• Argonautes' gene-silencing functions also help cells cope with rogue genetic activity from invading viruses or cancer-promoting DNA mutations. (scripps.edu)
  • He's currently researching whether these alleles alone cause resistance to PARP inhibitors and other cancer treatments-and therefore, these studies could impact clinical management of patients harboring BRCA2 mutations. (yale.edu)
  • With NFCR support since 2014, she seeks to develop new treatments for patients with anaplastic lymphoma kinase (ALK) mutations in non-small cell lung cancer. (nfcr.org)
  • Sensitivity to PARP-inhibitors requires tumors to have mutations that disable effective repair of damaged DNA. (pcf.org)
  • Most commonly, such mutations are in the BRCA2 gene. (pcf.org)
  • Feng's team have discovered that some prostate cancers become resistant to PARP-inhibitors by gaining mutations that overwrite the original BRCA2 mutation and restore the activity of the BRCA2 protein. (pcf.org)
  • In this project, the team will study patients being treated with PARP-inhibitors in clinical trials to comprehensively characterize mutations that cause tumors to be sensitive to PARP-inhibitors, and the mutations that lead to acquired PARP-inhibitor resistance. (pcf.org)
  • Despite these advances, additional mutations seem to develop in the lung cancer cells that allow them to develop resistance to these newer chemotherapy agents. (medpagetoday.com)
  • Prof. Lukas Dow, biochemistry, and his team published a study in Nature on Aug. 16, detailing a new, more specific gene editing tool that they created to study cancer mutations through preclinical mice models. (cornellsun.com)
  • The team combined Cas9, an enzyme that cuts DNA, and guide RNA, a type of RNA that determines which DNA region Cas9 cuts, with apolipoprotein B mRNA editing enzyme, catalytic polypeptide - an enzyme commonly known as APOBEC that creates single base mutations in DNA. (cornellsun.com)
  • Along with co-first author Shih- Shan Lang, MD, Sievert works in the translational laboratory of neurosurgeon Phillip Storm, MD, and Adam Resnick, PhD. Sievert and colleagues were among several groups that first identified that mutations in the BRAF gene were highly prevalent in astrocytomas, the most common type of brain tumor in children. (chop.edu)
  • With inherited diseases such as cystic fibrosis, mutations in the CFTR gene produce a protein that remains functional but is subject to excessive ubiquitination, leading to its rapid degradation via the proteasome. (businesswire.com)
  • Sovilnesib is in phase 1 for use in platinum-resistant high-grade serous ovarian cancer, triple-negative breast cancer as well as other solid tumors with mutations in the TP53 gene, the companies say in a press release . (acs.org)
  • An abnormal amount, caused by defects in DNA repair genes like BRCA, can result in mutations that drive cancer development and growth. (bcrf.org)
  • The knowledge built by the de Lange team is vital to furthering our understanding of how to effectively treat breast cancers with DNA repair deficiencies, especially those driven by mutations in the BRCA gene. (bcrf.org)
  • There is a highly sophisticated way to treat some breast and ovarian cancers-a class of drugs called PARP inhibitors, designed to exploit the very defects that make tumors with certain mutations especially deadly. (medicalxpress.com)
  • Mutations in BRCA1 -the subject of the new research-have been estimated to give a woman a roughly 72 percent chance of developing breast cancer and a 44 percent chance of developing ovarian cancer by the age of 80. (medicalxpress.com)
  • Without the BRCA genes, the broken DNA isn't fixed properly, producing mutations that can lead to cancer. (medicalxpress.com)
  • Mutations in a crucial gene are the key reason that chemotherapy fails in some patients with blood cancer, a study by Nanyang Technological University, Singapore (NTU Singapore) and Singapore General Hospital (SGH) has found. (eurekalert.org)
  • They found that mutations in the gene DDX3X - a type of protein responsible for processing and transmitting signals for cell growth - is the possible culprit behind cancer cells' resilience. (eurekalert.org)
  • The team combined their genetic data and those from previous studies and found through advanced analysis that lymphoma patients with DDX3X mutations had a significantly lower survival rate than those without such mutations. (eurekalert.org)
  • Although further research is needed, these findings provide hope that new and better drugs could be developed to block STAT activity and therefore improve the chances of survival for non-Hodgkin lymphoma patients with DDX3X mutations. (eurekalert.org)
  • Drug resistance mutations which restore activity of the BRCA1 or BRCA2 genes as a way of avoiding the effects of drug treatment could leave tumours vulnerable to the effects of immunotherapy, the research found. (ddw-online.com)
  • Scientists at The Institute of Cancer Research, London, compiled a database of more than 300 reported cases of mutations that rewire BRCA gene activity in order to become resistant to PARP inhibitors. (ddw-online.com)
  • PARP inhibitors attack cancers which have mutations in BRCA genes or various other genetic faults which leave them vulnerable to DNA damage. (ddw-online.com)
  • However, cancers can sidestep the effects of PARP inhibitors or chemotherapy through genetic changes that switch the BRCA genes back on - known as reversion mutations. (ddw-online.com)
  • The team from the CRUK Gene Function Laboratory and Breast Cancer Now Research Centre at the Institute of Cancer Research (ICR) studied every reported incident of resistance associated with reversion mutations in BRCA-mutant cancers. (ddw-online.com)
  • The researchers found that some types of BRCA mutation were more likely than others to develop reversion mutations that restarted BRCA gene activity. (ddw-online.com)
  • Detecting these mutations could pick out patients whose cancers might be expected to be at higher risk of developing resistance to treatment with PARP inhibitors or platinum chemotherapy. (ddw-online.com)
  • Where reversion mutations occurred, the team found that the repaired BRCA genes created proteins which differed from normal cells. (ddw-online.com)
  • That raises the prospect that immunotherapies that take the brakes off the immune system could be effective against cancers with reversion mutations - pushing the body to generate a strong immune response against the repaired BRCA proteins. (ddw-online.com)
  • It may even be possible to generate an immune response against the reverted BRCA proteins using a vaccine, if the reversion mutations can be predicted confidently. (ddw-online.com)
  • In 2005, scientists at the Breast Cancer Now Research Centre at the ICR found that PARP inhibitors kill cancer cells with BRCA gene mutations. (ddw-online.com)
  • Using high-throughput DNA sequencing, the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial viruses. (eurekalert.org)
  • In lung cancers, mutations in the KEAP1 and NFE2L2 genes, which regulate response to oxidative stress, sensitize cells to treatment with IPN60090. (mdanderson.org)
  • For example, patients with lung cancers harboring KEAP1/NRF2 mutations have not benefited from treatment with immune checkpoint inhibitors and have poorer outcomes overall, explained Yap, who leads the IPN60090 clinical trial at MD Anderson. (mdanderson.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
  • While pursuing medical oncology residency at the University of Toronto and fellowship at the Princess Margaret Cancer Centre, Dr. Rose and her colleagues developed the BEAVER trial (NCT03839342) which is an investigator initiated clinical trial testing the efficacy of specific BRAF + MEK inhibitors in cancer patients with non-V600 BRAF mutations. (ladydavis.ca)
  • APOL1-mediated kidney disease (AMKD) is a serious disease caused by mutations in the APOL1 gene that lead to damage in certain kidney cells. (kidney.org)
  • The underlying genetic cause of AMKD is toxic gain-of-function mutations in the APOL1 gene that enhance APOL1 pore function and damage glomerular cells, ultimately leading to proteinuria and kidney failure. (kidney.org)
  • In 2010, scientists discovered that specific changes (i.e., mutations) in a gene called APOL1 cause a serious kidney disease called APOL1-mediated kidney disease (AMKD). (kidney.org)
  • Interestingly, this discovery was facilitated by the identification of gain-of-function mutations, which are alterations in the human genetic code that increase the normal activity of a gene. (heartscandirect.com)
  • The mutations in the PCSK9 gene result in high LDL cholesterol levels and, thus, increase the risk of developing coronary artery disease. (heartscandirect.com)
  • It was not until 2004 that Vissers and colleagues reported the presence of mutations in the chromodomain helicase DNA-binding protein-7 (mutations were later identified in 16 out of 17 patients 8. (irjs.info)
  • Remarkably, most of the mutations in the BRAF gene involve the same single letter of DNA. (globenewswire.com)
  • To address ECM role in SVD, we developed a co-culture model of mural and endothelial cells using human induced pluripotent stem cells from patients with COL4A1/A2 SVD-related mutations. (bvsalud.org)
  • Genetic testing for mutations in the VHL gene is performed at many laboratories throughout the United States and the world. (medscape.com)
  • Zbtb7 is also involved in the regulation of p53, another tumor suppressor gene. (wikipedia.org)
  • In initial studies using mouse embryonic fibroblasts, researchers found that in the absence of Zbtb7, cellular pathways that convert normal cells into tumor cells did not develop. (wikipedia.org)
  • In collaboration with AstraZeneca, Jensen has focused on three BRCA2 reversion alleles, containing deletions in the BRCA2 gene that reactivate DNA repair functions, in tumor cell DNA from ovarian cancer patients who relapsed on a PARP inhibitor. (yale.edu)
  • Preclinical tests show that the inhibitor can change the microenvironment of a tumor by increasing populations of antitumor immune cells in the area. (genengnews.com)
  • The second team, led by Dr. Jeremy Rich, professor in the Department of Medicine at UC San Diego School of Medicine and director of neuro-oncology and of the Brain Tumor Institute at UC San Diego Health, took a different approach. (drugdiscoverynews.com)
  • Inhibition of sirtuins allows re-expression of silenced tumor suppressor genes, leading to reduced growth of cancer cells, and anticancer effects have been observed with SIRT1 inhibitors in vitro and in vivo, the firms said. (bioworld.com)
  • After surgery to remove PDAC, the team sent tumor samples from 19 people to partners at BioNTech, the company that produced one of the COVID-19 mRNA vaccines. (nih.gov)
  • A new study by a brain tumor research team at CHOP supports the development of targeted treatment paradigms for BRAF -altered pediatric astrocytomas. (chop.edu)
  • Further investigation by the team revealed how tumor behavior depended on which type of BRAF mutation was involved. (chop.edu)
  • When used against the fusion gene, first-generation drugs activated the MAPK signaling cascade and accelerated tumor growth. (chop.edu)
  • The direction of brain tumor research over the past several years reflects some of those data-driven advances, says Resnick, the senior author of the paper and principal investigator of the astrocytoma research team in the Division of Neurosurgery at CHOP. (chop.edu)
  • Excess ubiquitination is also a feature of cancer, where E3 ubiquitin ligases - enzymes that add ubiquitin to proteins - are frequently upregulated or amplified, driving the degradation of tumor suppressor proteins. (businesswire.com)
  • The expectation is that developing this new platform provides a more streamlined approach that will increase the throughput of tumor-reactive TCR discovery and, ultimately, therapeutic development. (swimacrossamerica.org)
  • A team from The University of Texas MD Anderson Cancer Center describes this week in the journal Nature a series of preclinical experiments using patient-derived tumor xenografts (PDXs) and mouse models that point to potential treatments for patients with a rapidly-progressing and resistant subgroup of tumor cells. (mdanderson.org)
  • Genovese and colleagues found, in a subset of tumor cells, after the original oncogenic driver fades, depletion of a gene called SMARCB1 results in a cellular change to mesenchymal status, a mobile and invasive cell state. (mdanderson.org)
  • Both genes are tumor suppressors, meaning they normally help keep the body cancer-free. (medicalxpress.com)
  • This type of resistance can emerge during or after PARP inhibitor treatment when some tumor cells thrive after mutating to lose 53BP1. (medicalxpress.com)
  • Yee and colleagues are developing another technique, endogenous T cells, which identifies and harvests tumor-attacking T cells in the blood. (newswise.com)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • In a study in Clinical Cancer Research published in June, the team reported that the drugs, known as small-molecule inhibitors of the SOX 11 oncogene, are toxic to MCL tumor development in human cells studied outside the body. (scitechdaily.com)
  • Therefore, we hypothesized that there may be a protein that acts as a tumor inhibitor during these early stages of life, preventing the development of leukemia. (lu.se)
  • Volastra's newly-licensed compound from Amgen, called sovilnesib, is an oral small molecule inhibitor of KIF18A. (acs.org)
  • In a first-time disclosure of IPN60090, a small-molecule inhibitor of the metabolic enzyme glutaminase (GLS1), researchers from The University of Texas MD Anderson Cancer Center's Therapeutics Discovery division and Ipsen Biopharmaceuticals reported the preclinical discovery and early-stage clinical development of this novel drug. (mdanderson.org)
  • But until now, no small-molecule inhibitor had been identified. (scitechdaily.com)
  • Our results connect viral proteins to human genetic architecture for COVID-19 severity and offer potential therapeutic targets," the study's authors wrote, noting that genetic or small molecule inhibitor-based knockdown of interacting host proteins, such as the ubiquitin-specific peptidase 25 enzyme, seemed to dial down SARS-CoV-2 replication in cell line experiments. (genomeweb.com)
  • High expression of the gene was apparent in patients with grades II and III cancer, while low expression of the gene was found in patients with grade I and II tumors. (wikipedia.org)
  • For example, King has identified that if BRCA1 tumors stop expressing the 53BP1 or REV7 protein-both of which play a role in repairing DNA double-strand breaks-they become resistant to PARP inhibitors. (yale.edu)
  • The team will compare the biological differences in what these imaging methods detect, the molecular characteristics of tumors visible on MRI and Micro-Ultrasound vs. tumors visible by only one modality. (pcf.org)
  • Dr. Shaw demonstrated a marked regression of ALK+ lung cancer tumors in mice when treated with a combination of FDA-approved ALK+ lung cancer agents and inhibitors of SHP2 - a cancer gene that regulates cancer cell survival and growth and suppresses an immune system protein. (nfcr.org)
  • Therefore, FAK inhibitors have been developed to control migration, invasion, and metastasis of various tumors. (drugdiscoverynews.com)
  • BioNTech performed gene sequencing on the tumors to find proteins that might trigger an immune response. (nih.gov)
  • Despite these difficulties, the gene editing tool presents favorable opportunities to understand the effects of single-base genetic changes on tumors through models and determine which therapy is effective against cancer. (cornellsun.com)
  • BRAF inhibitors that were effective in adult melanomas paradoxically made brain tumors worse via drug-induced activation. (chop.edu)
  • Tumors adapt to DNA damage by activating DNA repair processes, which not only enable their survival but allow them to develop resistance to some cancer therapies. (bcrf.org)
  • However, some tumors that should be vulnerable to PARP inhibitors don't respond. (medicalxpress.com)
  • These improvements could include the development of screening tests to see which tumors would best respond to PARP inhibitors, or to determine which other drugs should-or should not-be given along with them, the researchers say. (medicalxpress.com)
  • She and her team found that tumors with certain types of nonV600 BRAF mutation may be amenable to therapeutic intervention with clinically approved targeted therapies. (ladydavis.ca)
  • These small molecule inhibitors could also be useful tools for understanding the pathogenesis of other malignancies that can be traced to SOX 11, including epithelial ovarian tumors, medulloblastoma, gliomas, and basal-like breast cancer," says Dr. Parekh. (scitechdaily.com)
  • The Scripps Research Institute team has developed Histone Deacetylase (HDAC) inhibitors that, in test cells, reactivate the frataxin gene that appears to be "silenced" in Friedreich's ataxia. (curefa.org)
  • Like the developers of LSD1 combination therapies, 4SC AG researchers are pairing an epigenetic drug, in this case an HDAC inhibitor, with immunotherapies. (genengnews.com)
  • The sirtuin collaboration was a natural progression for MethylGene and Pharmion, Allen said, because those companies already have a collaborative project on a class I specific HDAC inhibitor, MGCD0103. (bioworld.com)
  • The sirtuin inhibitor research agreement expands the January 2006 license and collaboration agreement between MethylGene and Pharmion for the research, development and commercialization of MethylGene's oncology HDAC inhibitors, led by MGCD0103, which currently is in Phase II clinical trials. (bioworld.com)
  • Two epigenetic therapy combinations already are under active investigation in Phase II studies combining Pharmion's Vidaza, a DNA hypomethylating agent, with MethylGene and Pharmion's HDAC inhibitor, MGCD0103. (bioworld.com)
  • Drugs called histone deacetylase (HDAC) inhibitors protect the acetyl group connection and allow transcription factors to connect with genes' promoter regions to activate them. (newswise.com)
  • The team treated human T cell lines with the HDAC inhibitor vorinostat and IL-21. (newswise.com)
  • A second round of experiments using the HDAC inhibitor panobinostat, which is less toxic to T cells than vorinostat, produced even stronger central memory T cell expansion. (newswise.com)
  • Those mechanisms affect which kind of therapies might work once cancer patients relapse on PARP inhibitors, a treatment that stops PARP proteins from repairing DNA damage in cancer cells and leads to cell death. (yale.edu)
  • Furthermore, by leveraging genetic changes in BRCA2 directly from patients, Jensen's team hopes this "reverse translation" approach will accelerate our understanding of why BRCA2 plays such a crucial role in responding to PARP inhibitors. (yale.edu)
  • Recent studies have found that PARP-inhibitors may be an effective treatment option for up to a third of men with metastatic prostate cancer. (pcf.org)
  • Feng and team are studying the mechanisms of resistance to PARP-inhibitors and are developing strategies to identify and treat these patients. (pcf.org)
  • But excessive DNA damage, brought on by therapies like PARP inhibitors, results in cancer cell death. (bcrf.org)
  • Dr. de Lange and her team identified a protein complex, known as CST/Pol⍺/primase (CPP), that is critical for the effectiveness of PARP inhibitors in BRCA1-deficient cells. (bcrf.org)
  • Using an extensive array of molecular tools, the team determined how CPP interacts with other DNA repair proteins and enables PARP inhibitors to kill breast cancer cells-it prevents the formation of what is known as a 3' overhang in the broken DNA, which would otherwise initiate a DNA repair process that circumvents the action of PARP inhibitors. (bcrf.org)
  • By preventing DNA repair, PARP inhibitor drugs cause cancer cells to accumulate mutated chromosomes, ultimately killing them. (medicalxpress.com)
  • Described in Nature on July 18, their work challenges previous assumptions about the mechanics by which these PARP inhibitors succeed or fail to help patients. (medicalxpress.com)
  • Their discovery helps to explain why some cancers respond to PARP inhibitors, while others do not-an insight that could ultimately be used to help improve treatments for patients. (medicalxpress.com)
  • In recent years, the development of new drugs called PARP inhibitors made it possible to turn those same genetic defects against the disease. (medicalxpress.com)
  • In BRCA1- deficient cancers treated with PARP inhibitors, the rewriting function of 53BP1 leads to faulty repair of DNA and the death of the cancerous cells. (medicalxpress.com)
  • In the big picture, this new insight into 53BP1's function and its role in drug resistance provides a foundation for advancements in PARP inhibitor therapy," Mirman says. (medicalxpress.com)
  • Scientists studied cancers that had evaded the effects of platinum chemotherapies and drugs called PARP inhibitors by repairing their BRCA genes - and found the new versions of the genes were subtly different from the same genes in healthy cells. (ddw-online.com)
  • It aimed to characterise the molecular changes in cancers that have become resistant to platinum chemotherapy or PARP inhibitors - drugs which are now licensed for ovarian, breast, pancreatic and prostate cancers - and to open up new treatment strategies against them. (ddw-online.com)
  • By studying the DNA sequence of more than 300 patients across the world who had received a PARP inhibitor or platinum drug as part of their treatment, the scientists found how cancer cells rewire BRCA gene activity in order to become resistant to these drugs. (ddw-online.com)
  • This year, the U.S. Food and Drug Administration approved a PCSK9 inhibitor , with more medicines likely to come. (nationalgeographic.com)
  • A team led by scientists at The Scripps Research Institute (TSRI) has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells' activities. (scripps.edu)
  • Pharmaceutical companies also are developing drugs that bind directly to miRNAs to inhibit their activity. (scripps.edu)
  • The NRIs inhibit ribosomes from both gram-positive and -negative pathogenic bacteria but will not disturb eukaryotic protein synthesis. (cdc.gov)
  • Furthermore, the new compounds inhibit bacterial growth without toxicity to human cells, consistent with developing a new drug that kills bugs without disturbing the human host. (cdc.gov)
  • Researchers have begun to home in on these proteins, looking for drugs that inhibit their actions in the cell. (genengnews.com)
  • Molecules that target and inhibit STAT protein function are therefore of great interest to scientists developing new cancer therapeutics. (selectscience.net)
  • Over the past 10 years, Gunning and his team have taken on the daunting challenge of identifying molecules that inhibit STAT3 function. (selectscience.net)
  • However, because proteasome inhibitors globally inhibit protein degradation in a non-specific manner, their use outside of oncology is limited by poor tolerability, highlighting the need for targeted approaches. (businesswire.com)
  • A drug-like compound that can inhibit a key family of enzymes associated with several types of cancer has been developed and tested successfully in cells. (drugtargetreview.com)
  • A team of scientists the has developed what they say are the first drug-like compounds to inhibit a key family of enzymes whose malfunction is associated with several types of cancer. (drugtargetreview.com)
  • It is clear that tyrosine kinase inhibitors do not simply inhibit the enzyme, but rather remodel the machine," Superti-Furga aid. (sciencedaily.com)
  • Nucleoside analogue inhibitors of the cell-encoded enzyme S-adenosylhomocysteine hydrolase (SAH) have been shown to inhibit Zaire ebolavirus replication in adult BALB/c mice infected with mouse-adapted Ebola virus. (medscape.com)
  • To identify cell surface proteins on leukemia cells that inhibit Natural killer cells ( Aim 1a ) or macrophages ( Aim 1b ) using CRISPR screens. (lu.se)
  • The discovery of ALK gene rearrangements and the development of tyrosine kinase inhibitors (TKIs) that target them have achieved unprecedented success in the management of patients with ALK-positive NSCLC. (medpagetoday.com)
  • These changes led to the constitutive activation of a prominent oncogene - receptor tyrosine kinase gene PDGFRA. (biospace.com)
  • Together with other receptor tyrosine kinases, PDGFRA, is a prominent target not only in gliomas, but also in a number of haematological malignancies for targeted therapies based on tyrosine kinase inhibitors (TKI) and anti-PDGFRA monoclonal antibodies. (biospace.com)
  • Short description: The goal of this grant is to develop a nanosystem to deliver nanoparticles loaded with gene inhibitors against the protein tyrosine phosphatase N22 (PTPN22) into T cells. (uniroma2.it)
  • Superti-Furga's team has been investigating a particular enzyme, a tyrosine kinase called Bcr-Abl, which is involved in leukaemia. (sciencedaily.com)
  • That's because the absence of those proteins allows a third enzyme, called the Bloom syndrome protein (BLM), to not only resume the resection of DNA double-strand breaks, but go into repair overdrive, called "hyper-resection. (yale.edu)
  • A new study shows that an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells is also a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
  • In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells. (sciencedaily.com)
  • Now, in a study published online today in the June 26 issue of Chemistry & Biology, Shiekhattar and his team show that the enzyme is itself a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
  • For example, Shiekhattar notes that the enzyme studied exists in a complex with another type of gene-regulating enzyme that has been implicated in the development of cancer. (sciencedaily.com)
  • Inhibitors of that second enzyme are currently in clinical trails as cancer therapies. (sciencedaily.com)
  • Because the primary role of the enzyme is to repress sets of related genes, many other areas of potential influence for the monoamine oxidase inhibitors are possible too, according to Shiekhattar. (sciencedaily.com)
  • Called a deacetylase, this enzyme removes acetyl groups from histones to repress gene expression. (sciencedaily.com)
  • Wang and colleagues focused on a protease - an enzyme that breaks down protein - called cathepsin L, or CTSL. (wraltechwire.com)
  • Our study, which was years in the making, demonstrates that targeting this key enzyme with small-molecule inhibitors is a feasible approach," said lead researcher Dr Tomasz Cierpicki, an associate professor of biophysics and pathology at U-M. "These findings will facilitate the development of the next generation of potent and selective inhibitors of these enzymes, which are overexpressed, mutated or undergo translocations in several types of cancer. (drugtargetreview.com)
  • A 2019 SAA grantee, Dr. Smith's past research project used a laboratory test called MANAFEST, for Mutation Associated NeoAntigen Functional Expansion of Specific T cells , which she designed, to identify cancer-specific proteins that can be recognized by immune cells called T cells. (swimacrossamerica.org)
  • Upon further investigations, the team tested the STAT3 inhibitors - a substance and member of the STAT family that interferes with biologic activity including growth and proliferation - and discovered that these inhibitors killed lymphoma cells with DDX3X mutation (or altered DDX3X) more effectively than standard chemotherapy agents. (eurekalert.org)
  • A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
  • In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. (southampton.ac.uk)
  • The research team concluded that the mutation of a specific pathway drives fibrosis in an array of body organs. (worldhealth.net)
  • Gene Tests ( www.genetests.org ) cites 48 different laboratories in the United States that can test for the VHL gene mutation. (medscape.com)
  • Our hypothesis was that maybe it's a somatic genetic disease" or due to a mutation in the genes of a single cell. (medscape.com)
  • The team in Finland replicated the tests and found the same mutation in 16 of 33 patients (48%) with AVM. (medscape.com)
  • Yale Cancer Center has an especially impressive armamentarium in the study of BRCA1 and BRCA2, proteins involved with DNA repair that, when mutated, can cause breast , ovarian , prostate , and pancreatic cancers. (yale.edu)
  • Both the BRCA1 and BRCA2 protein are involved in DNA repair," said Megan King , PhD , associate professor of cell biology and of molecular, cellular and development biology, and co-leader of the Radiobiology and Genome Integrity Research Program at Yale Cancer Center. (yale.edu)
  • He was the first scientist to purify and study the properties of the full-length BRCA2 protein . (yale.edu)
  • In addition, the team discovered a previously unanticipated role for a protein known as CRL4WDR70, in the regulation of generation of the DNA repair proteins BRCA1 and BRCA2. (bcrf.org)
  • A substantial fraction of these cancers are caused by harmful errors in two of the most infamous constituents of the human genome: the genes known as BRCA1 and BRCA2 . (medicalxpress.com)
  • Early tests in cell cultures from patients have boosted the gene's product - frataxin protein - to therapeutic levels. (curefa.org)
  • Dr. McNeel and team will conduct a clinical trial testing the combination of two therapeutic prostate cancer vaccines plus the checkpoint immunotherapy anti-PD1, which may result in an effective new therapy for prostate cancer patients. (pcf.org)
  • The therapeutic value of augmenting protein stabilization has also been demonstrated with proteasome inhibitors. (businesswire.com)
  • The research team shows that these prolyl hydroxylase inhibitors protect cells and mice against the toxic effects of manganese, suggesting that these drugs may be potential therapeutic agents for the management of manganese-induced parkinsonism in humans. (utexas.edu)
  • The fact that the protein is only important for cancer cell survival makes it "really attractive" as a therapeutic target. (acs.org)
  • The Mount Sinai research showed the efficacy of the molecules as single agents, as well as the synergy of ibrutinib in combination with a SOX 11 inhibitor - either of which could potentially represent a therapeutic strategy for treating MCL. (scitechdaily.com)
  • Dr. Harren Jhoti, Founder and CSO of Astex said, "We are extremely pleased to be part of this world-class team in this important and exciting new therapeutic opportunity for cancer. (globenewswire.com)
  • Taken together, this illustrates the value of an unbiased and multiplex screening platform for developing combinatorial therapeutic approaches for AML. (lu.se)
  • I will also provide in vivo proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in mouse models of leukemia. (lu.se)
  • To demonstrate proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in patient-derived xenograft models of leukemia. (lu.se)
  • Some CRC patients have developed resistance to 5-FU. (wikipedia.org)
  • However, the introduction of SN50, an NF-[kappa]B inhibitor reverses resistance caused by Zbtb7. (wikipedia.org)
  • These therapies have dramatically improved the outlook for patients, but, eventually, almost all patients will develop resistance. (nfcr.org)
  • By using multiple research models, Dr. Shaw and her team quickly identified new drug combinations for lung cancer patients who have developed resistance to their current therapy. (nfcr.org)
  • Dr. de Lange and her team study these survival mechanisms to help identify new vulnerabilities to target with therapy and new strategies for overcoming drug resistance. (bcrf.org)
  • Since then, the same scientists have been studying how resistance to these drugs develops. (ddw-online.com)
  • A major obstacle to the development of compounds that could overcome cellular resistance to treatment has been the fact that SOX 11 - a transcription factor that binds to DNA and acts as a master switch to turn genes off and on - is generally considered "undruggable. (scitechdaily.com)
  • She already has a candidate in mind for the job: a new class of drugs called ATR kinase inhibitors. (yale.edu)
  • These vaccine strategies, with data demonstrating that existing anti-influenza drugs would be effective against 1918 virus genes, provide the basis for prophylactic measures against the reemergence of new 1918-like viruses ( 2 ). (cdc.gov)
  • Sirtris Pharmaceuticals and Elixir Pharmaceuticals, both of Cambridge, Mass., are two companies competing in developing drugs for disease treatment and longevity based on the agonist approach of sirtuins, Allen noted. (bioworld.com)
  • Importantly, drugs that target hypoxia-inducible factors, called prolyl hydroxylase inhibitors, have already been developed for treatment for other diseases, such as renal anemia. (utexas.edu)
  • Scientists in Titia de Lange's lab and their colleagues have discovered the molecular means by which some cancers caused by errors in the gene BRCA1 evade treatment by drugs custom-tailored to kill them. (medicalxpress.com)
  • They believe the differences in these genes are big enough that it should be possible to train the body's immune system to spot and kill cancer cells with the repaired BRCA genes - opening up an exciting new way of treating cancers that are resistant to current drugs. (ddw-online.com)
  • Our goal is to develop topical, sustained-release drugs for corneal wound healing," said Ljubimov. (newskarnataka.com)
  • Short description: The goal of this grant is to develop targeted nanoparticles to deliver drugs into chondrocytes of a mouse model of age-associated osteoarthritis. (uniroma2.it)
  • Short description: The goal of this career development grant is to develop a nanosystem to deliver drugs into specific cell sub-populations residing in arthritic joints. (uniroma2.it)
  • Our lack of understanding of the way that drugs work is illustrated by the fact that around four in ten drugs currently on the market were developed for one use but were subsequently found to be better for a different condition. (sciencedaily.com)
  • When they overlaid drug screening profiles for nearly 3,000 existing or proposed drugs, meanwhile, the investigators tracked down nearly two dozen compounds near host network sites that appear to be impacted by SARS-CoV-2 proteins. (genomeweb.com)
  • Here at The Institute we have been responsible for isolating more cancer genes, and taking more anti- cancer drugs into clinical trials than any other academic organisation in the world. (globenewswire.com)
  • We are delighted that our experts will be working alongside other world leaders in the field to develop drugs in the laboratory which can quickly be translated into patient benefit. (globenewswire.com)
  • The study indicated that Zbtb7 was present in abundance in renal carcinoma specimens and that overexpression of the gene was related to increases in cell growth and invasion into other cells and tissues. (wikipedia.org)
  • The gene-silencer in question is Argonaute 2, a molecular machine in cells that can grab and destroy the RNA transcripts of specific genes, preventing them from being translated into proteins. (scripps.edu)
  • Argonaute 2 and other Argonaute proteins regulate the influence of about a third of the genes found in humans and other mammals-and thus are among the most important modulators of our cells' day-to-day activities. (scripps.edu)
  • In their study, the Campisi team developed a transgenic mouse model to label and eliminate cells undergoing cellular senescence. (jax.org)
  • To understand how senescent cells promote repair, the Campisi team surveyed wound sites in GCV-treated p16-3MR mice and found fewer endothelial cells and fibroblasts, including myofibroblasts, which are contractile cells responsible for wound closure. (jax.org)
  • Based on these findings, the Campisi team proposes that PDGF-AA derived from senescent cells stimulates local myofibroblast differentiation, allowing for greater contractility and more efficient wound closure. (jax.org)
  • Such epigenetic marks are essential for cells to develop normally. (genengnews.com)
  • Research has shown that lysine-specific histone demethylase 1 (LSD1) plays an essential role in the self-renewal of these "leukemic stem cells," Incyte principal investigator Sang Hyun Lee, Ph.D., tells GEN . Building on this finding, Dr. Lee and colleagues developed an LSD1 inhibitor called INCB059872, which spurs myeloid cell differentiation. (genengnews.com)
  • Signal transducers and activators of transcription (STATs) are a group of cytosolic proteins that regulate the expression of several genes associated with the uncontrolled growth and immortality of cancer cells. (selectscience.net)
  • While this protein is present in most cells, in cancer it is permanently switched on, driving the expression of genes that lead to uncontrolled cell growth and survival. (selectscience.net)
  • Gunning highlights the BioTek Cytation™ cell imaging multi-mode reader as playing a crucial role in this research by enabling the visualization of STAT proteins and the effects of inhibitors in cancer cells, adding another dimension to the team's research. (selectscience.net)
  • The researchers identified for the first time a connection between a cancer gene that controls motility and how cancer cells metabolize energy to move and divide so quickly. (phys.org)
  • Researchers looked at inflammatory breast cancer cells and found the gene RhoC interacts with the cell's machinery at a molecular level to regulate how it produces energy. (phys.org)
  • We are very excited to discover a connection between a known metastasis-causing gene and alterations to the metabolic characteristics of the cells. (phys.org)
  • It's referred to as sickle cell disease because when you look under a microscope, the cells have a classic sickled shape, and people with sickle cell disease make a form of the protein called hemoglobin that carries oxygen in the blood that is prone to aggregation, prone to sticking together and forming aggregates that lead to these sickled shape of the cells. (capgemini.com)
  • Dr. Tariq Rana, professor and chief of the Division of Genetics in the Department of Pediatrics at UC San Diego School of Medicine and Moores Cancer Center, led one of the teams, who used CRISPR to delete every gene in a 3D culture of in-vitro human glioblastoma stem cells. (drugdiscoverynews.com)
  • They labeled the Zika virus with green fluorescent protein to make its movements more visible, then exposed each variation of the cancer cells to the virus to determine which proteins' presence was necessary for Zika to invade cells. (drugdiscoverynews.com)
  • All told, 92 human brain cancer stem cell genes were identified as necessary for Zika virus to infect and replicate in the cells, but of those, the gene that encodes the αvβ5 integrin was identified as a key culprit. (drugdiscoverynews.com)
  • Sirtuins, including SIRT1, have been shown to deacetylate histone proteins and numerous transcription factors, leading to promotion of normal cell survival and aberrant gene silencing in cancer cells. (bioworld.com)
  • Whether pancreatic cancer cells produce neoantigens-proteins that can be effectively targeted by the immune system-hasn't been clear. (nih.gov)
  • This drug, called an immune checkpoint inhibitor, prevents cancer cells from suppressing the immune system. (nih.gov)
  • In addition, the gene expression of APOBEC varies among different types of cells. (cornellsun.com)
  • Thus, Dow inserted two copies of the gene in these cells instead of one to compensate for the lower expression of APOBEC. (cornellsun.com)
  • Dow proposed that various other delivery methods could be used in lieu of the gene editing tool, such as using viruses or zapping cells to open up the cell membrane. (cornellsun.com)
  • Second, a suite of biochemical and functional assays is used to monitor the ubiquitination and functional status of target proteins in cells. (businesswire.com)
  • It's an interesting protein that is really only critical when cancer cells go through cell division, but normal cells can dispense of it quite easily," says Scott Drutman, Volastra's chief medical officer. (acs.org)
  • Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted. (mdanderson.org)
  • The team also found a vulnerability for mesenchymal cells: they are overly reliant on accelerated protein production to meet increased metabolic needs. (mdanderson.org)
  • Draetta, who is corresponding author of the paper, noted that identifying the subpopulation of aggressive cells and establishing their vulnerability to proteostasis inhibitors allows a match of treatment to specific cell type. (mdanderson.org)
  • The team is also studying how cancer cells add new telomeres on the ends of broken chromosomes. (bcrf.org)
  • For nearly a decade, scientists had known that the loss of a protein called 53BP1 made it possible for BRCA1 -deficient cells to overcome their inherent defect and properly repair double-strand breaks. (medicalxpress.com)
  • But it wasn't clear why losing this protein gives these cancer cells such a deadly advantage. (medicalxpress.com)
  • The combination of panobinostat and interleukin-21 converts the less vigorously expanding effector T cells that attack cancer cells to a more proliferative and enduring central memory T cell type capable of self-renewal, the team found. (newswise.com)
  • Their team found that in effector T cells, this process is blocked by histone proteins that intertwine with DNA to form chromatin. (newswise.com)
  • To further confirm the central memory properties of treated cells, the team assessed expression of genes involved in differentiating T cells and found expression of central-memory differentiating genes to be highly expressed on the identified central memory cells generated by the combination. (newswise.com)
  • BC8-15 is a potent PDE4/8 inhibitor that elevates steroidogenesis in mouse Leydig cells. (sigmaaldrich.com)
  • A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition. (sigmaaldrich.com)
  • cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP. (sigmaaldrich.com)
  • The new research also identifies for the first time an important role of Wnt-5a, a secreted signalling protein investigators found responsible for corneal wound healing and the function of stem cells - cells capable of differentiating into many cell types. (newskarnataka.com)
  • For the study, the team compared cells from the corneas from six diabetic patients with those of five healthy donors. (newskarnataka.com)
  • The team of scientists then induced wounds to corneal cells in culture and corneal organ cultures, and tested three interventions designed to normalise Wnt-5a protein expression. (newskarnataka.com)
  • In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells. (eurekalert.org)
  • The inhibitor was found to cripple the activity of a protein vital to bacterial cells -- a protein that maintains the bacterial cell structure. (eurekalert.org)
  • The team say that their covalent lead compound, known as BT5, demonstrated promising activity in leukaemia cells with the NUP98-NSD1 chromosomal translocation that is seen in a subset of paediatric leukaemia patients. (drugtargetreview.com)
  • Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways.Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. (southampton.ac.uk)
  • A particular interest of our work has been how HDM2 and HDMX protein synthesis is controlled in response to cell-signalling pathways in different cell types, and how this affects p53 function in these cells. (southampton.ac.uk)
  • New research into how proteins in human cells interact and 'talk' to each other is leading to a better understanding of how drug molecules work and should result in more effective therapies, according to scientist. (sciencedaily.com)
  • Functional genomics describes the way in which genes and their products, proteins, interact together in complex networks in living cells. (sciencedaily.com)
  • Tested inhibitors of additional genes activated by c-Jun across abnormal fibroblastic cells. (worldhealth.net)
  • When these kidney cells are damaged, a large amount of protein is lost from the blood and leaks into the urine, which affects the kidneys' ability to work properly. (kidney.org)
  • NEW YORK - Studies by two independent research teams have spelled out interactions between SARS-CoV-2 viral proteins and proteins from human host cells during COVID-19 infections, revealing protein-protein interaction networks with clues to disease biology and potential treatment strategies. (genomeweb.com)
  • Members of that team emphasized the apparent transcriptional consequences of SARS-CoV-2 proteins that make their way into human cells - in particular, those stemming from a co-immunoprecipitation-confirmed protein-protein interaction between SARS-CoV-2's ORF3a and the proposed human transcription factor ZNF579. (genomeweb.com)
  • In subsequent chromatin immunoprecipitation sequencing and quantitative PCR experiments in a human cell line, the investigators saw signs that ZNF579 targets some of the same genes altered in SARS-CoV-2-infected cells. (genomeweb.com)
  • The major goals of my research are to identify how acute myeloid leukemia (AML) cells suppress the innate immune system and use this knowledge to develop new immunotherapies. (lu.se)
  • I will accomplish this by identifying and mechanistically characterize cell surface proteins that protect leukemia cells against the innate immune system. (lu.se)
  • To characterize the function and expression patterns of the identified cell surface proteins in acute myeloid leukemia cells from patients. (lu.se)
  • The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
  • Results of their new study suggest that these malformations are a result of KRAS -induced activation of the mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling pathway in brain endothelial cells. (medscape.com)
  • Genetic sequence analysis of the 1918 "Spanish" influenza virus genes have not shown any features that could account for its high virulence. (cdc.gov)
  • To unravel the puzzle of why chemotherapy fails in certain patients with non-Hodgkin lymphoma, the research team led by Assistant Professor Navin Verma at NTU's Lee Kong Chian School of Medicine (LKCMedicine) and Assistant Professor Nicholas Grigoropoulos, Senior Consultant from the Department of Haematology at SGH, scrutinised the publicly available genetic database of over a thousand UK patients. (eurekalert.org)
  • The team has also been developing methods to understand how the human body can recognise invading foreign genetic material - comprising nucleic acids - from bacteria or viruses for example, and distinguish it from its own, innate genetic material. (sciencedaily.com)
  • They have also observed which genes in the cell are switched on or 'up regulated' when foreign genetic material is present - and whether the proteins that are encoded by these genes are the same as those that bind to the material. (sciencedaily.com)
  • Vertex is developing a new therapy for AMKD, called VX-147, that treats the genetic cause of the disease by blocking APOL1 function, which allows for the kidney to function properly," said lead author Glenn Chertow, MD, Stanford University School of Medicine. (kidney.org)
  • The team's analyses highlighted a host of interactions between SARS-CoV-2-encoded and human proteins, dubbed the SARS-CoV-2 interactome (HuSCI), prompting more detailed analyses and genetic knockdown experiments with gene-edited viruses and ACE2 receptor-expressing lung cell lines. (genomeweb.com)
  • The team's results suggested that proteins encoded by SARS-CoV-2 may be particularly prone to interacting with human proteins that contain genetic alterations previously implicated in individuals' risk of severe COVID-19 or "long COVID" cases that persist over long periods of time. (genomeweb.com)
  • Here as a complement to genetic profiling, we used unbiased, combinatorial in vitro drug screening to identify pathways that drive AML and to develop personalized combinatorial treatments. (lu.se)
  • In this model, the senescence-sensitive promoter from the cyclin-dependent kinase inhibitor 2A ( Cdkn2a ) gene, also known as p16 INK4a , drives expression of 3MR, a fusion protein that is composed of luciferase and red fluorescent protein (RFP) reporters and herpes simplex virus-1 thymidine kinase, which converts ganciclovir (GCV) into an apoptosis inducer. (jax.org)
  • A decade ago, the echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified from the DNA of a 62-year-old man with lung adenocarcinoma. (medpagetoday.com)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • Genes within the Mitogen Activated Protein Kinase (MAPK) pathway are frequently mutated driver oncogenes in cancer. (ladydavis.ca)
  • By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)
  • Somshuvra Mukhopadhyay, M.B.B.S., Ph.D. , associate professor in the Division of Pharmacology and Toxicology and Hamm Centennial Fellow in Pharmacy, and a team of researchers have released new findings defining the first homeostatic regulatory pathway for manganese in mammalian systems. (utexas.edu)
  • Elevations in manganese levels increase expression of SLC30A10, a protein that excretes manganese, thereby providing a pathway to reduce the amount of manganese in the body. (utexas.edu)
  • The p53 tumour suppressor protein is a key component of one such stress-response pathway, and virtually all cancers loose functionality of the p53-stress response pathway. (southampton.ac.uk)
  • Crizotinib was one of a trio of targeted therapies -- ceritinib (Sykadia) and alectinib (Alecensa) being the others -- that were developed by molecular profiling of NSCLC. (medpagetoday.com)
  • Because recently developed BRAF -targeted therapies, such as vemurafenib, have shown promise in treating melanomas in adults, there was hope that they would be effective against pediatric astrocytomas. (chop.edu)
  • It is gratifying to see the work on precise stabilization of proteins now being translated into new therapies," said Dr. Colecraft. (businesswire.com)
  • Wang said there are challenges ahead, notably developing a way to deliver the therapy as an inhalant, similar to how asthma therapies are taken. (wraltechwire.com)
  • The implications of what EpiSwitchTM biomarker stratifications could deliver for patients with deregulated PDGFRA has direct impact on achieving high efficacy of treatment and assisting in the clinical decision process for a broad choice of existing and newly developed TKI and other anti PDGFRA therapies. (biospace.com)
  • We anticipate that these findings and the contactome resource will stimulate important research toward characterizing new viral strains, understanding the mechanism of COVID-19 symptoms, and developing therapies for current and future pandemics," the authors of the study reported. (genomeweb.com)
  • SelectScience ® speaks with Patrick Gunning , Ph.D., Canada Research Chair in Medicinal Chemistry and Professor of Chemistry at University of Toronto Mississauga, to learn about his exciting advances in the development of small molecule inhibitors of the STAT3 and STAT5 oncoproteins. (selectscience.net)
  • Gunning, whose work focuses on developing small molecule inhibitors for targeting and treating cancer, explains that STAT3 is hyperactivated in over 70% of all human cancers - making it a major target for drug discovery. (selectscience.net)
  • If the STAT3 inhibitor molecule is functioning correctly it will stop the translocation of STAT3 from the cytoplasm to the nucleus and effects of this can be observed. (selectscience.net)
  • Their research confirmed that IL-21 activates STAT3, a protein that then connects with the promoter region of the gene encoding the T cell stimulatory protein CD28, firing up CD28. (newswise.com)
  • Similarly, low expression of the metabolic protein asparagine synthetase (ASNS) in ovarian cancers predicts response to IPN60090 in preclinical models. (mdanderson.org)
  • Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
  • Researchers have determined that human cancers avoid the immune system with the expression of abnormally high levels of the protein CD47 on their surfaces. (worldhealth.net)
  • BRAF was first identified as a key target implicated in a variety of cancers in 2002 when scientists from The Institute of Cancer Research, in partnership with scientists from the Cancer Genome Project at The Wellcome Trust Sanger Institute in Cambridge, discovered that the gene is involved in up to 70% of certain cancer types including malignant melanoma. (globenewswire.com)
  • Acetyl groups that connect to histone proteins cause a more "open" status for gene transcription. (newswise.com)
  • IACS drug-discovery scientists identified IPN60090 as a potent and selective inhibitor of GLS1 suitable for clinical trials, and translational researchers in TRACTION demonstrated its activity against subsets of lung and ovarian cancer preclinical models. (mdanderson.org)
  • The team will conduct a randomized phase II clinical trial in prostate cancer patients testing the PAP vaccine + the anti-PD1 checkpoint inhibitor pembrolizumab, versus the PAP vaccine + the AR vaccine + pembrolizumab. (pcf.org)
  • These are monoclonal antibodies that prevent the PCSK9 protein from functioning 3 . (heartscandirect.com)
  • Inhibitors of these enzymes have long been used to treat depression, certain other psychiatric and emotional disorders, and Parkinson's disease. (sciencedaily.com)
  • In the body's scheme for safely storing genes away until needed, DNA is tightly looped around the histones, kept secure by enzymes similar to the ones studied by the Wistar team until made accessible by the activity of other enzymes responsible for gene expression. (sciencedaily.com)
  • To accomplish his goal, Dow moved to optimizing base editing enzymes and developing a system that allows him to turn the expression of these enzymes on and off with doxycycline, an antibiotic also typically used to regulate gene expression. (cornellsun.com)
  • Stablix's RESTORED platform generates heterobifunctional small molecules (RESTORACS) that recruit deubiquitinase enzymes to remove ubiquitin from targeted proteins and consequently stabilize or increase target protein levels and activity. (businesswire.com)
  • The fragments could be used to develop inhibitors that supplant key enzymes activated by the protein-an application which holds potential to block the viral replication process. (lu.se)
  • In the three years since, Yale's team has made significant advances in targeting the BRCA gene-dependent DNA repair axis for cancer therapy. (yale.edu)
  • The companies plan to study sirtuin inhibitors as monotherapy and combination therapy in the treatment of cancer once a clinical candidate is identified. (bioworld.com)
  • There are ways that the gene editing tool can be used as both therapy, as well as development of models to understand disease," Dow said. (cornellsun.com)
  • The SOX 11 protein, which is expressed in up to 90 percent of mantle cell lymphoma patients, is an attractive target for therapy," said senior author Samir Parekh, MD, Professor of Medicine (Hematology and Medical Oncology), Icahn School of Medicine at Mount Sinai. (scitechdaily.com)
  • It has been a scientific mystery and technical conundrum for researchers, who have found it hard to separate Argonaute proteins from miRNAs in the lab dish. (scripps.edu)
  • Researchers are continuing to work to develop new, molecularly targeted agents that will hopefully improve the progression-free and overall survival of lung cancer patients. (medpagetoday.com)
  • Teams of other researchers have attempted to use CTSL inhibitors to thwart coronavirus infections for many years. (wraltechwire.com)
  • The presentation entitled: 'Chromatin Conformation Signatures Associated with Epigenetic Deregulation of the FIP1L1 and PDGFRA Genes,' focused on the technical application of its EpiSwitch™ platform based on observation published in Nature by the researchers from Massachusetts General Hospital, Harvard Medical School, Broad Institute of MIT and Harvard and the Howard Hughes Medical Institute (Flavahan et al. (biospace.com)
  • The scholarships support the most innovative young researchers at a critical stage of their careers-their postdoctoral research-as they develop the new ideas and directions that will help establish them as independent neuroscientists. (nyas.org)
  • The researchers are continuing their study of bacterial viruses in the hope of identifying compounds and processes that facilitate improved treatment of antibiotic-resistant bacteria using yet uncharacterized bacterial viruses' proteins. (eurekalert.org)
  • Researchers such as Superti-Furga are taking a taking a 'proteomics' approach to understanding precisely how certain proteins that are key drug targets organise themselves in the cell, and how they make complex interactions with often dozens of other proteins. (sciencedaily.com)
  • For another paper appearing in Nature Biotechnology , researchers at the Cleveland Clinic, Cornell University, and elsewhere reported on findings from their own yeast-two-hybrid- and mass spectrometry-based interactome analyses, which unearthed more than 700 apparent ties between SARS-CoV-2 proteins and human host proteins. (genomeweb.com)
  • Amongst the first 20 genes they looked at the researchers found preliminary evidence that the BRAF gene was mutated. (globenewswire.com)
  • Researchers have developed computational approaches and machine learning algorithms to accurately obtain clinically useful information from genomic and transcriptomic sequencing data. (cdc.gov)
  • Based on these studies and working with the pharmaceutical industry, the investigators identified a newly developed second-generation selective BRAF inhibitor that, unlike vemurafenib, did not induce activation of BRAF in cell cultures and animals. (chop.edu)
  • Stablix possesses a first-in-category platform that can restore protein stability and function in a target-selective manner," said Carlo Rizzuto, Ph.D., partner at Versant and acting CEO of Stablix. (businesswire.com)
  • Antibiotic-resistant infections are on the rise, foiling efforts to reduce death rates in developing countries where uncontrolled use of antibiotics and poor sanitation run amok. (eurekalert.org)
  • Learning to control natural gene silencing processes will allow an entirely new approach to treating human disease," said Ian J. MacRae, associate professor in TSRI's Department of Integrative Structural and Computational Biology and principal investigator for the study, which appears as the cover story in the May 9, 2013 issue of the journal Molecular Cell . (scripps.edu)
  • Senior author Ramin Shiekhattar is a professor in two programs at Wistar, the gene expression and regulation program and molecular and cellular oncogenesis program. (sciencedaily.com)
  • Through metabolomics we can describe exactly what is happening at the molecular level even if we do not know exactly all the connections between the signaling proteins in the cell," Merajver says. (phys.org)
  • The Cas protein then acts as molecular scissors, cutting the DNA. (capgemini.com)
  • Can we understand the 3-d protein as a molecular machine much better? (sciencedaily.com)
  • They discovered that the protein exists as a complex of some 46 separate components and operates as a giant molecular machine, with each part in close communication with the others. (sciencedaily.com)
  • The existing option Navitoclax tyrosianse inhibitor of molecular tests for both circumstances provides an chance for improved early analysis that may result in better management. (irjs.info)
  • When this gene binds to a consensus sequence, it prevents transcription by controlling the conformation of chromatin and bringing other transcription factors to gene regulation sites. (wikipedia.org)
  • This gene controls access to gene transcription regulation regions. (wikipedia.org)
  • Some Example Projects: Regulation of HDM2 and HDMX proteins The HDM2 oncoprotein is the major negative regulator of p53 function in the cell. (southampton.ac.uk)
  • The PCSK9 gene plays a vital role in cholesterol metabolism, specifically in the regulation of LDL receptor degradation 1 . (heartscandirect.com)
  • it produced a fusion gene, KIAA1549-BRAF . (chop.edu)
  • The CHOP team characterized the distinct mechanisms of action of KIAA1549-BRAF and its differential responsiveness to first-generation BRAF inhibitors. (chop.edu)
  • In addition, the KIAA1549-BRAF fusion displays distinct additional protein interactions that likely facilitate MEK phosphorylation by BRAF . (chop.edu)
  • In contrast to vemurafenib, these second generation inhibitors successfully target BRAF -fusions. (chop.edu)
  • The Institute of Cancer Research, The Wellcome Trust and Cancer Research Technology began a drug discovery collaboration in 2003 to identify BRAF inhibitors, and have now been joined by Astex who will contribute expertise in fragment based drug discovery to the collaboration. (globenewswire.com)
  • The BRAF gene consists of about 2200 letters of DNA code. (globenewswire.com)
  • Because mutated BRAF is permanently stuck in the 'on' position the collaboration will look to develop specific inhibitors that will switch it back off. (globenewswire.com)
  • The scientists had been investigating a liver protein, dubbed PCSK9, that's responsible for circulating harmful LDL cholesterol in the human body. (nationalgeographic.com)
  • The Fundamental Physics of $3 million is shared by five teams comprised of 1,370 scientists. (nationalgeographic.com)
  • MD Anderson's GLS1 program was initiated and advanced by a team of scientists in the Institute for Applied Cancer Science (IACS) and Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platforms, both engines within Therapeutics Discovery. (mdanderson.org)
  • An international collaboration of scientists identified four fragments that interact with the nsp10 protein of the SARS-CoV-2 virus using the FragMAX platform and BioMAX beamline. (lu.se)
  • McNeel and team are developing prostate cancer vaccines and testing them in combination with checkpoint immunotherapy for the treatment of prostate cancer. (pcf.org)
  • Ultimately, treatment decisions should be made by a multidisciplinary lung oncology team to provide the best care for each patient. (medpagetoday.com)
  • An NIH-funded research team led by Dr. Vinod Balachandran from Memorial Sloan Kettering Cancer Center (MSKCC) have been developing a personalized mRNA cancer-treatment vaccine approach. (nih.gov)
  • The Stanford research team believes their findings will eventually spur the development of a reliable treatment of several different types of fibrotic diseases. (worldhealth.net)
  • The team will also attempt to determine if the anti-CD47 antibody is an effective treatment for those with fibrosis. (worldhealth.net)
  • In this trial, we measured the amount of protein in the urine to understand how well treatment with VX147 was working. (kidney.org)
  • If the amount of protein in the urine is lower after treatment with VX147, then it suggests that treatment is working because the amount of protein in the urine is widely recognized as a sign of the extent of kidney damage," Dr. Chertow said. (kidney.org)
  • Together, these results support APOL1 inhibitors like VX-147 as a potential treatment for people with AMKD. (kidney.org)
  • The latest cholesterol treatment guidelines recommend PCSK9 inhibitors as a potential treatment for individuals with high risk of CVD 8 . (heartscandirect.com)
  • This includes whether and how the immune system reacts to emerging tumours, whether antitumour immune responses are reactivated during treatment with immune-checkpoint inhibitors (ICIs), and whether unintended destructive immune pathologies accompany such treatment. (cdc.gov)
  • Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
  • She is working to design a clinical trial for ATR inhibitors in BRCA1 patients with fellow Gray Foundation team member Patricia LoRusso, DO , professor of medicine and associate cancer center director of experimental therapeutics. (yale.edu)
  • MethylGene and Pharmion are the first to publicly state that they are studying the antagonist approach of sirtuins, Allen said, adding that no companies have entered the clinical trial phase of development of a sirtuin inhibitor. (bioworld.com)
  • Sirtuin inhibitors is the third epigenetic modality to be explored for anticancer activity by Pharmion and is the second in collaboration with MethylGene. (bioworld.com)
  • The original study identified epigenetic changes that occurred in gliomas with mutant IDH1 protein. (biospace.com)
  • We are very glad to be able to quickly develop and provide practical tools for patient monitoring and stratification, based on definitive epigenetic biomarkers. (biospace.com)
  • The discovery does not affect gene sequence but entails specific DNA modifications altering gene expression - what are known as epigenetic alterations," he added. (newskarnataka.com)
  • It was shown that patients with low expression of Zbtb7 were less likely to experience a recurrence in the following five years compared to those with high expression of the gene. (wikipedia.org)
  • I look forward to working closely with the Stablix team to bring these treatments to patients. (businesswire.com)
  • For her recently approved SAA grant, Dr. Smith proposes to develop a next-generation MANAFEST platform and test its implementation in patients with lung cancer. (swimacrossamerica.org)
  • Our personalized portal helps you refer your patients and communicate with their MD Anderson care team. (mdanderson.org)
  • In addition, the research team analysed a total of 167 non-Hodgkin lymphoma specimens from patients in the UK in collaboration with research groups at the University of Cambridge, UK. (eurekalert.org)
  • Through advanced gene sequencing technology, the research team mapped cancer-causing gene abnormalities from samples of patients whose chemotherapy failed. (eurekalert.org)
  • Furthermore, a 2019 study published in JAMA Cardiology found that adding a PCSK9 inhibitor to a statin in patients with stable CVD and elevated LDL cholesterol levels (greater than 70 mg/dl) significantly reduced future CVD events 11 . (heartscandirect.com)
  • Defects in humoral immunity were documented in 4 patients and included severe hypogammaglobulinemia with decreased T-cell numbers, transient Navitoclax tyrosianse inhibitor hypogammaglobulinemia during infancy, and IgA deficiency. (irjs.info)
  • Early inclusion of immunologists to the multi-disciplinary care team (as with 22q11.2 deletion) may be of great benefit to affected patients. (irjs.info)
  • Ninety percent of patients diagnosed with DGS Navitoclax tyrosianse inhibitor (cardiac anomalies, hypocalcemia, immune deficiency) and velocardiofacial syndrome (cardiac anomalies, pharyngeal dysfunction, dysmorphic facies) have a hemizygous 22q11.2 deletion 14. (irjs.info)
  • Patients often develop episodes of fever while neutropenic, resulting in 3- to 7-day hospitalizations between cycles of chemotherapy. (medscape.com)
  • Between 21 February 2020, the date of the first confirmed case of COVID-19 in Lebanon, and 3 April 2020, our team treated 150 patients diagnosed with COVID-19. (who.int)
  • For the study, he and his team analyzed tissue from 39 adult patients with AVMs of the brain who had undergone surgery in Toronto. (medscape.com)
  • They found that in diabetic corneas, the protein product of the WNT5A gene was repressed. (newskarnataka.com)
  • Wernig developed a mouse model and found that fibroblasts generated egregiously high levels of the signaling molecule known as c-Jun. (worldhealth.net)
  • Wernig's team found that c-Jun was overexpressed and highly activated. (worldhealth.net)
  • The team conducted a comprehensive series of biologic and biochemical experiments to discover and characterize the new class, as recently reported in the journal, Antimicrobial Agents and Chemotherapy. (cdc.gov)
  • Additionally, the gene editing tool has a domain called the uracil glycosylase inhibitor, which prevents the newly changed bases from being reverted back to cytosine. (cornellsun.com)
  • In these studies, proteasome inhibitors were able to increase levels of deficient proteins across a range of targets and organ systems. (businesswire.com)
  • We hope our approach will be used to further identify new growth inhibitors and their targets across bacterial species and in higher organisms. (eurekalert.org)
  • To identify and study the impact of pancreatic cancer cell plasticity, the team established an experimental approach to isolate and characterize single cell clones called "escapers" that spontaneously acquire malignant features. (mdanderson.org)
  • What could be truly exciting, Dr. Lee notes, is the combination of LSD1 inhibitors with antibodies that block programmed cell death-1 (PD-1), a cell surface receptor that keeps the immune system in check. (genengnews.com)
  • When analyzing the function of potential STAT inhibitors, it is important to know the location of the STAT protein within the cell. (selectscience.net)
  • About 4 years later, crizotinib (Xalkori), an epithelial-mesenchymal transition (EMT) inhibitor, was granted accelerated approval by the Food and Drug Administration for ALK-positive non-small cell lung cancer (NSCLC), and in 2013, the oral agent won an FDA green light for use in this patient population. (medpagetoday.com)
  • The teams published their work in a pair of papers, one in Cell Press and the other in Cell Stem Cell . (drugdiscoverynews.com)
  • These essential RNAs could potentially become translated into dysfunctional proteins that are detrimental for the cell. (cornellsun.com)
  • A major focus of Dr. de Lange's research is to isolate the protein components in human telomeres and understand their roles in the cell. (bcrf.org)
  • Located on the X chromosome, the gene DDX3X processes cell information and transmits signals for cell growth. (eurekalert.org)
  • A cell-based high-throughput screen (HTS) was developed to detect phosphodiesterase 8 (PDE8) and PDE4/8 combination inhibitors. (sigmaaldrich.com)
  • Malfunction of this bacterial protein consequently resulted in the rupture and consequent death of the bacterial cell. (eurekalert.org)
  • We have also developed interests in other pathways which regulate gene transcription and cancer cell proliferation in response to stress and changes in cell metabolism. (southampton.ac.uk)
  • Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)
  • It is thought that proteins in the human cell can tell if a sequence of nucleic acids is from an invading organism. (sciencedaily.com)
  • To try to identify these proteins the research team has developed a technique to test which proteins in a cell bind specifically to foreign nucleic acids. (sciencedaily.com)
  • First, we looked at LIN28B, a gene recognized as the master regulator of fetal blood cell formation. (lu.se)
  • Zbtb7, whose protein product is also known as Pokemon, is a gene that functions as a regulator of cellular growth and a proto oncogene. (wikipedia.org)
  • So when a $1 million grant became available for BRCA gene research from the Gray Foundation in 2018, a diverse team of Yale experts whose perspectives on BRCA gene-driven malignancies provide a 360-degree view from bench to bedside combined their collective skills to secure the sizable gift . (yale.edu)
  • Higher expression of this gene was associated with later stage, more severe grade, higher recurrence, and lower survival. (wikipedia.org)
  • In situ hybridization analysis of during human development has demonstrated expression of this gene in the central nervous system, semicircular canals, and the neural crest of the pharyngeal arches. (irjs.info)
  • Children with this disorder have an abnormal form of a protein called nephrin. (medlineplus.gov)
  • NEW YORK--( BUSINESS WIRE )--Stablix Therapeutics, a biotechnology company pioneering the field of Targeted Protein Stabilization (TPS), today announced a $63 million Series A financing led by founding investor Versant Ventures together with NEA, Cormorant, Euclidean Capital and Alexandria Real Estate Equities. (businesswire.com)
  • These inhibitors are potent cancer therapeutics but have also been profiled for activity in Mendelian diseases in multiple animal and patient studies. (businesswire.com)
  • Not only is this essential for academic and scientific discovery, but such an assay will significantly enhance the speed with which TCR-based therapeutics are developed and clinically implemented. (swimacrossamerica.org)
  • The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
  • Their experiments revealed that some African Americans who naturally lacked PCSK9 had an incredible 88 percent reduction in their risk of developing coronary heart disease . (nationalgeographic.com)
  • Pokemon is the name given to the protein product of Zbtb7 gene by the research team at Memorial Sloan Kettering Cancer Center (MSKCC), which discovered its oncogenic function. (wikipedia.org)
  • MethylGene and Pharmion will share in the research, development and commercialization of the sirtuin inhibitor program, the companies stated. (bioworld.com)
  • DURHAM - In what is believed to be a first, a research team led by Duke Health has demonstrated a way to use CRISPR technology to successfully prevent and treat COVID infections. (wraltechwire.com)
  • We hope to be as successful this year as we were last year, so please join our team as a donor, swimmer, or volunteer to fund much needed cancer research. (swimacrossamerica.org)
  • This research was supported by the Parker Institute for Cancer Immunotherapy, Stand Up To Cancer-Cancer Research Institute Dream Team and a grant from the National Institute of Allergy and Infectious Diseases (RO1AI109294). (newswise.com)
  • The research team determined that the antibody anti-CD47 reverses fibrosis in mice. (worldhealth.net)
  • The research team wondered whether the fibroblasts were proliferating beyond their usual limit as a result of a possible "Don't eat! (worldhealth.net)
  • For the first of these studies, published in Nature Biotechnology on Monday, an international team led by investigators at the Pasteur Institute, Dana-Farber Cancer Institute, the University of Toronto, and the German Research Center for Environmental Health turned to yeast-two-hybrid experiments and other assays to examine interactions between more than two dozen viral open reading frames (ORFs) and almost 17,500 human ORFs. (genomeweb.com)
  • Among the specific contacts examined was an interaction between the viral protein NSP14 and a human transcription network under the control of NF-kappa-B, along with other interactions that impact human immune activity. (genomeweb.com)
  • Even so, the authors noted, their results suggest that alterations affecting protein-coding portions of the SARS-CoV-2 genome - including changes linked to known SARS-CoV-2 variants - can lead to changes in interactions and network patterns associated with the viral proteins. (genomeweb.com)
  • Applying CRISPR technology - basically turning down genes to knock out certain misfunctions or, in this case, the function of CTSL - Wang's team created a way to safely initiate CTSL inhibition. (wraltechwire.com)
  • The paper also provides the involved mechanisms by showing that manganese increases SLC30A10 expression by activating a group of proteins called hypoxia-inducible factors, which regulate gene expression. (utexas.edu)