• One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)
  • Khimani (Revvity): Cell and gene therapies are delivering on the promise of curing diseases.Initially starting with CAR-T [chimeric antigen receptor T cells] treatments for hematological malignancies, therapies are now in the clinic for rare inherited genetic disease, infectious diseases, and solid tumors. (biopharminternational.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • It has been proved to have a beneficial treatment effect on BIBX 1382 prevention of tumor recurrence in individuals with HCC [23 24 We generated a mouse-human chimeric cHAb18 antibody that derived from murine HAb18 and showed inhibition of HCC cell. (immune-source.com)
  • Generating and characterising chimeric antigen receptors to target the tumour vasculature. (bham.ac.uk)
  • Project 1: the role of PTPN22.6 in Intermediate Uveitis and Project 2: cord blood mononuclear cells as an alternative source for Chimeric Antigen Receptor-mediated cancer immunotherapy. (bham.ac.uk)
  • The development of novel T cell receptor - and chimeric antigen receptor - engineered T cell therapies for the treatment of cancer. (bham.ac.uk)
  • Chimeric antigen receptors (CAR) are fusion molecules that couple the HLA- independent binding of a selected cell surface target antigen to the delivery of a tailored T-cell activating signal. (aacrjournals.org)
  • Primary T cells expressing chimeric receptors specific for tumor or viral antigens have considerable therapeutic potential. (nih.gov)
  • Unfortunately, their clinical value is limited by their rapid loss of function and failure to expand in vivo, presumably due to the lack of costimulator molecules on tumor cells and the inherent limitations of signaling exclusively through the chimeric receptor. (nih.gov)
  • We now report that EBV-specific (but not primary) T cells transduced with tumor-specific chimeric receptor genes can be expanded and maintained long-term in the presence of EBV-infected B cells. (nih.gov)
  • They recognize EBV-infected targets through their conventional T-cell receptor and tumor targets through their chimeric receptors. (nih.gov)
  • The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
  • identified the Insulinlike growth factor 1 receptor (IGF-1R) as a potential therapeutic target in GIST. (liferaftgroup.org)
  • PSMA is a cell surface glycoprotein receptor present on tumor vascular endothelium of many types of cancer [6, 7]. (aiche.org)
  • The use of CD20 as suicide gene was investigated in CMV specific T cells and in T cells genetically modified with an antigen specific T-cell receptor. (haematologica.org)
  • CD20-transduced T cells with and without co-transferred T-cell receptor were efficiently eliminated by complement dependent cytotoxicity induced by therapeutic anti-CD20 antibody rituximab. (haematologica.org)
  • T-cell receptor (TCR) gene transfer is an attractive strategy for rapid in vitro generation of high numbers of antigen specific T cells. (haematologica.org)
  • You will find particular proteins with indicated tumor-type specificity: prostate certain antigen in prostate tumors, tyrosinase for melanomas, estrogen receptor protein and foetoprotein for hepatocarcinomas [258]. (estrogen-receptor.com)
  • Human telomerase reverse transcriptase (hTERT), epithelial development aspect receptor, and survivin are normally active and overexpressed proteins within a variety of tumor types [259]. (estrogen-receptor.com)
  • The study demonstrated that specific T cell responses against mutations uniquely harbored in tumor cells can be induced in cancer patients by vaccination. (wikipedia.org)
  • Recent findings show how T cells exert selection pressures on a tumor, influencing its genetic composition and future susceptibility to the immune system. (massgeneral.org)
  • Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect with a lower dose. (biosyn.com)
  • For example, tumor cells have certain upregulated receptors, enzymes, and other metabolic features that are not present in normal cells in the body. (biosyn.com)
  • In the first part of the study, we engineered CAR T cells through non-viral Sleeping Beauty (SB) transposition of CAR genes from minimalistic DNA vectors called minicircles rather than conventional SB plasmids. (uni-wuerzburg.de)
  • This novel approach dramatically increased stable gene transfer rate and cell viability and resulted in higher yield of CAR+ T cells without the need of long ex vivo expansion to generate therapeutic doses of CAR+ T cells. (uni-wuerzburg.de)
  • In the second part of the study, we ablated expression of PD-1, a checkpoint and negative regulator of T cell function to improve the therapeutic index of CAR T cells. (uni-wuerzburg.de)
  • Based on the promising results achieved from antibody-mediated PD-1 blockade in the treatment of hematological and solid tumors, we are confident that PD-1 knockout CAR T cells enhance the potency of CAR T cell therapies for treatment of cancers without the side effects of antibody-based therapies. (uni-wuerzburg.de)
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
  • Various biological processes including immunoreaction of infection, tumor prevention, and human aging could cause telomere damage, tumor-related stress responses, and T regulatory (Treg) cells activation, which even trigger T cell senescence showing the distinctive phenotypic and functional alternation [ 9 , 10 ]. (hindawi.com)
  • Furthermore, the ability to isolate and expand cells of sufficient therapeutic quality and quantity in a patient-to-patient model can limit progress. (scienceboard.net)
  • Techniques such as cellular reprogramming will allow the exploration of scalable allogeneic cell sources and the optimizable generation of cells for therapeutic development. (scienceboard.net)
  • Coupled with well-established in vitro culture and expansion protocols for T lymphocytes, CAR enabled the antigen-directed cytotoxicity of T cells to be harnessed, expanding the scope of cell therapy. (scienceboard.net)
  • First-generation ex vivo cell therapies, such as autologous anti-CD19 CAR T cells, demonstrated the clinical value and curative potential of enhancing the therapeutic qualities of immune and other patient-derived cell types. (scienceboard.net)
  • A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
  • Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
  • Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)
  • The discovery of MHC-II on tumour cells has been less characterized. (portlandpress.com)
  • However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
  • This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)
  • When these chemotherapeutic or gene-based cytokine agents are injected into a locally targeted treatment area such as a tumor and the predominantly healthy tissue in the margin surrounding a tumor, they have been shown to selectively and quickly destroy the tumor and cancer cells in the tumor margin. (inknowvation.com)
  • Gene-based cytokine agents act by inducing broad, non-antigen specific immune responses that have been shown to kill cancerous cells. (inknowvation.com)
  • Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
  • The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
  • Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
  • The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
  • During the tumor initiation stage, cancer cells escape from immune surveillance. (biomedcentral.com)
  • During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
  • The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
  • Cancer gene therapy approaches include the direct killing of tumor cells by injecting a therapeutic gene into the tumor cell or employing vaccine strategies to deliver an immunomodulatory gene that stimulates the immune system to recognize tumor antigens [ 1 ]. (biomedcentral.com)
  • When expressed in tumors, TK converts the non-toxic precursor GCV into GCV- 3-phosphate, a toxic substance that kills tumor cells. (biomedcentral.com)
  • Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
  • Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
  • Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
  • In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)
  • Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
  • Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
  • In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
  • As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • OncoVEXGM-CSF a recombinant HSV expressing GM-CSF in phase III trial for treatment of melanoma was proved to eliminate malignancy cells by inducing local and systemic antigen-specific T cell reactions and reducing suppressive immune cell populations [12]. (immune-source.com)
  • CD147 is definitely over-expressed in HCC cells and involved in tumor cell invasion [17] and closely related to prognosis in individuals with HCC [18-22]. (immune-source.com)
  • Here we show that across multiple cancer types, responses (as evaluated by Response Evaluation Criteria in Solid Tumours, version 1.1) were observed in patients with tumours expressing high levels of PD-L1, especially when PD-L1 was expressed by tumour-infiltrating immune cells. (nih.gov)
  • One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
  • Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)
  • Evidence exists that immune activation against hematopoietic elements frequently occurs in MDS patients, based on the identification of lymphocytic infiltrates in the marrow, oligoclonal expansion of T cells, and excessive production of tumor necrosis factor alpha. (acgtfoundation.org)
  • K562 cells express many of the antigens shown to be overexpressed in myeloid leukemias and MDS. (acgtfoundation.org)
  • Exploring the therapeutic potential of CAR-engineered T-cells targeting endothelial markers on tumour and inflamed vasculature. (bham.ac.uk)
  • Researchers have engineered a tissue-mimicking hydrogel model to show that more elastic tissues induce T cells to become effector-like T cells with strong tumor-killing potential, while more viscous tissues induce them to become memory-like T cells. (sciencedaily.com)
  • Researchers at Harvard's Wyss Institute and Harvard SEAS led by David Mooney engineered a tissue-mimicking hydrogel model to show that more elastic tissues induce T cells to become effector-like T cells with strong tumor-killing potential, while more viscous tissues induce them to become memory-like T cells. (sciencedaily.com)
  • Importantly, the phenotypes, functions, and gene expression programs of T cells trained in variations of the system correlated well with those we found in T cells in mechanically distinct tissues from patients with cancer or fibrosis," said Mooney who also is the Robert P. Pinkas Family Professor of Bioengineering at SEAS, and leads the Wyss Institute's Immunomaterials Initiative. (sciencedaily.com)
  • Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
  • Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. (lifeboat.com)
  • Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies. (lifeboat.com)
  • Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)
  • However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. (lifeboat.com)
  • 8-10 Long-lasting protective immunity relies on the efficient establishment of long-lived memory CD8 + T cells, which have the potential to eradicate primary and disseminated tumors. (lifeboat.com)
  • Another approach is recombinant oncolytic viruses that can replicate specifically in tumor cells and induce toxic effects leading to cell lysis and apoptosis. (mdpi.com)
  • These molecules are delivered to patient T-cells using retroviral gene-transfer, thereby stably re-directing their specificity for antigen. (aacrjournals.org)
  • Results: Studies to date have shown that human T-cells engineered to express cMet CARs can destroy mesothelioma tumour cell monolayers, accompanied by T-cell proliferation and cytokine production. (aacrjournals.org)
  • Conclusions: These findings demonstrate proof of concept for the utility of CAR engineered T-cells to recognise and destroy cMet-expressing MPM tumour cells. (aacrjournals.org)
  • We envisage that regional i.e. intrapleural delivery of human CAR positive T-cells could be used to maximise therapeutic index of this approach. (aacrjournals.org)
  • Because overexpression of IGF-1R has been identified in several tumor types and because of its role in cellular metabolism, which potentially has relevance to the survival of malignant cells, IGF-1R has become a target for anticancer therapy. (liferaftgroup.org)
  • Antivascular therapy aims to kill tumor cells by cutting off blood flow, depriving tumors of nutrients they need to survive [2]. (aiche.org)
  • The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. (haematologica.org)
  • 1 , 2 The anti-tumor effect of DLI is mediated by donor T cells recognizing allo-antigens on the malignant cells of the recipient. (haematologica.org)
  • Donor T cells may also induce GvHD due to recognition of allo-antigens on non-malignant tissues of the patient. (haematologica.org)
  • Transfer of HSV-tk to DLI preserves the beneficial anti-tumor effect and allows in vivo elimination of donor T cells if severe GvHD occurs. (haematologica.org)
  • 4 In addition, TCRs for minor histocompatibility antigens, including HA-1 and HA-2, have been transferred to donor-derived virus-specific T cells to treat patients with hematologic malignancies after allogeneic stem cell transplantation. (haematologica.org)
  • Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
  • Both biopharmaceuticals are regarded as vaccines because they elicit an immune response, either against a pathogenic microorganism or against the host's own tumour cells. (intechopen.com)
  • Intracellular antigens must be processed before presentation to CD8 + T cells by major histocompatibility complex (MHC) class I molecules. (johnshopkins.edu)
  • Mesenchymal stem cells (MSCs) transplantation has been used for therapeutic applications in various diseases. (oncotarget.com)
  • The K3 cells expressed surface antigens and pluripotent genes similar to those of rBM-MSCs and presented tumor cell features. (oncotarget.com)
  • Non-virally transformed T cells, induced to genomically integrate CAR by Sleeping Beauty transposase, were numerically expanded on artificial antigen presenting cells (aAPC) derived from K562. (bmj.com)
  • Furthermore, the anti-tumor activity of the CAR+ T cells numerically expanded on aAPC with or without co-stimulation was tested by adoptive transfer into mice containing CD19+ tumor. (bmj.com)
  • These data highlight that the use of co-stimulation in the ex vivo culture could potentially impact the therapeutic potential of CAR+ T cells. (bmj.com)
  • However, HLA-II complexes almost never are expressed naturally in GMB cells, and scientists believe their absence contributes to the poor anti-tumor immune response commonly seen in GBM. (asbmb.org)
  • Importantly, the effects of these agents on CG antigen gene expression often show marked specificity for tumor cells as compared to normal cells. (nebraska.edu)
  • Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
  • Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. (biomedcentral.com)
  • This innovative approach enhances the patient's immune system to target and eliminate tumor cells. (biomedcentral.com)
  • Additionally, deletion from the RK3616 gene inside the HSV-1 virus inhibited the downstream phosphatase, PKR (dsRNA induced protein kinase), producing normal cells resistant to infection whilst leaving tumorigenic cells vulnerable as a consequence of disturbance of cellular antiviral pathways [257]. (estrogen-receptor.com)
  • We hope to provide the blueprints for a new generation of smart circuit immune cells that can be tailored to perform precise actions upon combinatorial antigen signatures to enable safe and effective targeting of tumor cells. (lu.se)
  • These sophisticated cells will hopefully provide a new potent therapeutic avenue for currently untreatable tumors. (lu.se)
  • Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
  • Tumor-associated antigens (TAAs) are relatively restricted to tumor cells. (msdmanuals.com)
  • Tumor-specific antigens (TSAs) are unique to tumor cells. (msdmanuals.com)
  • However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)
  • References Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
  • This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
  • We have developed genetic and genomics approaches to explain the large variance in anti-tumor immunity across people, and to discover how tumors evolve to resist productive immunity. (massgeneral.org)
  • We've identified somatic mutations in tumors that are associated with anti-tumor immunity in patients, found T cell subtypes that are associated with a response to anti- PD-1 immunotherapy in melanoma and are studying their properties now (Sade-Feldman et al. (massgeneral.org)
  • Thus, their reactivation represents an attractive way to unleash anti-tumour immunity. (portlandpress.com)
  • Central to this proposal is the observation that all three classes of drugs augment discrete elements of host immunity, making their integration with therapeutic cancer vaccines ripe for exploration. (acgtfoundation.org)
  • In early phase clinical trials for both acute and chronic myeloid leukemias, we have observed the induction of anti-tumor immunity and associated clinical responses following K562/GM-CSF vaccination (see preliminary data). (acgtfoundation.org)
  • The presence of variable numbers of intratumoral lymphocytes and primitive round cell areas are the unique defining features for this tumor. (allenpress.com)
  • MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
  • Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
  • Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
  • Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
  • We investigated the use of human CD20 as suicide gene in T-lymphocytes. (haematologica.org)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • Binding of PD-L1 to its receptors suppresses T-cell migration, proliferation and secretion of cytotoxic mediators, and restricts tumour cell killing. (nih.gov)
  • Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)
  • Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies. (lu.se)
  • 4, 2011 - OncoSec Medical Incorporated (OTCBB: ONCS.OB), a developer of innovative medical approaches to treat solid tumor cancers with unmet medical needs, announced today that on March 24, 2011 it completed its acquisition of certain assets of Inovio Pharmaceuticals, Inc. (NYSE Amex: INO) and entered into a license agreement with Inovio, pursuant to the terms of an asset purchase agreement with Inovio entered into on March 14, 2011. (inknowvation.com)
  • Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. (biomedcentral.com)
  • Treatment of a solid tumor by an effective vector for a suicide gene remains a challenge. (biomedcentral.com)
  • Meanwhile, three human digestive system xenograft tumor models (colorectal cancer colo320, gastric cancer MKN-45 and liver cancer SSMC-7721) and a breast cancer (MDA-MB-231) model were employed to validate the universality of BF-rTK + GCV in solid tumor gene therapy. (biomedcentral.com)
  • Survival analysis results of multiple cancer models confirmed that BF-rTK + GCV system has a wide field of application in solid tumor gene therapy. (biomedcentral.com)
  • The disease is undoubtedly an all natural OV for solid tumor therapy in center trials and displays minimal side-effects with systemic administration [3 4 Lately the toxicity biodistribution and dropping of NDV in nonhuman primates under intravenous shot were examined demonstrating the protection for intravenous administration [5]. (immune-source.com)
  • SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. (lu.se)
  • The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
  • One such mechanism involves the upregulation of immune checkpoints, such as programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1), cluster of differentiation 86 (CD86)/cytotoxic T-lymphocyte antigen 4 (CTLA-4) [ 16 ]. (biomedcentral.com)
  • Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
  • Nat Biotech 2020), which are now being used to develop novel therapeutic approaches and targets for immunotherapy, such as personal tumor vaccines targeting multiple HLA-associated neoantigens in human tumors (together with Dr. Catherine Wu at DFCI, Ott et al. (massgeneral.org)
  • It will offer many researchers a wider perspective into the proteomic signatures characteristic of DMD and potential therapeutic targets and also will be useful for researchers studying the effects of aging on the muscle proteome. (asbmb.org)
  • It is less appreciated that medically important tumor-associated antigens, particularly the Cancer Testis or Cancer/Germ-line family of antigens (CG antigens), which are being actively tested as cancer vaccine targets, are epigenetically activated in many human cancers. (nebraska.edu)
  • CTAs are emerging as attractive targets for therapeutic cancer vaccines due to their expression in tumors but not in normal tissues except testis. (endocrine-abstracts.org)
  • therapeutic targets? (lu.se)
  • These solo-LTRs contain functional sequences like promoters, enhancers, polyadenylation signals and are frequently located near cellular genes. (frontiersin.org)
  • He is involved in several ongoing cellular and immuno-gene therapeutic clinical trials and his research group has put major efforts into the development of various T cell-based immunotherapeutic strategies. (wikipedia.org)
  • In addition to discovering and studying specific molecular and cellular mechanisms, we also address how and why the immune response (to tumors, pathogens or self) varies so dramatically across individuals. (massgeneral.org)
  • The high level of gene transfer rate and efficient genome editing, superior safety profile as well as ease-of-handling and production of non-viral MC vectors and Cas9 RNP position our developed non-viral strategies to become preferred approaches in advanced cellular and gene-therapy. (uni-wuerzburg.de)
  • Cellular reprogramming involves remodeling gene expression to generate a desired cell lineage or type. (scienceboard.net)
  • There has been an increase in the identification of disease-associated risk factors, such as histone deacetylases (HDACs) and vimentin, as well as the signaling pathways involved, including activation of the Wnt signaling pathway and inactivation of the cellular tumor antigen p53 signaling pathway ( 9 ). (spandidos-publications.com)
  • In a recent paper in the journal Molecular & Cellular Proteomics , Greta Forlani and a team of Swiss researchers write that they discovered how to induce HLA-II expression by inserting the gene histocompatibility complex transactivator, or CIITA, into various GMB cell lines. (asbmb.org)
  • Our recent studies aim to better understand the role of FATE1 in tumor cellular metabolism, mitochondrial morphology and signaling and in drug resistance, potentially important for the aggressive phenotype of adrenocortical carcinoma. (endocrine-abstracts.org)
  • It had also been recommended by the FDA's Oncologic Drugs Advisory Committee and the Cellular, Tissue, and Gene Therapies Advisory Committee last April, by a vote of 22 to 1. (medscape.com)
  • Host Response to Tumors The immune response to foreign antigens consists of Humoral mechanisms (eg, antibodies) Cellular mechanisms (See also Tumor Antigens. (msdmanuals.com)
  • T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
  • Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
  • Vaccination strategies eliciting CTL responses specific for tumor-specific and self-antigens have shown promising results in recent clinical trials. (lifeboat.com)
  • Tumor markers are tumor-derived or tumor-associated proteins, antigens, genes or hormones that can also aid in diagnosis, in the measurement of therapeutic response, in locating tumor origin or in determining recurrence. (oncolink.org)
  • From accurately targeting the diseased tissue, to ensuring that the corrected gene is expressing proteins at sufficient level to resolve the clinical symptoms, to ensuring that the products are robust, affordable, scalable, and accessible. (biopharminternational.com)
  • One example of base editing, the Pin-point™ system, has been demonstrated as able to knock-out immunogenic proteins and knock-in a targeted CAR within the same editing reaction, creating an effective functional CAR-T cell line with tumor-killing activity. (biopharminternational.com)
  • Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
  • The Wnt pathway contains quite a few other proteins typically implicated in many types of tumors, particularly inside the stomach and intestines. (estrogen-receptor.com)
  • Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (bvsalud.org)
  • In children and adolescents, salivary gland tumors make up 0.5% of all malignancies. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
  • An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)
  • An area that has witnessed significant breakthroughs over recent years has been that of cell and gene therapies. (biopharminternational.com)
  • As the tools used for gene editing to create allogeneic cell therapies continue to evolve and become more robust, it is imaginable that there will be an increasing interest and eventual preference for allogeneic cell therapies over autologous cell therapies. (biopharminternational.com)
  • OncoSec has also licensed the right to use this electroporation technology to deliver gene-based cytokine immune therapies for treating solid tumors. (inknowvation.com)
  • These electrochemical and gene-based cytokine therapies have previously achieved important clinical outcomes, and we look forward to initiating advanced stage clinical studies by the end of this year. (inknowvation.com)
  • Initial data has shown that, these therapies may enable heightened concentrations of medicine to be directed to the cancer while reducing overall dosage and moderating or eliminating side effects associated with systemically-applied therapeutic approaches. (inknowvation.com)
  • How can our knowledge of the immune system be applied to develop innovative therapies, including the identification of novel antigens for immune therapies and gene repair strategies in monogenic immune diseases? (mdc-berlin.de)
  • Based on the difficulties encountered in treatment, future effective interventions will likely require a combination of therapies to provide effective tumor control, of which antivascular therapy may be a key element. (aiche.org)
  • Taken together, these data encourage clinical evaluation of combination therapies involving epigenetic modulatory drugs and CG antigen-directed tumor vaccines for the treatment of human malignancies. (nebraska.edu)
  • The outcome of the advisory meeting was somewhat of a surprise, as the FDA briefing document released prior to the meeting contained many queries and stated that it was unclear whether the product offers an acceptable benefit-risk profile in a therapeutic field in which many new therapies have recently been launched. (medscape.com)
  • Our aim was to provide information about the production of Egg White Immunoglobulin (EWIg) with specificity to Staphylococcal protein-A , a surface antigen of Staphylococcus aureus and to study the inhibition of this bacterium growth in pre- and post-immunized hens. (omicsonline.org)
  • These nanoparticles do not contain a viral genome and display the hepatitis B virus L antigen, which is essential to confer hepatic specificity. (elsevierpure.com)
  • One such study demonstrated that an E1B-19kDa gene deletion mutant enhanced cancer specificity by means of TNF pathways, substantially enhancing viral spread and antitumoral capacity whilst simultaneously sustaining selectivity [259]. (estrogen-receptor.com)
  • Aberrations of this molecular pathway such as over-expression of IGF-1R, or elevated plasma levels of IGF1, or genetic polymorphisms of the gene encoding IGF1 have been found in association with a variety of cancers including sarcoma. (liferaftgroup.org)
  • Recent work has begun to dissect the specific epigenetic mechanisms controlling differential expression of CG antigen genes in human cancers. (nebraska.edu)
  • Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
  • OncoSec purchased certain electroporation technology assets and licensed additional electroporation applications based on Inovio's industry-leading electroporation technology platform that, in addition to DNA vaccines and immune therapeutics, also efficiently delivers chemotherapeutic or gene-based cytokine agents for the treatment of cancerous tumors. (inknowvation.com)
  • Other Inovio clinical programs include those for avian flu (preventive) and HIV vaccines (both preventive and therapeutic). (inknowvation.com)
  • 1. Examine the in vivo effect of: a) DNA methyltransferase inhibitors, b) HDACi, and c) IMiDs on the response to GM-CSF tumor vaccines in a mouse model (year 1). (acgtfoundation.org)
  • 2. Conduct a clinical trial in MDS testing K562/GM-CSF vaccination integrated with the systemic agent(s) identified in aim 1 as being most active in combination with GM-CSF tumor vaccines (years 2 and 3). (acgtfoundation.org)
  • However, a major limitation to the therapeutic value of CG antigen-directed vaccines is the limited and heterogeneous expression of CG antigens in tumors. (nebraska.edu)
  • These tumors and accessories represent the hallmark characteristics that support tumor progression and lead to metastasis. (biomedcentral.com)
  • The ratio of pro- to antitumor immune populations in the TIME plays a critical role in the regulation of tumor progression and metastasis. (biomedcentral.com)
  • The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. (nih.gov)
  • Potential therapeutic avenues were identified for each risk group, with special attention to mutations in MYC, particularly amplifications, hinting at its role in tumor progression. (bvsalud.org)
  • Therefore, elucidating the mechanisms underlying HCC pathogenesis and progression is of significant importance in improving the therapeutic options for HCC. (spandidos-publications.com)
  • Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. (cusabio.cn)
  • This therapeutic approach has shown remarkable results against B-cell malignancies in pilot clinical trials. (uni-wuerzburg.de)
  • Restorative antibodies have accomplished considerable success in treating individuals with haematological BIBX 1382 malignancies and solid tumors. (immune-source.com)
  • We have developed a genetically modified tumor cell vaccine for the treatment of myeloid malignancies. (acgtfoundation.org)
  • Development of MHC class II-restricted TCR gene therapy for epstein barr virus associated malignancies. (bham.ac.uk)
  • Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
  • Furthermore, responses were associated with T-helper type 1 (TH1) gene expression, CTLA4 expression and the absence of fractalkine (CX3CL1) in baseline tumour specimens. (nih.gov)
  • Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
  • Most humoral responses cannot prevent tumor growth. (msdmanuals.com)
  • The objective of this study is to design a new class of liposomes that can target tumor vasculature via Prostate-Specific Membrane Antigen (PSMA) and rapidly and extensively release therapeutic agents intracellularly by using the pH-sensitive peptide GALA conjugated to lipid moieties to destabilize the integrity of intracellular endosomes and achieve better tumor killing outcomes. (aiche.org)
  • In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
  • Finally, we are adapting our unbiased analytical strategies into real-world therapeutics, having performed clinical trials (with our collaborator Dr. Catherine Wu), in which patients are vaccinated against their own tumors with a fully personal vaccine that is designed based on a computational analysis of their tumor genome. (massgeneral.org)
  • The clinical findings are related to the site of tumor manifestation. (allenpress.com)
  • Each of these therapeutic areas brings with it new technical and clinical challenges. (biopharminternational.com)
  • Tumour-specific expression of MHC-I and MHC-II has been associated with improved patient survival in most clinical studies. (portlandpress.com)
  • Examples are CRISPR/Cas9-mediated mutagenesis, genetic mouse models, cell-fate-mapping, organoids and tumor explants, as well as GMP production of pharmaceuticals and many years of experience in conducting clinical studies. (mdc-berlin.de)
  • The MDC's participating research groups bring a broad range of technological expertise to the initiative - ranging from biochemical assays, structure and function analysis, and gene editing to the development of preclinical mouse models, GMP production, and even clinical trials. (mdc-berlin.de)
  • Co-transfer of a suicide gene would provide a desirable safety switch in clinical TCR gene therapy. (haematologica.org)
  • From a clinical perspective, convincing data indicate that epigenetic modulatory agents, including DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors, robustly promote the expression of CG antigens, as well as class I major histocompatibility complex (MHC I) and other immune costimulatory molecules, in tumors. (nebraska.edu)
  • Due to their efficient gene delivery, viral vectors have been successfully used in T-cell engineering to provide gene transfer medicinal products for the treatment of human disease. (uni-wuerzburg.de)
  • In order to address these concerns, we aimed to improve non-viral gene transfer and genome editing tools as an effective, safe and broadly applicable alternative to viral delivery methods for T-cell engineering. (uni-wuerzburg.de)
  • Viral replication and virulence weren't attenuated from the incorporation of cHAb18 gene ICOS which considerably improved the suppression of relict tumor cell migration. (immune-source.com)
  • Proteínas transcritas a partir de la región E1B del genoma de ADENOVIRUS, que estan involucradas en la regulación de los niveles precoces y tardios de expresión genética viral. (bvsalud.org)
  • The mechanisms of tumor cell killing by antibodies are summarized as the direct action of the antibody payload delivery and specific effects of an antibody within the tumor vasculature and stroma. (immune-source.com)
  • This study explores the mechanism of GALA anchored to gel-phase lipid vesicles in both clustered (pH and non-pH responsive) and uniform presentations with the goal of optimizing GALA presentation for improving therapeutic efficacy of tumor vasculature targeted liposome compositions. (aiche.org)
  • Therefore, tumor vasculature is directly and easily accessible to intravenously injected PSMA targeted treatments, whereas healthy vasculature and PSMA-expressing tissues are not expected to exhibit significant localization. (aiche.org)
  • Epstein-Barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. (allenpress.com)
  • Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is an uncommon neoplasm typically manifesting in immunodeficient individuals. (allenpress.com)
  • The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs (rBM-MSCs) and the new tumor cell line, K3, was isolated from the neoplasm. (oncotarget.com)
  • In October 2015 the US Food and Drug Administration authorized the injectable formulation of OncoVEXGM-CSF with the brand name Imlygic for the treatment of melanoma in individuals with inoperable tumors. (immune-source.com)
  • Advanced melanoma remains a complex disease to treat, requiring the use of several modalities over the course of a patient's therapeutic journey," commented Howard L. Kaufman, MD, the principal investigator for the pivotal trial (OPTiM) that led to the drug's approval, in a statement issued by the company. (medscape.com)
  • The aAPC were genetically modified to present the target antigen CD19 along with no co-stimulation, or co-stimulation via CD86, CD137L, or both molecules. (bmj.com)
  • NSCLC known to have a known or likely oncogenic-driver mutation in the EGFR gene, as identified by site local testing or Sponsor central testing Liver disease Positive hepatitis B surface antigen test at screening Patients known to be positive for hepatitis C virus antibody HIV infection, patients are excluded if HIV is not adequately controlled (specific criteria apply). (who.int)
  • Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. (biomedcentral.com)
  • The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)
  • Multiple level regulation of SF-1 activity is exerted by interaction with cofactors, post-translational modifications and epigenetic gene expression regulation. (endocrine-abstracts.org)
  • We showed that SF-1 dosage differentially regulates the expression of numerous and distinct genes, involved in a variety of biological processes, suggesting that fine regulation of SF-1 dosage is a critical determinant of its action during adrenal development, function and tumourigenesis. (endocrine-abstracts.org)
  • Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
  • Genetic polymorphism studies demonstrated that the can develop immediate, late or dual asthmatic reactions glutathione-S-transferase gene family is associated with after chemical exposure. (cdc.gov)
  • The tumor tissues were analyzed using apoptosis antibody arrays, real time PCR and western blot. (biomedcentral.com)
  • The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. (hindawi.com)
  • However, the microsized particles could only stay in blood circulation and penetrate poorly into tumor tissues, so that the wide application of the particles for in vivo tumor therapy is limited [ 3 ]. (hindawi.com)
  • Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
  • The small packaging allows nanoparticles to extravasate into tumor tissues. (hindawi.com)
  • Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)
  • The mechanical features of tissues, for example, bone, muscle, different internal organs, and blood, can vary widely, and pathological tissues such as tumor masses or fibrotic tissues are mechanically significantly different from healthy tissues. (sciencedaily.com)
  • OncoSec has purchased from Inovio certain non-DNA vaccine electroporation technology and intellectual property useful for an electrochemical therapy against solid tumors. (inknowvation.com)
  • Karpf, AR 2006, ' Potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy ', Epigenetics , vol. 1, no. 3, pp. 116-120. (nebraska.edu)
  • veloping preventive and therapeutic vaccine candidates. (cdc.gov)
  • While cancer immunology has been deeply studied in animal models, there remain many open questions in human tumor immunology. (massgeneral.org)
  • These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
  • We identified new functional interactions between SF-1 and neuron-restrictive silencer factor/RE1-silencing transcription factor (NRSF/REST) suggesting that SF-1 has a broader role than initially thought in regulating tissue-specific gene expression programs. (endocrine-abstracts.org)
  • Tumor-derived DNA from pleural effusion supernatant as a promising alternative to tumor tissue in genomic profiling of advanced lung cancer. (cdc.gov)
  • Optimizing these first-in-class approaches focuses on improving their safety and efficacy profile via a plethora of modifications, including targeting tumor-associated antigens, incorporating control switches, and employing gene editing to prevent graft-versus-host disease and/or other toxicity risk components. (scienceboard.net)
  • New therapeutic approaches are required to improve outcome in this disease. (aacrjournals.org)
  • The development of safe and efficient liver-specific gene delivery approaches offers new perspectives for the treatment of liver disease, in particular, liver cancer. (elsevierpure.com)
  • New target molecules and mediators as well animal model, diisocyanate, diphenyl-methane diisocyanate, as new therapeutic approaches for allergic asthma have hexamethylene diisocyanate, murine model, occupational been identified using animal models. (cdc.gov)
  • 9 , 10 Rituximab (RTX) is a therapeutic anti-CD20 antibody, which is widely used in the clinic. (haematologica.org)
  • Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
  • Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo. (lu.se)
  • The processes of tumor initiation, expansion, and metastasis are governed by the TIME, where immunosuppressive and antitumor immune crosstalk play an important role. (biomedcentral.com)
  • While tumor expansion, contact-dependent or independent crosstalk between tumor and TIME affects the production of various cytokines that help in the polarization of antitumor immune response in the immunosuppressive TIME. (biomedcentral.com)
  • This in turn ruptures the tumors and releases tumor-derived antigens, which, along with GM-CSF, may promote an antitumor immune response. (medscape.com)
  • Additionally, a contrast was observed between MYC and GOT2's associations with HLA molecules, emphasizing their distinct roles in antigen presentation. (bvsalud.org)
  • Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. (cusabio.cn)
  • Aberrant expression of these two enzymes may result in epigenetic alteration and, consequently, dysregulated gene expression ( 10 , 11 ). (spandidos-publications.com)
  • The discovery of epigenetic silencing as a key mechanism of tumor suppressor gene inactivation in human cancer has led to great interest in utilizing epigenetic modulatory drugs as cancer therapeutics. (nebraska.edu)
  • Immune checkpoint-inhibitor combinations are the best therapeutic option for advanced hepatocellular car-cinoma (HCC) patients, but improvements in efficacy are needed to improve response rates. (unav.edu)
  • Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)
  • On the other hand, LTR-retrotransposons, so called mammalian apparent LTR retrotransposons (MaLRs) represent 3.6% of the genome and lack primer binding sites and gag-pol genes ( 1 ). (frontiersin.org)
  • We've used genome-wide CRISPR libraries to discover mammalian genes mediating the sensing of pathogens (Parnas et al. (massgeneral.org)
  • Critical to sub-classify SRBCTs, Khan et al .6 used to measure genome-wide gene expres- .com decisions in cancer therapeutics are to microarrays to monitor the expression sion for a variety of biological samples. (lu.se)
  • High tumor proliferation has previously been associated with response to chemotherapy. (lu.se)
  • High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
  • This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
  • A meticulous evaluation of 329 LRGs within the TARGET dataset spotlighted 27 paramount genes, intricately intertwined with survival. (bvsalud.org)
  • We show that treatment of the mice with a combination of anti-CTLA-4 + anti-PD1 mAbs results in partial clearance of the tumor with an improvement in survival. (unav.edu)
  • A 6-Gene Risk Signature Predicts Survival of Glioblastoma Multiforme. (cdc.gov)
  • Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. (hindawi.com)
  • for example, recombinant viruses can be genetically engineered to express immunomodulatory genes or tumor-specific antigens to stimulate an anti-cancer immune response. (mdpi.com)
  • Talimogene laherparepvec is a genetically modified herpes simplex virus type 1 that is designed to replicate within tumors and produce the immunostimulatory protein granulocyte-macrophage colony-stimulating factor (GM-CSF). (medscape.com)
  • Recombinant viruses are a novel therapeutic tool that can be utilized in the treatment of various diseases, including cancer. (mdpi.com)
  • Given the limitations of imatinib for treating wild-type GIST, numerous investigators have sought to identify other biologic abnormalities that could be used to devise novel therapeutic strategies. (liferaftgroup.org)
  • Using a recombinant vaccinia virus (Vac) to transiently express the K d molecule, we studied the antigen processing efficiency of 26 different human tumor lines. (johnshopkins.edu)
  • Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
  • Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)
  • It has not been shown whether a therapeutic effect could be obtained using L nanoparticles in a human liver tumor xenograft model. (elsevierpure.com)
  • Human CD20 has been proposed as non-immunogenic protein with a dual function as selection marker and suicide gene. (haematologica.org)
  • Rats bearing human hepatic (NuE) and non-hepatic tumors were injected with L nanoparticles containing a green fluorescent protein (GFP) expression plasmid. (elsevierpure.com)
  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Demonstration of Epstein-Barr virus infection by in situ hybridization within tumor cell remains critical for the diagnosis. (allenpress.com)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Tumors include Ewing sarcoma (EWS), neu- while Ewing sarcomas are aggres- roblastoma (NB), rhabdomyosarcoma (RMS) and Burkitt lym- rently used in tumor diagnosis do sive enough to warrant treatment phomas (BL, subset of non-Hodgkin lymphoma). (lu.se)
  • These lesions are considered to be independent primary lesions rather than metastatic disease when multiple tumors are encountered in the same patient. (allenpress.com)
  • Scientific advances now allow us to improve and utilize this strength of the immune system against tumors. (lu.se)
  • Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)
  • A key role of the immune system is detection of these antigens to permit subsequent targeting for eradication. (msdmanuals.com)
  • The increasing number of processes being developed to address the cell therapy market will need to be consolidated at some point to create a standardized, scalable therapeutic approach. (biopharminternational.com)
  • The Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-TK + GCV) system is currently one of the best-studied tumor suicide gene therapy systems [ 9 - 11 ]. (biomedcentral.com)
  • As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)
  • In recent years, tumor-targeted therapy has been appearing as a promising therapeutic choice for cancer treatment. (hindawi.com)
  • Immuno-gene therapy of myelodysplastic syndrome. (acgtfoundation.org)
  • The combination of virus-mediated therapy with other therapeutic agents allows one to find the most effective approach to cancer treatment. (mdpi.com)
  • 5 - 8 A drawback of TCR gene therapy is the formation of mixed TCR dimers, consisting of transgenic and endogenous TCR α and β chains. (haematologica.org)
  • We evaluated the therapeutic potential of hepatotropic nanoparticles for gene therapy of liver tumor. (elsevierpure.com)
  • Cancer Gene Therapy , 14 (1), 74-81. (elsevierpure.com)
  • The analysis of inflammatory markers (TNF-α) in tumor indicated that BF-rTK + GCV significantly inhibited TNF-α expression. (biomedcentral.com)