• DEPDC1B promoter region contains several transcription factors associated with proteins of ubiquitous expression. (wikipedia.org)
  • The DEP domain is primarily found in proteins involved in G-protein signalling pathways and regulation of GTPase. (wikipedia.org)
  • The domain has been verified to interact with other proteins to form complexes or interact with other structures of the cell such as the cytoskeleton or plasma membrane. (wikipedia.org)
  • Cell cycle proteins are altered in differently in HPV-positive and HPV-negative cancers, suggesting that treating these cancers should be treated according to their subtype. (cancer.gov)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. (antikoerper-online.de)
  • Second, it appears to block cell cycle progression, possibly via a down-regulation of CDK proteins. (rndsystems.com)
  • HCF-1 interacts with proteins called transcription factors, which attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • In experiments with mouse HSCs cultured on immobilized delta-like 4 proteins, the researchers found that progenitors developing toward T cells were arrested in the absence of so-called feeder cells, which support survival and growth. (riken.jp)
  • this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
  • This CAC is associated with the cell cycle and its regulation is affected by the tumor suppressor proteins. (biomedcentral.com)
  • E2's presence also affects the expression of a variety of cellular genes involved in a wide range of biological processes, including cell cycle regulation and apoptosis, which are mediated by E2's interaction with cellular proteins. (elis.sk)
  • Several genetic alterations have been described in SCCHN, including mutations in the p53 tumor suppressor gene and mutations in genes that encode cell cycle proteins such as p16 and cyclin D1. (oncotarget.com)
  • Human being breasts cancers MDA-MB-231 cells had been cultured in Improved Eagle's Moderate, supplemented with nonessential proteins, sodium pyruvate and 10% fetal bovine serum. (accessibletech4all.org)
  • Cells had been infected using the ALK5QD-expressing adenovirus 100.A Stream of human being ESTs using the 1st coding exon of TRIII revealed the current presence of 80 ESTs, 75 which contained sequences homologous towards the proximal 5 UTR (A). message and proteins amounts in ovarian (Ovca420) and breasts cancers (MDA-MB-231) cell lines in both a dosage- and time-dependent way. (accessibletech4all.org)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • These transcription factors possess a central theme of cellular proliferation, cell cycle regulation, apoptosis, and differentiation. (wikipedia.org)
  • ChIRP-seq of candidate lncRNAs revealed that lncRNA occupancy sites within the parasite genome are focal and sequence-specific with a particular enrichment for several parasite-specific gene families, including those involved in pathogenesis, erythrocyte remodeling, and regulation of sexual differentiation. (biorxiv.org)
  • The reversible lysine acetylation of histone H3 may play a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication and repair, nuclear import and neuronal repression. (abcam.com)
  • The transcriptional networks critical for the proper development, differentiation, and expansion of beta cells, work through islet enhancers, super enhancers and active promoters that form 3- dimensional hubs. (upenn.edu)
  • 3. We hypothesize that PDX1-Onecut1 (OC1) interactions, in part mediated by their intrinsically disordered protein regions (IDPRs), regulate Pdx1 stability, cell cycle progression, and pancreatic endocrine differentiation during development. (upenn.edu)
  • Histone deacetylase (HDAC) inhibitors may be useful for cancer prevention and therapy by virtue of their ability to 'reactivate' the expression of epigenetically silenced genes, including those involved in differentiation, cell cycle regulation, apoptosis, angiogenesis, invasion, and metastasis. (oregonstate.edu)
  • A research team in Japan has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell lineages to the activity of a single gene encoding a transcription factor. (riken.jp)
  • Testing of various conditions revealed that reduction of the cytokine interleukin-7 (IL-7), possibly corresponding to an environmental signal in the thymus, triggered resumption of development and differentiation into T cells. (riken.jp)
  • Together, the findings identify Bcl11b as a "master gene" governing the final step toward differentiation into T cells, confirming the proposed model and heralding a paradigm shift in our understanding of blood cell lineages. (riken.jp)
  • However, the tumour cells have undergone hypermutation, 21 23 a feature of the GC reaction during B-cell activation and differentiation. (bmj.com)
  • This is due to the lack of expression of cell cycle inhibitors, which ultimately determines naïve pluripotency by holding back differentiation. (upf.edu)
  • In most biological systems the down-regulation of proliferation is necessary for initiation of key steps in the differentiation process. (elsevierpure.com)
  • We have examined regulatory mechanisms controlling expression of the cell cycle-dependent histone genes, which are functionally coupled with DNA synthesis, in proliferating cells and during the onset of differentiation in several phenotypes including adipocytes. (elsevierpure.com)
  • Equally important for developmental transcriptional control, histone gene expression is repressed when differentiation is initiated. (elsevierpure.com)
  • Deletion analysis indicates that proximal Site II mediates the differentiation response of H4 gene transcription in adipocytes. (elsevierpure.com)
  • DMRs show continuous gain or loss of methylation during differentiation, and the overall change in DNA methylation correlates inversely with gene expression at key loci. (lu.se)
  • We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)
  • Introduction Transforming ST3932 development factor-beta (TGF-) regulates a different range of natural features including differentiation, proliferation, angiogenesis, immunosuppression and motility within a context-dependent way (1). (accessibletech4all.org)
  • Their promoter activity during the cell cycle is governed by a subtype-specific consensus element (SSCE). (news-medical.net)
  • It has histone deacetylase activity and represses transcription when tethered to a promoter. (cancerindex.org)
  • Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (PubMed:14602201). (proteopedia.org)
  • EBF3 bound directly to p21 cip1/waf1 promoter and regulated transcription from both p21 cip1/waf1 and p27 kip1 promoters in reporter assays. (aacrjournals.org)
  • Does the binding of a specific transcription factor to the promoter of a gene regulate its expression? (biomedcentral.com)
  • Tcf1, but not Tcf3, is recruited to a palindromic motif enriched in the promoter of cell cycle repressor genes, such as p15Ink4b, p16Ink4a and p19Arf, which mediate the Wnt-dependent anti-proliferative effect in mESCs. (upf.edu)
  • We have identified a histone H4 proximal promoter element, designated Site II, that mediates cell cycle transcriptional control. (elsevierpure.com)
  • Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
  • To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)
  • We define choice promoters for the gene, a distal and proximal promoter. (accessibletech4all.org)
  • Taken jointly, these research define TGF-1-mediated downregulation of TRIII mRNA appearance through effects in the ALK5/Smad2/3 pathway in the gene proximal promoter being a potential system for reduced TRIII appearance in individual malignancies. (accessibletech4all.org)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
  • There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
  • 2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)
  • DEP Domain Containing Protein 1B also known as XTP1, XTP8, HBV XAg-Transactivated Protein 8, [formerly referred to as BRCC3] is a human protein encoded by a gene of similar name located on chromosome 5. (wikipedia.org)
  • Also, DEPDC1B expression decreases in environments of beta-catenin depletion in multiple myeloma cell lines No interactions of DEPDC1B within any other protein product characterized by experimentation have been verified. (wikipedia.org)
  • The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
  • The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)
  • This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • The protein encoded by this gene has sequence homology to members of the histone deacetylase family. (caslab.com)
  • This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. (caslab.com)
  • The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. (antikoerper-online.de)
  • The HCFC1 gene provides instructions for making a protein, called HCF-1, that helps regulate the activity of other genes. (medlineplus.gov)
  • One of several functions of the HCF-1 protein is to control the activity of a gene called MMACHC that is involved in the processing of vitamin B12 (also known as cobalamin). (medlineplus.gov)
  • This protein also plays a role in the distribution of cells in developing tissues and organs, including the brain. (medlineplus.gov)
  • Neurological and developmental problems are especially severe in individuals with cblX type, in part due to disruption of the activity of other genes normally regulated by the HCF-1 protein. (medlineplus.gov)
  • The HCFC1 gene variants lead to production of an HCF-1 protein with reduced function. (medlineplus.gov)
  • These molecules are involved in cell division, metastasis, apoptosis, cell cycle regulation and regulation of protein degradation. (pennmedicine.org)
  • 1. The Stoffers laboratory recently identified the polyC binding protein (PCBP) family of RBPs as important players in the post-transcriptional regulatory landscape of pancreatic beta cells. (upenn.edu)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • Oncogenic transcription factors such as the leukemic fusion protein RUNX1/ETO, which drives t(8;21) acute myeloid leukemia (AML), constitute cancer-specific but highly challenging therapeutic targets. (prinsesmaximacentrum.nl)
  • 1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
  • The factors interacting with Site II include cdc2, cyclin A, an RB-related protein and interferon regulatory factors (IRFs). (elsevierpure.com)
  • The early viral gene E2 encodes a protein involved in several key processes in HPV biology, such as replication, genome segregation, and viral gene transcription. (elis.sk)
  • In HPV16 E2-positive cells, we observed a statistically significant increase in mRNA and protein levels of TAF1 and p27, a basal transcription factor and one of its target genes, respectively. (elis.sk)
  • P53 (or TP53 for "tumor protein 53") is a transcription factor regulating multiple important cellular functions such as cell cycle regulation, autophagy or apoptosis (programmed cell death). (eaglebio.com)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
  • Gene-based association testing identified increased risk for iHLHS associated with variation in CAPN2 (p= 1.810(-5)), encoding a protein involved in functional adhesion. (cdc.gov)
  • In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
  • One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
  • By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • HCF-1 helps regulate genes that are important in other cellular processes, such as progression of cells through the step-by-step process it takes to replicate themselves (called the cell cycle). (medlineplus.gov)
  • Reduced number and function of insulin-secreting beta cells underlies the progression of all forms of diabetes, underscoring the translational relevance of deciphering molecular pathways regulating the formation, growth, and function of beta cells. (upenn.edu)
  • The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)
  • In this dissertation, I explore the mechanisms that coordinate and regulate cell-cycle progression in the budding yeast, Saccharomyces cerevisiae. (duke.edu)
  • We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
  • The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
  • Our data demonstrate that RUNX1/ETO maintains leukemia by promoting cell cycle progression and identifies G1 CCND-CDK complexes as promising therapeutic targets for treatment of RUNX1/ETO-driven AML. (prinsesmaximacentrum.nl)
  • This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
  • Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (affbiotech.cn)
  • [ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
  • Several HCFC1 gene variants (also known as mutations) have been identified in people with methylmalonic acidemia with homocystinuria, cblX type, which is one form of a disorder that causes developmental delay, eye defects, neurological problems, and blood abnormalities. (medlineplus.gov)
  • These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
  • We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)
  • Genetic testing for mutations in the VHL gene is performed at many laboratories throughout the United States and the world. (medscape.com)
  • We are using genetics, genomics and biochemical approaches to establish unknown pathways involved in these cellular events and attempting to develop models that explain how gammaherpesviruses establish transformation in human cells. (pennmedicine.org)
  • Reversal of aberrant epigenetic events, including those that modulate the transcriptional activity of genes associated with various signaling pathways, holds the prospect of influencing multiple stages of tumorigenesis. (oregonstate.edu)
  • Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). (proteopedia.org)
  • Although mutation- or pathway-directed targeted therapy (e.g., using tyrosine kinase inhibitors to treat Philadelphia chromosome [Ph]-positive and Phlike B-cell-ALL) is currently available for only a minority of children with ALL, many of the newly identified molecular alterations have led to the exploration of approaches targeting deregulated cell pathways. (haematologica.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Colon cancer is caused by many factors that affect multiple etiological pathways. (biomedcentral.com)
  • This mechanism is hypothesized to transduce a shared signal that activates the transcription of histone genes when the G1/S phase boundary is reached. (news-medical.net)
  • In the context of DNA damage, p53 is thought to be a decision-making transcription factor that selectively activates genes as part of specific gene expression programmes to determine cellular outcomes. (nih.gov)
  • But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)
  • Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)
  • E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (PubMed:22855500). (proteopedia.org)
  • TRI recruits then, phosphorylates and activates the Smad2/3 transcription elements, which type a complex using the co-Smad and Smad4, and translocate like a complex in to the nucleus to modify transcription of TGF-responsive genes (3). (accessibletech4all.org)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • Further, I show that during a wild-type cell cycle, checkpoints are responsible for arresting the bulk of periodic transcription. (duke.edu)
  • Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
  • Many more investigations have been made on cells, sorted according to size, or artificially arrested at various cell cycle checkpoints. (frontiersin.org)
  • Our results demonstrate that combined targeting of EGFR and Aurora kinases represents a therapeutic means to activate cell cycle checkpoints and apoptosis in SCCHN. (oncotarget.com)
  • Specifically, we discuss how the interaction of p53 with DNA and chromatin affects gene expression, and how p53 post-translational modifications, its temporal expression dynamics and its interactions with chromatin regulators and transcription factors influence cell fate. (nih.gov)
  • In general, histone acetylation leads to chromatin remodeling and a de-repression of transcription. (oregonstate.edu)
  • methylates H3, including histones in the HOX area for allowing chromatin to be open to transcription. (atlasgeneticsoncology.org)
  • Chromatin immunoprecipitation (ChIP)-RT PCR analysis indicates that metformin treatment results in an increased H2A.Z occupancy on the androgen receptor (AR) and AR-regulated genes that is more prominent in the androgen dependent AR positive LNCaP cells. (oncotarget.com)
  • Trans -acting splicing factors, pre-mRNA secondary structure and chromatin organization are now known to directly affect alternative splicing decisions [ 6 ]. (biomedcentral.com)
  • It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
  • Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence. (nih.gov)
  • 2. We recently identified a novel PDX1 stress inducible complex (es) positioned over CARE sites and involving ATF4 and ATF5 that regulates expression of stress and apoptosis genes to govern β cell survival. (upenn.edu)
  • Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). (proteopedia.org)
  • Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (nih.gov)
  • EBNA3C is a large nuclear transcription factor involved in modulating transcription activated by a cellular repressor RBP-Jkappa and other transcription factors. (pennmedicine.org)
  • Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. (affbiotech.cn)
  • Increasing evidence now suggests a major role for epigenetic mechanisms in gene expression in the parasite. (biorxiv.org)
  • Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection. (pennmedicine.org)
  • Epigenetic mechanisms involved in prostate cancer include hypermethylation of tumor suppressor genes, general hypomethylation of the genome, and alterations in histone posttranslational modifications (PTMs). (oncotarget.com)
  • This study provides a comprehensive genome-wide resource for the functional exploration of molecular, cellular, and epigenetic regulation at the top of the hematopoietic hierarchy. (lu.se)
  • While multiple systems potentially take into account the increased loss of TRIII manifestation in these human being malignancies, including lack of heterozygocity from the gene and epigenetic rules (11C13), we'd also determined TGF-1-mediated repression of TRIII message amounts inside a breasts cancers model (11). (accessibletech4all.org)
  • The TP53 gene is inactivated in almost 50% of human cancers. (eaglebio.com)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)
  • The exploration of PDX1 partners and targets takes us into new areas including mechanistic investigations of beta cell development, metabolism and postnatal cell survival. (upenn.edu)
  • We are characterizing these targets comprehensively and we are beginning to pursue the specific roles of novel targets in the beta cell, with a particular focus on the transaminase Gpt2. (upenn.edu)
  • We provide data showing that metformin epigenetically targets PCa by altering the levels and gene binding dynamics of histone variant H2A.Z. Moreover, we show that the increase in H2A.Z upon metformin treatment occurs preferentially due to H2A.Z.1 isoform. (oncotarget.com)
  • Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. (affbiotech.cn)
  • These findings indicate that the DPE could inhibit colonic epithelial cells proliferation through p53 pathway independently. (biomedcentral.com)
  • Subsequent transcriptomic analysis identified genes differentially regulated by MeJA+NaCl treatment and NaCl alone. (frontiersin.org)
  • Preferentially retained introns and differentially used exons in the affected genes contain weak 5′ splice sites, but are otherwise indistinguishable from adjacent spliced introns. (biomedcentral.com)
  • A total of 173 genes were differentially expressed, many of which were not found in previous transcriptional studies of other flaviviruses ( 3 ). (cdc.gov)
  • Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)
  • In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
  • In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • The epic battle for the cell is to have the regularly expected circadian cycles found in our environment and "yoke" those signals to its metabolic cycle and to its growth cycle. (jackkruse.com)
  • VIP actually is what sets the circadian pacemaker to the light cycles. (jackkruse.com)
  • This means that leptin uncouples the SCN to be unable use light as the main stimulus to yoke circadian cycles. (jackkruse.com)
  • Another interesting coupling occurs between the circadian cycle and with the cell cycle. (jackkruse.com)
  • It should be clear because of these links that just a simple mismatch in circadian cycles can lead to the development of cancer and neolithic disease. (jackkruse.com)
  • How does cancer occur when the circadian cycles are off? (jackkruse.com)
  • Vasoactive intrinsic peptide receptor (VIPR2), a circadian gene, is involved in metabolic homeostasis and metabolic syndrome (MetS). (bvsalud.org)
  • This induces dimerization with ARNT, translocation to the nucleus, and activation of P450 genes such as CYP1A1 and UGT1A6. (rndsystems.com)
  • The genes involved in the translocation were determined in one case (Meyer et al. (atlasgeneticsoncology.org)
  • This translocation seems to create nonfunctional fusion genes. (atlasgeneticsoncology.org)
  • It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. (bmj.com)
  • The hallmark of all BL tumours is the translocation between the MYC gene and one of the immunoglobulin (Ig) heavy or light chain loci. (bmj.com)
  • Moreover, the breakpoint in the Ig gene to which MYC is transferred in eBL occurs at the V(D)J region, suggesting that translocation occurs during V(D)J recombination. (bmj.com)
  • Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. (medscape.com)
  • Xp11.2 translocation-associated renal cell carcinomas are generally cortical or subcapsular, well-circumscribed lesions with yellow-tan, variegated cut surfaces. (medscape.com)
  • Xp11.2 translocation-associated renal cell carcinomas (RCCs) may have well-developed papillae, mimicking papillary RCCs. (medscape.com)
  • The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)
  • In yeast, transcription is regulated by the same elements, whereas in mammals, there are different cis -acting DNA elements and other factors regulating transcription. (news-medical.net)
  • In this talk, first I wll present our work on transcription regulation in yeast, ranging from large-scale experimental studies to computational analyses of regulatory networks. (cam.ac.uk)
  • Our regression-based approach allows us to build a general model of transcriptional regulation of the yeast cell cycle that includes additional factors and couplings not reported in previously-published models. (biomedcentral.com)
  • The myc recognition binding site of ECA39 is located 3' to the start site of transcription in the mouse and human genes, but this element is absent in the nematode and yeast. (bdbiosciences.com)
  • Disruption of the ECA39 gene in yeast results in an increased growth rate in comparison to wild type, such that G1 is shorter. (bdbiosciences.com)
  • Eden A, Simchen G, Benvenisty N. Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases. (bdbiosciences.com)
  • Schuldiner O, Eden A, Ben-Yosef T, Yanuka O, Simchen G, Benvenisty N. ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast. (bdbiosciences.com)
  • HPV-negative tumors contained novel co-amplifications of 11q13 and 11q22, an event that likely promotes the interaction of BIRC2 and FADD , genes that together work to inhibit cell death. (cancer.gov)
  • In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. (aacrjournals.org)
  • We profiled 162 breast tumors using expression microarrays to stratify tumors based on gene expression. (biomedcentral.com)
  • A subset of 55 tumors with extensive follow-up was used to identify gene sets that predicted outcome. (biomedcentral.com)
  • By comparing outcome prediction within subgroups based on ER status, grade, and nodal status, we found that our gene set was most effective in predicting outcome in ER positive and node negative tumors. (biomedcentral.com)
  • We report gene expression profiling on a diverse panel of breast tumors using both unsupervised and supervised methods to distinguish clinically relevant subgroups on the basis of gene expression. (biomedcentral.com)
  • Another characteristic architectural feature found in many of these tumors is a pseudoalveolar pattern in which cells are arranged in alveolae with central cellular discohesion (see the fourth image below). (medscape.com)
  • Psammoma bodies and scattered xanthoma cells have been described in some tumors. (medscape.com)
  • Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
  • PageMan analysis revealed several significantly enriched categories altered by MeJA+NaCl treatment, compared with NaCl treatment alone, including genes involved in secondary metabolism, glutathione-based redox regulation, cell cycle, transcription factors (TFs), and other signal transductions (such as calcium and ROS). (frontiersin.org)
  • During a low redox time cells are usually recycling their components using autophagy during sleep. (jackkruse.com)
  • Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
  • In humans, this gene is located on chromosome 172. (eaglebio.com)
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
  • To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
  • In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
  • Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
  • We are investigating the fundamental mechanisms utilized by these gammaherpesviruses to induce cell mediated growth transformation. (pennmedicine.org)
  • In this Review, we discuss the multiple molecular mechanisms of p53 regulation and how they modulate the induction of apoptosis or cell cycle arrest following DNA damage. (nih.gov)
  • The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
  • Understanding the regulatory mechanisms that control cell-cycle events remains to be a fundamental question in cell biology. (duke.edu)
  • Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. (birmingham.ac.uk)
  • Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. (upf.edu)
  • We conducted a global transcriptional analysis of human glioblastoma cell response to infection with WNV during peak virus production to determine the crucial virus-host interactions that take place during a severe neuroinvasive attack and identify putative mechanisms involved in WNV pathogenesis. (cdc.gov)
  • These regulations do not the exposure with the potential health effects or address explicitly the question regarding return mechanisms. (who.int)
  • The following includes the top twenty Predicted Transcription Factors: DEPDC1B possesses 13 mRNA splice variants that form two isoforms. (wikipedia.org)
  • This occurs in part due to increased transcription, which constitutes a 3-10 fold increase in mRNA, as well as due to pre-mRNA processing and mRNA stability. (news-medical.net)
  • PER 2 directly affects the cell cycle when the cell divides. (jackkruse.com)
  • However, it is likely that transcription factor binding affects gene expression in a nonlinear fashion, e.g., below some level it has no effect and above some higher level the effect might saturate. (biomedcentral.com)
  • However, impaired splicing affects only a subset of human transcripts, enriched for mitotic cell cycle factors, leading to mitotic arrest. (biomedcentral.com)
  • Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
  • Several natural and synthetic HDAC inhibitors have been shown to affect the growth and survival of tumor cells in vitro and in vivo. (oregonstate.edu)
  • The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
  • We used different statistical methods to identify three gene sets associated with disease free survival. (biomedcentral.com)
  • This gene set resulted in significant separation of patients on the basis of survival in these data sets, correctly predicting outcome in 62-65% of patients. (biomedcentral.com)
  • Currently, its standard treatment includes surgery and platinum chemotherapy, but most patients will relapse within 16-22 months due to drug resistance and other factors, and the 5-year survival rate of ovarian cancer is only 46% [ 6 ]. (hindawi.com)
  • KSHV infects human B-cells and endothelial cells. (pennmedicine.org)
  • [ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)
  • It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
  • The integration of HPV, a virus harboring oncoproteins E6 and E7 that cause HPV positive head and neck squamous cell carcinomas, is linked to increased somatic copy number variants. (cancer.gov)
  • Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (caslab.com)
  • Variants in the HCFC1 gene have also been found in individuals with X-linked intellectual disability. (medlineplus.gov)
  • and (iv) genes harboring germline non-silent variants presumed to confer a risk of sporadic ALL. (haematologica.org)
  • Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
  • Silencing of the EBF3 locus was observed in brain, colorectal, breast, liver, and bone tumor cell lines and its reactivation was achieved on treatment with 5-aza-2′-deoxycytidine and trichostatin A in a significant portion of these tumor cells. (aacrjournals.org)
  • Here we show that the Wnt-effector Tcf1 is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus. (upf.edu)
  • These translocations most commonly involve the TFE3 gene on locus Xp11.2 and less commonly involve the TFEB gene on locus 6p21. (medscape.com)
  • Intragenic recombination among ospC genes is known, but the extent to which recombination extended beyond the ospC locus itself is undefined. (cdc.gov)
  • This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • in vitro, factor binding to Site II is not observed post-proliferatively. (elsevierpure.com)
  • The Human p53 ELISA Assay is to be used for the in-vitro quantitative determination of p53 in serum, plasma, or cell lysates. (eaglebio.com)
  • Due to their affiliation with DNA, histones are important for successful cell replication, which takes place via the cell cycle. (news-medical.net)
  • Each histone subtype has several copies of the same gene to allow for the large demand placed during DNA replication. (news-medical.net)
  • Histones can be classified as replication dependent or replication independent, which is decided by their expression pattern during the cell cycle. (news-medical.net)
  • The replication independent histone genes are transcribed at a relatively constant low rate, regardless of cell cycle stage. (news-medical.net)
  • However, most of the vertebrate histone genes are replication dependent and are therefore more highly expressed during the cell cycle's S phase. (news-medical.net)
  • Given that the replication dependent histone genes all activate upon entry into the S phase, it is speculated that there exists some further upstream regulatory element. (news-medical.net)
  • The proper copying and repair of DNA to maintain the correct sequence and structure of genomes is critical to the proper function of cells, and repair and replication is frequently disrupted in cancers and targeted by cancer treatments. (birmingham.ac.uk)
  • We examine the impact that processes such as transcription and replication have on genome stability. (birmingham.ac.uk)
  • This suggests that E2's expression promotes a transcriptionally-favorable cellular environment that allows HPV to successfully complete its replication cycle. (elis.sk)
  • Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
  • Histologically, BL cells are monomorphic medium sized cells with round nuclei, a number of nucleoli and abundant cytoplasm. (bmj.com)
  • at least focally, tumor cells often have abundant clear cytoplasm, mimicking clear cell RCC. (medscape.com)
  • I will introduce results from ChIP-chip experiments that identify genome-wide DNA -binding sites of transcription factors, particularly focusing on the cell cycle regulatory system. (cam.ac.uk)
  • The model utilizes linear regression to first estimate the activities of transcription factors from expression time series and genome-wide transcription factor binding data. (biomedcentral.com)
  • In the future, we plan to apply our technique to reverse-engineer other systems where both genome-wide time series expression data and transcription factor binding data are available. (biomedcentral.com)
  • abstract = "Proliferation is a requirement during the initial stages of cell and tissue specialization. (elsevierpure.com)
  • These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
  • For the current Regulation with respect to cancer evaluation, the Working Group elected to change patients the agent name to "night shift work" in order to better reflect the main evidence base for the Regulations on shift work are in place in studies of cancer in humans, and to avoid mixing many countries. (who.int)
  • While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)
  • By measuring global gene expression dynamics in cells with persistent CDK activity, I show that periodic transcription continues. (duke.edu)
  • Most studies have been performed on large cell populations, but detailed understanding of cell dynamics and heterogeneity requires single-cell analysis. (frontiersin.org)
  • In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
  • A cyclin E-CDK2 substrate called NPAT has been found to be associated with histone gene clusters, and cyclin E-CDK2 bolsters activation of histone gene transcription by NPAT. (news-medical.net)
  • Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
  • Using toxin-induced lesions we investigated to what extent transgene expression could be regulated in accordance with the activation of the endogenous GFAP gene. (lu.se)
  • The present study aimed to determine a multimodal brain empowerment (MBE) program to mitigate the modifiable risk factors in mild cognitive impairment (MCI), and its therapeutic effects are unknown. (bvsalud.org)
  • And third, it blocks apoptosis by interacting with E2F1, thus silencing TP73 and Apaf1 genes. (rndsystems.com)
  • The present study is aimed at exploring whether rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer. (hindawi.com)
  • The rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene were detected by the fluorescent probe method. (hindawi.com)
  • E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. (hindawi.com)
  • The CT genotype of E2F1 gene rs3213172 polymorphism is associated with an increased risk of ovarian cancer, and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
  • E2F1 is one of the transcription factors that cells enter the S phase and plays a key role in cell cycle. (hindawi.com)
  • The present study is to explore whether E2F1 gene polymorphisms confer risk for ovarian cancer. (hindawi.com)
  • Medium coexpression of DEPDC1B with ECT2 in cell cycle regulation and DNA synthesis was verified by similarity of expression in various tissues. (wikipedia.org)
  • ab115124 is suitable for specifically measuring total histone H3 acetylation using a variety of mammalian cells including fresh and frozen tissues, and cultured adherent and suspension cells. (abcam.com)
  • The DNA within the nuclei of our cells carries the information to generate the machinery of the cell, the cell itself, our tissues and then the whole human. (birmingham.ac.uk)
  • The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
  • Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
  • Studies have demonstrated that only a subset of the viral latent genes is essential for EBV mediated transformation. (pennmedicine.org)
  • The use of viral vectors to deliver foreign genes to the brain is highly logical states in the human brain (Eng et al. (lu.se)
  • The regulation of transcription of histone genes differs between eukaryotes. (news-medical.net)
  • In eukaryotes, many lncRNAs have been identified and shown to be pivotal regulators of genome structure and gene expression. (biorxiv.org)