Genes of salmonella typhimurium. Medical search. Frequent questions

OmpW of Salmonella enterica serovar Typhimurium has been described as a minor porin involved in osmoregulation, and is also affected by environmental conditions. (uandes.cl)
This is the release of four single chitinase deletion mutants in Salmonella enterica serovar Typhimurium LT2. (researchgate.net)
monella enterica serovar Typhimurium LT2. (researchgate.net)
Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169). (kegg.jp)
Throughout the time period Salmonella enterica serovar Typhimurium was the most prevalent MDR serotype, therefore a MDR S. Typhimurium isolate was chosen from each animal source (cattle, chicken and swine) for each year of the study (n=33). (usda.gov)
We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. (ed.ac.uk)
Salmonella enterica serovar Typhimurium produces a non-homoserine lactone autoinducer in exponential phase as detected by a Vibrio harveyi reporter assay for autoinducer 2 (AI-2) (M. G. Surette and B. L. Bassler, Proc. (mcmaster.ca)
Here we report that luxS expression is constitutive but that the transcription of pfs is tightly correlated to AI-2 production in Salmonella serovar Typhimurium 14028. (mcmaster.ca)
Genome-wide analysis of genes involved in efflux function and regulation within Escherichia coli and Salmonella enterica serovar Typhimurium. (bvsalud.org)

Genetic toxicology studies were conducted in Salmonella typhimurium and Escherichia coli , Drosophila melanogaster , and mouse peripheral blood erythrocytes. (nih.gov)
It is not mutagenic to Salmonella typhimurium or Escherichia coli . (inchem.org)
In addition, the presence of available nutrients in necrotic tumor tissues attracts facultative anaerobes like Salmonella and Escherichia to the cancerous site via chemotaxis. (nature.com)

In both strain backgrounds, cnr gene disruption reduced nitrofurazone-reductase activity. (unboundmedicine.com)
Isolated from the spleen of a chick orally inoculated 3 days earlier with a highly virulent S. Typhimurium strain retrieved from an infected horse in 1991. (kegg.jp)
A PA0171 mutant and a PA1822 mutant were constructed by gene replacement in the P. aeruginosa PAO1 strain. (microbiologyresearch.org)
The assay (the SOS umu test) was based on the test agent inducing beta-galactosidase (GAL) activity in Salmonella- typhimurium strain (TA-1535/pSK1002). (cdc.gov)
Fourteen people infected with the outbreak strain of Salmonella Typhimurium were reported from eight states and the District of Columbia. (cdc.gov)
FDA testing identified the outbreak strain of Salmonella Typhimurium in an unopened sample of Natural Grocers Coconut Smiles Organic collected from Natural Grocers. (cdc.gov)
FDA also collected dried coconut from International Harvest, Inc. The outbreak strain of Salmonella Typhimurium was identified in samples of International Harvest Brand Organic Go Smile! (cdc.gov)

The Salmonella isolates were sent to the National Center of Microbiology Reference Laboratory, Carlos III Institute of Health (National Laboratory) for characterization. (cdc.gov)
All isolates were serotyped and found to be Salmonella serotype Typhimurium 4,12:i:1,2 (var. (cdc.gov)
To understand how antimicrobial resistance (AR) develops, the genetic elements responsible for MDR phenotypes in Salmonella animal isolates were investigated. (usda.gov)
Results: Antimicrobial susceptibilities were determined for 54,395 Salmonella animal isolates collected by NARMS from 1997-2007. (usda.gov)
Microarray analysis detected multiple resistance genes in all of the isolates. (usda.gov)
An average of 30 resistance genes was detected in the isolates. (usda.gov)
The genes identified also correlated well with the isolates' phenotypic susceptibility. (usda.gov)
Interestingly, over the 11 year study the number of AR genes detected in MDR isolates increased in total while certain core genes remained the same. (usda.gov)
Conclusions: These data demonstrate that AR genes found in MDR isolates of S. Typhimurium have increased during the study period. (usda.gov)
Acid environments affect biofilm formation and gene expression in isolates of Salmonella enterica Typhimurium DT104. (teagasc.ie)

Bacterial glycerol facilitator protein (gene glpF), which facilitates the movement of glycerol non-specifically across the cytoplasmic membrane. (wikipedia.org)
We have studied how bacterial species such as the pathogen Salmonella enterica maintain a discrete number of flagellar per cell during cell growth and division. (ncl.ac.uk)
Bacterial intercellular communication provides a mechanism for signal-dependent regulation of gene expression to promote coordinated population behavior. (mcmaster.ca)
NASA?s STS-115space shuttle mission, launched in September 2006, carried Nickerson and hercolleague's Salmonella typhimurium bacterial experiment into space whileher group conducted an identical experiment on Earth. (space.com)

These results suggest that the cnr gene of S. typhimurium is a counterpart of the nfsB and nfnB genes of E. coli, and that the newly constructed cnr-deletion strains are useful to assess the role of nitroreductases in the metabolic activation of mutagenic nitro compounds. (unboundmedicine.com)
TY - JOUR T1 - Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538. (unboundmedicine.com)
Histidine requirement in the Salmonella typhimurium strains (Histidine operon). (europa.eu)
Spontaneous reversion of the test strains to histidine (Salmonella typhimurium strains) independence is measured routinely in mutagenicity experiments and expressed as the number of spontaneous revertants per plate. (europa.eu)
Survival characteristics of monophasic Salmonella typhimurium 4,[5],12:i:- strains derived from pig feed ingredients and compound feed. (teagasc.ie)
A large number of publications are based on gene mutation tests in Salmonella typhimurium , most of them used the strains TA98 and TA100. (europa.eu)

In addition, there is limited information regarding the repertoire of effector proteins encoded within T6SS SPI-6 and T6SS SPI-19 gene clusters in S . Dublin. (frontiersin.org)
Of note, the genes encoding these effectors and immunity proteins are widely distributed in Salmonella genomes, suggesting a relevant role in interbacterial competition and virulence. (frontiersin.org)

This serotype is widely distributed and associated with foodborne illness, and has been shown to carry a variety of antibiotic resistance genes ( 1 ). (cdc.gov)
One sample collected on each date grew Salmonella of the same serotype as that identified from the infected children. (cdc.gov)
Salmonella enterica serotype Dublin ( S . Dublin) is a cattle-adapted pathogen that harbors both T6SS SPI-6 and T6SS SPI-19 . (frontiersin.org)
Most nontyphoidal Salmonella infections are caused by S. enterica subspecies enterica serotype Enteritidis, S. Typhimurium , S. Newport , S. Heidelberg , and S. Javiana . (msdmanuals.com)
Each Salmonella serotype can cause any or all of the clinical syndromes described below, although given serotypes tend to produce specific syndromes. (msdmanuals.com)

These mutants were deficient in twitching motility, showing that both the PA1822 and the PA0171 gene are involved in twitching motility. (microbiologyresearch.org)

Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, mouse bone marrow erythrocytes, and mouse peripheral blood erythrocytes. (nih.gov)
This may indicate that the genetic elements responsible for MDR have been accumulating in S. Typhimurium during 1997-2007. (usda.gov)
Prior toNickerson and her team's study, the genetic behavior of Salmonellatyphimurium --the main culprit in cases of food poisoning and typhoid fever--wasunknown. (space.com)
The researchers'experiment revealed that a genetic switch called "Hfq," which maycontrol more than 160 genes in S. typhimurium , turns on in spaceand causes S. typhimurium to become three times more virulentthan on the Earth's surface. (space.com)
In spite ofthe microbe's increased danger to astronauts, Nickerson and her group thinks theHfq genetic regulator could be used to control food-borne disease caused by S. typhimurium --especially since no vaccine exists for it. (space.com)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

Many serotypes of Salmonella have been given names and are referred to informally as if they were separate species even though they are not. (msdmanuals.com)

However, the results on TA100 are quite obvious and were obtained in a lot of different laboratories: quinoline induces gene mutation (missense mutations, by base pair substitution) with metabolic activation from liver of rat, mice, human or hamster. (europa.eu)
Only one test about the gene mutation properties was performed on mammalian cells (mouse lymphoma assay) and considered reliable. (europa.eu)
Based on these tests, quinoline didn't induced gene mutation in testis, spleen, kidneys and bone marrow of the mouse. (europa.eu)

In Salmonella , five T6SS gene clusters have been identified within pathogenicity islands SPI-6, SPI-19, SPI-20, SPI-21, and SPI-22, which are differentially distributed among serotypes. (frontiersin.org)

To further investigate regulation of AI-2 production in Salmonella , we constructed pfs and luxS promoter fusions to a luxCDABE reporter in a low-copy-number vector, allowing an examination of transcription of the genes in the pathway for signal synthesis. (mcmaster.ca)

The cnr gene of S. typhimurium positively hybridized with DNA at 13 min on the E. coli chromosome where the nfsB and nfnB genes of E. coli are mapped. (unboundmedicine.com)
My research focuses on understanding the transmission and behaviour of microbial pathogens, in particular verocytotoxigenic E. coli , Salmonella and Campylobacter along the farm to fork chain. (teagasc.ie)

Historical control values for spontaneous revertants (revertants/plate) for untreated control sample without metabolic activation were in the period of 2011-2014 were as follows: Salmonella typhimurium TA98: 9-46, TA100: 54-210, TA1535: 1-46, TA1537: 1-24. (europa.eu)

However, the mutagenicity of 2-nitronaphthalene in YG7128 was between those observed with TA100 and TA100NR, suggesting that a nitroreductase in S. typhimurium other than CNR is involved in the metabolic activation of this compound. (unboundmedicine.com)

Transformed attenuated Salmonella typhimurium (ST) have been suggested as an efficient means of tumor vaccination. (tau.ac.il)
Mice were vaccinated with SL7207 or SL7207ΔyejE transformed with a eukaryotic expression vector carrying the lacZ or the gp100 gene and later received lacZ-transfected RENCA or YC8 or gp100-expressing B16F1 tumor cells. (tau.ac.il)
The emerging technology known as targeted therapy facilitates selective delivery of chemotherapeutic agents involving therapeutic genes and drugs to tumor sites, which enhances the therapeutic efficacy and reduces side effects 2 . (nature.com)

Seven other patients had an epidemiologic link to a laboratory-confirmed case of Salmonella and were classified as probable cases. (cdc.gov)

The intrinsic limitation of P BAD for the gene expression is known to be negated by glucose and afflicted with all-or-nothing induction in host bacteria. (nature.com)
Nontyphoidal salmonellae are gram-negative bacteria that primarily cause gastroenteritis, bacteremia, and focal infection. (msdmanuals.com)

Here we show that flagellar secretion in Salmonella enterica requires the proton motive force (PMF) and does not require ATP hydrolysis by FliI. (nature.com)
Some evidence for a different view has also been reported: it was observed that type III secretion in Yersinia enterocolitica was prevented by the protonophore CCCP 7 , and it was shown that the secretion ATPase InvC of Salmonella functions to dissociate export substrate from the chaperone 8 , a role distinct from transport itself. (nature.com)

AR gene content was determined by analysis with a DNA microarray containing probes for 775 resistance genes. (usda.gov)
One isolate contained resistance genes for ampicillin and azithromycin. (cdc.gov)

Bioinformatic and comparative genomic analyses allowed us to identify genes encoding three candidate antibacterial effectors located within SPI-6 and two candidate effectors located within SPI-19. (frontiersin.org)

Identification of a gene, pilV , required for type 4 fimbrial biogenesis in Pseudomonas aeruginosa , whose product possesses a pre-pilin-like leader sequence. (microbiologyresearch.org)
An interactive web-based Pseudomonas aeruginosa genome database: discovery of new genes, pathways and structures. (microbiologyresearch.org)
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY. (microbiologyresearch.org)

The SoxS site is in the forward orientation and its location suggests that the ompW gene has a class I SoxS-dependent promoter. (uandes.cl)

FlgM inhibits transcription of its own gene, and so reduced FlgM export might partially reflect decreased cellular levels of the protein 9 . (nature.com)

The sequences of the constructs were first gene-optimized for vector expression and synthesized, representing in total 186 expression clones. (europa.eu)

However, conflicting results were obtained in assays for mitotic gene conversion and recombination. (inchem.org)

The twitching-motility defect in the PA1822 mutant was partially complemented by providing the PA1822 gene in trans , and the defect in the PA0171 mutant was fully complemented when PA0171 was provided. (microbiologyresearch.org)

CDC, public health and regulatory officials in several states, and the FDA investigated a multistate outbreak of Salmonella Typhimurium infections. (cdc.gov)

Salmonella enterica is an opportunistic pathogen that produces a [NiFe]-hydrogenase under aerobic conditions. (rcsb.org)

In this background, cnr gene disruption resulted in a reduction in nitroreductase activity by a similar absolute amount as in TA1538, but representing only about one-quarter of the original activity of TA1535. (unboundmedicine.com)

are all risk factors for Salmonella infection. (msdmanuals.com)

KEGG GENOME: Salmonella enterica subsp. (kegg.jp)

Persistent shedding of organisms in the stool for ≥ 1 year occurs in only 0.2 to 0.6% of patients with nontyphoidal Salmonella infections. (msdmanuals.com)

GAL was coded by the lacZ gene and controlled by the fused umuC and lacZ gene in the pSK plasmid. (cdc.gov)

Also, additional Salmonella genes apparently interfere with maintenance of a sustained immune response. (tau.ac.il)

Anatomy11

Organisms21

Diseases8

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes49

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Technology, Industry, Agriculture7

Information Science3

Health Care6

Serovar Typhimurium9

Escherichia3

Strain7

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Bacterial4

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Proteins2

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Genetic6

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TA981

TA1001

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TA15351

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Immune response1