• The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (wikipedia.org)
  • Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene. (wikipedia.org)
  • During meiosis in yeast and in mammals, RAD17 protein functions as a DNA damage sensor promoting DNA checkpoint control. (wikipedia.org)
  • In yeast, the RAD17 protein facilitates proper assembly of the meiotic crossover recombination complex containing the RAD51 protein, thus promoting efficient repair of meiotic DNA double-strand breaks. (wikipedia.org)
  • Jiang R S,Liu M,Li C,et al.Cell cycle checkpoint protein Rad17[J].Chinese Journal of Cell Biology,2008,30(4):417-420. (nefu.edu.cn)
  • protein allows mutations to accumulate in other genes, which may cause cells to grow and divide in an uncontrolled way. (diff.org)
  • Cells that are missing one copy of the ATM gene produce half the normal amount of ATM protein. (diff.org)
  • this protein prevents efficient repair of DNA damage, leading to the accumulation of mutations in other genes. (diff.org)
  • Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. (wikipedia.org)
  • Li Q J,Wang D R.Rad17 and its significance in tumor[J].Journal of International Oncology,2011,38(5):336-338. (nefu.edu.cn)
  • Using Cell Cycle-Restricted Alleles to Study the Chromatin Dynamics and Functions of the Structural Maintenance of Chromosomes (SMC) Complexes In Vivo. (ifom.eu)
  • Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites. (ifom.eu)
  • TP53 mutation-associated genomic instability may promote chromosome 7 accumulation and MDR1 amplification during ovarian cancer chemoresistance and recurrence. (biomedcentral.com)
  • Researchers have identified several hundred mutations in the ATM gene that cause ataxia-telangiectasia. (diff.org)
  • disorder have mutations in both copies of the ATM gene in each cell. (diff.org)
  • TP53 is a checkpoint molecule that maintains genomic stability, prevents cell mitosis and induces apoptosis following abnormal chromosome segregation or chemical damage to DNA sequences [ 9 , 10 ]. (biomedcentral.com)
  • 2. Shen J P,Srivas R,Gross A,et al.Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition[J].Oncotarget,2015,6(34):35755-35769. (nefu.edu.cn)
  • in DNA strands also occur naturally when chromosomes exchange genetic material during cell division. (diff.org)
  • During male meiosis in maize (Zea mays), the ZmRAD17 gene is involved in repair of DNA double strand breaks, likely by promoting synaptonemal complex assembly. (wikipedia.org)
  • percent of the United States population carries one mutated copy of the ATM gene in each cell. (diff.org)
  • 4. Gohlke G,Scholz C J,Kneitz S,et al.DNA methylation mediated control of gene expression is critical for development of crown gall tumors[J].PLoS Genetics,2013,9(2):e1003267. (nefu.edu.cn)
  • We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1 . (biomedcentral.com)
  • According to the transcriptome database of Halostachys caspica under the salt stress, the DNA damage repair gene DMC1 of H. caspica was cloned and named HcDMC1 . (nefu.edu.cn)
  • The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (wikipedia.org)
  • This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (genetex.com)
  • This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. (genetex.com)
  • 13. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (nih.gov)
  • Linkage studies in the 1990s led to the discovery of several predisposition genes associated with many rare familial cancer syndromes, thus providing fundamental insights into various pathways of carcinogenesis [ 4 ]. (biomedcentral.com)
  • We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1 . (biomedcentral.com)
  • TP53 mutation-associated genomic instability may promote chromosome 7 accumulation and MDR1 amplification during ovarian cancer chemoresistance and recurrence. (biomedcentral.com)
  • An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. (genetex.com)
  • Many bacterial or mammalian cell-based test systems, such as the Ames test, chromosomal aberration assays, or gene mutation assays, are commonly used in developed countries to detect the genotoxicity of industrial chemicals. (nih.gov)
  • Failure to repair these defects can result in chromosomal instabilities leading to dysregulated gene expression and carcinogenesis. (diff.org)
  • 10. The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. (nih.gov)
  • Direct Reversal The simplest of the human DNA repair pathways involves the direct reversal of the highly mutagenic alkylation lesion O6-methylguanine (O6-mG) by the product of the MGMT gene (O6-methylguanine DNA methyltransferase).26 The O6-mG adduct is generated in low levels by the reaction of cellular catabolites with the guanine residues in the DNA. (diff.org)
  • 9. Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. (nih.gov)
  • During male meiosis in maize (Zea mays), the ZmRAD17 gene is involved in repair of DNA double strand breaks, likely by promoting synaptonemal complex assembly. (wikipedia.org)
  • If most cancer susceptibility is related to fundamental processes of cellular control, rare alleles might turn out to be the more important component and should be detectable by linkage analysis and/or the candidate gene re-sequencing approach [ 5 , 6 ]. (biomedcentral.com)