Genes structurally carrier proteins. Medical search. Frequent questions

Hybrid biomaterials composed of functionalized nanoparticles, covalently linked to biomolecules such as peptides, proteins, and polynucleotides, are especially interesting for their size-dependent properties and dimensional similarities to biomacromolecules [ 1 - 8 ]. (hindawi.com)
Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
An increasing number of three-dimensional virus structures known to atomic resolution paved the way for derivatization of VBNPs with dyes, metals, peptides, proteins, and small molecules and is being explored for generating novel nanomaterials. (biomedcentral.com)

Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. (rndsystems.com)

Spinocerebellar ataxia type 35 (SCA35) is a rare, autosomal dominant neurodegenerative disorder associated with mutations in TGM6 gene that encode the protein transglutaminase 6 (TG6). (ataxia.org)
All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. (rndsystems.com)
The study assessed the impact of point mutations on the genes that encode the proteins that transfer vitamin B1 into cells and consequently the susceptibility for additional complications associated with diabetes. (nordiclifescience.org)

Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
The ability of ion channels to accomplish these three physiological functions also requires the housekeeping operation of another class of membrane proteins, the transporters and pumps, to set up standing ion concentration gradients across cell membranes. (scholarpedia.org)
1 Similarly, succinate may derive from the γ-aminobutyric acid shunt pathway that correlates with levels of expression of the γ-aminobutyric acid transporters solute carrier family 6 members 12 and 13 (SLC6A12, SLC6A13). (haematologica.org)
ABC transporters are membrane proteins that transport various substances from one side of the cell membrane to the other. (nanowerk.com)
Through facilitated diffusion, glucose molecules can travel across the cell membrane along a concentration gradient, from an area of high concentration (outside the cell) to an area of low concentration (inside the cell), thanks to the binding of specialized proteins known as glucose transporters. (reflectivethought.net)
Glucose transporters are specialized carrier proteins that facilitate glucose uptake into cells. (reflectivethought.net)
these structurally related transport proteins are called glucose transporters. (reflectivethought.net)
Gene mutation of glucose transporters at the intestinal level may alter glucose absorption and transportation functions. (reflectivethought.net)
Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)

The genetic alteration causative of SCAN-1 is a mutation altering the function of a gene called tdp1 (tyrosyl- DNA phosphodiesterase 1). (ataxia.org)
The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy. (bmj.com)
An intronic mutation may well result in a non-functional gene (like the splicing site mutation in CYP21A2 ). (tripod.com)
The other one is that mutation is any variation in the gene that causes an obvious change in phenotype whereas polymorphisms do not cause any obvious phenotypic variation. (tripod.com)
Resistance arises by mutation (influencing the target or efflux of the antimicrobial agent) or by the acquisition of resistance genes (encoding antimicrobial or target alter- ation, or alternate pathways) (2,3). (cdc.gov)
A new mutation has been reported, making a total of 15 different mutations that can cause premature stop codons in the alpha-L-iduronidase gene ( IDUA ), and the biochemistry of these mutations has been investigated. (medscape.com)

Like other signaling proteins, ion channels are flexible molecules that undergo conformational changes between open (active) and closed (inactive) states. (scholarpedia.org)
Towards this goal, CPV virus-like particles (VLPs) produced by expression of the CPV-VP2 capsid protein in a baculovirus expression system were examined for attachment of small molecules and delivery to tumor cells. (biomedcentral.com)
Simultaneously, the method also records changes in the molecules the protein interacts with - in this case ATP. (nanowerk.com)
If this is successful, you can see which groups of molecules are structurally changed and when. (nanowerk.com)
Because an abnormality in type II collagen should affect the molecules throughout the body, it remains unclear how the currently defined abnormality can translate into major structural abnormalities of the vertebrae and capital femoral epiphysis while leaving the distal femur, proximal tibia, and other regions structurally unaffected. (medscape.com)
Chapter 1B: Efficacious Gene Silencing in Serum and Significant Apoptotic Activity Induction by Survivin Downregulation Mediated by Cationic Gemini Tocopheryl Lipids Non-viral gene delivery offers cationic liposomes as promising instruments for the delivery of double-stranded RNA (ds RNA) molecules for successful sequence-specific gene silencing (RNA interference). (iisc.ac.in)
The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)

We report now that NEPH1 belongs to a family of three closely related proteins that interact with the C-terminal domain of podocin. (nih.gov)
They fall into a few large families of closely related proteins and many small outlying families that lack any known evolutionary relationship to the others. (scholarpedia.org)

To cause sensitization, a chemical must bind to macromolecules (proteins) in the skin. (cdc.gov)

Certain commensal Escherichia coli contain the clb biosynthetic gene cluster that codes for small molecule prodrugs known as precolibactins. (omicsdi.org)
The biosynthetic gene cluster of A-102395 was previously identified and includes 35 putative open reading frames responsible for biosynthesis and resistance. (uky.edu)

Transcriptional analysis of ACBP-deficient parasites revealed differentially expressed genes involved in a wide range of biological processes such as lipid metabolism, posttranslational modification, and membrane biogenesis. (biomedcentral.com)
Ion channels are membrane proteins. (scholarpedia.org)
Ion channels have many features of typical membrane proteins. (scholarpedia.org)
Using time-resolved infrared spectroscopy, they measured the structural changes in the bacterial membrane protein MsbA and its interaction partner ATP. (nanowerk.com)
This lays the foundation for the study of the whole membrane protein, which we are going to tackle next", says Professor Hofmann. (nanowerk.com)
The investigations were supported by the Protein Research Department at the RUB and funds of the collaborative research centre SFB 642 "GTP and ATP dependent membrane processes", whose speaker is Prof. Dr. Klaus Gerwert. (nanowerk.com)
Human IL-17 RB cDNA encodes a 502 amino acid (aa) residue type I membrane protein with a putative 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail. (rndsystems.com)
Glucose-protein binding may bring shape changes and glucose close to the cell membrane. (reflectivethought.net)
ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. (assaygenie.com)

The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
Biotinylated Recombinant Human FGFR2 alpha (IIIb) Fc Chimera Avi-tag (Catalog # AVI663) binds Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein (Catalog # 232-FA ) with an ED 50 of 0.0500-0.500 μg/mL. (rndsystems.com)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
2 μg/lane of Biotinylated Recombinant Human FGFR2 alpha (IIIb) Fc Chimera Avi-tag Protein (Catalog # AVI663) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 100-112 kDa and 200-220 kDa, respectively. (rndsystems.com)
As a result, we prepared a recombinant protein composed of the benzo[a]pyrene immunomimetic peptide and pIII-encoding sequences. (actanaturae.ru)
Using ELISA, we demonstrated that the recombinant protein specifically interacts with the anti-benzo[a]pyrene monoclonal antibody (mAB B2). (actanaturae.ru)
Transcriptomic analysis of the two recombinant strains in comparison with the control strain showed that the correct folding of proteins assisted by molecular chaperones played a key role in the improvement of FumDM expression and its enzyme activity. (inra.fr)

Homologs of CylC are also found in other characterized cyanobacterial secondary metabolite biosynthetic gene clusters. (biomedcentral.com)
While we found non-cyanobacterial homologs of these enzymes to be rare, we identified a large number of genes encoding CylC-like enzymes in publicly available cyanobacterial genomes and in our in-house culture collection of cyanobacteria. (biomedcentral.com)
Genes encoding CylC homologs are widely distributed throughout the cyanobacterial tree of life, within biosynthetic gene clusters of distinct architectures (combination of unique gene groups). (biomedcentral.com)
In the vancomycin producer Amycolatopsis orientalis C329.2, homologs of these genes are present, suggesting an origin for the cluster. (cdc.gov)

[10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)

Most mutations in the gene are 'truncating': in the main these induce premature termination codons, resulting in nonsense-mediated decay, loss of the transcript and/or the entire protein. (biomedcentral.com)
Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)

Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. (omicsdi.org)
Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans. (cdc.gov)
all possessed mutations in penicillin-binding protein 2, mostly from commensal Neisseria . (cdc.gov)

GPR91 is a G protein-coupled cell surface receptor for extracellular succinate (Sucnr1). (haematologica.org)
[2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
The human IL-17 RB protein sequence is only 19.2% identical to the human IL-17 R sequence, but the two receptors share many conserved cysteine residues within their extracellular domains as well as additional conserved elements within their cytoplasmic domains. (rndsystems.com)

NEPH1, a member of the immunoglobulin superfamily, is structurally related to nephrin. (nih.gov)

Although the architecture of the nanomachines is known, a detailed understanding of how the splitting of the energy carrier ATP dynamically enables the transport of various substances across biological membranes has so far been lacking. (nanowerk.com)
We now know those structures are very relevant to many critical biological processes like gene regulation, expression of telomerase and telomere maintenance, understanding of growth/oncogenes like C-myc, understanding of organismic development, comprehension of certain enigmatic diseases like ALS and possible new cancer treatments. (anti-agingfirewalls.com)
Insulin-like growth factor-1 (IGF-1), a member of a family of growth factors that are structurally closely related to pro-insulin, has shown profound effects on chondrocyte biological behavior and fundamentally regulates cartilage matrix metabolism during cartilage repair. (biomedcentral.com)

These structures thus support the hypothesis that it is subtle rearrangements, rather than dramatic conformational changes, which govern carrier protein interactions and selectivity during non-ribosomal peptide synthesis. (rcsb.org)

Hence, succinate links metabolism to processes like gene expression and intercellular communication. (haematologica.org)
Scientists led by the St. Anna Children's Cancer Research Institute and the Marmara University Istanbul have now shown for the first time that a defect in the gene for the transcription factor NFATC1 leads to an immune defect with a disruption of metabolism in T lymphocytes. (cemm.at)
This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)

Here we report the 2.1 Å X-ray structure and molecular function of ClbS, a gene product that confers resistance to colibactin toxicity in host bacteria and which has been shown to be important for bacterial viability. (omicsdi.org)
The N-acetyltransferase provides resistance by disrupting the metal-binding domain of the antibiotic that is required for activity, while the binding protein confers resistance by sequestering the metal-bound antibiotic and preventing drug activation via molecular oxygen. (nycu.edu.tw)

In addition, mice lacking NEPH1 develop a nephrotic syndrome that resembles NPHS mutations, suggesting that all three proteins are essential for the integrity of glomerular podocytes. (nih.gov)

Chapter 1A: Dimeric Lipids Derived from α-Tocopherol as Efficient Gene Transfection Agents. (iisc.ac.in)
We discuss in this chapter about six tocopherol based cationic gemini lipids, which induce substantial gene knockdown without any obvious cytotoxicity. (iisc.ac.in)

A trans-AT polyketide synthase cluster, designated as the Psy cluster, contained two large groups of genes coding for two PKSs. (wikipedia.org)
Large portions of the gene cluster psyD have very close counterparts in the pederin gene clusters. (wikipedia.org)
clb+ E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917. (omicsdi.org)
The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. (omicsdi.org)
Cpr12, encoded by a gene that was originally proposed to be outside the gene cluster and sharing similarity to proteins annotated as ADC lyase, was revealed to catalyze the elimination of pyruvate to form PABA. (uky.edu)
A cluster and humans coming into contact with the animals (farm that includes three genes, vanH , vanA , and vanX , is required for high-level resistance to glycopeptides. (cdc.gov)

These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)
Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. (bvsalud.org)

Furthermore, transcriptome analysis was performed to compare the gene expression in different strains. (biomedcentral.com)
The loss of NcACBP resulted in global changes in the expression of multiple genes. (biomedcentral.com)
It is how electrical signals in electrically excitable cells couple to hormone secretion, neurotransmitter release, muscle contraction, and changes in gene expression. (scholarpedia.org)
This focuses on the expression of the human tdp1 mutant gene in brain tissue of flies lacking the endogenous Gkt protein. (ataxia.org)
Effects of aliskiren-loaded nanoparticles on (pro-)renin and renin receptor gene expression in the heart and kidney of spontaneously hypertensive rats. (sav.sk)
In this study, we investigated the effects of changes in intracellular c-di-GMP levels on gene expression and protein production in the opportunistic pathogen Pseudomonas aeruginosa. (bvsalud.org)
However, production of VLPs in adequate quantities has been achieved by expression of virus capsid proteins in heterologous systems (insect cells, yeast, and bacteria). (biomedcentral.com)
Furthermore, monitoring QS signaling gene expression revealed that AHL synthases LasI/RhlI and QS transcriptional regulators LasR/RhlR genes were inhibited and antagonized, respectively, by cerPAC. (nature.com)
Manifestations of folate deficiency thereafter, not surprisingly, would involve impairment of cell division, accumulation of possibly toxic metabolites such as homocysteine, and impairment of methylation reactions involved in the regulation of gene expression, thus increasing neoplastic risks. (medscape.com)

We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
The E2 component is particularly sensitive to missense alteration in BRCA1, with the majority of currently unclassified variants in the region inhibiting interaction, whereas the BARD1 component is disrupted by a smaller, but overlapping, subset restricted to substitution of the structurally detrimental zinc-ligation residues. (biomedcentral.com)

Three protein variants were originally identified in invasive meningococci and named NadA-1, NadA-2, and NadA-3, whereas most carrier isolates either lacked the gene or harbored a different variant, NadA-4. (ox.ac.uk)
The improved screening methods now in use across the UK will identify many carriers of unclassified BRCA1 variants. (biomedcentral.com)
Currently, discovery of the majority of missense variants leaves both variant carriers and their families in an ambiguous position. (biomedcentral.com)
Highly polymorphic regions (such as HLA genes) are not represented either due to difficulty with designing primers because of the lack of constant regions flanking the variants. (tripod.com)
As new SARS-CoV-2 variants emerge and displace circulating virus strains, we recommend that standardized binding antibody assays that include spike protein-based antigens be utilized to estimate antibody concentrations correlated with protection from COVID-19. (cdc.gov)

This led researchers to investigate the genes of the organism that code for the respective natural product. (wikipedia.org)

These data have been combined with Grantham variation and Grantham deviance scores (a measure of how conserved an amino acid is, together with how different the protein change is) to assess the relationship between protein:protein interaction and measures of disease risk. (biomedcentral.com)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)

Genome-wide scans localized the disease phenotype to chromosome 8q, a region harboring RP1, a gene previously implicated in the pathogenesis of RP. (molvis.org)
To date, 73 genes have been implicated in the pathogenesis of RP. (molvis.org)
The presence of inactivating mutations, together with the deletion of the normal copy of the ATM gene in some patients with T-PLL, B-CLL, and MCL, establishes somatic inactivation of the ATM gene in the pathogenesis of lymphoid malignancies, and strongly suggests that ATM functions as a tumour suppressor. (bmj.com)

The genetic material of viruses is housed in protein shells. (newscientist.com)
Yang Zhang at the University of Michigan says that in addition to vaccines, AI-designed protein shells could be useful for gene therapy where genetic material could be placed inside of a shell tailored so that the patient's cells don't react to it adversely. (newscientist.com)
The AT locus was mapped to the chromosomal region 11q22-23 using genetic linkage analysis in the late 1980s and the causative gene was identified by positional cloning several years later. (bmj.com)
Some studies have suggested a role for this protein in maintaining centriole-nucleated sensory organelles termed primary cilia, and AS is now considered to belong to the growing class of human genetic disorders linked to ciliary dysfunction (ciliopathies). (springer.com)
In an important model of premature aging, Werner's Syndrome, the genetic problem seems to be lack of a helicase protein that can unwind G-quadruplexes. (anti-agingfirewalls.com)
Therefore, carriers of the genetic variant were less likely to have such complications, with its protective effect remaining significant even when other common risk factors were taken into account. (nordiclifescience.org)

Mitochondrial genes are also protected against degradation by the protective shape and size of mitochondrion. (hindawi.com)
5 4 Succinate functions as a competitive inhibitor for prolyl hydroxylase domain (PHD) proteins that are central to degradation of hypoxia-inducible factor (HIF)-1α subunit. (haematologica.org)

The figure below shows the proposed biosynthesis of psymberin based on analysis of the gene clusters. (wikipedia.org)
Though advances toward elucidating (pre)colibactin biosynthesis have been made, the functions and mechanisms of several clb gene products remain poorly understood. (omicsdi.org)
The structures exhibit the same general fold as the majority of known carrier protein structures, in spite of the complex biosynthetic role that PCP domains from the final non-ribosomal peptide synthetase module must play in glycopeptide antibiotic biosynthesis. (rcsb.org)
Here we present the functional assignment and biochemical characterization of seven proteins, Cpr33-38 and Cpr12, that initiate the biosynthesis of the polyamide. (uky.edu)
Cpr37, which belongs to the adenylation domain protein in the nonribosomal peptide synthase (NRPS), subsequently activates PABA and loads it to holo-Cpr36 Two proteins Cpr34 and Cpr35 work in concert to catalyze decarboxylative condensation between a thioester linked PABA and malonyl- S -acyl carrier protein (ACP) during aromatic polyketide biosynthesis catalyzed by type II polyketide synthases. (uky.edu)

They evolve and increase in number through phylogeny and can be placed in gene families and superfamilies according to their sequence similarities. (scholarpedia.org)
Further analysis of isolates belonging to the sequence type 213 (ST-213) clonal complex identified NadA-5, which was structurally similar to NadA-4, but more distantly related to NadA-1, -2, and -3. (ox.ac.uk)
Functional characterization of Cpr38, which has sequence similarity to the gene products encoded by pabA and pabB from E. coli , revealed that it functions as a 4-amino-4-deoxychorismate (ADC) synthase catalyzing a two-step reaction involving amidohydrolysis of L-Gln with ammonia channeled and incorporated into chorismic acid to generate ADC. (uky.edu)
8 , 9 The protein is a member of a novel family of large proteins, which show sequence homology to the catalytic domain of phosphatidylinositol 3 kinase, 3 and are implicated in cell cycle regulation, signal transduction, and the response to DNA damage. (bmj.com)

A-102339 is structurally classified as a nucleoside antibiotic, which like all members of the capuramycin family, inhibits bacterial MraY (translocase I) with IC 50 of 11 nM which is the lowest among the capuramycin family. (uky.edu)

The ATM gene encodes a large protein that belongs to a family of kinases possessing a highly conserved C-terminal kinase domain related to the phosphatidylinositol 3-kinase domain. (bmj.com)

Lutz says this is because it started with very small building blocks that could be made to fit together more neatly than bigger protein structures that researchers previously used. (newscientist.com)
Nanowerk News ) How a transport protein obtains its driving force from the energy storage molecule ATP, has been tracked dynamically by RUB researchers. (nanowerk.com)
Using this method, researchers can track minute changes in the protein in the range of nanoseconds. (nanowerk.com)

The enzymatically synthesized heparosan was a useful tool to identify the tailspike protein KflB of ΦK5B as heparosan lyase and to characterize its endolytic depolymerization mechanism. (bvsalud.org)

Most mutations in ATM result in truncation and destabilisation of the protein, but certain missense and splicing errors have been shown to produce a less severe phenotype. (bmj.com)
three different genes may cause the same phenotype). (tripod.com)

Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. (rndsystems.com)
23. What are distinct characteristics of only protein-mediated transport? (fsu.edu)

These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)

Las proteínas comparten un DOMINIO DE HOMOLOGÍA PLECKSTRIN, un dominio de unión a fosfotirosina que interacciona con el RECEPTOR DE INSULINA fosforilado y un dominio C-terminal rico en TIROSINA. (bvsalud.org)
Tras la fosforilación de la tirosina, las proteínas sustrato del receptor de insulina interaccionan con proteínas específicas que contienen el DOMINIO SH2 y que participan en la señalización del receptor de insulina. (bvsalud.org)
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. (bvsalud.org)
The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. (bvsalud.org)

The BLM-producing Streptomyces verticillus ATCC15003 and the TLM-producing Streptoalloteichus hindustanus E465-94 ATCC31158 both possess at least two self-resistance elements, an N-acetyltransferase and a binding protein. (nycu.edu.tw)
We recently established that the ZBM producer, Streptomyces flavoviridis ATCC21892, lacks the N-acetyltransferase resistance gene and that the ZBM-binding protein, ZbmA, is sufficient to confer resistance in the producing strain. (nycu.edu.tw)
A comparison and contrast with other structurally characterized members of the BLM-binding protein family revealed key differences in the protein-ligand binding environment that fine-tunes the ability of ZbmA to sequester metal-bound ZBM and supports drug sequestration as the primary resistance mechanism in the producing organisms of the BLM family of antitumor antibiotics. (nycu.edu.tw)
The actual origins of acquired resistance genes are unknown, but environmental microbes, including the strains producing antimicrobial agents, are believed to be important sources (4,5). (cdc.gov)

This is because Drosophila genes controlling fundamental cellular functions, such as cell growth and death, are quite identical to those found in human cells. (ataxia.org)
VLPs are generally found to be structurally identical to native virus particles and more importantly are non-infectious. (biomedcentral.com)

These are chiefly missense mutations, introducing an amino acid change in the context of an expressed protein. (biomedcentral.com)

Outstanding and innovative research is made possible through structurally optimal conditions, and with the HR Excellence Research Award comes a continued dedication to fostering an environment conducive to scientific innovation. (cemm.at)

In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. (rndsystems.com)

The interleukin 17 (IL-17) family of cytokines, comprising six members (IL-17, IL-17B through IL-17F), are structurally related proteins with a conserved cysteine-knot structure. (rndsystems.com)
IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. (biomedcentral.com)
Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. (assaygenie.com)

ANXA2 is part of the putative cell surface vitamin D binding protein binding site complex and functions to mediate the chemotactic cofactor effect. (assaygenie.com)

We have structurally characterized the final peptidyl carrier protein domain of the teicoplanin non-ribosomal peptide synthetase machinery: this domain is believed to mediate the interactions with tailoring Oxy enzymes in addition to its function as a shuttle for intermediates between multiple non-ribosomal peptide synthetase domains. (rcsb.org)

It takes evolution billions of years to design single proteins that fold just right, but this is another level of complexity, to fold proteins to fit so well together and make closed structures," says Martin Noble at Newcastle University in the UK. (newscientist.com)

Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
THFA plays a key role in the transfer of 1-carbon units (such as methyl, methylene, and formyl groups) to the essential substrates involved in the synthesis of DNA, RNA, and proteins. (medscape.com)

4 , 10 There is evidence to suggest that these proteins respond to DNA damage by phosphorylating one or more substrates, including p53, c-Abl, and replication protein A (RPA), to recruit proteins to regions of DNA repair and/or to activate radiation signal transduction pathways. (bmj.com)
Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)

Additionally, the role of such pH sensitive gold nanoparticles in association with liposomes for the co-delivery of drug and gene has been discussed. (iisc.ac.in)

Anatomy9

Organisms19

Diseases1

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes58

Technology, Industry, Agriculture3

Information Science4

Named Groups1

Health Care4

Peptides3

Related proteins that are involved1

Encode3

Transporters9

Mutation6

Molecules7

Closely related proteins2

Macromolecules1

Biosynthetic gene cluster2

Membrane9

Recombinant10

Homologs4

Differentially1

Mutations in the gene2

Commensal3

Extracellular3

Immunoglobulin1

Biological3

Conformational changes1

Metabolism3

Confers resistance2

Mice1

Lipids2

Cluster6

Interact2

Expression9

Residues2

Variants5

Organism1

Interaction2

Pathogenesis3

Genetic6

Degradation2

Biosynthesis5

Sequence4

Antibiotic1

Belongs1

Researchers3

Lyase1

Phenotype2

Distinct2

Polyketide1

Receptor4

Resistance4

Identical2

Amino acid1

Optimal1

Contrast1

Family3

Putative1

Domain1

Fold1

Synthesis2

Pathways2

Nanoparticles1