Genes rna polymerase iii. Medical search. Frequent questions

Depending on the organism, a RNA polymerase can be a protein complex (multi-subunit RNAP) or only consist of one subunit (single-subunit RNAP, ssRNAP), each representing an independent lineage. (wikipedia.org)
RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (wikipedia.org)
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. (nih.gov)
Co-transcriptional pre-mRNA processing relies on reversible phosphorylation of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNA polymerase II (RNAP II). (cipsm.de)

Eukaryotes have multiple types of nuclear RNAP, each responsible for synthesis of a distinct subset of RNA: RNA polymerase I synthesizes a pre-rRNA 45S (35S in yeast), which matures and will form the major RNA sections of the ribosome. (wikipedia.org)
We reveal a nucleolar Pol-II-dependent mechanism that drives ribosome biogenesis, identify disease-associated disruption of nucleoli by noncoding RNAs, and establish locus-targeted R-loop modulation. (nature.com)
Traditionally, the nucleolar Pol I and nucleoplasmic Pol III are viewed as the sole mammalian RNA polymerases that directly mediate housekeeping ribosome biogenesis. (nature.com)

RNA polymerase III synthesizes tRNAs, rRNA 5S and other small RNAs found in the nucleus and cytosol. (wikipedia.org)
The most prominent examples of RNA genes are transfer RNA (tRNA) and ribosomal RNA (rRNA), both of which are involved in the process of translation. (wikipedia.org)
Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. (nih.gov)
Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the only enzymes that directly mediate the expression of the ribosomal RNA (rRNA) components of ribosomes. (nature.com)
Pol II, assisted by the neurodegeneration-associated enzyme senataxin, generates a shield comprising triplex nucleic acid structures known as R-loops at intergenic spacers flanking nucleolar rRNA genes. (nature.com)
The shield prevents Pol I from producing sense intergenic noncoding RNAs (sincRNAs) that can disrupt nucleolar organization and rRNA expression. (nature.com)
Within rDNA, rRNA genes are separated by large intergenic spacers (IGSs) (Extended Data Fig. 1a ). (nature.com)
At nucleolar rRNA genes, Pol I synthesizes precursor rRNAs (pre-rRNAs) that are processed into mature 28S, 18S and 5.8S rRNA molecules as they migrate to the granular component at the nucleolar periphery. (nature.com)
Outside nucleoli, Pol III synthesizes 5S rRNA molecules that are targeted to nucleoli for processing. (nature.com)
POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (thermofisher.com)

Unique to the norVW promoter in Escherichia coli is the presence of three enhancer sites associated with a binding site for 54-RNA polymerase. (strath.ac.uk)
We report here expression of a truncated gene, encoding the copper A (Cu_A) domain of cytochrome ba_3, that is regulated by a T7 RNA polymerase promoter in Escherichia coli. (caltech.edu)

Products of RNAP include: Messenger RNA (mRNA)-template for the synthesis of proteins by ribosomes. (wikipedia.org)
Findings from the new study-published recently in Nature through an article titled, " A high-resolution protein architecture of the budding yeast genome "-mapped precise binding sites of more than 400 different chromosomal proteins in the yeast genome, most of which regulate the expression of genes. (genengnews.com)
We identified 21 meta-assemblages consisting of roughly 400 different proteins that are related to DNA replication, centromeres, subtelomeres, transposons, and transcription by RNA polymerase (Pol) I, II, and III. (genengnews.com)
Replication proteins engulf a nucleosome, centromeres lack a nucleosome, and repressive proteins encompass three nucleosomes at subtelomeric X-elements. (genengnews.com)
In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Three of these RNP segments encode the virus' surface proteins, i.e., the HA, NA and M proteins. (cdc.gov)
Using 3′-UTR sequence probes, we have observed specific DNA protein binding with nuclear proteins from lymphocyte, astrocytoma, and neuroblastoma cell lines, but not from the microglia cell line. (bmj.com)
ADP-ribosylation is a post-translational modification of proteins that occurs mostly in response to cellular stress and is catalysed by members of the diverse poly-ADP-ribose (PAR) polymerase (PARP/ARTD) family. (cipsm.de)
RNA, lipids, and proteins. (who.int)
Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)

Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III. (nih.gov)
The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. (einsteinmed.edu)

Using the enzyme helicase, RNAP locally opens the double-stranded DNA so that one strand of the exposed nucleotides can be used as a template for the synthesis of RNA, a process called transcription. (wikipedia.org)
Our findings revise theories of labour division between the major RNA polymerases, and identify nucleolar Pol II as a major factor in protein synthesis and nuclear organization, with potential implications for health and disease. (nature.com)
Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. (or.jp)
In vivo, some dst1 mutants were partly defective in tRNA synthesis and showed a reduced Pol III occupancy at the restrictive temperature.In vitro transcription assays suggested that TFIIS may affect Pol III start siteselection. (ens-lyon.fr)
In this report, we show that foci of unmasking co-localize with areas of increased chitin within the yeast cell wall in response to caspofungin, and that inhibition of chitin synthesis via nikkomycin Z attenuates caspofungin-induced ß(1,3)-glucan exposure. (bvsalud.org)
Furthermore, we find that both the calcineurin and Mkc1 mitogen-activated protein kinase pathways work synergistically to regulate ß(1,3)-glucan exposure and chitin synthesis in response to drug treatment. (bvsalud.org)
These include RNAs that are central players in cell growth, notably in protein synthesis, and molecules that function in RNA processing, protein secretion and in various regulatory capacities. (einsteinmed.edu)
Our current mechanistic understanding of these phenotypes is based on a novel futile RNA cycle hypothesis wherein deregulated Pol III transcription serves as an energy sink, consuming energetically costly nucleotides in the wasteful synthesis of RNA that does not accumulate and is mostly degraded. (einsteinmed.edu)
Reverse transcription is the synthesis of a complementary DNA sequence from an RNA template using reverse transcriptase, which is an RNA-dependent DNA polymerase. (medscape.com)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)

During the early 1990s, breakthroughs in cloning and sequencing of Norwalk virus and Southampton virus ( 15--18 ) led to the development of sensitive molecular assays (e.g., reverse transcription-polymerase chain reaction [RT-PCR]), nucleotide hybridization probes, and enzyme-linked immunosorbent assays (ELISA) that used baculovirus-expressed viral antigens ( 19--33 ). (cdc.gov)
Detection of rotavirus RNA in hospital air samples by polymerase chain reaction (PCR) * 828. (folkhalsomyndigheten.se)
Reverse transcription polymerase chain reaction (RT-PCR) was used to detect viral RNA in brain tissue. (who.int)
5 We used data of all cases that were confirmed at the National Reference Laboratory of NCZD by enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA) and polymerase chain reaction (PCR). (who.int)
The diagnosis of many infectious diseases, both viral and bacterial, may include the use of reverse transcriptase-polymerase chain reaction (RT-PCR). (medscape.com)
1] The resultant complementary DNA is amplified by polymerase chain reaction (PCR). (medscape.com)
Diagnosis is with enzyme-linked immunosorbent assay or reverse transcriptase-polymerase chain reaction (RT-PCR). (msdmanuals.com)

RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA, transfer RNAs, and U6 small nuclear RNA. (nih.gov)

RNAP will preferentially release its RNA transcript at specific DNA sequences encoded at the end of genes, which are known as terminators. (wikipedia.org)
Neighbor-joining phylogenetic tree of group C orthobunyaviruses constructed by using MEGA5 ( 23 ) on the basis of the large gene segments of published virus sequences and Itaya virus strains isolated in Peru in 1999 and 2006 (boldface). (cdc.gov)
The traditional model of gene regulation involves transcription factors, which bind to specific DNA sequences to control the expression of a nearby gene. (genengnews.com)
Score represents the degree of relatedness of a KO to the query gene based on the clustering in the phylogenetic tree of protein sequences ( see below for the tree ). (umassmed.edu)
Score represents the degree of relatedness of a KO to the query gene based on the Smith-Waterman alignment of protein sequence with most similar sequences from all organisms in the KEGG database. (umassmed.edu)
Primers were designed to target sequences in the nodavirus capsid protein gene, yielding an amplification product of 120 nucleotides. (int-res.com)
The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed. (who.int)

RNAP not only initiates RNA transcription, it also guides the nucleotides into position, facilitates attachment and elongation, has intrinsic proofreading and replacement capabilities, and termination recognition capability. (wikipedia.org)
in eukaryotes, RNAP can build chains as long as 2.4 million nucleotides (the full length of the dystrophin gene). (wikipedia.org)
Initially, DNA is taken from the clinical specimen, as well as certain sequence-specific oligonucleotide primers, thermostable DNA polymerase, nucleotides, and buffer. (medscape.com)
Finally, nucleotides complementary to the target DNA are added extending each primer by the thermostable DNA polymerase. (medscape.com)

A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. (unil.ch)
Genome-wide analyses indicate that when CTD S2P is inhibited, onlya subset of growth-related genes is not properly expressed. (ens-lyon.fr)
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)

The research teams describe in a new study an extensive and high-resolution map of chromosome architecture and gene regulation in Saccharomyces cerevisiae -an effort they say is a major step toward improving understanding of development, evolution, and environmental responses in higher organisms. (genengnews.com)
The study revealed two distinct gene regulatory architectures, expanding the traditional model of gene regulation. (genengnews.com)
Home / Teams / Epigenetic regulation of cell identity and environmental stress responses - F. Palladino / Publications / RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. (ens-lyon.fr)
We also suggest tests that could discriminate between a variety of feedforward regulation architectures of the target genes by OCT4, SOX2 and NANOG. (lu.se)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
In particular, there are incremental examples of the participation of the distinct class of long non-coding RNAs (lncRNAs) in AML epigenetic regulation, some of which have translational potential. (frontiersin.org)
In addition, a dramatic fruit size change due to a CNV with an insertion of 6-8 kb that affected gene regulation, was described during tomato breeding [ 27 ]. (biomedcentral.com)
each step provides a platform for regulation of gene expression. (bham.ac.uk)
It was previously thought that AT-rich genes are subject to canonical regulation by H-NS. (bham.ac.uk)
These various classes of cofactors, as well as others (p300/CBP, STAGA) implicated in chromatin template modifications, offer important new mechanisms for gene regulation. (rockefeller.edu)
Proper regulation of Pol III transcription is critical for balanced growth and its deregulation is a key event in cell transformation and tumorigenesis. (einsteinmed.edu)

A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
What structures do RNA molecules adopt in solution? (lsu.edu)

Eukaryotic and archaeal RNA polymerases have a similar core structure and work in a similar manner, although they have many extra subunits. (wikipedia.org)
Most of the general factors (classes II and III) have been purified and individual subunits cloned for further structural and functional studies. (rockefeller.edu)
HA is a trimer, comprised of three subunits, while NA is a tetramer, comprised of four subunits, with a head region resembling a 4-leaf clover. (cdc.gov)
POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. (thermofisher.com)
Surprisingly, it was discovered in the last decade that various inherited mutations in genes encoding nine distinct subunits of Pol III cause tissue-specific diseases rather than a general failure of all vital functions. (nih.gov)
Furthermore, other rare diseases are also associated with mutations in genes encoding subunits of Pol III (POLR3H, POLR3GL) and the BRF1 component of the TFIIIB transcription initiation factor. (nih.gov)

Our study provides high-resolution structures of medically relevant FluPol A , as well as insights into the replication mechanisms of the viral RNA genome. (nature.com)
To this end, our specific objectives are to determine the nature and mechanism of action of both the general transcription initiation factors that are commonly used by all genes and the gene- and cell type-specific factors that directly regulate target genes in response to various growth, developmental and viral stimuli. (rockefeller.edu)
Viral RNA was isolated by guanidine thiocyanate lysis followed by purification on silica particles. (int-res.com)
Numerous clinical trials revealed significantly different response rates that were dependent not only on drug dosage and treatment duration, but on a number of host (allelic forms of some genes) and viral factors, in particular the viral GT. (biopaqc.com)
These new inhibitors target the NS3/4A protease, the non-structural protein NS5A or the viral polymerase NS5B [66,67]. (biopaqc.com)
Inhibitors target the NS3/4A protease, the non-structural protein NS5A, and the viral polymerase NS5B. (biopaqc.com)

Similarly, the transcription of small structural RNA genes (5S RNA, tRNA) by RNA polymerase III involves the assembly of common factors (TFIIIC and TFIIIB) into highly stable complexes via an ordered pathway. (rockefeller.edu)
Structural basis for RNA polymerase III transcription repression by Maf1. (einsteinmed.edu)
and capsid protein (orf2) and minor structural protein (orf3) genes, complete cds. (cdc.gov)

TFIIS is a transcription elongation factor that stimulates transcript cleavage activity of arrested RNA polymerase II (Pol II). (ens-lyon.fr)

ABSTRACT: Nucleic acid sequence based amplification (NASBA) is an isothermal nucleic acid amplification procedure based on target-specific primers and probes, and the co-ordinated activity of 3 enzymes: AMV reverse transcriptase, RNase H, and T7 RNA polymerase. (int-res.com)
Reverse transcriptase (RT) PCR is PCR performed on RNA targets. (medscape.com)

Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. (nih.gov)
Novel POLR1C mutation in RNA polymerase III-related leukodystrophy with severe myoclonus and dystonia. (nih.gov)
Pol III-related leukodystrophy was recently identified as a genetically inherited neurodegenerative disease. (einsteinmed.edu)

We also find that site-specific DNA binding per se promotes oligomerisation but the DNA flanking the three sites is needed to further stabilise the functional higher order oligomer of NorR at the enhancers. (strath.ac.uk)
The transcription of protein-coding genes involves RNA polymerase II and a number of common factors (TFIIA, -B, -D, -E, -F and -H) that form functional preinitiation complexes (on promoters) via an ordered assembly pathway. (rockefeller.edu)
Our laboratory studies gene transcription by RNA polymerase (Pol) III and the functional impact of this system on normal and disease processes. (einsteinmed.edu)
Here, we review the current knowledge on the functional impact of specific mutations, possible Pol III-related disease-causing mechanisms, and animal models that may help to better understand the links between Pol III mutations and disease. (nih.gov)

and, RNA silencing Catalytic RNA (ribozyme) Functions as an enzymatically active RNA molecule. (wikipedia.org)
The secondary structure prediction from the far-UV CD spectrum indicates that this domain is predominantly β-sheet, in agreement with the recent X-ray structure reported for the complete P. denitrificans cytochrome aa_3 molecule [Iwata, S., et al. (caltech.edu)
The virion consists of a single-stranded RNA molecule enclosed by the core membrane and the envelope (E) protein. (who.int)

So-called constitutive genes-those that perform basic "housekeeping" functions and are nearly always active at low levels-required only a basic set of regulatory controls, whereas those activated by environmental signals, known as inducible genes, had a more specialized architecture. (genengnews.com)
The resolution and completeness of the data allowed us to identify 21 protein assemblages and also to identify the absence of specific regulatory control signals at housekeeping genes," concluded study co-author Shaun Mahony, PhD, an assistant professor of biochemistry and molecular biology at Penn State. (genengnews.com)
The computational methods that we've developed to analyze this data could serve as a jumping-off point for further development for gene regulatory studies in more complex organisms. (genengnews.com)
Kyoto Prize laureate Robert Roeder has revealed the principle of the regulatory mechanism of gene transcription in eukaryotes through more than 50 years of research, by identifying the functions of a series of factors - including three distinct RNA polymerases, basic transcription factors, one of the first gene-specific factors, and regulators in transcription from chromatin. (uctv.tv)
The switch stabilizes the expression levels of the three genes, and through their regulatory roles on the downstream target genes, leads to a binary decision: When OCT4, SOX2 and NANOG are expressed and the switch is ON, the self-renewal genes are ON and the differentiation genes are OFF. (lu.se)
Binding of Fis to the cbpA regulatory region prevents the action of a strong σ70-dependent promoter found within the coding region of a neighbouring gene, yccE. (bham.ac.uk)
Some of the general factors have been shown to be direct targets for specific regulatory factors, while more recent studies have implicated a number of general and gene-specific cofactors in the function of gene-specific activators. (rockefeller.edu)

An influenza virus' RNP is composed of both RNA and protein. (cdc.gov)
Every influenza virus has eight RNP segments, corresponding to the virus' eight total gene segments. (cdc.gov)
The polymerase of influenza is very mistake prone and causes the virus to mutate rapidly. (cdc.gov)
Influenza viruses are considered one of and NA genes of A(H1N1)pdm09 erated with SeqMan DNA Lasergene the most common causes of respira- and H3N2 viruses in Jordan between 7 software (DNASTAR, Madison, tory infection among humans and they March 2010 and March 2013. (who.int)

In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that catalyzes the chemical reactions that synthesize RNA from a DNA template. (wikipedia.org)
With a kinetic modeling approach we ascribe function to the observed OCT4-SOX2-NANOG network by making plausible assumptions about the interactions between the transcription factors at the gene promoter binding sites and RNA polymerase (RNAP), at each of the three genes as well as the target genes. (lu.se)
Here we show that all three sites are required for NorR-dependent catalysis of open complex formation by 54-RNAP holoenzyme (E54). (strath.ac.uk)

Thus, RNA polymerase copies information from template DNA to generate the mRNA template for protein production. (bham.ac.uk)

Mutations in three genes coding for the amyloid precursor protein ( APP ), presenilin 1 ( PS-1 ), and presenilin 2 ( PS-2 ) account for most cases of early onset, autosomal dominant familial AD (FAD), but only for 2% of all the AD cases. (bmj.com)
Jordanian H1N1 viruses had mutations that are characteristic of antigenic group 6 while H3N2 virus mutations belonged to group 3. (who.int)
Peu de renseignements sont disponibles sur les mutations des virus saisonniers de la grippe A(H1N1)pdm09 et H3N2 en Jordanie. (who.int)
Les virus H1N1 jordaniens présentaient des mutations caractéristiques du groupe antigénique 6, tandis que les virus H3N2 appartenaient au groupe 3. (who.int)
Les mutations individuelles sont décrites en détail. (who.int)
Mutations in two genes, CBP (CREBBP) and EP300 , have been identified in affected individuals. (medscape.com)
Disruption of the human CBP gene, either by gross chromosomal rearrangements or by point mutations, leads to Rubinstein-Taybi syndrome. (medscape.com)
Point mutations and small deletions or insertions of the CBP and EP300 genes 3,18,19, as well as deletions and duplications 41000 bp in length to megabases, have been shown to lead to Rubinstein-Taybi syndrome. (medscape.com)
[ 12 ] reported EP300 gene mutations in 3 (3.3%) of 92 patients with either true Rubinstein-Taybi syndrome or different syndromes resembling Rubinstein-Taybi syndrome. (medscape.com)

Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)

Although possession of the ε4 allele of the apolipoprotein E gene appears to be an important biological marker for Alzheimer's disease (AD) susceptibility, strong evidence indicates that at least one additional risk gene exists on chromosome 12. (bmj.com)
Here, we describe an association of the 3′-UTR +1073 C/T polymorphism of the OLR1 (oxidised LDL receptor 1) on chromosome 12 with AD in French sporadic (589 cases and 663 controls) and American familial (230 affected sibs and 143 unaffected sibs) populations. (bmj.com)

It encodes an extremely large virion-associated RNA polymerase unique for bacterial viruses that became characteristic for this group. (mdpi.com)
The bacterial activator protein NorR binds to enhancer-like elements, upstream of the promoter site, and activates 54-dependent transcription of genes that encode nitric oxide detoxifying enzymes (NorVW), in response to NO stress. (strath.ac.uk)

RNA polymerase is essential to life, and is found in all living organisms and many viruses. (wikipedia.org)
Subsequently, with the discovery of Norwalk virus ( 1 ), rotavirus ( 2 ), astrovirus ( 3,4 ), and enteric adenovirus ( 5 ), researchers began to recognize viruses as causative agents of gastroenteritis. (cdc.gov)
The processes of animal cell growth, differentiation and infection by viruses result from the differential expression of specific genes, controlled primarily at the level of transcription. (rockefeller.edu)
47 (2), 145-152 (1995) PUBMED 8830118 REFERENCE 2 (bases 1 to 3057) AUTHORS Ando,T., Monroe,S.S., Noel,J.S. and Glass,R.I. TITLE A one-tube method of reverse transcription-PCR to efficiently amplify a 3-kilobase region from the RNA polymerase gene to the poly(A) tail of small round-structured viruses (Norwalk-like viruses) JOURNAL J. Clin. (cdc.gov)
35 (3), 570-577 (1997) PUBMED 9041391 REFERENCE 3 (bases 1 to 3057) AUTHORS Ando,T., Noel,J.S. and Fankhauser,R.L. TITLE Genetic classification of 'Norwalk-like viruses. (cdc.gov)
CDC is using next-generation gene sequencing tools to analyze flu viruses as part of CDC's Advanced Molecular Detection (AMD) initiative. (cdc.gov)
There is little information on their evolution in Jordan so this study investigated the genetic and antigenic variability of A(H1N1)pdm09 and H3N2 viruses in Jordan by performing phylogenetic and genetic analyses of the HA and NA genes of A(H1N1)pdm09 and H3N2 viruses between 2011 and 2013. (who.int)

Non-coding RNA or "RNA genes"-a broad class of genes that encode RNA that is not translated into protein. (wikipedia.org)

Enzymes that are associated with this gene in the WormFlux database, but not included in the current network model . (umassmed.edu)
SACURE pipeline annotates genes based on a logistic function that converts evidence from multiple resources into a KEGG orthology decision, which is then associated with enzymes and reactions . (umassmed.edu)

The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. (thermofisher.com)

Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcription. (ens-lyon.fr)
Home / Teams / Developmental epigenomics - Y. GHAVI-HELM / Publications / publications-ghavi-helm / Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcription. (ens-lyon.fr)
TFIIS and Pol III occupancies correlated well genome-wide on this novel class of targets. (ens-lyon.fr)

For these and other reasons, much of our research has focused on the Maf1 protein, a master negative regulator of Pol III transcription, and its posttranslational control by nutrient- and stress-signaling pathways. (einsteinmed.edu)

The question is, how many of these gene families show gain or loss of numbers during mammalian evolution? (blogspot.com)
DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation. (cipsm.de)

The latter is found in phages as well as eukaryotic chloroplasts and mitochondria, and is related to modern DNA polymerases. (wikipedia.org)
The products of Pol III transcription are small non-coding RNAs that have diverse and expanding functions in eukaryotic cells. (einsteinmed.edu)

Organization and sequence studies of the 17-piece chicken conalbumin gene. (wikidata.org)
The rpoB gene target sequence was amplified using mutagenesis forward and reverse primers followed by HindIII enzyme digestion. (who.int)

Defective myelination in an RNA polymerase III mutant leukodystrophic mouse. (einsteinmed.edu)

In general, selection of a resistance mutation against a classical inhibitor is easier than for a mutagen [3]. (biopaqc.com)
Is genotoxic whereas a mutation is defined as a 3. (who.int)

Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
Because of the functions of these RNAs, Pol III transcription is best known for its essential contribution to RNA maturation and translation. (nih.gov)

RNA polymerase II synthesizes precursors of mRNAs and most sRNA and microRNAs. (wikipedia.org)

It then produces an RNA chain, which is complementary to the template DNA strand. (wikipedia.org)

In most prokaryotes, a single RNA polymerase species transcribes all types of RNA. (wikipedia.org)
Of these, 3,114 were single genes confined to a single species. (blogspot.com)

In addition to regulating each other through feedback loops, these genes also regulate downstream target genes involved in the maintenance and differentiation of embryonic stem cells. (lu.se)

Control of the process of gene transcription affects patterns of gene expression and, thereby, allows a cell to adapt to a changing environment, perform specialized roles within an organism, and maintain basic metabolic processes necessary for survival. (wikipedia.org)
Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)

Here we show, however, that RNA polymerase II (Pol II) inside human nucleoli operates near genes encoding rRNAs to drive their expression. (nature.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
Copy number variations (CNVs) can create new genes, change gene dosage, reshape gene structures, and modify elements regulating gene expression. (biomedcentral.com)
As with all types of genetic variation, CNVs may influence phenotypic variation and gene expression. (biomedcentral.com)
Thus, CNVs are considered likely major sources of genetic variation, and may influence phenotypic variation and gene expression. (biomedcentral.com)
CNVs also have an impact on fitness and gene expression. (biomedcentral.com)
Transcription is the first step in gene expression. (bham.ac.uk)

The 2006 Nobel Prize in Chemistry was awarded to Roger D. Kornberg for creating detailed molecular images of RNA polymerase during various stages of the transcription process. (wikipedia.org)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

A CNV was described as early as 1936, with the duplication of the Bar gene in Drosophila melanogaster [ 6 ]. (biomedcentral.com)

Additionally, small amounts of input RNA are required. (medscape.com)

The core RNA polymerase complex forms a "crab claw" or "clamp-jaw" structure with an internal channel running along the full length. (wikipedia.org)
Yeast cells provide a simple model system with 6,000 genes, most of which are found in other organisms, including humans, making them excellent candidates for studying fundamental genetics and complex biological pathways. (genengnews.com)
By breeding two of these mating-type engineered K. marxianus strains, we combined three complex traits-thermotolerance, lipid production, and facile transformation with exogenous DNA-into a single host. (asm.org)
We demonstrate that this is essentially due to the need for all three enhancers for maximal ATPase activity of NorR, energy from which is used to remodel the closed E54 complex and allow melting of the promoter DNA. (strath.ac.uk)
The RNPs were shown in white, with their coiled structures, and three-bulbed polymerase complex on the ends. (cdc.gov)
POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. (thermofisher.com)

Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. (thermofisher.com)

Anatomy8

Organisms16

Diseases2

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes73

Information Science3

Health Care2

Subunit4

Ribosome3

RRNA10

Promoter in Escherichia coli2

Proteins11

Biogenesis2

Synthesis9

Transcriptional2

Chain reaction7

Ribosomal RNA1

Sequences7

Nucleotides4

Subset3

Regulation11

Molecules2

Subunits6

Viral6

Structural3

Elongation1

Reverse transcriptase2

Leukodystrophy3

Functional4

Molecule3

Regulatory7

Influenza4

RNAP3

MRNA1

Mutations9

Assays1

Chromosome2

Bacterial2

Viruses7

Encode1

Enzymes2

Transcripts1

Genome3

Negative regulator1

Mammalian2

Eukaryotic2

Sequence2

Defective1

Mutation2

Functions2

Synthesizes1

Complementary1

Species2

Regulate1

Metabolic2

Expression8

Molecular2

Drosophila1

Small1

Complex6

Myeloma1