AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceBinding SitesTranscriptional ActivationTrans-ActivatorsProtein BindingRNA, MessengerBasic Helix-Loop-Helix Transcription FactorsNuclear ProteinsCell LineTranscription Factor AP-1Amino Acid SequenceRepressor ProteinsForkhead Transcription FactorsHomeodomain ProteinsSignal TransductionGene Expression Regulation, DevelopmentalDNABasic-Leucine Zipper Transcription FactorsRats, Inbred F344Transcription Factor AP-2MutationTransfectionCell NucleusCell DifferentiationKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDCells, CulturedNFATC Transcription FactorsActivating Transcription Factor 3Transcription Initiation SiteSp3 Transcription FactorNF-kappa BReverse Transcriptase Polymerase Chain ReactionElectrophoretic Mobility Shift AssayZinc FingersPaired Box Transcription FactorsActivating Transcription Factor 2Transcription Factor TFIIBPlasmidsEnhancer Elements, GeneticRegulatory Sequences, Nucleic AcidE2F1 Transcription FactorRNA Polymerase IIGene Expression ProfilingGene ExpressionCloning, MolecularBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsRecombinant Fusion ProteinsGATA3 Transcription FactorGATA1 Transcription FactorGene Expression Regulation, FungalGATA2 Transcription FactorF FactorTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorSTAT1 Transcription FactorLuciferasesProtein Structure, TertiaryActivating Transcription FactorsSaccharomyces cerevisiaeOligonucleotide Array Sequence AnalysisChromatinTranscription Factor RelAE2F Transcription FactorsCell Line, TumorPhosphorylationHelix-Loop-Helix MotifsF2-IsoprostanesSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantGATA6 Transcription FactorActivating Transcription Factor 4Models, BiologicalTranscription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinSequence Homology, Amino AcidSequence AlignmentTranscription Factor TFIIIAProto-Oncogene ProteinsBlotting, WesternMice, KnockoutTATA BoxNFI Transcription Factors
E2F1ProteinsTumorPathwaysProgressionEncoding the mRNAEukaryoticSpecific genesRegulatorPromotersTumorigenesisDifferentiallyMRNAEncodesCellularOrthologsKinaseTargetsE2FsOntologyVitroTargetCellRegulationEndogenousHomologousActivatesRYBPDatasetEnrichmentPromoterCancersInteractionFamilyShown2000MolecularMethylationBiologicalActinHumanActivationRoleProcessesCancer
E2F14
  • Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. (icr.ac.uk)
  • Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). (icr.ac.uk)
  • E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
  • The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
Proteins9
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
  • E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. (journalsmededu.pl)
  • download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
  • opposed factor is and stimulates group of transport proteins to DNA DSBs( Beamish et al. (erik-mill.de)
  • These particular genes code for several proteins including heat shock proteins, chaperonins, neurotrophic growth factors, transcriptional growth promoters and proteinases. (emerging-researchers.org)
  • The oncogenic activity of Myc family proteins is initiated when their transcriptional regulation is disrupted by events such as gene amplification and gene translocation, which typically lead to elevated cellular Myc levels. (silverchair.com)
  • It is widely believed that in mammalian cells the cellular transcription factor (DRTF1/E2F integrates cell-cycle events with the transcription apparatus by interacting with important regulators of the cell cycle, such as the retinoblastoma gene product (pRb) and related proteins, cyclins, and cyclin-dependent kinases. (ox.ac.uk)
  • Both DP-1 and DP-2 synergistically interact with members of the E2F family of proteins, E2F-1, E2F-2, and E2F-3, to generate DNA binding complexes that specifically recognize the E2F site and functionally interact with E2F-1 in E2F site-dependent transcriptional activation of cellular genes. (ox.ac.uk)
  • This study therefore defines a new family of transcription factors, the DP proteins, members of which can interact combinatorially with E2F proteins to generate an array of DNA binding complexes that integrate cell-cycle progression with the transcription apparatus through the E2F binding site. (ox.ac.uk)
Tumor7
  • TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. (avivasysbio.com)
  • Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
  • A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
  • have uncovered a key tumor suppressor among those genes frequently lost on chromosome 20. (elifesciences.org)
  • In addition to revealing a new tumor suppressor gene and its contribution to myeloid malignancies, the study by Heinrichs et al. (elifesciences.org)
  • highlights the importance of gene dosage in mediating the effects of tumor suppressors. (elifesciences.org)
  • Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
Pathways6
  • The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. (journalsmededu.pl)
  • Numerous studies have demonstrated a role for E2F2 in various signaling pathways. (journalsmededu.pl)
  • Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments. (journalsmededu.pl)
  • Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. (journalsmededu.pl)
  • Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
  • Gene mutations and aberrant signaling pathways play key roles in GBC tumorigenesis. (biomedcentral.com)
Progression1
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
Encoding the mRNA1
  • An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. (idrblab.net)
Eukaryotic1
  • Splicing of introns is required for the expression of most eukaryotic genes. (biomedcentral.com)
Specific genes2
  • Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
  • We hypothesized that specific genes involved in stress, neuronal growth, and repair (Hsp70Aa, Cct γ, Appl) would be upregulated as an adaptive response to TBI. (emerging-researchers.org)
Regulator1
  • To further explore the molecular function of Rasd1, we performed a yeast two-hybrid screen and identified Ear2, a negative regulator of renin transcription, as an interaction partner of Rasd1. (biomedcentral.com)
Promoters1
  • The E2F transcription factor family regulates the expression of various cellular promoters, particularly those involved in the cell cycle. (avivasysbio.com)
Tumorigenesis2
  • E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. (journalsmededu.pl)
  • Many ncRNAs have critical roles in tumorigenesis, and some ncRNAs function as competing endogenous RNAs (ceRNAs) to perturb gene expression. (biomedcentral.com)
Differentially2
  • The RA-related targets were retrieved by analyzing the differentially expressed genes between RA patients and healthy individuals. (hindawi.com)
  • The function of differentially expressed E2Fs and their neighboring genes were mainly linked to P53 signaling pathway, cell cycle, and oocyte meiosis. (fortunepublish.com)
MRNA1
Encodes2
Cellular1
  • We established a conditional LMP1 allele in the context of the intact EBV genome to define the immediate-early cellular target genes regulated by LMP1 in order to assess its contributions to infected human B cells. (gsea-msigdb.org)
Orthologs1
Kinase2
  • Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
  • Most importantly, the natural NNMT inhibitor yuanhuadine can reverse epidermal growth factor receptor tyrosine kinase inhibitor resistance in lung cancer cells. (bvsalud.org)
Targets3
  • E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. (journalsmededu.pl)
  • download history Thanks and genes Activation include the acid of and precursor between targets with exciting regulated students and SRC-phosphorylated types. (erik-mill.de)
  • Given that the minor spliceosome is ubiquitously expressed, we hypothesized that these restricted phenotypes might be caused by the tissue-specific regulation of the minor spliceosome targets, i.e. minor intron-containing genes (MIGs). (biomedcentral.com)
E2Fs1
  • Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
Ontology1
  • Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed in R software (Bioconductor, clusterProfiler). (hindawi.com)
Vitro1
  • Down-regulation of the PAPSS1 gene increased the cisplatin sensitivity of EOC in vitro and in vivo. (bvsalud.org)
Target5
  • The core target gene of HGWD in RA treatment was JUN. (hindawi.com)
  • The ornithine decarboxylase gene is a transcriptional target of c-Myc. (idrblab.net)
  • Here, we show that c-Myc induction during cell cycle entry leads to a transient decrease in Mnt-Max complexes and a transient switch in the ratio of Mnt-Max to c-Myc-Max on shared target genes. (silverchair.com)
  • Once released from IκB, NF-κB migrates to the nucleus and activates numerous target genes [ 9 ]. (oncotarget.com)
  • the regulatory regions of target genes. (scirp.org)
Cell7
  • E2F Transcription Factors in Cancer, More than the Cell Cycle. (journalsmededu.pl)
  • Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. (idrblab.net)
  • The functional analysis of this conditional system indicated that LMP1 specifically induces mitogenic B-cell activation through c-myc and Jun/AP1 family members and confirms its direct role in upregulating expression of multiple genes with opposing activities involved in cell survival. (gsea-msigdb.org)
  • The lncRNA TMPO-AS1 promotes cell proliferation, migration, invasion and epithelial-to-mesenchymal transition by regulating the miR-1179/E2F2 axis [ 13 ]. (biomedcentral.com)
  • Description: A sandwich ELISA kit for detection of Myogenic Factor 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
  • Description: Quantitative sandwich ELISA for measuring Human Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
  • Description: Quantitative sandwich ELISA for measuring Mouse Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Regulation1
  • Interestingly, real-time PCR and translation inhibition studies revealed that survivin was over-expressed partially through the up-regulation of protein translation instead of gene transcription in A549 cancer cells. (biomedcentral.com)
Endogenous2
  • The main risk factor is exposure to endogenous and exogenous estrogens associated with obesity, diabetes, and the use of tamoxifen 5 . (researchsquare.com)
  • Moreover, real-time RT-PCR showed upregulation of endogenous renin transcription in As4.1 cells over-expressing Rasd1. (biomedcentral.com)
Homologous1
  • The detection of genetic mutations affecting treatment, especially breast cancer susceptibility gene (BRCA) mutations and mutations of other homologous recombination repair defect (HRD) genes, can guide the targeted drug treatment of patients, effectively improve the treatment effect and achieve a better patient prognosis. (bvsalud.org)
Activates1
  • Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. (icr.ac.uk)
RYBP1
  • E2F2 has been shown to interact with: BRD2, RYBP, and RB1. (wikipedia.org)
Dataset1
Enrichment2
  • We then performed the gene enrichment and protein-protein interaction (PPI) network analysis to obtain the interacting map. (researchsquare.com)
  • We also identified differential enrichment of transcription factor binding motifs in CGIs acquiring methylation early or late in oocyte growth. (biomedcentral.com)
Promoter2
  • C-Myc is a potent transactivator of ODC promoter-reporter gene constructs in fibroblasts that requires the CACGTG repeat. (idrblab.net)
  • Ear2 is an orphan nuclear hormone receptor that belongs to the chicken ovalbumin upstream promoter-transcription factors (COUP-TF) gene family [ 14 ]. (biomedcentral.com)
Cancers1
  • These genes and biological processes may help understand the mechanism for inhibiting LINC00958 in cancers. (researchsquare.com)
Interaction2
  • Finally, our study showed that Rasd1 missense mutations not only attenuate their physical interaction with Ear2 but also abolish their ability to counteract repression of renin transcription mediated by Ear2. (biomedcentral.com)
  • Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb ( http://tmliang.cn/gbc/ ), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. (biomedcentral.com)
Family2
Shown2
  • However, several types of genes have been shown to be either over or under expressed when a TBI has taken place. (emerging-researchers.org)
  • The top up- and down-regulated genes were shown by the heatmap and volcano plot (Figure 1). (researchsquare.com)
20001
  • As a result, there is highly programmed methylation of a defined set of ~2000 CGIs in oocytes, mostly on account of their location within active transcription units. (biomedcentral.com)
Molecular3
  • BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
  • We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Methylation3
  • In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. (biomedcentral.com)
  • Given the predominant role of transcription, we sought to investigate whether transcription timing is rate limiting for de novo methylation and determines the asynchrony of methylation events. (biomedcentral.com)
  • Although more highly transcribed genes acquire methylation earlier, the major transitions in the oocyte transcriptome occur well before the de novo methylation phase, indicating that transcription is generally not rate limiting in conferring permissiveness to DNA methylation. (biomedcentral.com)
Biological1
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myogenic Factor 5 (MYF5) in Tissue homogenates and other biological fluids. (1elisakits.com)
Actin2
  • Gene expression was normalized against the expression of actin 42A and TBI-induced flies were compared to untreated control flies. (emerging-researchers.org)
  • WASP actin nucleation promoting factor [S. (gsea-msigdb.org)
Human3
  • Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). (idrblab.net)
  • Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)
  • The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
Activation1
  • Cluster 4: genes down-regulated in B2264-19/3 cells (primary B lymphocytes) within 60-180 min after activation of LMP1 (an oncogene encoded by Epstein-Barr virus, EBV). (gsea-msigdb.org)
Role1
  • Hence, this finding reveals a more general role for MYBL2 as it indicates that more patients are likely to be affected by altered expression of this gene. (elifesciences.org)
Processes1
  • Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. (icr.ac.uk)
Cancer1
  • Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. (idrblab.net)