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  • protein
  • The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. (nih.gov)
  • Two transcript variants encoding the same protein have been found for this gene. (nih.gov)
  • SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. (nih.gov)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • It has been shown in healthy subjects that CAG repeat length in several genes is polymorphic and that a longer CAG repeat length in the AR gene, which encodes the polyglutamine region in the AR protein, interferes with AR transcriptional activation (and thereby, AR function). (aacrjournals.org)
  • To determine whether connexin43, a major gap junction protein expressed in fibroblasts, is a target for the v-src protein tyrosine kinase activity, we examined the phosphorylation state of connexin43 in cells expressing variants of src. (biomedsearch.com)
  • Using an antipeptide serum that recognizes connexin43, we demonstrate that this protein is phosphorylated on serine and tyrosine residues in avian and mammalian cells expressing activated src proteins. (biomedsearch.com)
  • Connexin43 from control cells and cells expressing nonactivated variants of the src protein was phosphorylated solely on serine residues. (biomedsearch.com)
  • We now report on the characterization of the 80/85-kDa protein that is encoded by the EMS1 gene. (semanticscholar.org)
  • The information contained in a retroviral gene is thus used to generate the corresponding protein via the sequence: RNA → DNA → RNA → polypeptide. (wikipedia.org)
  • The gag-onc fusion protein (also written as Gag-v-Onc, with "v" indicating that the Onc sequence resides in a viral genome) is a general term for a fusion protein formed from a group-specific antigen ('gag') gene and that of an oncogene ('onc'), a gene that plays a role in the development of a cancer. (wikipedia.org)
  • In the case of the murine leukemia viruses, a species of viruses capable of causing cancer in murines (mice), the viral life cycle can also be responsible for oncogenesis through a Gag-v-Onc fusion protein called "Mo-MuLV(src)", which is a Gag-v-Src protein capable of inducing oncogenesis in living mice. (wikipedia.org)
  • The results of gene expression revealed that a recombinant protein with a molecular weight of about 19 kDa was efficiently expressed and it was identified by Western blotting analysis. (koreascience.or.kr)
  • Genetic specificity of DNA synthesized in the absence of T4 bacteriophage gene 44 protein. (asm.org)
  • Sequence analysis of the polymerase 1 gene and the secondary structure prediction of polymerase 1 protein of human influenza virus A/WSN/33. (asm.org)
  • OBJECTIVE: To investigate whether cartilage injury activates protein tyrosine kinases distinct from fibroblast growth factor (FGF)-related signaling, and whether they contribute to injury-induced gene responses. (ox.ac.uk)
  • The characteristics of this gene, including the striking evolutionary conservation at the locus, suggest that the encoded protein may function in brain development. (uni-wuerzburg.de)
  • Fragment
  • In the current study, the cDNA fragment of the FSHb gene from Dagu chicken was amplified using reverse transcription polymerase chain reaction (RT-PCR), and inserted into the pET-28a (+) vector to construct the pET-28a-FSHb plasmid. (koreascience.or.kr)
  • chromosome
  • We have previously identified two genes (EMS1 and PRAD1/cyclin D1) in the chromosome 11q13 region that are frequently coamplified and overexpressed in human breast cancer and in squamous cell carcinomas of the head and neck (E. Schuuring, E. Verhoeven, W.J. Mooi, and R.J.A.M. Michalides, Oncogene 7:355-361, 1992). (semanticscholar.org)
  • characterization
  • FSH signal transduction is mediated by the FSH receptor (FSHR) that exclusively interacts with the beta-subunit of FSH, but characterization of prokaryotic expression of the FSHb gene and its effect on the expression of the FSHR gene in local chickens have received very little attention. (koreascience.or.kr)
  • Delineation, by specific probes, of multiple intervals above and below the critical region and of five intervals within the overlap area provides a framework map for molecular characterization of WAGR gene loci and of deletion boundary regions. (uni-wuerzburg.de)
  • kinases
  • CONCLUSION: Injury to the surface of intact articular cartilage activates Src-like kinases as well as MAPKs and IKK (implying NF-κB activation). (ox.ac.uk)
  • polymorphism
  • Because AR coactivators enhance transactivation of AR, in this report we evaluated the relationship of a CAG/CAA repeat length polymorphism in the AIB1/SRC-3 gene (amplified in breast cancer gene 1, a steroid receptor coactivator and an AR coactivator) with prostate cancer risk in a population-based case-control study in China. (aacrjournals.org)
  • 2006. Effect of Alpha-lactalbumin Gene Polymorphism on Milk Production Traits in Water Buffalo. (koreascience.or.kr)
  • Mutations
  • Mutations in this gene could be involved in the malignant progression of colon cancer. (nih.gov)
  • Genome
  • However, retroviruses function differently, as their RNA is reverse-transcribed into DNA, which is integrated into the host cell's genome (when it becomes a provirus ), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. (wikipedia.org)
  • vitro
  • Bacteriophage T7 defective in the gene 6 exonuclease promotes site-specific cleavages of T7 DNA in vivo and in vitro. (asm.org)
  • variants
  • These DNA primer pairs were designed by prioritizing the gene regions most commonly found in transcript variants. (bio-rad.com)
  • transformation
  • Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. (nih.gov)
  • transcription
  • to examine as to whether other transcription factors bound to the uPAR promoter act as downstream mediators of Src, 2. (aacrjournals.org)
  • In gelshift analysis, SW480 cells stably transfected with constitutively active Src demonstrated an increase of AP-1 transcription factors (c-Jun, JunD, c-Fos, Fra-1) bound to region -190/-171. (aacrjournals.org)
  • Cloning
  • This map wiu allow higher resolution mapping of new Ilp15 markers, facilitate positional cloning of disease genes, and provide a framework for the physical mapping of llp15 in clone contigs. (uni-wuerzburg.de)
  • previously
  • The gene maps distal to PAX-6 but proximal to the loci for brain-derived neurotrophic factor (BDNF) and the beta subunit of follicle stimulating hormone (FSHB), within a region previously implicated in the mental retardation component of some WAGR syndrome patients. (uni-wuerzburg.de)
  • product
  • When search by key word or gene name, make sure you do not include product type descriptions, such as clone, antibody, or shRNA, etc. (origene.com)
  • mink cell
  • Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA. (asm.org)
  • effect
  • The combined effect of CAG repeat lengths in the AR and AIB1/SRC-3 genes was also evaluated. (aacrjournals.org)
  • Expanded studies in other populations are needed to confirm this association and the combined effect of AIB1/SRC-3 and other hormone-related genes in prostate cancer etiology. (aacrjournals.org)
  • In contrast, FGF signaling blockade with PD173074 reduced all MAPK and IKK activation by ∼50% and inhibited a different subset of genes but had no effect on Src-like signaling. (ox.ac.uk)
  • differences
  • however, several structural differences distinguish this clone from other SRC subfamily members. (nih.gov)
  • virus
  • Conditions leading to the establishment of the N (a gene dependent) and A (a gene independent) transformed states after polyoma virus infection of rat fibroblasts. (asm.org)
  • activity
  • Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. (nih.gov)
  • Co-transfection of a dominant negative AP-2 construct (AP-2αB) did not inhibit Src-inducible u-PAR promoter activity. (aacrjournals.org)
  • Dr. Suga and his ex-students Kojiro Tokiyasu and Shuhei Murakami demonstrated (1) the Creolimax Src is involved in the process of cell growth and (2) CfrPTP-3, which removes phosphate from Src, suppresses the Src activity without Csk. (pu-hiroshima.ac.jp)
  • A figure in the paper, demonstrating the Src is involved in cell growth, and its activity is regulated by CfrPTP-7. (pu-hiroshima.ac.jp)