Genes mitogen activated protein kinase 8. Medical search. Frequent questions

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. (nih.gov)
Oncogenic Ras induces the constitutive activation of Ras/Raf/MEK/ERK signaling pathway, which, in turn, activates other effector pathways, in particular, PI3K-mTOR signaling [ 17 ]. (aging-us.com)
This resulted in the recognition of RAF1 a serine/threonine protein kinase that plays a key role in the Ras/MAPK signaling pathway. (biomedigs.org)

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). (wikipedia.org)
citation needed] MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. (wikipedia.org)
Because plants cannot "flee" from stress, terrestrial plants have the highest number of MAPK genes per organism ever found[citation needed]. (wikipedia.org)
clarification needed] The mammalian MAPK family of kinases includes three subfamilies: Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated protein kinases (p38s) Generally, ERKs are activated by growth factors and mitogens, whereas cellular stresses and inflammatory cytokines activate JNKs and p38s. (wikipedia.org)
Because MAP2 kinases display very little activity on substrates other than their cognate MAPK, classical MAPK pathways form multi-tiered, but relatively linear pathways. (wikipedia.org)
citation needed] In comparison to the three-tiered classical MAPK pathways, some atypical MAP kinases appear to have a more ancient, two-tiered system. (wikipedia.org)
p38 mitogen-activated protein kinase (MAPK) signaling is known to be increased in chronic obstructive pulmonary disease (COPD) macrophages. (ox.ac.uk)
We have studied the effects of the p38 MAPK inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl]amino}ethyl)guanidine (SB706504) and dexamethasone on COPD macrophage inflammatory gene expression and protein secretion. (ox.ac.uk)
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. (wikipathways.org)
Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. (wikipathways.org)
LSA has speedy and profound effects on critical aspects of cell biology including inhibition of cell adhesion activation of PKC and activation of the mitogen-activated protein kinases (MAPK) ERK1/2 and p38 [8 12 13 Figure 1 shRNA screen for genetic determinants of lasonolide A (LSA) sensitivity. (biomedigs.org)
The inhibitory effects of EGCG were mainly mediated by inhibiting the activation of NF-κB and c-Jun N-terminal Kinase (JNK)-MAPK in human chondrocytes. (biomedcentral.com)
In recent years, the MAPK family has been found to be an important signal-regulating enzyme between cell surface receptors and determinants of gene expression ( 8 ). (spandidos-publications.com)
We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because inhibition of MAPK/ERK kinase activity by U0126 completely abolished both serum-induced activation of ERK and proliferation of mouse (MBA-15.4) and human (MG-63) osteoblast cell lines. (ox.ac.uk)
Coupled with the rapidity of Dex action, this indicates immediate-early gene phosphatase involvement, and we therefore used quantitative, real-time PCR to examine expression profiles of the dual-specificity MAPK phosphatases, MKP-1 and MKP-3. (ox.ac.uk)
Stimulation of CD30 leads signal mediation through tumor necrosis factor receptor-associated proteins (TRAF), thereby stimulating the nuclear factor-kappa B (NFkB) pathway and the mitogen-activated protein kinase (MAPK) pathways. (aad.org)
Increase in IL-8 promoter activity was due to enhanced binding of activator protein 1 and NF-?B. IL-8 induction was associated with protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) activation and inhibited by PKC and MAPK inhibitors. (cdc.gov)
The term RASopathies includes disorders with mutations in the genes that code for the proteins of the RAS/MAPK pathway, such as neurofibromatosis type 1, Noonan syndrome, Legius syndrome, LEOPARD syndrome, Costello syndrome, and cardiofaciocutaneous syndrome. (medscape.com)

MAP2 kinases in turn, are also activated by phosphorylation, by a number of different upstream serine-threonine kinases (MAP3 kinases). (wikipedia.org)
This results in a multistep mechanism that activates RAF and in the case of RAF1 it involves the phosphorylation of RAF1 on serine 338 and tyrosine 341 [16]. (biomedigs.org)

citation needed] This tandem activation loop phosphorylation (that was proposed to be either distributive or processive, dependent on the cellular environment) is performed by members of the Ste7 protein kinase family, also known as MAP2 kinases. (wikipedia.org)
Mapk8 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. (creativebiomart.net)
It has been shown that S338 phosphorylation on RAF1 is carried out via autophosphorylation and via phosphorylation by PAKs (p21-activated kinases) [17 18 19 20 RAF kinases in turn activate the MEK/ERK cascade which was recently found to be rapidly activated by LSA [12]. (biomedigs.org)
The mRNA and protein levels of α smooth muscle actin (α-SMA) and Snail and the phosphorylation levels of Smad2/3, p38 mitogen-activated protein kinase (p38MAPK), and extracellular signal-regulated kinase ½ (ERK1/2) were determined by quantitative reverse transcription polymerase chain reaction (RT-PCR), western blot, and immunofluorescence staining. (molvis.org)
Disruption of Wis1 or Spc1 kinase or the downstream bZip transcription factors Atf1 and Pap1 resulted in a marked increase in eIF2alpha phosphorylation which was dependent on the eIF2alpha kinases Hri2 and Gcn2. (ox.ac.uk)

This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. (nih.gov)

2010) A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. (guidetopharmacology.org)
Interestingly, the expression of two IκB kinases (IKK)-α/β, the degradation of cytosolic IκB-β inhibitor and the NF-κB deoxyribonucleic acid binding activity were markedly reduced after FP treatment in both CF and non-CF bronchial epithelial cells. (ersjournals.com)
Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504). (ox.ac.uk)
This inhibition is reversed by cotreatment with the protein synthesis inhibitor, cycloheximide, and by the GC receptor antagonist, RU486, suggesting a classical transcriptional mechanism. (ox.ac.uk)
Phosphatase activity was up-regulated by Dex treatment, and inhibition of ERK activity by Dex was also reversed by the protein tyrosine phosphatase inhibitor, vanadate. (ox.ac.uk)
There is expected hCG-driven upsurge in mRNA great quantity of several ovulation-related genes including in vehicle-treated granulosa cells, however, not (P 0.05) in inhibitor-treated group. (phytid.org)
There is also decreased mRNA and proteins great quantity from the transcription element, early development response 1 (Egr1) in inhibitor-treated granulosa cells. (phytid.org)

Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. (wikipathways.org)

These pathways can effectively convey stimuli from the cell membrane (where many MAP3Ks are activated) to the nucleus (where only MAPKs may enter) or to many other subcellular targets. (wikipedia.org)
Therapeutic strategies include the blocking of transcription factors such as NF-κB that lead to inflammatory gene activation and the inhibition of signaling pathways that are stimulated in lung diseases. (ersjournals.com)
Pharmacologic treatments approved by the US Food and Drug Administration (FDA) include three drugs that increase deficient survival motor neuron protein levels through SMN1 - or SMN2 - directed pathways: nusinersen, onasemnogene abeparvovec, and risdiplam. (bvsalud.org)
2 Results and Discussion 2.1 A Kinome shRNA Screen Identified Candidate LSA Molecular Targets and Pathways To probe the genetic pathways that might mediate the cellular response to LSA we screened a pool of 2951 retroviral shRNA targeting most kinases and phosphatases (1140 RefSeq transcripts) at two different drug concentrations of 10 and 100 nM in the colorectal cancer cell line HCT-116. (biomedigs.org)
The anti-inflammatory effects of SHE treatment involved blocking of the mitogen-activated protein kinase and signal transducer and activator of transcription 1 signaling pathways. (researchgate.net)
Intro Ovulation can be a multi-gene, multi-step procedure involving complicated signaling pathways, which facilitates synchronization of oocyte maturation and cumulus development with this of follicular rupture. (phytid.org)
CD30 is a transmembrane glycoprotein receptor of the tumor necrosis factor receptor super family 8 (TNFRSF8), mediating its effects through a number of signaling pathways that produce a survival advantage to the cells on which the protein is overexpressed. (aad.org)
Our findings identify key roles for transcriptional mechanisms and protein kinase signaling pathways for IL-8 induction and provide insights into the mechanisms regulating lung inflammatory responses to organic dust exposure. (cdc.gov)

Dual Specificity Phosphatase 26 (DUSP26) inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. (prospecbio.com)
FP induces apoptosis of eosinophils 18 and also reduces the production of several cytokines such as IL-1β, IL-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) by alveolar macrophages 19 and lymphocytes 20 , 21 . (ersjournals.com)
The results demonstrated that Vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase‑3 activity, apoptosis regulator BAX protein expression and malondialdehyde levels in sevoflurane‑induced newborn rats. (spandidos-publications.com)

The first mitogen-activated protein kinase to be discovered was ERK1 (MAPK3) in mammals. (wikipedia.org)
Thus the role of mammalian ERK1/2 kinases as regulators of cell proliferation is not a generic, but a highly specialized function. (wikipedia.org)
In the case of classical MAP kinases, the activation loop contains a characteristic TxY (threonine-x-tyrosine) motif (TEY in mammalian ERK1 and ERK2, TDY in ERK5, TPY in JNKs, TGY in p38 kinases) that needs to be phosphorylated on both the threonine and the tyrosine residues in order to lock the kinase domain in a catalytically competent conformation. (wikipedia.org)
For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. (wikipathways.org)
MK-8776 ERK1/2) pathway and phosphatidylinositide 3-kinases (PI3K) pathway [1C4]. (phytid.org)

Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. (ox.ac.uk)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)

MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. (wikipedia.org)
The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). (wikipedia.org)
In contrast to the classical MAP kinases, these atypical MAPKs require only a single residue in their activation loops to be phosphorylated. (wikipedia.org)
MAPKs are short for the mitogen-activated protein kinase family. (spandidos-publications.com)

VEGF is purified from bovine pituitary follicular cells in 1959 and is a vascular endothelial cell-specific mitogen that promotes the growth of vascular endothelial cells. (spandidos-publications.com)
CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. (exbio.cz)
Zhu Y, Sun Y, Xie L, Jin K, Sheibani N, Greenberg DA: Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells. (exbio.cz)

Furthermore, nintedanib prevented HTF myofibroblast differentiation via downregulation of mRNA and protein expression of α-SMA and Snail. (molvis.org)
In rats, hepatic ketogenic capacity increases rapidly during postnatal development ( 4 ) or fasting ( 5 ) when the mRNA, protein, and activity of HMGCS2 increase in liver ( 6 - 8 ). (aacrjournals.org)
Administration of dibutyryl-cyclic AMP to adult rats increases mRNA, protein levels, and enzymatic activity of HMGCS2 in the liver ( 6, 9 ). (aacrjournals.org)
Our findings indicate that poultry dust extract potently induces IL-8 levels by increasing IL-8 gene transcription without altering IL-8 mRNA stability. (cdc.gov)

A screen of 72 inhibitors against 456 human kinases. (guidetopharmacology.org)
2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. (guidetopharmacology.org)

Hydrogen peroxide does not function downstream of salicylic acid in the induction of PR protein expression. (springer.com)
Hypoxia inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional regulator that regulates more than 70 downstream target genes, including vascular endothelial growth factor, erythropoietin, glucose transporter and so on ( 5 ). (spandidos-publications.com)

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. (dogcancerblog.com)
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. (dogcancerblog.com)
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (dogcancerblog.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

The effects of corticosteroids are predominantly mediated by the inhibition of NF-κB deoxyribonucleic acid (DNA)-binding activity, which controls genes encoding inflammatory cytokines, chemokines and adhesion molecules in respiratory epithelial cells 10 - 13 . (ersjournals.com)
Multiple pro-inflammatory cytokines such as IL-1β, TNF-α, IL-6 and chemokines (IL-8 and others) are produced by activated chondrocytes in OA [ 3 - 6 ]. (biomedcentral.com)

IL-8 increase was not inhibited by polymyxin B or l-nitroarginine methyl ester, indicating lack of involvement of lipopolysaccharide and nitric oxide in the induction. (cdc.gov)

The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
We studied the effects of poultry dust extract on molecular regulation of interleukin-8 (IL-8), a proinflammatory cytokine, in A549 and Beas2B lung epithelial and THP-1 monocytic cells. (cdc.gov)

Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. (nih.gov)
We conclude that Mapk3/1 regulates ovulation, at least partly, through Egr1 and its own focus on gene, in granulosa cells of ovulating follicles in mice. (phytid.org)
Granulosa cells from KO mice demonstrated altered appearance of a huge selection of LH governed genes [5], but which transcription elements become mediators of their indicators never have been completely discovered [6]. (phytid.org)
It had been reported that 19% from the LH-driven genes had been controlled in granulosa cells of both and conditional KO mice at 4h hCG [6]. (phytid.org)

To determine whether FP reduces cytokine production in bronchial epithelial cells via NF-κB, the authors investigated the nonstimulated and the Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulated production of NF-κB-dependent interleukin (IL)-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) along with the activation of NF-κB in non-CF and CF human bronchial gland epithelial cells. (ersjournals.com)
It was demonstrated that a relevant concentration of FP (10 −8 M) inhibited constitutive and P. aeruginosa LPS-induced IL-6 and IL-8 production of non-CF and CF bronchial epithelial cells. (ersjournals.com)
It was shown by the authors that fluticasone propionate exerts an anti-inflammatory effect by blocking a signal transduction leading to a reduced level of IκB-α/β kinases in bronchial epithelial cells. (ersjournals.com)
In particular the strong effect on the IκB-β kinase, which is known to be elevated in bronchial epithelial cells in cystic fibrosis patients, was observed. (ersjournals.com)
Cystic fibrosis (CF) is a lethal inherited disorder caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) in airway epithelial cells 1 . (ersjournals.com)
The present authors and previous studies, have previously demonstrated that epithelial expression of interleukin (IL)-8 is excessively elevated in the bronchial epithelial cells of human CF adults 6 . (ersjournals.com)
In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
Transcriptional mechanisms and protein kinase signaling mediate organic dust induction of IL-8 expression in lung epithelial and THP-1 cells. (cdc.gov)
Lung epithelial and THP-1 cells share common mechanisms for induction of IL-8 levels. (cdc.gov)

A pooled retroviral shRNA library directed against kinases and … We recently showed that a major cellular effect of LSA is the induction of premature chromosome condensation (PCC) [13]. (biomedigs.org)
The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)

We hypothesized that Mapk3/1 pathway regulates ovulation through transcriptional rules of ovulatory genes. (phytid.org)

MDMs were used for gene array and protein studies, whereas tumor necrosis factor (TNF) alpha protein production was measured from AMs. (ox.ac.uk)
in the Country wide Cancer tumor Institute cell display screen -panel (the NCI60) [8]. (biomedigs.org)
Effect of EGCG on IL-1β-induced expression of 18 selected genes was verified by Real time-PCR and effect on IL-6, IL-8 and tumor necrosis factor-alpha (TNF-α) production was determined using specific ELISAs. (biomedcentral.com)
The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway PLoS One. (usc.edu)
The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. (dogcancerblog.com)
Incidence has remained steady over the last 8 years (it had previously been increasing at a faster rate than any other malignant tumor). (msdmanuals.com)

We conclude that SB706504 targets a subset of inflammatory macrophage genes and when used with dexamethasone causes effective suppression of these genes. (ox.ac.uk)
Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene expression. (biomedcentral.com)
IL-8 is a chemoattractant factor involved in synovial inflammation in the joint [ 4 ] and IL-6 reportedly plays a contributory role to the OA pathogenesis by increasing the number of inflammatory cells in synovial tissue, stimulating proliferation of chondrocytes, and inducing amplification of IL-1 effects [ 6 ]. (biomedcentral.com)
IL-1β is an inflammatory cytokine and its inhibition has been shown to ameliorate osteoarthritis-like pathology in animal models [ 7 , 8 ]. (biomedcentral.com)

LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare autosomal dominant disorder most often caused by missense mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP2. (medscape.com)
[ 4 ] Molecular studies have proven that LEOPARD syndrome and Noonan syndrome are allelic disorders caused by different missense mutations in PTPN11, a gene encoding the protein tyrosine phosphatase SHP-2 located at band 12q24.1. (medscape.com)
[ 9 ] Because the vast majority of mutations reside in and around the broad intramolecular interaction surface between the N-SH2 and PTP domains of the PTPN11 protein, they have been suggested to affect the intramolecular N-SH2/PTP binding in the absence of a phosphopeptide, leading to excessive phosphatase activities. (medscape.com)

DUSP26 also induces activation of MAP kinase p38 and c-Jun N-terminal kinase. (prospecbio.com)
The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in Ras pathway. (aging-us.com)
Rapid and transient activation of myelin basic protein kinase in tobacco leaves treated with hairpin from Erwinia amylovora . (springer.com)
Son and K. Kim, Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation. (atto.co.jp)

Son, K. Kim, Effect of Mefloquine, a Gap Junction Blocker, on Circadian Period2 Gene Oscillation in the Mouse Suprachiasmatic Nucleus Ex Vivo . (atto.co.jp)
And it is the hub between the cytoplasm and the nucleus ( 8 ). (spandidos-publications.com)

DUSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a decrease in its DNA-binding activity. (prospecbio.com)
This means that that the others 81% Mapk3/1-reliant genes are governed by transcription elements apart from Cebpa/b, that are yet to become discovered. (phytid.org)
To check this hypothesis we used an pharmacologic approach to inhibition of Mapk3/1 activity devoid of disrupting the gene manifestation. (phytid.org)

This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. (nih.gov)

In this way protein dynamics can induce a conformational change in the structure of the protein via long-range allostery. (wikipedia.org)
MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)

Twenty-three genes were insensitive to the effects of both drugs, including interleukin (IL)-1beta, IL-18, and chemokine (CC motif) ligand (CCL) 5. (ox.ac.uk)
Western immunoblotting was used to analyze the effect of EGCG on the interleukin-1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF-6) proteins in IL-1β-stimulated chondrocytes. (biomedcentral.com)

Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)

The stress-activated protein kinase (SAPK) pathway plays a central role in coordinating gene expression in response to diverse environmental stress stimuli. (ox.ac.uk)

Nature communications 2017 May 8 15539. (cdc.gov)

In reactive conditions, CD30 receptor and ligand (CD30L, CD153) expression is normally seen on activated T-immunoblasts and B-immunoblasts. (aad.org)

To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)

Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
Primary cultured HTFs were incubated with transforming growth factor β1 (TGF-β1) alone or combined with nintedanib, and cell proliferation and migration were measured by cell counting kit-8 (CCK8) and the scratch wound assay, respectively. (molvis.org)

This is conducted by specialized enzymes of the STE protein kinase group. (wikipedia.org)

2020;8(1):62-79. (nationaljewish.org)

Fibroblast growth factor homologous factors are intracellular signaling proteins. (nih.gov)

MKP-1 protein was also markedly up-regulated following 1-8 h of Dex treatment, and this correlated precisely with dephosphorylation of ERK. (ox.ac.uk)

Analysis of the WNK1-dependent transcriptome by RNA-Seq demonstrated that WNK1 regulates the expression of 1858 genes during decidualization. (bioone.org)
HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)

Culture supernatants were incubated with cytokine antibody arrays and immunoreactive proteins (80 proteins) were visualized by enhanced chemiluminiscence. (biomedcentral.com)

There are three RAF kinases in human A-RAF B-RAF and RAF1 (C-RAF) M2 ion channel blocker that are believed to play nonredundant roles. (biomedigs.org)
In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. (uml.edu)

Anatomy20

Organisms8

Chemicals and Drugs173

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes39

Information Science3

Signaling pathway3

MAPK18

Serine2

Phosphorylation5

MAPK81

Inhibitor7

JNK11

Pathways8

Apoptosis3

ERK15

Extracellular signal2

Lysine deficient protein kinase1

MAPKs4

Endothelial cells3

MRNA4

Inhibitors2

Downstream2

Nuclear4

Cytokines2

Nitric Oxide1

Regulation2

Mice4

Epithelial9

Induction2

Transcriptional1

Tumor6

Inflammatory4

Phosphatase3

Activation4

Nucleus2

MAPK33

Insulin1

Scaffold1

Induce2

Interleukin2

Vascular endoth1

Stimuli1

20171

Ligand1

Human genes2

Proliferation2

Enzymes1

20201

Intracellular1

Dephosphorylation1

Regulates2

Cytokine1

Roles2