PombeHomologousProteinProteinsTumorVivoReplicationAccumulationMutationsCheckpointGeneticMeiosisCellControlExpressionStressCell cycle checkpoinCheckpoint proteinsSchizosaccharomycesSegregationPredispositionGenomicAlternatively spliced transcriptMutationChromosomalHumanLocalizationAssemblyBreast cancerAnalysis
Pombe1
- The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (wikipedia.org)
Homologous1
- DMC1 is a necessary meiotic specific protein for homologous chromosome pairing and recombinant repair during meiosis. (nefu.edu.cn)
Protein7
- Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene. (wikipedia.org)
- During meiosis in yeast and in mammals, RAD17 protein functions as a DNA damage sensor promoting DNA checkpoint control. (wikipedia.org)
- In yeast, the RAD17 protein facilitates proper assembly of the meiotic crossover recombination complex containing the RAD51 protein, thus promoting efficient repair of meiotic DNA double-strand breaks. (wikipedia.org)
- Jiang R S,Liu M,Li C,et al.Cell cycle checkpoint protein Rad17[J].Chinese Journal of Cell Biology,2008,30(4):417-420. (nefu.edu.cn)
- protein allows mutations to accumulate in other genes, which may cause cells to grow and divide in an uncontrolled way. (diff.org)
- Cells that are missing one copy of the ATM gene produce half the normal amount of ATM protein. (diff.org)
- this protein prevents efficient repair of DNA damage, leading to the accumulation of mutations in other genes. (diff.org)
Proteins1
- Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. (wikipedia.org)
Tumor1
- Li Q J,Wang D R.Rad17 and its significance in tumor[J].Journal of International Oncology,2011,38(5):336-338. (nefu.edu.cn)
Vivo1
- Using Cell Cycle-Restricted Alleles to Study the Chromatin Dynamics and Functions of the Structural Maintenance of Chromosomes (SMC) Complexes In Vivo. (ifom.eu)
Replication1
- Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites. (ifom.eu)
Accumulation1
- TP53 mutation-associated genomic instability may promote chromosome 7 accumulation and MDR1 amplification during ovarian cancer chemoresistance and recurrence. (biomedcentral.com)
Mutations2
Checkpoint2
- TP53 is a checkpoint molecule that maintains genomic stability, prevents cell mitosis and induces apoptosis following abnormal chromosome segregation or chemical damage to DNA sequences [ 9 , 10 ]. (biomedcentral.com)
- 2. Shen J P,Srivas R,Gross A,et al.Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition[J].Oncotarget,2015,6(34):35755-35769. (nefu.edu.cn)
Genetic1
- in DNA strands also occur naturally when chromosomes exchange genetic material during cell division. (diff.org)
Meiosis1
- During male meiosis in maize (Zea mays), the ZmRAD17 gene is involved in repair of DNA double strand breaks, likely by promoting synaptonemal complex assembly. (wikipedia.org)
Cell1
- percent of the United States population carries one mutated copy of the ATM gene in each cell. (diff.org)
Control1
- 4. Gohlke G,Scholz C J,Kneitz S,et al.DNA methylation mediated control of gene expression is critical for development of crown gall tumors[J].PLoS Genetics,2013,9(2):e1003267. (nefu.edu.cn)
Expression1
- We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1 . (biomedcentral.com)
Stress1
- According to the transcriptome database of Halostachys caspica under the salt stress, the DNA damage repair gene DMC1 of H. caspica was cloned and named HcDMC1 . (nefu.edu.cn)
Cell cycle checkpoin2
- The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (wikipedia.org)
- This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (genetex.com)
Checkpoint proteins1
- This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. (genetex.com)
Schizosaccharomyces1
- 13. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (nih.gov)
Segregation2
- TP53 is a checkpoint molecule that maintains genomic stability, prevents cell mitosis and induces apoptosis following abnormal chromosome segregation or chemical damage to DNA sequences [ 9 , 10 ]. (biomedcentral.com)
- Repair Double-strand breaks (DSBs) are perhaps the most serious form of DNA damage because they pose problems for transcription, replication, and chromosome segregation. (diff.org)
Predisposition1
- Linkage studies in the 1990s led to the discovery of several predisposition genes associated with many rare familial cancer syndromes, thus providing fundamental insights into various pathways of carcinogenesis [ 4 ]. (biomedcentral.com)
Genomic2
- We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1 . (biomedcentral.com)
- TP53 mutation-associated genomic instability may promote chromosome 7 accumulation and MDR1 amplification during ovarian cancer chemoresistance and recurrence. (biomedcentral.com)
Alternatively spliced transcript1
- An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. (genetex.com)
Mutation1
Chromosomal1
- Failure to repair these defects can result in chromosomal instabilities leading to dysregulated gene expression and carcinogenesis. (diff.org)
Human2
- 10. The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. (nih.gov)
- Direct Reversal The simplest of the human DNA repair pathways involves the direct reversal of the highly mutagenic alkylation lesion O6-methylguanine (O6-mG) by the product of the MGMT gene (O6-methylguanine DNA methyltransferase).26 The O6-mG adduct is generated in low levels by the reaction of cellular catabolites with the guanine residues in the DNA. (diff.org)
Localization1
- 9. Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. (nih.gov)
Assembly1
- During male meiosis in maize (Zea mays), the ZmRAD17 gene is involved in repair of DNA double strand breaks, likely by promoting synaptonemal complex assembly. (wikipedia.org)
Breast cancer1
- Analyses of risk attributable to such alleles in the known breast cancer susceptibility genes (e.g. (biomedcentral.com)
Analysis1
- If most cancer susceptibility is related to fundamental processes of cellular control, rare alleles might turn out to be the more important component and should be detectable by linkage analysis and/or the candidate gene re-sequencing approach [ 5 , 6 ]. (biomedcentral.com)