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  • hMLH1
  • Inactivation of hMLH1/hMSH2 of DNA mismatch repair genes seems to have an important role to play in the mutagenesis of the tumor-suppressor genes in ASPS. (nii.ac.jp)
  • mutation
  • Histones also help regulate which genes turn on and off, a process that goes awry when there is a histone mutation. (eurekalert.org)
  • Using a genetic mouse model of DIPG, we found that the histone mutation turns off p16, which is a gene that acts like a break on dividing cells," says senior author Oren J. Becher, MD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago. (eurekalert.org)
  • cdks
  • Beyond cell cycle regulation, CDKs also play critical roles in gene transcription and neuronal function. (springer.com)
  • chromosome
  • Common regions of chromosome (chr) 3 loss have been observed in all types of serous ovarian tumours, including benign, suggesting that these regions contain genes important in the development of all ovarian serous carcinomas. (pubmedcentralcanada.ca)
  • human
  • Genomic DNA derived from GBM cell lines and xenografts was interrogated with Affymetrix 250K Nsp I Human Gene Chip microarrays using protocols described by the manufacturer. (aacrjournals.org)
  • survival
  • The homozygously deleted p16 T-ALL patients ( n = 34) treated with the modern multiagent chemotherapy schemes of the Dutch Childhood Leukaemia Study Group ALL-VII/-VIII or Co-operative ALL-92/-97 protocols have a significantly lower 5-year disease-free survival (DFS) than germ-line p16 T-ALL ( n = 25) (65·1 ± 9·1% vs. 95·5 ± 4·4%, P log rank = 0·021). (wiley.com)
  • role
  • The role of p16 is gaining importance in non-small cell lung cancer (NSCLC) because of epigenetic therapy options. (unibas.ch)
  • The rare cases of balanced translocations in MDS have allowed the identification of genes whose rearrangements appear to play a role in the pathogenesis of some cases of MDS. (springer.com)
  • study
  • Gene therapy in these models successfully attenuated the symptoms of Huntington's disease and increased life span," noted Dr. Paul Patterson, the senior author of the study. (bioquicknews.com)
  • cases
  • There was a complete overlap of individual LC 50 values of p16 gene homozygously deleted and p16 germ-line cases for most of the nine classes of drugs tested. (wiley.com)
  • Genes more frequently implicated in the pathogenesis of MDS cases, such as those involving del5 q , remain unknown, although some candidate genes are currently being studied. (springer.com)