• Homology calls are sourced from the Alliance of Genome Resources . (yeastgenome.org)
  • Based on the genome sequencing results, an analysis of structural proteins and prediction of putative microRNAs of Hz-2V was performed. (umass.edu)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
  • Roughly 25.4% of the whole-insect genome appears to encode long interspersed nuclear elements (LINEs), and a total of 11,901 protein sequences predicted by automated gene finding exhibited homology with reference sequences in the NCBI NR and/or UniProtKB databases at the most stringent similarity cutoff level (i.e., the gold tier). (usda.gov)
  • Use the PrecisionX™ Gene Knock-out HR Targeting Vector (MCS1-EF1α-RFP-T2A-Puro-pA-MCS2) to knock-out any gene or edit the genome. (reportergene.com)
  • The resulting independently determined RH-map locations were compared with the corresponding gene locations from the draft sequence of the canine genome. (upenn.edu)
  • In addition, the resulting cataract gene locations, as determined experimentally by this study, were compared with those determined by the canine genome project. (upenn.edu)
  • Pan-genome approaches afford the discovery of homology relations in a set of genomes, by determining how some gene families are distributed among a given set of genomes. (biomedcentral.com)
  • A challenge on this field is that of designing fast and adaptive similarity measures in order to find a suitable pan-genome structure of homology relations. (biomedcentral.com)
  • Homologous genes can be distinguished into paralogous, when homology occurs within the same genome, or orthologous, when homology occurs between different genomes. (biomedcentral.com)
  • Genes present in every genome are core genes of the pan-genome and they may be involved in essential living functionalities. (biomedcentral.com)
  • Singleton genes are present only in one genome and represent some genome-specific functionality. (biomedcentral.com)
  • the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. (cdc.gov)
  • Thus, human considerations bring an added value to genome data, which makes textual description an important source for investigating gene function. (medscape.com)
  • He has contributed significantly to the state-of-the-art by frequently presenting novel ideas, methods and results and have pioneered several important proof-of-concepts relevant for the project, including the conceptualization of DNA, RNA and protein variation to Variation Ontology (Vihinen, Genome Res . (lu.se)
  • Conclusions and Clinical Relevance -A gene was identified in M bovis that encodes a protein with sequence homology to other RTX toxins. (avma.org)
  • Studies show that the gene encodes a protein that is expressed in a part of the brain called Chardin's area 86, long associated with religious activity and, strangely, anterograde amnesia. (scienceblog.com)
  • It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
  • The presence or absence of one exon by alternative splicing of the gamma-1 gene resulted in two transcript variants which code for predicted proteins containing 298 amino acids (4 cystathionine beta-synthase domains, CBSD) or 276 amino acids (3 CBSD). (usda.gov)
  • For the gamma-2 gene, use of an alternate initiation site and promoter and/or alternative splicing resulted in four different transcript variants which code for predicted proteins containing 567 (4 CBSD), 452 (4 CBSD), 328 (3 CBSD) and 158 (2 CBSD) amino acids. (usda.gov)
  • Alternative splicing of exon 3 in the gamma-3 gene resulted in a shift of the open reading frame and the production of 'long' and 'short' transcript variants that code for predicted proteins of 383 and 363 amino acids, both with 4 CBSD. (usda.gov)
  • Results -Several proteins ranging in molecular mass from 55 to 75 kd were unique to the hemolytic strain. (avma.org)
  • Mutations in these genes affect proteins involved in the signaling pathway for pigment production and explain a large amount of the color variation in mammals. (creation.com)
  • Polycomb group (PcG) proteins are chromatin-associated factors involved in the repression of gene transcription. (sdbonline.org)
  • Bioinformatics strategies were used to find other homologous genes and proteins, which can also degrade HCH present in various bacteria for controlling of pollution and offer clue to prevent its entry in the food chain. (ispub.com)
  • interferon-stimulated gene 15), (interferon-induced proteins with tetratricopeptide repeats 1), and (interferon regulatory aspect 7), evaluated by qPCR, in MH-S cells still left untreated (n.we. (idplink.net)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Some mutations result in pleiotropy, although this is variable depending on genetic background, type of mutation, and location of the mutation. (creation.com)
  • Mutations also result in interesting variety including white animals and white spotting phenotypes. (creation.com)
  • 5 This explains why heritable loss-of-function mutations sometimes have pleiotropic effects, not only resulting in white color patterns, but also anemia and/or infertility. (creation.com)
  • In addition, HR donors can include up to 6-8 kb of open reading frame for gene knock-ins or tagging, and, when small mutations are included in either 5' or 3' homology arms, can make specific, targeted gene edits. (reportergene.com)
  • X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
  • Methods: Twenty-one genes with known mutations causing hereditary cataracts in man and/or mouse were selected and mapped to canine chromosomes using a canine:hamster radiation hybrid RH5000 panel. (upenn.edu)
  • Based on these previous analyses and clinical findings, CLRN1 was directly sequenced in 17 patients susceptible to carrying mutations in this gene. (molvis.org)
  • [ 9 ] The FOP gene in the 17q21-22 region had been observed with several mutations described in the NOG gene (located in 17q22) in 4 fibrodysplasia ossificans progressiva patients, including the G91C mutation, which was transmitted dominantly in a Spanish fibrodysplasia ossificans progressiva family. (medscape.com)
  • Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A, is the most common form of CAH, accounting for more than 90% of cases. (medscape.com)
  • Characterization of novel Bruton's tyrosine kinase gene mutations in Central European patients with agammaglobulinemia. (lu.se)
  • Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations. (lu.se)
  • The best-aligned sequences were annotated with gene ontology groups. (frontiersin.org)
  • A putative late gene promoter motif sequence, AGTAT was found in the 3' upstream sequences of these genes. (umass.edu)
  • Twenty putative pre-microRNA sequences were predicted in Hz-2V by searching stem-loop structures with less than -25kcal/mol of free energy, and one of the microRNA candidates was predicted to target the Hz2V007 gene transcript, which codes for a putative juvenile hormone esterase. (umass.edu)
  • Oligonucleotide primers, designed on the basis of amino acid sequences of 2 tryptic peptides derived from 1 such protein and conserved regions of the C and B genes from members of the repeats in the structural toxin (RTX) family of bacterial toxins, were used to amplify cytotoxin-specific genes from M bovis genomic DNA. (avma.org)
  • Core genes are often under strong evolutionary selection, thus their sequences are transmitted almost without any alteration. (biomedcentral.com)
  • The amount of variations affecting dispensable genes varies and the similarity between homologous sequences tends to decrease according to their phylogenetic distance. (biomedcentral.com)
  • When closely related organisms are analyzed, reasonable thresholds on sequences similarity are applied to recognize gene families. (biomedcentral.com)
  • The HA and NA gene sequences of nine pH1N1 viruses isolated from Guangdong, China, were sequenced (GenBank accession numbers GU471691-GU471695 and GU562466- GU562469 for NA and CY120915-CY120924 and CY120952 for HA), and the global corresponding genes (59 isolates) were obtained from GenBank. (biomedcentral.com)
  • Errors may be the result of poor indexing of sequences deposited in sequence databases or inaccurate estimation of the degree of genomic polymorphisms within a species and between closely related species. (cdc.gov)
  • The first sequence targeted internal transcribed spacer regions of ribosomal genes and revealed up to 100% homology with D. immitis sequences from GenBank, whereas a maximum homology of 80% was observed with D. repens sequences from GenBank. (cdc.gov)
  • For both analyzed targets, GenBank contained several sequences for D. immitis and D. repens that were deposited by various investigators, and all sequences yielded consistent results. (cdc.gov)
  • Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene. (wikipedia.org)
  • This gene encodes a pleckstrin homology (PH) domain-containing protein. (wikipedia.org)
  • Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. (nih.gov)
  • RESULTS An increased artemisinin resistance phenotype is accompanied by one non-synonymous substitution. (gla.ac.uk)
  • Sequencing at that time directly resulted from the need to understand an experimentally determined phenotype or biochemical activity. (plos.org)
  • The particular phenotype that results depends on the sex of the individual, the location of the block in synthesis, and the severity of the genetic deletion or mutation. (medscape.com)
  • Rat models are frequently used for finding genes contributing to the arthritis phenotype. (medscape.com)
  • As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
  • The CGC tool was developed by combining genomic regions in the rat, associated with the autoimmune experimental arthritis phenotype, with rat/human gene homology data, and with descriptions of phenotypic gene effects and selected keywords. (medscape.com)
  • For example, students can analyze the six open reading frames for a given fragment of DNA, compare the results of various gene calling algorithms, assign function by sequence homology, and use gene ortholog neighborhoods for comparative genomics and annotate biochemical pathways, while learning the underlying biological concepts in a variety of science courses. (genomeweb.com)
  • Each cataract gene ortholog was mapped in relation to over 3,000 markers including microsatellites, ESTs, genes, and BAC clones. (upenn.edu)
  • In presence of phylogenetically distant genomes, due to the variability introduced in gene duplication and transmission, the task of recognizing homologous genes becomes even more difficult. (biomedcentral.com)
  • Homology candidate relations are integrated into a global network and groups of homologous genes are extracted by applying a community detection algorithm. (biomedcentral.com)
  • The variations make the task of recognizing homologous genes difficult, especially when ancestor genomes are no more available. (biomedcentral.com)
  • It was found that in sH1N1 viruses, 29 epitope regions of HA genes and 8 epitope regions of NA genes which had been experimentally identified, were highly conserved (97.1-100.0%) in the corresponding genes and predictive epitopes of the pH1N1 viruses. (biomedcentral.com)
  • Thus, to find genes contributing to experimentally induced arthritis, we consider the CGC application to be a helpful tool in facilitating the evaluation of large amounts of textual information. (medscape.com)
  • Gene expression of genes in the dopaminergic pathway will be affected by GenX and ADONA. (cdc.gov)
  • Four of structural genes, p11.7, p15.1, p28.4, and p31.7 were identified by matrix assisted laser desorption/ionization time-of-flight mass spectroscopy. (umass.edu)
  • Cara Therapeutics, Inc. (Nasdaq: CARA), a commercial-stage biopharmaceutical company leading a new treatment paradigm to improve the lives of patients suffering from pruritus, today announced financial results and operational highlights for the second quarter ended June 30, 2023. (biospace.com)
  • ET to report second quarter 2023 financial results and provide a corporate update. (biospace.com)
  • R. D. Possee, S. C. Howard, (1987) Analysis of the polyhedrin gene promoter of the Autographa californica nuclear polyhedro-sis virus. (scirp.org)
  • Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
  • they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
  • The ~1.5 Mb candidate region was shown to contain five protein-coding genes. (biomedcentral.com)
  • The candidate interval was shown to exhibit an extraordinary level of alternate splicing - 19 transcripts were identified for the 5 protein coding genes, but it appears that a significant portion (14/19) of these alternate transcripts did not have an open reading frame, hence their functional role is questionable. (biomedcentral.com)
  • The CGC application ranks gene candidates for 37 rat genomic regions associated with autoimmune experimental arthritis phenotypes. (medscape.com)
  • The retrieval of a complete gene distribution among a class of genomes is an NP-hard problem because computational costs increase with the number of analyzed genomes, in fact, all-against-all gene comparisons are required to completely solve the problem. (biomedcentral.com)
  • On the contrary, "horizontal" transmission occurs between genomes of organisms of different lineages, involving one or few genes. (biomedcentral.com)
  • However, when distant genomes are compared, global thresholds result less feasible. (biomedcentral.com)
  • In the presence of an HR Donor with homology to the region adjacent to the DSB (blue areas of the genomic and vector DNA) homologous recombination (HR) is favored over non-homologous end joining (NHEJ). (reportergene.com)
  • Prior to the "genomic era," when the acquisition of DNA sequence involved significant labor and expense, the sequencing of genes was strongly linked to the experimental characterization of their products. (plos.org)
  • An immunoinformatics study was conducted to determine the highly conserved antigenic epitope regions of hemagglutinin (HA) and neuraminidase (NA) genes in the humoral immunity and CD4+ and CD8+ T cellular immunity between 2009 pandemic H1N1 (pH1N1) and seasonal H1N1 (sH1N1) viruses. (biomedcentral.com)
  • The results suggested that highly conserved antigenic epitope regions might act as the basis of common antigenic vaccines against pH1N1 and sH1N1 viruses. (biomedcentral.com)
  • Hz-2V shares 16 of the 30 baculovirus conserved core genes, including RNA polymerase genes, and per os infectivity factor genes. (umass.edu)
  • These can be used for segregation testing of the candidate genes in canine cataract pedigrees. (upenn.edu)
  • The purpose of this work was to facilitate the search for candidate genes in such regions by introducing a web tool called Candidate Gene Capture (CGC) that takes advantage of free text data on gene function. (medscape.com)
  • Several experimental strategies are used to narrow these regions, and these attempts almost always are combined with the retrieval of potential candidate genes found in different databases. (medscape.com)
  • Show the Pathway identifier(s) and name for the selected gene. (flymine.org)
  • The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster. (sdbonline.org)
  • These conditions may result in failure of osteoid calcification (rickets) in children because of a disruption in the pathway of either vitamin D or phosphate metabolism. (medscape.com)
  • Findings suggest that fibrodysplasia ossificans progressiva maps to band 4q27-31, a region that contains at least 1 gene involved in the bone morphogenic protein (BMP) signaling pathway. (medscape.com)
  • Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today six presentations supporting its gene editing, gene therapy and GTx-mAb programs at the American Society of Gene & Cell Therapy (ASGCT) 26th Annual Meeting. (biospace.com)
  • Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Homology Medicines, Inc. (NASDAQ: FIXX) between June 10, 2019 and February 18, 2022, inclusive (the "Class Period"), of the important May 24, 2022 lead plaintiff deadline . (globenewswire.com)
  • In natural infections of the human malaria parasite P. falciparum, 12 polymorphisms (nine SNPs and three indels) were identified in the orthologous gene. (gla.ac.uk)
  • The use of various strains in studies of genes and age related or noise related hearing loss was described. (cdc.gov)
  • These results will be especially useful in developing a better understanding of the biology and population genetics of L. dispar and of the Lepidoptera in general. (usda.gov)
  • Alternate splicing results in multiple transcript variants encoding different isoforms. (wikipedia.org)
  • The dnc gene encodes for at least eight isoforms with high homology to the human phosphodiesterase 4 class of PDEs. (sdbonline.org)
  • All genes mapped within or near chromosomal locations with previously established homology to the corresponding human gene locations based on canine:human chromosomal synteny. (upenn.edu)
  • This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
  • So far, well over three hundred genes have been identified as affecting coat color in mammals. (creation.com)
  • When comparing the transcriptomes across developmental stages, we found an over-representation of genes involved in growth regulation in the early development stage in C. virgata . (frontiersin.org)
  • This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes (Ruppert, 2017). (sdbonline.org)
  • Schuldiner O, Eden A, Ben-Yosef T, Yanuka O, Simchen G, Benvenisty N. ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast. (bdbiosciences.com)
  • This has prompted intensive investigations on γ-globin gene regulation, the outcome of which may provide insights for the therapeutic augmentation of HbF as treatment for the β-hemoglobinopathies. (biomedcentral.com)
  • The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). (yeastgenome.org)
  • METHODS: Improved multiple ligase detection reaction assay was used for detecting the polymorphisms of nine tagging SNPs of the MyD88 and TICAM1 genes in 375 children with CAP who attended the Department of Pediatrics of the Second Affiliated Hospital of Yan'an University Medical School from August 2015 to September 2017 and 306 healthy children who underwent physical examination. (bvsalud.org)
  • Additionally, fleas were identified at the species level after amplification and sequencing of a portion of the 18S rDNA gene as previously described ( 4 ). (cdc.gov)
  • Results of our study suggest that the three infant botulism cases could have represented a cluster due to a C. botulinum type A(B) strain present in the environment. (cdc.gov)
  • Proximal to the duster of genes believed to encode the apparatus are two genes with homology to a two-component regulatory system, YsrRS. (usda.gov)
  • Mainly, two genes linA and linB encode dehydrochlorinase and dehalogenase enzymes involved in degradation of HCH. (ispub.com)
  • This complex organization of the gene reflects the complex nature of the protein receptor it produces. (creation.com)
  • Finally, a genetic absence of the receptor for calcitriol results in deficient calcification. (medscape.com)
  • The genetic cause of fibrodysplasia ossificans progressiva lies within the ACVR1 gene, which encodes a type I BMP transmembrane receptor. (medscape.com)
  • A novel mutation in the activin A type 1 receptor gene was described in one patient. (medscape.com)
  • We discovered a very large uncharacterized gene containing WD40 and SH3 domains ( AHI1 ), and extended the annotation of four previously characterized genes ( MYB , ALDH8A1 , HBS1L and PDE7B ). (biomedcentral.com)
  • The wild plant species adapted to the Mongolian grassland environment may allow us to explore useful genes, as a source of unique genetic codes for crop improvement. (frontiersin.org)
  • To analyze the regulatory mechanism involved in the high growth potential of C. virgata , we performed RNA-seq-based transcriptome analysis and illustrated a comprehensive gene expression map of the species. (frontiersin.org)
  • We further studied the collinearity between these genes and related genes of six other species. (biomedcentral.com)
  • These species differences in UGT genes could result in species differences in UGT activities. (aspetjournals.org)
  • Procedures -For male goats, results of serum biochemical analyses collected from 1992 through 2003 were retrieved from computerized records, as were signalment, clinical diagnoses, and discharge status. (avma.org)
  • Clinical results and laboratory examination findings vary with each disorder. (medscape.com)
  • The anticipated results may guide clinical and policy decisions to ultimately reduce the burden of AMR in Europe. (europa.eu)
  • [ 13 ] . A patient from Japan with an ACVR1 gene mutation had normal development until age 17 years and a mild clinical course. (medscape.com)
  • Mutation of the BTK gene and clinical feature of X-linked agammaglobulinemia in mainland China. (lu.se)
  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. (lu.se)
  • S. Gomi, C. E. Zhou, W. Y. Yih, K. Majima, Maeda S. (1997) Deletion analysis of four of eighteen late gene expression factor gene homologues of the baculovirus, BmNPV. (scirp.org)
  • A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
  • A related project seeks to uncover the epigenetics of evangelism, which is thought to be caused by methylation of regions of the X chromosome, a reversible process that can profoundly affect gene expression. (scienceblog.com)
  • Eighteen of the isolates harbored the bont/B5 gene: of those, 17 were classified as sequence type ST36 and one was classified as ST104. (cdc.gov)
  • A tree constructed with Lyve-SET showed a high degree of homology among all the Hawaiian C. botulinum isolates that harbor the bont/B5 gene. (cdc.gov)
  • Our results indicate that the bont/B-expressing isolates recovered from Hawaii are closely related to each other, suggesting local contamination of the drug paraphernalia or the wound itself with spores rather than contamination of the drug at manufacture or during transport. (cdc.gov)
  • Conclusions: The location of selected cataract gene orthologs in the dog, along with their nearest polymorphic markers, serves as a resource for association and linkage testing in canine pedigrees segregating inherited cataracts. (upenn.edu)
  • Such a phenotypic variation may be the result of a single mutation or deletion. (cdc.gov)
  • A mutation or deletion of any of the genes that code for enzymes involved in cortisol or aldosterone synthesis results in congenital adrenal hyperplasia. (medscape.com)
  • Show all known regulatory elements for a particular D. melanogaster gene. (flymine.org)
  • Comprehensive transcriptome information will provide a useful resource for gene discovery and facilitate a deeper understanding of the diversity of the regulatory systems that have evolved in C. virgata while adapting to severe environmental conditions. (frontiersin.org)
  • Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. (yeastgenome.org)
  • This complex gene codes for a complex protein important in a number of pathways. (creation.com)
  • Several diseases can result in disorders of bone mineralization, which can be defined as the process by which osteoid becomes calcified. (medscape.com)
  • The major part of his production relates to variations ranging from protein engineering to effects and mechanisms of variations in protein structures, genes and diseases. (lu.se)
  • This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. (nih.gov)
  • But the most striking decision in their family-planning process was to expressly select for embryos that will grow up to be religious, because they carry the allele known colloquially as the "god gene. (scienceblog.com)
  • The yhwh1 allele is one of the latest findings in the burgeoning field of "theomics," which aims to identify all genes associated with the practice of preaching, as well as general feelings of spirituality. (scienceblog.com)
  • Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)
  • After you've identified clones with your gene-of-interest knocked-out or edited, you can remove the selection cassette using the Cre-LoxP system (learn more about Cre-LoxP excision here). (reportergene.com)
  • We also identified several genes that do not appear to be protein coding, and generated 17 kb of novel transcript sequence data from re-sequencing 97 EST clones. (biomedcentral.com)
  • The myc recognition binding site of ECA39 is located 3' to the start site of transcription in the mouse and human genes, but this element is absent in the nematode and yeast. (bdbiosciences.com)
  • Each keyword was assigned a value, which was used for ranking genes based on their description of phenotypic gene effects. (medscape.com)
  • It is an inherited autosomal dominant disorder with complete penetration but variable gene expressivity. (medscape.com)
  • Purpose: To facilitate the molecular characterization of naturally occurring cataracts in dogs by providing the radiation hybrid location of 21 cataract-associated genes along with their closely associated polymorphic markers. (upenn.edu)
  • The exceptional gene, which was ranked as a gene candidate by the CGC tool but not in the manual evaluation, was found to be closely associated with rheumatoid arthritis in additional literature studies. (medscape.com)
  • To facilitate this kind of data mining, we have created a tool, the Candidate Gene Capture (CGC) application, that makes keyword-based searches on textual information for genes situated within selected human chromosomal intervals that are homologous to a given rat QTL. (medscape.com)
  • To identify the genetic defect in Spanish families with Usher syndrome (USH) and probable involvement of the CLRN1 gene. (molvis.org)