• In the regulation of gene expression, studied in evolutionary developmental biology (evo-devo), both activators and repressors play important roles. (wikipedia.org)
  • A team from the US and Korea documents rare variants with apparent ties to gene expression regulation across dozens of human tissue types for another paper in PLOS Genetics . (genomeweb.com)
  • Gene expression analysis suggested that the differences derived from repression of PPARdelta gene regulation activity. (anl.gov)
  • Transcription and expression regulation of some individual cel genes (cel5A, cel5I, cel5D and cel44O) of Clostridium cellulolyticum were investigated. (nottingham.ac.uk)
  • The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. (nottingham.ac.uk)
  • specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions. (ucdenver.edu)
  • Further, we show differential regulation of other transcriptional regulators and sigma factors by AmpR, accounting for the extensive AmpR regulon. (psu.edu)
  • Regulation of these genes may be particularly sensitive to environmental influences during this critical early life period. (rensberrypublishing.com)
  • Current models of transcription regulation have also shown the involvement of higher-order transcriptional coactivators, proteins that nucleate around DNA sequence-specific transcription factors, enhancing transcription of the target gene by interacting with components of the basal transcriptional apparatus and by enabling chromatin remodeling. (nih.gov)
  • To identify the involvement of specific, primary and higher-order transcriptional regulators in the EpRE-mediated regulation of the GFP reporter gene, we microinjected antibodies directed against specific transcription factors into the HepG2/GFP cells and determined their effect upon tBHQ-induced expression of the GFP gene. (nih.gov)
  • Transcriptional regulation information for a gene, including any predicted DNA binding site motifs ( YeTFaSCo ) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence. (yeastgenome.org)
  • Notably, the analysis highlighted the NR3C1 transcription factor as a strong candidate gene involved in the regulation of the 45 genes analysed. (irta.cat)
  • In eukaryotes, gene expression is a complex process, with many steps, all amenable to regulation. (unibas.ch)
  • A regulator gene may encode a protein, or it may work at the level of RNA, as in the case of genes encoding microRNAs. (wikipedia.org)
  • An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operator (a gene which binds repressor proteins thus inhibiting the translation of RNA to protein via RNA polymerase). (wikipedia.org)
  • This gene encodes a member of the regulator of G-protein signaling family. (nih.gov)
  • Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. (nih.gov)
  • The protein encoded by this gene belongs to the GSK-3-binding protein family. (nih.gov)
  • One of those molecules, phosphatidylcholine transfer protein (PCTP), suppresses the activity of the other, PPARdelta, a gene regulator critical in burning fat and energy metabolism, under conditions of overnutrition. (anl.gov)
  • Here, we hypothesized that multiple transcriptional regulators, including: (i) a primary Nrf2-Maf heterodimer, (ii) a proposed secondary, EpRE-specific, p160 family coactivator, ARE-binding protein-1, and (iii) a tertiary coactivator, CBP/p300, nucleate to form a complex at the EpRE that regulates transcription of the dependent gene. (nih.gov)
  • Moreover, we found that the same anti-MafK antibody that blocked induction of the EpRE-regulated GFP gene completely ablated the gel-shift complex that we hypothesize contains an Nrf2:Maf dimer, ARE-binding protein-1, and CBP or p300. (nih.gov)
  • The ATRX gene provides instructions for making a protein that plays an essential role in normal development. (medlineplus.gov)
  • Although the specific function of the ATRX protein is unknown, studies suggest that it helps regulate the activity (expression) of other genes through a process known as chromatin remodeling. (medlineplus.gov)
  • The ATRX protein appears to regulate the expression of two genes, HBA1 and HBA2 , that are necessary for the production of hemoglobin. (medlineplus.gov)
  • Other genes regulated by the ATRX protein have not been identified. (medlineplus.gov)
  • Other mutations insert or delete genetic material in the ATRX gene or alter how the gene's instructions are used to make the protein. (medlineplus.gov)
  • These changes prevent the ATRX protein from effectively regulating gene expression. (medlineplus.gov)
  • Background: Cystic Fibrosis (CF) is a life-threatening recessive genetic disorder resulting from mutations in the gene encoding the fibrosis transmembrane conductance regulator protein (CFTR). (tanaffosjournal.ir)
  • Collection of domains associated with the protein based on various sources, including the protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain. (yeastgenome.org)
  • Of those 12, the researchers focused on IER3IP1 , a gene that produces a protein involved in packaging other proteins for extracellular export. (the-scientist.com)
  • MEN1 encodes a transcriptional regulator protein, menin. (medscape.com)
  • Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
  • Identified gene candidates will be studied further in the context of determining sensitivity of protein degrader drugs which are currently emerging as alternative therapies for leukemia. (lu.se)
  • In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site. (wikipedia.org)
  • In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family, regulates the expression of a chromosomal β-lactamase AmpC. (psu.edu)
  • AmpR, a member of the core genome, also regulates genes in the regions of genome plasticity that are acquired by horizontal gene transfer. (psu.edu)
  • In order to directly target a generally conserved feature, elevated trimethyl-lysine 27 on histone H3 (H3K27me3), we developed the Polycomb-based Transcription Factor (PcTF), a fusion activator that targets methyl-histone marks via its N-terminal H3K27me3-binding motif, and co-regulates sets of silenced genes. (elsevierpure.com)
  • Golden Promise carries a loss-of-function mutation in HvDep1, an AGG3-type subunit encoding gene that positively regulates culm elongation and seed size in barley. (lu.se)
  • In terms of the lac operon, the negative regulator would be the lac repressor which binds to the promoter in the same site that RNA polymerase normally binds. (wikipedia.org)
  • Therefore, BTS is thought to be a negative regulator of the iron deficiency response. (molcells.org)
  • It has been proposed that upon iron deficiency, BTS is produced as a negative regulator together with those involved in iron uptake in order to prevent excess iron uptake that might happen due to over-activation of the uptake process in response to iron deficiency. (molcells.org)
  • In terms of the lac operon, the positive regulator would be the CRP-cAMP complex that must be bound close to the site of the start of transcription of the lac genes. (wikipedia.org)
  • The data demonstrates that AmpR functions as a global regulator in P. aeruginosa and is a positive regulator of acute virulence while negatively regulating biofilm formation, a chronic infection phenotype. (psu.edu)
  • In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)
  • 7 In CML and acute myeloid leukemia (AML), we and others have shown that IL-1 is a positive regulator of LSC, and blocking IL-1 signaling inhibits the LSC. (haematologica.org)
  • The report describes the roles and responsibilities of the Gene Technology Regulator (the Regulator) and the Office of the Gene Technology Regulator (OGTR) during 2021-22. (ogtr.gov.au)
  • Whether you are a member of the public or a community organisation, the Office of the Gene Technology Regulator (the OGTR) invites your involvement. (ogtr.gov.au)
  • Because of this reason, its approval by the Office of the Gene Technology Regulator (OGTR) has been done. (gmo-safety.eu)
  • The type I IFN signaling pathway includes toll-like receptor 3 ( TLR3 ) and interferon regulator factor 7 ( IRF7 ). (cdc.gov)
  • Moreno DF, Acar M. Chromatin regulatory genes differentially interact in networks to facilitate distinct GAL1 activity and noise profiles. (ucdenver.edu)
  • Most of the m 6 A RNA methylation regulators were confirmed to be differentially expressed among groups stratified by clinical characteristics and tissues. (hindawi.com)
  • High-density oligonucleotide arrays were used to identify genes differentially expressed between high and low ERG expressers. (nih.gov)
  • The number of differentially expressed genes were time- and dose-dependent. (cdc.gov)
  • This unexpected synergy between gene variants demonstrated how even subtle genetic variations can impact neuronal function," said Brennand. (nih.gov)
  • Many of the genes affected downstream contained variants that had been linked to autism spectrum disorder or bipolar disorder , in addition to schizophrenia - consistent with other research suggesting genetic overlap across mental disorders. (nih.gov)
  • These results demonstrate the functional effects of rare variants, especially on gene expression," they report, "which provides important biological insights in understanding the genetic mechanism of rare variants in complex traits and diseases. (genomeweb.com)
  • Our study reveals that methylation in a family of these genes changes dramatically during the transition from fetal to postnatal life - and that this process is influenced by methylation itself, as well as genetic variability. (rensberrypublishing.com)
  • This process is influenced, in turn, by methylation in other genes, as well as by genetic variation. (rensberrypublishing.com)
  • In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
  • In the course of analysis to identify potential allergens in GMO crops, the European Food Safety Authority (EFSA) has belatedly discovered that the most common genetic regulatory sequence in commercial GMOs also encodes a significant fragment of a viral gene (Podevin and du Jardin 2012) . (tf52.com)
  • Functional enrichment analysis suggested that these three genes may be involved in genetic and epigenetic events with known links to HCC. (hindawi.com)
  • Here we show that several previously uncharacterized B. pseudomallei genes bearing genetic signatures of rapid adaptation (positive selection) can induce diverse cellular phenotypes when expressed in mammalian cells . (bvsalud.org)
  • The situation is more complex when it comes to patents that in some way claim genes isolated, extracted or derived from viruses and related genetic information, or that claim potentially new uses or applications of genes or genetic information. (who.int)
  • In some countries laws specifically provide that isolated genetic material, such as gene sequences, may be considered patentable inventions (as long as they meet the other criteria for the granting of a patent) even if corresponding genes occur in nature. (who.int)
  • This situation typically arises when it is considered that the isolated gene or genetic material may serve a distinct useful purpose. (who.int)
  • The suspected diagnosis of cystic fibrosis was confirmed with a sweat chloride level of 120 mmol/L and homo-zygozity for the Delta F 508 gene on genetic studies. (who.int)
  • These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • these phenotypes were rescued by introduction of an intact BPSS0180 gene . (bvsalud.org)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • This enabled us to identify novel regulators of RNA processing. (unibas.ch)
  • The aim of this project is to identify novel regulators of the ubiquitin-proteasomal patway in leukemia. (lu.se)
  • Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. (wikipedia.org)
  • The current study instead examined methylation at 27,000 sites within PFC genes that regulate such expression. (rensberrypublishing.com)
  • We describe an innovative framework, NeTFactor, that combines network analyses with gene expression data to identify transcription factors (TFs) that significantly and maximally regulate such a biomarker. (ibm.com)
  • Identification of CiaR Regulated Genes That Promote Group B Streptococcal Virulence and Interaction with Brain Endothelial Cells. (ucdenver.edu)
  • Evolutionary analysis of Burkholderia pseudomallei identifies putative novel virulence genes, including a microbial regulator of host cell autophagy. (bvsalud.org)
  • More generally, our study highlights the utility of applying evolutionary principles to microbial genomes to identify novel virulence genes . (bvsalud.org)
  • Regulatory genes can also be described as positive or negative regulators, based on the environmental conditions that surround the cell. (wikipedia.org)
  • There are several different techniques to detect regulatory genes, but of the many there are a certain few that are used more frequently than others. (wikipedia.org)
  • Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition. (ucdenver.edu)
  • When gene technology is used to create a genetically modified (GM) plant, animal or other living thing (organism), the genetically modified organism (GMO), for example GM canola, is regulated by the Gene Technology Regulator to protect people and the environment. (ogtr.gov.au)
  • Positive regulators are regulatory elements that permit RNA polymerase binding to the promoter region, thus allowing transcription to occur. (wikipedia.org)
  • lac Z, lac Y, and lac A. Negative regulators are regulatory elements which obstruct the binding of RNA polymerase to the promoter region, thus repressing transcription. (wikipedia.org)
  • Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
  • They could 1) recall all CaMV Gene VI-containing crops (in Europe that would mean revoking importation and planting approvals) or, 2) undertake a retrospective risk assessment of the CaMV promoter and its Gene VI sequences and hope to give it a clean bill of health. (tf52.com)
  • These targets were identified based on the presence of predicted regulator binding sites or experimental regulator binding in the target promoter, and/or changes in the target gene's transcript levels in regulator mutant strains. (yeastgenome.org)
  • Oncology researchers have identified many gene pathways and networks that when perturbed, result in specific types of cancer. (newmindjournal.com)
  • In spite of the advantages and successful applications, the identification of causal oncogenic pathways and driver-regulators remains a challenge [ 6 ]. (biomedcentral.com)
  • One study included in the review found that mutations in TLR3 and IRF7 and genes in related pathways were more common in patients with severe COVID-19, compared to patients with mild or asymptomatic COVID-19. (cdc.gov)
  • Although only a small proportion of patients are ill due to rare, single gene disorders, studying them may improve understanding of underlying biological pathways, eventually leading to new therapies that are relevant across the disease spectrum. (cdc.gov)
  • Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
  • Researchers have discovered that gene expression regulators work together to raise an individual's risk of developing schizophrenia . (nih.gov)
  • The researchers used the model to take a closer look at the downstream molecular consequences of gene expression changes known to occur in schizophrenia, and compared them with changes seen in postmortem brains and similarly modeled neurons of people with the illness. (nih.gov)
  • The researchers experimentally mimicked the interaction of multiple risk genes thought to contribute to schizophrenia. (nih.gov)
  • If you are importing genetically modified grain or you are importing genetically modified organisms (GMOs) on behalf of researchers, then you have specific obligations under the Gene Technology Act 2000. (ogtr.gov.au)
  • In a companion study published last October, the NIMH researchers traced expression of gene products in the PFC across the lifespan. (rensberrypublishing.com)
  • In the most extreme case, researchers have recently proposed an "omnigenic" model, in which nearly all the genes in a disease-relevant cell type contribute to a specific neuropsychiatric disorder, but Wang points out, "Not all the genes carry equal weight-the problem is to determine which are more important than others. (newmindjournal.com)
  • In particular, researchers have found somatic ATRX gene mutations in some cases of myelodysplastic syndrome (MDS), which is a bone marrow disorder that usually occurs in older males. (medlineplus.gov)
  • Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size. (the-scientist.com)
  • The researchers recently trialed their approach, dubbed CRISPR-LIneage tracing at Cellular resolution in Heterogeneous Tissue (CRISPR-LICHT), in a screen for genes linked to microcephaly, a condition in which a baby's head is smaller than expected. (the-scientist.com)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • These genes are associated with the interferon response pathway. (elsevierpure.com)
  • Fig. 3: Cancer-type specificity of neoloop-involved genes. (nature.com)
  • To be able to predict binding sites for these regulators genome-wide, we need to know their sequence specificity. (unibas.ch)
  • Transcriptome analysis demonstrates that the AmpR regulon is much more extensive than previously thought, with the deletion of ampR influencing the differential expression of over 500 genes. (psu.edu)
  • The results demonstrated that PPARγ functions as a master regulator of PARIS-induced molecular changes at the transcriptome level, confirming that PARIS acts primarily on PGC-1α to lead to neurodegeneration in PD. (nature.com)
  • Comparative transcriptome analysis with shoot and root tissues revealed that BTS is involved in regulating energy metabolism by modulating expression of mitochondrial and chloroplast genes in shoot tissues. (molcells.org)
  • Our group develops computational methods to infer binding sites for various regulators across the transcriptome and to link these interactions to specific functional outcomes, such as isoform selection and transcript degradation. (unibas.ch)
  • Pinpointing master regulators may help guide us toward priority targets for novel treatments in the future. (newmindjournal.com)
  • Their upstream regulators such as transcription factors (TFs) may take a more critical role as drivers or master regulators to provide better clues on the underlying regulatory mechanisms and therapeutic applications. (biomedcentral.com)
  • In order to identify prognostic master regulators, we took the known 85 prognostic signature genes for colorectal cancer and inferred their upstream TFs. (biomedcentral.com)
  • We selected the top 10 TFs as candidate master regulators to show the highest coverage of the signature genes among the total 846 TF-target sub-networks or regulons. (biomedcentral.com)
  • Gibbons RJ, Pellagatti A, Garrick D, Wood WG, Malik N, Ayyub H, Langford C, Boultwood J, Wainscoat JS, Higgs DR. Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS). (medlineplus.gov)
  • A human tissue screen identifies a regulator of ER secretion as a brain-size determinant," Science , 370:935-41, 2020. (the-scientist.com)
  • This table lists putative transcriptional regulatory targets for the central gene represented on this page. (yeastgenome.org)
  • Abstract Background Mounting evidence from genome-wide studies of cancer shows that chromatin-mediated epigenetic silencing at large cohorts of genes is strongly linked to a poor prognosis. (elsevierpure.com)
  • With advances in genome-wide gene expression technologies, classification of cancer subtypes based on expression signatures is widespread and results in many biomarkers for various cancers. (biomedcentral.com)
  • With this purpose, expression Genome-Wide Association Study (eGWAS) of 45 lipid-related genes associated with meat quality traits in swine muscle (Longissimus dorsi) of 114 Iberian× Landrace backcross animals was performed. (irta.cat)
  • download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, SPELL, or YeastMine. (yeastgenome.org)
  • shared GO terms, the number of target genes that share them, and the P-value are all indicated in the table. (yeastgenome.org)
  • But they're often difficult to work with-especially when it comes to assessing multiple candidate genes that underlie a particular condition. (the-scientist.com)
  • Insulators, also called boundary elements, are DNA sequences that create cis-regulatory boundaries that prevent the regulatory elements of one gene from affecting neighboring genes. (wikipedia.org)
  • Cis-acting DNA sequences which can increase transcription of genes. (bvsalud.org)
  • These interactions emphasize the importance of considering the complex nature of schizophrenia and other psychiatric disorders, where a combination of gene variants contributes to disease. (nih.gov)
  • With the help of an analytical approach called a "likelihood ratio test for quantitative traits" (LRT-q), the investigators analyzed whole-genome sequence and RNA sequence data spanning samples from 49 tissue types in nearly 700 Genotype-Tissue Expression (GTEx) project participants of European ancestry, highlighting genes with particularly pronounced expression patterns or disease associations that appeared to be regulated by rare rather than common variants. (genomeweb.com)
  • in codon 38 of the Rv2042c gene, and waterbucks ( 5 ), although their exact host range remains directly upstream from pncA , a GTC to GGC (SerAla) unsettled. (cdc.gov)
  • Our network approach leads to the identification of the upstream transcription factors for prognostic signature genes to provide leads to their regulatory mechanisms. (biomedcentral.com)
  • We demonstrate that our approach could identify upstream biomarkers for a given set of signature genes with markedly smaller size and comparable performances. (biomedcentral.com)
  • This provides an exemplary case to pinpoint upstream regulators of known cancer signatures as cancer drivers and, accordingly, to a promising therapeutic target. (biomedcentral.com)
  • Regulator genes can be located within an operon, adjacent to it, or far away from it. (wikipedia.org)
  • Unlike the cip-cel operon, these genes are transcribed as monocistronic units of transcription, except cel5D. (nottingham.ac.uk)
  • In the same paper we also demonstrated that accumulating PARIS acts on PGC-1α, the master regulator of mitochondrial biogenesis, along the NRF1/2-TFAM axis to intervene in mitochondrial biogenesis, and that the transcriptionally inactive PARIS mutant (C571A) lacks repression capacity to induce the phenotype. (nature.com)
  • Thus, the study team used computational systems biology approaches to discern a disease-relevant core pathway in schizophrenia and to discover a master regulator in that pathway that affects hundreds of downstream genes. (newmindjournal.com)
  • MEN-1 is due to mutations in the tumor suppressor gene MEN1, located on chromosome 11q13. (medscape.com)
  • Schizophrenia-like gene expression changes modeled in human neurons matched changes found in patients' brains. (nih.gov)
  • They used the gene editing tool CRISPR to simultaneously increase or decrease expression of four schizophrenia-implicated genes known to harbor eQTLs. (nih.gov)
  • To trigger changes in the direction predicted to heighten risk for schizophrenia, expression was increased for three of the genes and decreased for one. (nih.gov)
  • We have added several of them to a list of genes worthy of further study for possible involvement in schizophrenia. (nih.gov)
  • Among key findings of the study by National Institutes of Health scientists: genes implicated in schizophrenia and autism turn out to be members of a select club of genes in which regulatory activity peaks during an environmentally-sensitive critical period in development. (rensberrypublishing.com)
  • For example, genes that code for the enzymes that carry out methylation have been implicated in schizophrenia. (rensberrypublishing.com)
  • Some of the suspect genes found to peak in methylation around birth code for enzymes, called methytransferases, that are over-expressed in people with schizophrenia and bipolar disorder. (rensberrypublishing.com)
  • An illustration of the study design to identify and validate TCF4 as a key gene in schizophrenia. (newmindjournal.com)
  • Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development. (newmindjournal.com)
  • Because hundreds, or even thousands, of genes may contribute to the risk of schizophrenia, it is crucial to understand which are the most important ones, orchestrating core networks in the disease," said study leader Kai Wang, Ph.D., of the Department of Pathology and Laboratory Medicine and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics (CCMT) at Children's Hospital of Philadelphia (CHOP). (newmindjournal.com)
  • The experimentally induced gene expression changes mirrored those seen in postmortem brains of people with the three mental illnesses. (nih.gov)
  • We applied NeoLoopFinder in Hi-C data from 50 cancer cell lines and primary tumors and identified tens of recurrent genes associated with enhancer hijacking. (nature.com)
  • Kitaoka M, Miyata ST, Brooks TM, Unterweger D, Pukatzki S. VasH is a transcriptional regulator of the type VI secretion system functional in endemic and pandemic Vibrio cholerae. (ucdenver.edu)
  • As methylation increases, gene expression slows down after birth. (rensberrypublishing.com)
  • Developmental brain disorders may be traceable to altered methylation of genes early in life," said Barbara Lipska, a scientist in the NIH's National Institute of Mental Health (NIMH) and lead author of the study. (rensberrypublishing.com)
  • Usually, the more methylation, the less gene expression.Lipska's team found that the overall level of PFC methylation is low prenatally when gene expression is highest and then switches direction at birth, increasing as gene expression plummets in early childhood. (rensberrypublishing.com)
  • But methylation in some genes shows an opposite trajectory. (rensberrypublishing.com)
  • So genes associated with risk for such psychiatric disorders may influence gene expression through methylation in addition to inherited DNA. (rensberrypublishing.com)
  • We identified an m 6 A RNA methylation regulator-based signature (including METTL3, YTHDC2, and YTHDF2) that could effectively stratify a high-risk subset of these patients by univariate and LASSO Cox regression, and receiver operating characteristic (ROC) analysis indicated that the signature had a powerful predictive ability. (hindawi.com)
  • In summary, we demonstrated the vital role of m 6 A RNA methylation regulators in the initial presentation and progression of HCC and constructed a nomogram which would predict the clinical outcome and provide a basis for individualized therapy. (hindawi.com)
  • In this section, we comprehensively analyzed the expression levels of fourteen m 6 A RNA methylation regulators and clinical factors in patients with HCC from the ICGC (International Cancer Genome Consortium, https://icgc.org/ ), Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/ ), and TCGA (The Cancer Genome Atlas, http://cancergenome.nih.gov/ ) databases. (hindawi.com)
  • The scientists first created a whole-body PCTP knockout male mouse (meaning one in which genes have been activated or deactivated), assessing its fat metabolism under different dietary conditions, including normal and high-fat diet. (anl.gov)
  • Gene knockout studies have demonstrated the primary regulatory role that an Nrf2:Maf dimer plays by binding to nucleotides within the EpRE consensus sequence. (nih.gov)
  • We obtained the expression profiles of m 6 A-related genes for HCC patients from the International Cancer Genome Consortium and The Cancer Genome Atlas datasets. (hindawi.com)
  • The team found 13 genes with obvious roles in organ growth-genes that would show up in a 2-D screen of cells as well as the team's 3-D organoid system, Knoblich says-plus an additional 12 that only influenced phenotype later in an organoid's development. (the-scientist.com)
  • Philadelphia: U.S. Food and Drug Administration official Peter Marks said on Wednesday he hopes to align global regulations to boost commercialization for gene and cell therapies to get more treatments launched for patients with rare diseases . (indiatimes.com)
  • Health regulators including the FDA and the European Medicines Agency have different rules for cell and gene therapies that make it harder to get treatments on their markets at similar times. (indiatimes.com)
  • We identified a set of 19 PcTF-upregulated genes, or PUGs, that were consistent across three distinct breast cancer cell lines. (elsevierpure.com)
  • Immune cell analysis revealed that the genes in the signature were correlated with B cell, CD4 T cell, CD8 T cell, dendritic cell, macrophage, and neutrophil. (hindawi.com)
  • Focusing on novel positive regulators of primitive CML cells, the myostatin antagonist myostatin propeptide gave the largest increase in cell expansion and was chosen for further studies. (haematologica.org)
  • High ERG expression was associated with upregulation of 112 expressed-sequenced tags and named genes, many of which are involved in cell proliferation, differentiation, and apoptosis. (nih.gov)
  • Division of Endocrinology, Diabetes, and Metabolism Associate Professor Chad Hunter, Ph.D., recently published an article exploring the role of a co-regulator, SSBP3, in pancreatic islet cell function. (uab.edu)
  • In this context, in the undifferentiated state, the entropy would be large since fewer constraints exist on the gene expression programmes of the cell. (lu.se)
  • The activities of transcription factors and other genes involved in cell fate decisions can be measured by a number of different gene expression quantification experiments. (lu.se)
  • Until recently, and due to technical limitations, for a given cell type such experiments had to be done on an ensemble of many cells and, hence, gene expression quantifi- cations represented the average over a given population. (lu.se)
  • Lulu and Nana, the genetically-modified Chinese twins reportedly born HIV-resistant courtesy of the CRISPR gene editing tool, may also have been born with markedly superior mental abilities linked to the same gene edit. (rt.com)
  • He Jiankui, a researcher at Southern University of Science and Technology in Shenzhen, made headlines in November after claiming his team had created the first HIV-resistant babies by deleting the CCR5 gene from human embryos using CRISPR, then implanting the embryos in women. (rt.com)
  • Their approach combines brain organoids with two other technologies-CRISPR-Cas9 to knock out specific genes and DNA barcoding to track individual cells and their progeny. (the-scientist.com)
  • In the past decade, methods have been perfected for the high-throughput isolation of binding sites of these regulators. (unibas.ch)
  • There is an overwhelming need for future studies to similarly model such multi-gene interactions in complex cells and circuits. (nih.gov)
  • Interactions with potential hosts and environmental factors may induce rapid adaptations in these B. pseudomallei genes , which can be discerned through evolutionary analysis of multiple B. pseudomallei genomes . (bvsalud.org)
  • In this study, they show that PCTPs can repress the activity of a nuclear receptor called PPARdelta, a gene regulator critical in burning fat, maintaining energy balance, and regulating fatty acid uptake. (anl.gov)