Genes self antigens. Medical search. Frequent questions

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (nih.gov)
Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances. (medlineplus.gov)
Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
a severe and sometimes fatal Type 1 reaction in a susceptible person after a second exposure to a specific antigen (e.g., food, pollen, proteins in latex gloves, or penicillin) after previous sensitization. (cdc.gov)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
We need to know more about the proteins that our genes produce. (lu.se)
We have around 20 000 genes that can produce at least 500 000 proteins. (lu.se)

The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. (nih.gov)
The protein is called human leukocyte antigen B27 (HLA-B27). (medlineplus.gov)
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. (wikipedia.org)
Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Here we present ATAC with select antigen profiling by sequencing (ASAP-seq), a tool to simultaneously profile accessible chromatin and protein levels. (nature.com)
The structure of a peptide antigen corresponding to the subtype P1.7 variant of the porin PorA from the human pathogen Neisseria meningitidis was determined by solution of the X-ray crystal structure of the ternary complex of the peptide (ANGGASGQVK) in complex with a Fab fragment and a domain from streptococcal protein G to 1.95 A resolution. (rcsb.org)
Glycoprotein (GP) is the major protective antigen of EBOV, and can generate virus-like particles (VLPs) by co-expression with matrix protein (VP40). (frontiersin.org)
There are currently no images for CFAP299 Recombinant Protein Antigen (NBP1-86203PEP). (novusbio.com)
A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human C4ORF22. (novusbio.com)
Discover related pathways, diseases and genes to CFAP299 Recombinant Protein Antigen (NBP1-86203PEP). (novusbio.com)
The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. (elifesciences.org)
While protein expression is dictated by the level of gene expression, the structure and function of the protein is largely determined by the isoforms of the mRNA of a given gene and are impacted by mutations or other structural alterations to the amino acids ( Faustino and Cooper, 2003 ). (elifesciences.org)
Furthermore, an explanation for the observed restricted germline gene usage in certain antibody responses against protein epitopes is provided. (lu.se)
As proof-of-concept, the established target antigen CD44 was identified as a commonly and abundantly expressed surface protein with high endocytic activity. (lu.se)
A lot happens in a cell when information is transferred from the genes' coding to a protein", explains Ákos Végvári, a researcher at the Division of Electrical Measurements at Lund University. (lu.se)
This means taking different types of cancer, for example, as the starting point and trying to identify the genes and the different protein variants that differ between healthy and ill individuals. (lu.se)

Antibodies against proliferating cell nuclear antigen (PCNA) or monoclonal antibody termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma. (wikipedia.org)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
Notably, vaccination with DREP-GP and DREP-VP40, which produces both GP and VP40 antigens, induced a significantly higher level of anti-GP IgG2a antibody and increased IFN-γ secreting CD8 + T-cell responses relative to vaccination with DREP-GP or DREP-VP40 vector alone. (frontiersin.org)
This product is intended to be used as a blocking antigen for antibody competition assays. (novusbio.com)
This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP1-86203. (novusbio.com)
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Several of these corresponding residues in the mouse monoclonal antibody are known to interact with the antigen. (lu.se)
In conclusion, critical residues important for maintaining a human antigen-specific binding site during the process of in vitro antibody evolution were defined. (lu.se)
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)

Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)

Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells. (jax.org)

Here, we use a combination of transposon mutagenesis and transcriptomic analysis to identify genes and pathways that contribute to ETEC persistence in water environments and colonization of a mammalian host. (uea.ac.uk)
The evolution pathways that led to the hyper-mutation clusters in single human leukocyte antigen (HLA) molecules were identified. (elifesciences.org)

Using reference distributions for the expression of each human gene in each major leukocyte subtype, we mapped the cellular origin of transcripts found to be differentially expressed in the circulating immune cells from chronically lonely individuals. (nih.gov)
Evolutionarily ancient myeloid antigen-presenting cells appear to have evolved a transcriptional sensitivity to socioenvironmental conditions that may allow them to shift basal gene expression profiles to counter the changing microbial threats associated with hostile vs. affine social conditions. (nih.gov)
One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)
In the first part of the study, we engineered CAR T cells through non-viral Sleeping Beauty (SB) transposition of CAR genes from minimalistic DNA vectors called minicircles rather than conventional SB plasmids. (uni-wuerzburg.de)
This novel approach dramatically increased stable gene transfer rate and cell viability and resulted in higher yield of CAR+ T cells without the need of long ex vivo expansion to generate therapeutic doses of CAR+ T cells. (uni-wuerzburg.de)
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. (wikipedia.org)
PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle. (wikipedia.org)
In approved products, a patient's own T lymphocytes are collected by apheresis and transduced with a gene that encodes for a CAR to direct the T cells against cancer cells. (medscape.com)
Peritoneal exudate cells recovered from mice injected intraperitoneally with ad-vIL-10 inhibited DTH reactions in recipient mice, but only when the donor mice had been sensitized to the antigen used to incite the DTH response. (elsevierpure.com)
Separation of normal and immune lymphoid cells by antigen-coated coated columns. (wikidata.org)
To better understand the potential positive and negative impacts of T-cells in ESCA, we recovered TCR recombination reads from the TCGA-ESCA whole exome sequence (WXS) files, obtained the TCR CDR3 AA sequences, and assessed the chemical complementarity of those sequences with CTAs, as those antigens have been characterized by many approaches over decades as candidate cancer antigens. (biotechnews.com.au)
The combination of gene expressions, fusion gene transcripts, and mutation gene expressions significantly improved the classification of liver cancer cells versus benign hepatocytes. (elifesciences.org)
The results showed evolutionary patterns of single molecule mutational gene expression from benign hepatocytes to liver cancer cells. (elifesciences.org)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)

LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (nih.gov)
Human leukocyte antigen: the major histocompatibility complex of humans. (medlineplus.gov)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region. (bvsalud.org)
Although NT1 showed a strong association with human leukocyte antigen (HLA)-DQB1*0602, the responsible antigens remain unidentified. (bvsalud.org)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)

Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres. (cdc.gov)
Clinical evaluation of Roche SD Biosensor rapid antigen test for SARS-CoV-2 in municipal health service testing site, the Netherlands. (cdc.gov)
Comparison of cycle threshold (Ct) values among symptomatic and asymptomatic study participants and across rapid antigen tests. (ajtmh.org)
however, the median Ct values were significantly higher in individuals with false-negative rapid antigen tests. (ajtmh.org)

Collectively, these data suggest a mechanism for the contralateral effect in which genetically modified macrophages and DCs present antigen in the context of high, local concentrations of vIL-10, thereby generating unresponsive T lymphocytes. (elsevierpure.com)

Knowledge of the structures of variable surface antigens such as PorA is an essential prerequisite to a molecular understanding of antigenic variation and its implications for vaccine design. (rcsb.org)
T cell recognition of cell surface antigens. (wikidata.org)

Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)

Demonstration of heavy and light chain antigenic determinants on the cell-bound receptor for antigen. (wikidata.org)
Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (thermofisher.com)

Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. (wikipedia.org)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)

An understanding of both the genetic and structural composition of Salmonella and E. coli O antigens is necessary for the development of novel molecular methods for serotyping these organisms. (microbiologyresearch.org)
8 Genetic tests based on these highly penetrant gene mutations have shown their usefulness, but they can explain only a small fraction (5-10%) of patients. (nature.com)
When neoplasms arise, they are modulated by the interactions of multiple genes based on a great diversity of genetic alterations, which leads to high tumoral heterogeneity. (nature.com)

A mutation in this gene results in amorph-type Rh-null disease. (nih.gov)
Unlike Glanzmann thrombasthenia, this disorder results from a mutation in only one copy of the ITGB3 gene in each cell, and the mutations result in the formation of some integrin αIIbβ3 that is abnormally turned on (active), even when no clot is being formed. (medlineplus.gov)
Because the mutation that causes this disorder affects only one copy of the ITGB3 gene, some normal integrin is formed and normal platelets produced, which accounts for the mild signs and symptoms in affected individuals. (medlineplus.gov)

Our study indicates that co-expression of GP and VP40 antigens based on the SFV replicon vector generates EBOV VLPs in vitro , and vaccination with recombinant DREP vectors containing GP and VP40 antigens induces Ebola antigen-specific humoral and cellular immune responses in mice. (frontiersin.org)
Overall, these data are consistent with the possibility that TCR-antigen interaction induces selective pressure that results in antigen loss, a process referred to as immuno-editing [ 16 - 18 ], and, eventually, tumor cell escape from an anti-tumor immune response. (biotechnews.com.au)

This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
Minimal tolerance to a tumor antigen encoded by a cancer-germline gene. (ox.ac.uk)
Central tolerance toward tissue-restricted Ags is considered to rely on ectopic expression in the thymus, which was also observed for tumor Ags encoded by cancer-germline genes. (ox.ac.uk)
Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)

Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (nih.gov)
The Human Cytomegalovirus Latency-Associated Gene Product Latency Unique Natural Antigen Regulates Latent Gene Expression. (cam.ac.uk)
Due to their efficient gene delivery, viral vectors have been successfully used in T-cell engineering to provide gene transfer medicinal products for the treatment of human disease. (uni-wuerzburg.de)
No human diseases associated to this gene by orthology or annotation . (mousephenotype.org)
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (ox.ac.uk)
We previously identified a novel cancer/testis antigen gene CAGE by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera of gastric cancer patients. (molcells.org)
Until ten years ago, it was hoped that the mapping of the human genome - all our genes - would enable us to better understand the course of different diseases. (lu.se)

BUFFALO, NY- November 17 , 2023 - A new research paper was published in Oncoscience ( Volume 10 ) on November 10, 2023, entitled, " An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen . (biotechnews.com.au)

Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)

This study was done to evaluate efficacy of HBV vaccination on hepatitis B virus surface antigen (HBsAg) carrier rate in children with thalassaemia major receiving multiple blood transfusions. (who.int)

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. (mousephenotype.org)
The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. (thermofisher.com)

Mutations in the common γ-chain (γc) of cytokine receptors, including those for IL-2, IL-4, IL-7, IL-9, and IL-15, are responsible for an X-linked form of the disease, while mutations of several other genes, including Janus-associated kinase-3, may cause autosomal recessive forms of SCID. (aston.ac.uk)

The E. coli O123 O-antigenic polysaccharide and its repeating unit were characterized, and the chemical structure for E. coli O123 was entirely consistent with the O antigen gene cluster sequences of E. coli O123 and the Salmonella O58 isolates. (microbiologyresearch.org)
These solo-LTRs contain functional sequences like promoters, enhancers, polyadenylation signals and are frequently located near cellular genes. (frontiersin.org)
The following Cd82 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

We addressed this question using mouse cancer-germline gene P1A, which encodes antigenic peptide P1A(35-43) presented by H-2L(d). (ox.ac.uk)

The high level of gene transfer rate and efficient genome editing, superior safety profile as well as ease-of-handling and production of non-viral MC vectors and Cas9 RNP position our developed non-viral strategies to become preferred approaches in advanced cellular and gene-therapy. (uni-wuerzburg.de)

Meanwhile, LMP-2 and TAP-1 genes polymorphism were not found to play a role in the immunology pathway of cervical cancer that is caused by HPV-16 infection. (balimedicaljournal.id)

In vitro reporter gene assay showed that the variant allele significantly reduced promoter activity. (elsevierpure.com)
Gene signatures derived from the genes containing functionally germline variants significantly distinguished recurred and non-recurred patients in two ER+ breast cancer independent cohorts ( n = 200 and 295, P = 1.4 × 10 −3 ). (nature.com)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)

Bone-marrow-derived DCs cultured ex vivo with ad-vIL-10 or recombinant mouse IL-10 also suppressed DTH reactions by adoptive transfer when pulsed with the inciting antigen. (elsevierpure.com)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
These results indicate the existence of a minimal tolerance to an Ag encoded by a cancer-germline gene and suggest that its endogenous expression only slightly affects diversification of the T cell repertoire against this Ag. (ox.ac.uk)

However, other viral genes are expressed during latency and this is correlated with activatory epigenetic modifications at latent gene promoters. (cam.ac.uk)
Intriguingly, we and others have also observed that LUNA enhances latency-associated expression of the viral UL138 gene. (cam.ac.uk)
As such, LUNA plays a key role in efficient latency-associated viral gene expression and carriage of viral genome during latent carriage. (cam.ac.uk)
In order to address these concerns, we aimed to improve non-viral gene transfer and genome editing tools as an effective, safe and broadly applicable alternative to viral delivery methods for T-cell engineering. (uni-wuerzburg.de)

To understand the role of each cell in an organism, broad spectrum mRNA isoform and mutational gene expression analyses at the single-cell level is necessary. (elifesciences.org)

O antigen clusters from two serogroup O58 S. enterica strains had approximately 85 % identity with the E. coli O123 O antigen region over their entire length, suggesting that these Salmonella and E. coli O antigen regions evolved from a common ancestor. (microbiologyresearch.org)
The O antigen cluster of a Salmonella serogroup O41 isolate had a lower level of identity with E. coli O123 over only part of its O antigen DNA cluster sequence, suggesting a different and more complex evolution of this gene cluster than those in the O58 strains. (microbiologyresearch.org)

Following antigen encounter, two distinct processes modify immunoglobulin genes. (lu.se)

To clarify the biological rationale for social regulation of gene expression, this study sought to identify the specific immune cell types that are transcriptionally sensitive to subjective social isolation (loneliness). (nih.gov)
Yet the molecular basis of the differential regulation of latent and lytic gene expression by epigenetics is unclear. (cam.ac.uk)

the gene expression profile during B lymphoid differentiation. (lu.se)

Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. (nih.gov)

The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)

The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. (medlineplus.gov)

We have therefore sequenced additional S. enterica O antigen gene clusters to provide information for the development of DNA-based serotyping methods. (microbiologyresearch.org)
Three S. enterica isolates had O antigen gene clusters with homology to the Escherichia coli O123 O antigen region. (microbiologyresearch.org)

Interestingly, we also show that LUNA interacts with the hematopoietic transcription factor GATA-2, which has previously been shown to bind to a number of latency-associated gene promoters, and that this interaction is dependent on the deSUMOylase domain of LUNA. (cam.ac.uk)

On the other hand, LTR-retrotransposons, so called mammalian apparent LTR retrotransposons (MaLRs) represent 3.6% of the genome and lack primer binding sites and gag-pol genes ( 1 ). (frontiersin.org)

In addition, the inherited germline variants from these gene signatures were predominately enriched in T cell function, antigen presentation, and cytokine interactions, likely impairing the adaptive and innate immune response thus favoring a pro-tumorigenic environment. (nature.com)
Family history remains one of the major risk factors that contribute to cancer, and recent studies have identified several genes whose germline mutations are associated with cancer. (nature.com)

Due to recombination events between 5' and 3' LTRs, throughout evolution internal genes were lost resulting in ERV solitary LTRs (solo-LTRs). (frontiersin.org)

The mutations that cause this disorder occur in both copies of the gene in each cell and impair the production or activity of the beta3 subunit, which disrupts the formation of functional integrin αIIbβ3. (medlineplus.gov)

Those dynamics reflected per-cell changes in the expression of inducible genes and related more strongly to the subjective experience of loneliness than to objective social network size. (nih.gov)
These findings suggest new ways in which to treat immune-driven diseases by gene and cell therapy. (elsevierpure.com)
Comparison of t and b cell reactivity to antigens under ir gene contro" by T J. Kipps, J Z. Weinberger et al. (jax.org)
Comparison of t and b cell reactivity to antigens under ir gene control. (jax.org)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

The antigen binding site within the Fab formed a distinct crevice lined by a high proportion of apolar amino acids. (rcsb.org)
5 Two distinct types of multiple endocrine neoplasias are associated with the RET and MEN1 6 genes while VHL alterations result in kidney and other types of cancer. (nature.com)

Anatomy23

Organisms12

Diseases9

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology7

Phenomena and Processes29

Disciplines and Occupations1

Information Science4

Health Care5

Proteins8

Protein18

Antibodies2

Antibody8

Severe acute respi1

Lymphocyte1

Pathways2

Cells16

Leukocyte antigen6

Rapid antigen4

Present antigen1

Surface antigens2

Chimeric antigen1

Receptor2

Chromosome2

Genetic3

Mutation3

Induces2

Tumor4

Human7

20231

HLAs1

Hepatitis B vir1

Mice2

Receptors1

Sequences3

Antigenic1

Cellular1

Immunology1

Significantly2

Alleles2

Recombinant1

Endogenous3

Viral4

Isoform1

Strains2

Immunoglobulin1

Regulation2

Lymphoid1

Isoforms1

Molecule1

Binds1

Clusters2

Interaction1

Genome1

Germline2

Recombination1

Subunit1

Cell5

Distinct2