ras GTPase-Activating Proteinsras Proteinsp120 GTPase Activating ProteinGTPase-Activating ProteinsProto-Oncogene Proteins p21(ras)GTP PhosphohydrolasesMutationPoint MutationNeurofibromin 1Mutation, MissenseGenes, rasMolecular Sequence DataProteinsAmino Acid SequenceFrameshift MutationDNA Mutational AnalysisSignal TransductionGerm-Line MutationPedigreePolymorphism, Single-Stranded ConformationalHeterozygoteBase SequenceExonsOncogene Protein p21(ras)Polymerase Chain ReactionPhenotypeAmino Acid SubstitutionGenes, p53Mutation RateAllelesGuanosine TriphosphateGenotypeGenetic TestingHomozygoteCodon, NonsenseSequence Analysis, DNArho GTP-Binding ProteinsProtein Structure, TertiaryMutagenesis, Site-DirectedCell LineGenes, DominantMonomeric GTP-Binding ProteinsMutagenesisDNA PrimersSequence DeletionProtein BindingMembrane Proteinsrab GTP-Binding ProteinsGTP-Binding ProteinsGenes, RecessiveCodonSequence Homology, Amino AcidGene DeletionGuanine Nucleotide Exchange FactorsDNA-Binding ProteinsDNA, NeoplasmModels, MolecularGenetic Predisposition to DiseaseBinding SitesTransfectionEscherichia coliGuanosine DiphosphateCarrier ProteinsNuclear ProteinsProto-Oncogene Proteinsrac1 GTP-Binding ProteinSaccharomyces cerevisiaeSyndromeTranscription FactorsCloning, Molecularrac GTP-Binding ProteinsChromosome MappingSequence AlignmentSuppression, GeneticDNATumor Suppressor Protein p53Polymorphism, GeneticFounder EffectProto-Oncogene Proteins B-rafRecombinant Fusion ProteinsEnzyme ActivationConsanguinityFamily HealthHeterozygote DetectionCOS CellsMutant ProteinsGenetic Complementation TestBacterial ProteinsProtein-Serine-Threonine KinasesrhoA GTP-Binding ProteinPlasmidsRecombinant ProteinsGene FrequencyRNA, MessengerSaccharomyces cerevisiae ProteinsCell Transformation, NeoplasticCells, CulturedGenetic LinkageGenetic Diseases, X-LinkedKinetics