine at St James's Hospital, Leeds. (news-medical.net)
  • Dose
  • There may be some clinical relevance of a gene-by-dose interaction for efficacy and bleeding, commented Stephen Wiviott, MD, of Brigham and Women's Hospital in Boston, who was a discussant at the late-breaking clinical trials session where the results were presented. (medpagetoday.com)
  • Biology
  • The IL23R gene provides a genetic link that sheds new light on their co-occurrence," said Cardon, a member of the Hutchinson Center's Human Biology Division. (emaxhealth.com)
  • Still other genes point to biology whose relationship with height isn't yet known. (medindia.net)
  • We are hopeful that additional molecular biology experiments will determine how to create sustained regular heart rhythms by studying the genes we and others have identified,' said Cristen Willer, associate professor at the University of Michigan (U-M). (mid-day.com)
  • severity
  • Goenjian said his team had expected to find a link between the so-called serotonin transporter gene and the severity of PTSD symptoms. (latimes.com)
  • diseases
  • The more genes we discover the better we are placed to treat the diseases by methods such as that recently announced at Moorfields Eye Hospital , also supported by the BRPS. (news-medical.net)
  • It's very challenging to map genes for complex diseases, and while many statistical methods have been developed, most don't work well in practice. (innovations-report.com)
  • therapies
  • Victor Velculescu, M.D., Ph.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center explains, "The mutations in ARID1A provide an important new link between genetic and epigenetic mechanisms in human cancer and may help identify epigenetic changes which can be targeted with therapies. (emaxhealth.com)
  • Finding the genes responsible for alternative lengthening of telomeres is the first step in understanding this process and provides opportunities to develop new drug therapies," says Nickolas Papadopoulos, Ph.D., associate professor at the Johns Hopkins Kimmel Cancer Center and director of translational genetics at Johns Hopkins' Ludwig Center. (redorbit.com)
  • Whether or not finding newly implicated genes will lead to new therapies, as the authors suggest, is, of course, something to be hoped and waited for. (drugs.com)
  • defects
  • However, mutations in the LCA5 gene only appear to cause defects in the retina. (news-medical.net)
  • This new gene is the thirteenth and adds a substantial new piece to a growing body of evidence that defects of the cilia are a major cause of inherited blindness. (news-medical.net)
  • Johns Hopkins
  • ATRX and DAXX had also been linked to similar functions in the telomere region, says Alan Meeker, Ph.D., assistant professor of pathology, urology and oncology at Johns Hopkins. (redorbit.com)
  • Although the Johns Hopkins team does not yet have an explanation for how the genes do their lengthening work in cancer, Meeker speculates that the mutations alter the way that telomere DNA is packaged, exposing those areas to instability. (redorbit.com)
  • treatments
  • If the correlation holds up, we could use alternative lengthening of telomeres and ATRX/DAXX mutations as a method of determining a patient's prognosis in addition to developing treatments that target these genes," says Meeker. (redorbit.com)
  • These genes could soon be new targets for lung cancer treatments," Meyerson said. (drugs.com)
  • strongly
  • Genes linked to the nerve transmitter chemical dopamine, which is targeted by existing anti-psychotic medications and has been implicated previously in the condition, were strongly represented. (thenakedscientists.com)
  • research
  • This is the first direct evidence that a deficiency in the CREB gene is associated with anxiety and alcohol-drinking behaviors," said Subhash Pandey, associate professor of psychiatry and director of neuroscience alcoholism research at the UIC College of Medicine. (innovations-report.com)
  • Previous research also has linked IL23R with inflammatory-bowel disease (Crohn's disease) and psoriasis. (emaxhealth.com)
  • Two large research teams were supported in their search for genes associated with MS by NIH's National Institute of Neurological Disorders and Stroke (NINDS) and the National Multiple Sclerosis Society as well as other NIH institutes. (nih.gov)
  • No previous studies have focused on how variants in women's genes may be linked with hot flashes, and these results were highly statistically significant," said principal investigator Dr. Carolyn Crandall, a professor of medicine in the division of general internal medicine and health services research at UCLA. (drugs.com)
  • results
  • Obviously we have to be careful how we interpret these results, as finding the genes doesn't automatically lead to a cure," says Mr Noble. (news-medical.net)
  • The results showed several mutations in the TREM2 gene occurred more frequently in people who had the disease than in those without the disease. (utoronto.ca)
  • faulty
  • A faulty gene could help to explain some cases of unexplained male infertility," reported BBC News. (www.nhs.uk)
  • Sufferers carry a faulty version of a gene containing a region with three letters of DNA repeated over and over again. (thenakedscientists.com)
  • lead
  • Finding the two gene mutations for the deadly form of ovarian cancer could lead to targeted gene therapy to treat the disease that is generally resistant to chemotherapeutic agents. (emaxhealth.com)
  • mechanisms
  • Using techniques such as animal models will help us to fully understand the mechanisms behind this gene and explore how we might be able to intervene in these mechanisms, to help people with the disorder. (innovations-report.com)
  • people
  • The finding, the thirteenth gene to be linked to Leber's congenital amaurosis (LCA), comes at a time of hope for the people born with the disorder. (news-medical.net)
  • previously
  • For example, the mTOR gene is well known to be involved in cellular growth, but had not previously been connected with human skeletal growth. (medindia.net)
  • Certain types of early-onset epilepsy are caused by previously unknown mutations of a potassium channel gene, KCNA2. (innovations-report.com)