• The status of the p53 gene of tumor cells can modify the sensitivity of the tumors to radiation and anti-cancer agents. (ingentaconnect.com)
  • Administration of cisplatin noticeably suppressed the growth of T.Tn/p53 tumors but not T.Tn tumors inoculated in nude mice. (ingentaconnect.com)
  • This is multicenter, open-label, randomized, active-controled, phase IV study of local direct intra-tumor injection of rAd-p53 monotherapy, with concurrent radioactive iodine , or combination with surgery for treatment of advanced malignant thyroid tumors. (clinicaltrials.gov)
  • Primary objectives of this study is to determine the efficacy profiles of rAd-p53 intra-tumor injection alone, with with concurrent radioactive iodine, or combination with surgery for treatment of advanced malignant thyroid tumors(stage III or IV) including target lesion complete response rate (LCR) and overall target lesion response rate (OLR), response duration (RD), and progress-free survival (PFS). (clinicaltrials.gov)
  • these two tumors, like most colorectal carcinomas, had allelic deletions of chromosome 17p and expressed considerable amounts of p53 messenger RNA from the remaining allele. (sciencemag.org)
  • The remaining p53 allele was mutated in both tumors, with an alanine substituted for valine at codon 143 of one tumor and a histidine substituted for arginine at codon 175 of the second tumor. (sciencemag.org)
  • In a pilot study using single-stranded conformation polymorphism analysis (SSCP), 200 node-negative breast tumors were examined for mutations in the region encompassing exons 5 through 9 of the p53 gene. (nih.gov)
  • Women with node-negative breast cancer who have tumors with alterations in the p53 gene, as indicated by SSCP analysis, have a significantly poorer prognosis and a higher rate of relapse at 5 years. (nih.gov)
  • Cancer researchers have long hailed p53, a tumor-suppressor protein, for its ability to keep unruly cells from forming tumors. (medicalxpress.com)
  • Mutations of the p53 gene occurred frequently in advanced tumors, although several tumors in the early stages also showed mutations. (aacrjournals.org)
  • Approximately half of all tumors overexpress p53, and up to 20% of prostate cancer cells overexpresses p53. (nature.com)
  • Researchers have known for a decade that the p53 tumor suppressor gene is important for killing cells as they proliferate under low-oxygen conditions inside tumors. (innovations-report.com)
  • Under conditions of stress to the cell - such as radiation or chemotherapy and hypoxia - p53 normally eliminates tumors. (innovations-report.com)
  • We think one of the ways that p53 suppresses tumors at their earliest stages is by turning on Bnip3L, and that s new. (innovations-report.com)
  • Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. (nii.ac.jp)
  • The status of wt1 may, therefore, have an effect on the development of these tumors in p53 -null mice. (aacrjournals.org)
  • The p53 gene is widely known as a cancer suppressor gene that reduces the frequency of tumors - but what if that wasn't the case? (jhunewsletter.com)
  • Scientists have found that altering members of the p53 gene family, known as tumor suppressor genes, causes rapid regression of tumors that are deficient in or totally missing p53. (healthcanal.com)
  • P53 is altered in most human cancers and p53 reactivation suppresses tumors in vivo in mice. (healthcanal.com)
  • One version, known as transactivation domain-bearing, is structurally and functionally similar to p53 in their ability to suppress tumors. (healthcanal.com)
  • Thus, a clear understanding of this interplay in cancer is needed to treat tumors with p53 alterations. (healthcanal.com)
  • Flores' team found that by deleting the p63 and p73 versions that lacked transactivation domains, they were able to metabolically reprogram cells so that the cancer progression was stopped and reversed in p53-deficient tumors. (healthcanal.com)
  • Flores sees IAPP as significant in trying new therapeutic approaches for treating p53-deficient tumors. (healthcanal.com)
  • Over 50% of human cancers harbor somatic p53 gene mutations, and, in addition to sporadic tumors, inherited heterozygous loss-of-function mutations cause Li-Fraumeni syndrome, which confers a high familial risk to various types of cancer (Giorgi et al. (babraham.ac.uk)
  • 2015). Mice lacking p53 (p53 -/-mice) have been shown to have enhanced susceptibility to spontaneous tumors of various types and a shorter lifespan. (babraham.ac.uk)
  • One explanation for multidrug resistance in some tumors is the increased activity of the p-glycoprotein, a product of the mdr1 gene and an energy-dependent multidrug transporter that acts to decrease the cellular efflux of many drugs. (rupress.org)
  • Inactivation of the p53 tumor suppressor is the most common genetic alteration detected in human malignancies, occurring in more than 50% of all tumors. (asm.org)
  • Genetically engineered mice that lack p53 expression invariably develop lethal tumors within 3 to 6 months of age, underscoring the importance of p53 in the prevention of cancer ( 9 , 21 ). (asm.org)
  • Those mice also have an inactive form of the p53 gene, but the gene includes a genetic "switch" that allows the researchers to turn it back on after tumors develop. (bio-medicine.org)
  • At first, the researchers turned on p53 in mice that were four weeks old and had developed tumors known as adenomas, which are benign. (bio-medicine.org)
  • To their surprise, restoring p53 had no effect on the tumors. (bio-medicine.org)
  • In benign tumors, there is not enough activity to engage the p53 system, so restoring it has no effect on those tumors. (bio-medicine.org)
  • The MIT researchers are now looking for drugs that reactivate mutant forms of p53, and also plan to study whether tumors that have metastasized would be vulnerable to p53 restoration. (bio-medicine.org)
  • Among the 30 patients with superficial bladder cancer, 4 were found to have the mutated p53 gene and 3 of them had recurrences.which involved either invasive or high grade tumors. (nii.ac.jp)
  • Two of thses recurrent tumors with the p53 gene have the same mutation. (nii.ac.jp)
  • To resolve this, we used a rapid and nonisotopic PCR-single strand conformation polymorphism method to screen for mutations in exons 4-8 of the p53 gene in primary tumors from 422 node-negative breast cancer patients. (aacrjournals.org)
  • Mutation or loss of p53 has been observed in over 50% of all tumors and in almost every tumor type ( 16 ). (asm.org)
  • Furthermore, it has been estimated that the p53 pathway is disrupted by mutation or inhibition of its function in the vast majority of tumors ( 48 ). (asm.org)
  • However, when existing drugs boost p53, only a few tumors die - the rest resist the challenge. (coloradocancerblogs.org)
  • The division of the two programs was found to act as a marker for tumor protein p53 ( TP53 ) gene status in luminal breast cancer, with the two programs being separated only in luminal tumors with functional p53 (encoded by TP53 ). (biomedcentral.com)
  • One example of classification disagreement reflects differences in the separation into luminal A and B tumors, which mainly depends on proliferation-related genes with luminal B tumors displaying higher expression of such genes. (biomedcentral.com)
  • As no mutations were detected in exons 5-8 in either tumor examined, the second p53 allele was most likely lost during tumorigenesis in both tumors. (aacrjournals.org)
  • 93.6% of the investigated tumors expressed a p53 mutation with a loss of the normal protein function, which was a significant correlation . (emf-portal.org)
  • This information was also compared with SAGE data from p53-null mouse mammary tumors. (aacrjournals.org)
  • Martins, C. P., Brown-Swigart, L. & Evan, G. I. Modeling the therapeutic efficacy of p53 restoration in tumors. (nature.com)
  • Additionally, many human tumors contain p53 mutations, which results in no induction of PUMA, even after DNA damage induced through irradiation or chemotherapy drugs. (wikipedia.org)
  • We individuated two possible pathways (VEGF-A, Otx2, p53, p63 and Otx1 and Otx3) involved in PVR progression that could influence in different manners the course of the pathology. (hindawi.com)
  • Vascular endothelial growth factor A (VEGF-A), platelet-derived growth factors (PDGFs), and non-PDGFs (growth factors outside of the PDGF family) are relevant to PVR pathogenesis because of their role in suppressing p53 levels through different pathways [ 17 ]. (hindawi.com)
  • Our data pinpoint a remarkable example of convergent evolution: the exaptation of lineage-specific transposons to shape p53-regulated neuronal morphogenesis-related pathways in both a hominid and a teleost fish. (sigmaaldrich.com)
  • These results showed that HBV and HCV infections affect carcinogenic pathways causing p53 abnormalities independently. (unboundmedicine.com)
  • A next-generation sequencing technique revealed that a majority of the patients in East Asia had aberration of p53 gene and the down-stream pathways, which consequently indicated that the p53 pathways was the major therapeutic target. (nii.ac.jp)
  • We then investigated a novel therapeutic approach to augment the p53 pathways with gene medicine and a molecular targeted agent. (nii.ac.jp)
  • However, despite the availability of compilations of gene sets relating to specific cellular states or signaling pathways [ 3 , 4 ], the biological interpretation of large-scale gene expression data often comes in second place. (biomedcentral.com)
  • Second, p53-regulated pro-apoptotic genes are epigenetically silenced in endocycling cells, preventing activation of a paused RNA Pol II by p53-dependent or p53-independent pathways. (iupui.edu)
  • The effective compounds, bexarotene and gefitinib, may exert their chemopreventive activity, at least in part, by affecting a set of 34 genes related to specific cellular pathways. (aacrjournals.org)
  • It is assumed that current study will play a significant contribution to design potential drug inhibitors by utilizing most interactive residue information with Nutlin-3 and Staurosporine ligands to restrain the interaction between p53 pathways and epidermal growth pathways. (sciencepublishinggroup.com)
  • Asif Mir, Syeda Naqsh e Zahra, Sobiah Rauf, Comparative Modeling and Molecular Docking Study of P53 and AKT1, Genes of Lung Cancer Pathways, International Journal of Clinical Oncology and Cancer Research . (sciencepublishinggroup.com)
  • Many chemotherapeutical drugs used to treat cancer exert their biological effects on tumor cells through activation of the p53 pathway. (news-medical.net)
  • Study results suggest existing diabetes drugs, which impact the same gene-protein pathway, might be effective for cancer treatment. (healthcanal.com)
  • This suggests that the p53 signaling pathway is recruited only when there is a lot of activity from other cancer genes. (bio-medicine.org)
  • In the malignant tumor cells, reactivated p53 eliminates cells with too much activity in a signaling pathway involving mitogen-activated protein kinase (MAPK), which is often overactive in cancer cells, leading to uncontrolled growth. (bio-medicine.org)
  • These results support a crucial role for Brn-3a in determining the pathway taken by p53 when co-expressed during development and thus in controlling the fate of these cells. (ucl.ac.uk)
  • Modules of highly connected genes were extracted from a gene co-expression network that was constructed based on Pearson correlation, and module activities were then calculated using a pathway activity score. (biomedcentral.com)
  • Our observations also underscore that the p53 pathway is not engaged by low levels of oncogene activity that are sufficient for early stages of lung tumour development. (nature.com)
  • The extent of apoptotic DNA cleavage is directly proportional to the period during which p53 is functional. (nih.gov)
  • Recent evidence (( 3 )-( 6 )) suggests that genes that regulate apoptotic cell death may play an important role in determining the sensitivity of tumor cells to chemotherapy. (rupress.org)
  • These results suggest that ei24 may play an important role in negative cell growth control by functioning as an apoptotic effector of p53 tumor suppressor activities. (asm.org)
  • In the present study, we demonstrate the potential role of PP1 nuclear targeting subunit (PNUTS) in regulating the phosphorylation and apoptotic activities of p53. (thebiogrid.org)
  • Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. (springermedizin.de)
  • Without irradiation, both p53A protein and a paused RNA pol II were pre-bound to the promoters of pro-apoptotic genes, preparing mitotic cycling cells for a rapid apoptotic response to genotoxic stress. (iupui.edu)
  • Exons 1-3 (EX1-EX3), and p53-responsive elements (PG) are indicated. (nih.gov)
  • The BRCA2 gene is composed of 27 exons and encodes a predicted 384-kDa protein possessing no obvious homology to other sequences in publicly available databases ( 4 ). (pnas.org)
  • Exons 5 through 9 were tested because they contain 80-90% of known p53 gene mutations. (nih.gov)
  • The long PCR technique of exons 5 to 8 of the p53. (springer.com)
  • Li LY, Tang JT, Jia LQ, Li PW (2005) Mutations of p53 gene exons 4-8 in human esophageal cancer. (springer.com)
  • We used single-stranded conformation polymorphism to screen samples for mutations in five conserved regions, exons 4, 5, 6, 7 and 8, of the p53 gene. (thescipub.com)
  • To facilitate robust large-scale DNA analysis of microdissected tumor biopsies, we describe a multiplex/nested PCR approach for a simultaneous outer amplification of exons 4-9 of the human p53 gene with parallel amplification of the HLA-DQB1 locus, involving a total of 14 primers. (diva-portal.org)
  • This approach reduces the required number of cells for analysis and avoids any variation in the amplifications of the individual p53 exons during the common outer amplification step. (diva-portal.org)
  • A nested primer polymerase chain reaction protocol was used for the amplification of exons 5 to 8 of the p53 gene. (bmj.com)
  • S1 nuclease mapping localized the insertion toward the 5' end of the p53 transcript near exons 4 and 5, and sequencing revealed a point mutation in the splice donor site of intron 4 in the germ-line of the two affected individuals, which accounted for the presence of the larger transcript. (aacrjournals.org)
  • In contrast to the gastric cancer, none of the 13 esophageal cancer cell lines, including two cell lines established from metastases, and none of the four cervical cancer cell lines showed any aberration in exons 5 to 11 of the p53 gene. (mysciencework.com)
  • The chief enzyme that maintains low levels of p53 is Hdm2, which under normal growth conditions degrades p53. (healthcanal.com)
  • Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. (nih.gov)
  • Germ-line mutations in the human BRCA2 gene confer susceptibility to breast cancer. (pnas.org)
  • COTI's previous research had identified a strong statistical relationship between the presence of several p53 mutations and COTI-2's in-vitro effectiveness in cancer cell lines with these mutations. (yahoo.com)
  • This new information represents an important advance in the understanding of COTI-2's specific gene mutation mechanism of action with the results extending the test outcomes generated by Dr. Yu et al from the University of New Jersey as published in the May 2012 edition of the journal, Cancer Cell. (yahoo.com)
  • A human ovarian cancer cell line (TOV-112D) that expresses the specific p53 mutation, R175H, was treated with a low concentration of COTI-2. (yahoo.com)
  • A human lung cancer cell line (H460) expressing normal p53 protein was also treated with a low concentration of COTI-2 as a control. (yahoo.com)
  • In this study we demonstrate that polymerase chain reaction (PCR) amplification of p53 gene DNA is achievable in a proportion of NAF samples from breast cancer patients. (springer.com)
  • Researchers are now investigating the potential of p53 protein as a tumor-associated antigen (TAA) loaded in DC-based cancer vaccine. (nature.com)
  • A team led by Wafik El-Deiry, MD, PhD, Associate Professor, Departments of Medicine, Genetics, and Pharmacology with the Abramson Cancer Center of the University of Pennsylvania, discovered a gene related to p53 called Bnip3L that can also cause cell death. (innovations-report.com)
  • PUBLIC DOMAIN Recently, researchers discovered that the p53 gene can both stop and accelerate cancer growth. (jhunewsletter.com)
  • In a multi-year study of liver cancer, researchers concluded that the WTp53 gene actually accelerates cancer growth once cancer has been initiated. (jhunewsletter.com)
  • While this all seems to support the tumor suppressing qualities of p53, it is still unclear in which cases cancer growth is enhanced due to the glycolysis stimulated by p53. (jhunewsletter.com)
  • Overall, it is clear that p53 is an extraordinarily complex gene that controls many factors of cancer and aging. (jhunewsletter.com)
  • The University of Texas MD Anderson Cancer Center investigation showed that, in vivo, the genes p63 and p73 can be manipulated to upregulate or increase levels of IAPP, a protein important for the body's ability to metabolize glucose. (healthcanal.com)
  • Flores tested Pramlintide on a variety of human cancer cell lines with p53 deletions and mutations and found the drug to be highly effective in inhibiting glucose metabolization and causing programmed cell death. (healthcanal.com)
  • Genetic deletion of the P2X7R in the p53-/- mice delayed cancer appearance and almost doubled the life span. (babraham.ac.uk)
  • We studied the effects of polymorphisms in nine genes involved in DNA repair and detoxification on occurrence and type of p53 mutation in 327 bladder cancer patients. (diva-portal.org)
  • Our findings suggest that altered repair and detoxification due to genetic polymorphism may influence the occurrence of p53 mutations in bladder cancer. (diva-portal.org)
  • Methods: The Cancer Genome Atlas (TCGA) RNA-seq data of lung adenocarcinoma were used to define a novel gene signature for P53 deficiency. (aacrjournals.org)
  • The p53 abnormalities correlated with the grade of cancer cell atypia which advanced with tumor growth. (unboundmedicine.com)
  • Cancer related gene p53 not regulated as indicated by previous tissue culture research ( The cellular cascade of molecular signa. (bio-medicine.org)
  • We investigated hepatoma, gastric cancer, colon cancer, and breast cancer cell lines upon treatment with different anticancer agents known to act via p53 accumulation. (rupress.org)
  • Inactivation of the p53 gene or shutting down the p53 protein is a key step in tumor development," says co-author Matthew Galbraith, PhD, investigator at the University of Colorado Cancer Center and instructor in the Department of Pharmacology at the CU School of Medicine. (medicalxpress.com)
  • Despite silencing over 300 genes regulated by p53 across cancer types, the group found no essential second in command. (medicalxpress.com)
  • People have always been after the silver bullet against cancer and there are few things that are as relevant across cancer types as p53. (medicalxpress.com)
  • Cancer researchers have known since the 1980s that p53 plays a critica. (bio-medicine.org)
  • As reported in Journal of the National Cancer Institute , Polato and colleagues have identified DRAGO (drug-activated gene overexpressed, KIAA0247) as a new p53-responsive gene inducible by treatment with DNA-damaging agents. (ascopost.com)
  • Our results demonstrate that PIPs in chronically exposed skin contain multiple mutations in cancer-related genes. (soton.ac.uk)
  • Therefore, the presence of the p53 gene mutation may provide important clues to the factors involved in bladder cancer. (nii.ac.jp)
  • IARC Homepage (2005) International Agency for Research on Cancer-p53 polymorphisms. (springer.com)
  • Here we show that p53, pRB, and p130 gene transfer mediated by US cavitation of microbubbles at the tumor site resulted in targeted gene transduction and increased reduction in tumor growth compared to DU-145 prostate cancer cell xenografts treated intratumorally with adenovirus (Ad) or radiation alone. (eurekaselect.com)
  • These findings highlight the potential therapeutic applications of this novel image-guided gene transfer technology in combination with external beam radiation for prostate cancer patients with therapy resistant disease. (eurekaselect.com)
  • In breast cancer, the presence of p53 gene alterations has been associated with worse prognosis. (thescipub.com)
  • He is co-founder and Chief Scientific Officer of Cleveland BioLabs, Inc and Tartis, Inc. His area of general research interest includes drug discovery, gene discovery, molecular targets for cancer treatment. (oncotarget.com)
  • When turned on, the gene p53 turns off cancer. (coloradocancerblogs.org)
  • The gene p53 is one of the most commonly mutated cancer genes. (coloradocancerblogs.org)
  • We wanted to know what genes fine-tune this p53 effectiveness," says Joaquin Espinosa, PhD, investigator at the University of Colorado Cancer Center, associate professor in the Department of Molecular, Cellular and Developmental Biology at CU Boulder, and the paper's senior author. (coloradocancerblogs.org)
  • The group's next step is likely repeating the genetic screen with additional tumor and healthy cell lines to discover which of their newly discovered candidate genes are common controllers of the p21/PUMA ratio across cancer types. (coloradocancerblogs.org)
  • Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer. (semanticscholar.org)
  • Intratumoral delivery of docetaxel enhances antitumor activity of Ad-p53 in murine head and neck cancer xenograft model. (semanticscholar.org)
  • Experimental study of adenovirus-mediated p53 gene on the reversal of multidrug resistance in breast cancer]. (semanticscholar.org)
  • In this study we have tested the concept of using wild-type p53 gene for immunotherapy of cancer. (semanticscholar.org)
  • Germ-line splicing mutation of the p53 gene in a cancer-prone family -- Warneford et al. (aacrjournals.org)
  • The p53-null mouse model of mammary carcinogenesis is a unique in vivo model of preneoplastic and neoplastic progression that reproduces many of the critical features of human breast cancer ( 4 , 5 ). (aacrjournals.org)
  • In a companion article, we assessed the antitumorigenic effectiveness of the same compounds in the same p53-null mammary epithelial cancer model ( 8 ). (aacrjournals.org)
  • Adduct sites coincided with colorectal cancer p53 mutation "hotspots," highlighting the potential carcinogenicity of fecal material. (cam.ac.uk)
  • The p53 gene is very important in dermatology for the prevention of skin cancer. (dermatologytimes.com)
  • Failure of the p53 gene to function properly results in photoaging and skin cancer, more commonly seen in Fitzpatrick skin types I and II, where the DNA protection by the melanin cap is deficient. (dermatologytimes.com)
  • It is apparent that modulation of p53 is important in preventing skin cancer and even aging, if we believe that aging is a state that precedes precancerous skin changes on a continuum to cancer. (dermatologytimes.com)
  • The transcription patterns of these genes, as well as previously described p53-regulated genes, were evaluated and classified in a panel of widely studied colorectal cancer cell lines. (elsevier.com)
  • p53 gene mutations in gastric cancer metastases and in gastric. (mysciencework.com)
  • However, no p53 mutations were identified in 19 primary lesions of gastric cancer, suggesting that the p53 gene abnormality preferentially occurs in the advanced stages of gastric cancer. (mysciencework.com)
  • Sue Armstrong's latest book, "p53: the gene that cracked the cancer code", written with financial support from the Pathological Society, is newly published by Bloomsbury. (pathsoc.org)
  • For clues to what the true nature of p53 might be we need to rewind the clock to the late 1960s to meet paediatrician and polymath Alfred Knudson, then working at the M D Anderson Cancer Center in Houston, Texas. (pathsoc.org)
  • The two-hit hypothesis is such an important concept in the history of p53, and the information about Knudson the man so sparse, that I decided to seek him out myself to hear his story, and flew into Philadelphia where he lives with his wife, Anna Meadows, a paediatric cancer specialist, on a hot July afternoon in 2012. (pathsoc.org)
  • The endeavor behind this work is to select most susceptible genes p53 and AKT1 which plays a vital role in lung cancer pathogencity. (sciencepublishinggroup.com)
  • Chandrachud, U & Gal, S 2009, ' Three assays show differences in binding of wild-type and mutant p53 to unique gene sequences ', Technology in Cancer Research and Treatment , vol. 8, no. 6, pp. 445-454. (elsevier.com)
  • Synthesis of Ang II and binding to AT 1 receptors may trigger distal events upregulating p38 mitogen-activated protein (MAP) kinase ( 14 ), which, in turn, may phosphorylate p53 at the COOH-terminal, sustaining its transcriptional activity ( 15 ). (diabetesjournals.org)
  • Likewise, the p53 sequence-specific DNA-binding activity and transcriptional activity increase during replicative senescence ( 9 ). (aacrjournals.org)
  • More detailed investigations revealed that the altered p53 protein still binds to Mdm2, one of the negative regulators of p53 that facilitate its degradation. (news-medical.net)
  • Ireland AP, Clarck GWB, DeMeester TR (1997) The significance of p53 in clinical practice. (springer.com)
  • Finally, we found that BRCA1 coimmunoprecipitates with p53, in vitro and in vivo. (nih.gov)
  • A new mouse model, created by scientists at the Salk Institute for Biological Studies , suggests that what researchers have learned about the regulation of p53 activity from in vitro studies may not be relevant to living, breathing organisms. (news-medical.net)
  • Infection of hTf with rAd.p53 resulted in significant inhibition of cell proliferation, DNA synthesis, and metabolic activity in vitro. (bmj.com)
  • In vitro, survival of irradiated Super-p53 macrophages and femoral SMCs was reduced, but only Super-p53 SMCs exhibited attenuated proliferation. (csic.es)
  • Adduction of human p53 gene by fecal water: an in vitro biomarker of mutagenesis in the human large bowel. (cam.ac.uk)
  • The protective effect of p53 in mechanically-injured femoral artery coincided with limited medial SMC proliferation at early time points preceding neointima formation, but neither medial nor neointimal cell proliferation was affected in vessels with established occlusive lesions. (csic.es)
  • In this way, each litter contributed equally to the genetic pool of both the wt1 het/ p53- null cohort and the p53- null cohort. (aacrjournals.org)
  • The study, led by Elsa R. Flores, Ph.D. , associate professor of molecular and cellular oncology , centered on p63 and p73 because of the genes' ability to cause tumor regression or spur its growth due to their unique genetic makeup. (healthcanal.com)
  • We have identified the Polo-like kinase family member serum inducible kinase ( Snk / Plk2 ) as a novel p53 target gene. (asm.org)
  • Our experiments showed that COTI-2, at a low dose, restored the normal protein configuration of the R175H p53 gene mutation and did not affect normal p53 protein," said Dr. Wayne Danter, COTI's President and CEO. (yahoo.com)
  • Motomura K, Koyama H, Noguchi S, Inaji H, Azuma C: Detection of c-erbB-2 gene amplification in nipple discharge by means of polymerase chain reaction. (springer.com)
  • Proteomics analysis of the p53 repressor complex, which was pulled down by theMTA1promoter, revealed that the poly(ADP-ribose) polymerase 1 (PARP-1) was part of the complex. (ovid.com)
  • The codon 249 p53 mutations as well as codon 72 polymorphisms were assayed by molecular methods, and their prevalence among the enrolled subjects was evaluated. (springer.com)
  • Although serum 249 serine p53 mutation is rarely found in Taiwanese patients, HBV carriers have a higher prevalence of codon 72 mutants than patients with much severe liver diseases or HCV infection, which implies that codon 72 mutants may affect at an earlier stage of HBV infection. (springer.com)
  • The secondary objectives of this study is to investigate overall response rate (OPCR) and overall complete response rate (OCR), overall survival (OS), ECOG, and safety of rAd-p53 monotherapy and combined with radioactive iodine,or surgery. (clinicaltrials.gov)
  • Results: In all datasets, P53-deficiency score was a significant predictor for recurrence-free survival where high P53-deficiency score was associated with poor survival. (aacrjournals.org)
  • We found a couple dozen genes involved in this ratio - genes that with p53 activated, lead to more p21 and better survival or more PUMA and more cell death," Espinosa says. (coloradocancerblogs.org)
  • Likewise, in cases in which toxicity in healthy tissue limits the use of p53 activating drugs, Espinosa's research could lead to new drugs that thumb the scale of the p21/PUMA ratio toward survival in these healthy tissues. (coloradocancerblogs.org)
  • The authors conclude that these results show a relationship between cell phone use, the occurrence of p53 in the peripheral zone of glioblastomas and the overall survival time and that further studies should address this topic more accurately. (emf-portal.org)
  • The new research indicates that these modifications are not necessary to activate p53 under conditions of stress or to prevent p53 from throwing a wrench into the cell cycle machinery, when nothing is wrong. (news-medical.net)
  • While p53 remains a promising target for therapy, this study shows us that we need to activate p53 itself and not something downstream. (medicalxpress.com)
  • Multiple stress signals that activate p53 include hypoxia, telomere erosion, oncogenes and DNA damage, which is the best studied of them all. (ntu.edu.sg)
  • Southern and Northern blot hybridization experiments provided no evidence for gross alterations of the p53 gene or surrounding sequences. (sciencemag.org)
  • Because an immediate cellular reponse to DNA damage is p53-mediated cell cycle arrest ( 37 ), and RAD51 has been reported to physically associate with p53 ( 38 , 39 ), we also investigated whether a physical and functional relationship could be detected between BRCA2 and p53. (pnas.org)
  • The p53 gene normally acts in response to stress signals - one of the most common being DNA damage - and triggers some form of cell death, cell-cycle arrest or senescence. (jhunewsletter.com)
  • Both mutations occurred in a highly conserved region of the p53 gene that was previously found to be mutated in murine p53 oncogenes. (sciencemag.org)
  • Here we show that restoration of p53 in established murine lung tumours leads to significant but incomplete tumour cell loss specifically in malignant adenocarcinomas, but not in adenomas. (nature.com)