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  • induces
  • Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. (genecards.org)
  • regulates genes
  • Recent findings indicate that Myod functions in an instructive chromatin context and directly regulates genes that are expressed throughout the myogenic program, achieving promoter-specific regulation of its own binding and activity through a feed-forward mechanism. (biologists.org)
  • MEF2A
  • Smith JA, Kohn TA, Chetty AK, Ojuka EO (2008) CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene. (springer.com)
  • The anti-diabetic effects of hybrid compounds ( 2a-h ) of thiosemicarbazone and triazole containing methoxy groups at C (4) positions were tested against genes involved in glucose metabolism ( Glut-4 , Mef2a and Nrf-1 ) using quantitative real time PCR (qPCR). (springer.com)
  • regulator
  • We find that one MEF2 family member in particular, MEF2D, is an essential regulator of the development and function of retinal photoreceptors, the primary sensory neurons responsible for vision. (harvard.edu)
  • The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. (embl-heidelberg.de)
  • oxidative
  • Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. (sigmaaldrich.com)
  • Indeed, HDAC4 represses the MEF2-dependent, PGC-1α-mediated oxidative metabolic gene program. (sigmaaldrich.com)
  • synaptic
  • A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity. (wikiversity.org)
  • homeobox
  • J:57340 Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S, Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [see comments]. (jax.org)
  • Regulation
  • From the results, hybrid compounds 2b and 2h showed more pronounced effects in up-regulating diabetes associated genes which are important in the up-regulation of glucose uptake. (springer.com)
  • characteristic
  • The class II HDACs (HDAC4, -5, -7, and -9) contain a characteristic MEF2-interacting domain at their N-termini [ 3 , 4 ] and an HDAC catalytic domain at their C-termini. (biomedcentral.com)
  • 2000
  • Wu H, Naya FJ, McKinsey TA, Mercer B, Shelton JM, Chin ER et al (2000) MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. (springer.com)
  • myoD
  • Based on our current understanding of Myod, it is reasonable to suggest that the regulated activity of a single factor that broadly interacts with many cellular components might be a common mechanism for orchestrating a complex response to an initiating event. (biologists.org)
  • pathogenesis
  • Taken together, the information provided here should enable a better understanding of FOX genes' function in CRC pathogenesis for basic science researchers and clinicians. (biomedcentral.com)
  • genetic
  • The importance of genetic risk factors is exemplified by the high concordance of DM in identical twins, the strong influence of family history and ethnicity on risk, and the identification of DNA sequence alterations in both rare and common forms of DM ( 9 ). (pnas.org)
  • Both genetic and environmental factors have been associated with the onset or delay of puberty, and recent evidence has suggested a role for epigenetic changes in the initiation. (paperity.org)