• Gene composition analyses of altered modules revealed that there were 56 common genes (such as MAPK1 , CCNA2 , and GSTM3 ) existing in the four stages. (hindawi.com)
  • ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. (assaygenie.com)
  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. (wuxibiortus.com)
  • Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene. (wikipedia.org)
  • This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. (cancerindex.org)
  • In addition, a PPI network can be modeled as an undirected graph, where vertices represent proteins and edges represent interactions between proteins, to prioritize disease associated genes or pathways and to understand the modus operandi of disease mechanisms [ 9 , 10 ]. (hindawi.com)
  • Bioinformatic analyses of differential proteins were performed included Gene Ontology (GO) enrichment, pathway enrichment and protein-protein interaction network analysis. (jneuropsychiatry.org)
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
  • A protein-protein interaction (PPI) network for DEIOGs was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins database, and hub genes were identified through the PPI network. (qxmd.com)
  • The objective of this work is to identify dysregulated genes and pathways of ccRCC temporally according to systematic tracking of the dysregulated modules of reweighted Protein-Protein Interaction (PPI) networks. (hindawi.com)
  • Finally, gene compositions of altered modules were analyzed, and pathways enrichment analyses of genes in altered modules were carried out based on Expression Analysis Systematic Explored (EASE) test. (hindawi.com)
  • We successfully identified dysregulated genes and pathways of ccRCC in different stages, and these might be potential biological markers and processes for treatment and etiology mechanism in ccRCC. (hindawi.com)
  • Delineating the pathogenesis of ccRCC by investigating the gene and epigenetic changes and their effects on key molecules and their respective biologic pathways is of crucial importance for the improvement of current diagnostics, prognostics, and drug development [ 4 ]. (hindawi.com)
  • Intro Ovulation can be a multi-gene, multi-step procedure involving complicated signaling pathways, which facilitates synchronization of oocyte maturation and cumulus development with this of follicular rupture. (phytid.org)
  • Moreover, we not only replicated previous studies regarding alterations of subnetworks involved in TCR and BCR signaling pathways ( PI3K / AKT , MAPK , VAV gene family, AP-1 transcription factor) but also distinguished several significant edges between genes (PPP3 to NFATC gene families). (biomedcentral.com)
  • The genome-wide association studies (GWAS) coupled with gene expression profiling data shed light on the critical role of genes involved in B cell receptor (BCR) and T cell receptor (TCR) signaling pathways in SLE pathogenesis [ 7 ]. (biomedcentral.com)
  • Materials/methods Quantitative real-time PCR for 36 insulin signaling pathway genes was performed in subcutaneous adipose tissue from 22 white PCOS and 13 healthy controls. (elsevierpure.com)
  • Results Genes in the insulin signaling pathway were not differentially expressed in subcutaneous adipose tissue between PCOS and controls (P 0.05 for all). (elsevierpure.com)
  • Correlation between clinical phenotypes and expression of several genes in the mitogenic limb of the insulin signaling pathway suggests mitogenic signaling by insulin may regulate steroidogenesis and glucose homeostasis. (elsevierpure.com)
  • DEIOGs were then analysed based on Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment. (qxmd.com)
  • Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. (nih.gov)
  • Granulosa cells from KO mice demonstrated altered appearance of a huge selection of LH governed genes [5], but which transcription elements become mediators of their indicators never have been completely discovered [6]. (phytid.org)
  • This means that that the others 81% Mapk3/1-reliant genes are governed by transcription elements apart from Cebpa/b, that are yet to become discovered. (phytid.org)
  • The purpose of our research was to recognize novel transcription elements that play a significant part downstream of Mapk3/1 signaling along the way of ovulation. (phytid.org)
  • Moreover, transcription factors and microRNAs (miRNAs) targeting hub genes were identified to explore the potential regulatory mechanisms of hub genes. (qxmd.com)
  • A total of 37 transcription factors and 481 miRNAs that played important roles in hub genes regulation were identified. (qxmd.com)
  • These included interferon-regulatory transcription factors (IRF1/IRF2/IRF6/IRF7/IRF9), chemokine/chemokine receptors (CCR5/CCR9/CCL5), cytokine/cytokine receptors (IFNG/IL10RA/TNFRSF1A), protein kinases (MAP2K4/MAPK3), growth factor receptor (TGFBR1). (gsea-msigdb.org)
  • Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. (wuxibiortus.com)
  • The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAP kinase) family. (wikipedia.org)
  • 14 ] combined PPI and gene expression data to construct tissue-specific PPI networks for 60 tissues and used them to prioritize disease genes. (hindawi.com)
  • For example, studies suggest that ccRCC is closely associated with tumor suppressor von-Hippel Lindau ( VHL ) gene mutations that lead to stabilization of hypoxia inducible factors (HIF-1 α and HIF-2 α , also known as HIF1A and EPAS1) in both sporadic and familial forms [ 5 , 6 ]. (hindawi.com)
  • The focus of this article is Tumor Suppressor Genes. (assaygenie.com)
  • Activates various genes related to cellular signaling. (theironden.com)
  • It also activates many genes related to tissue repair and wound healing. (theironden.com)
  • First, the differentially expressed immune and oxidative stress-related genes (DEIOGs) between the groups were identified. (qxmd.com)
  • We identified a number of uncharacterized genes (ZNF300, NUP1333, KLK1 and others) and confirmed previous studies demonstrating specific genes/genesets that are important mediators of host immune responses and that displayed associations with antibody response to influenza A/H1N1 vaccine. (gsea-msigdb.org)
  • the values of the node (gene) and edge (intergenic relationships) parameters were estimated within each integrated datasets. (biomedcentral.com)
  • It has been suggested that MAPK3, along with the gene IRAK1, is turned off by two microRNAs that were activated after the influenza A virus had been made to infect human lung cells. (wikipedia.org)
  • Only MTOR-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. (ucsc.edu)
  • Please see the Gene Interactions Track Manual . (ucsc.edu)
  • Four transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • for example, Chu and Chen [ 13 ] combined PPI and gene expression data to construct a cancer perturbed PPI network in cervical carcinoma to study gain- and loss-of-function genes as potential drug targets. (hindawi.com)
  • The identification of gene signatures associated with antibody response represents an early stage in the science for which further research is needed. (gsea-msigdb.org)
  • Genes down-regulated in peripheral blood mononuclear cell responders vs nonresponders in adults (55-64) after exposure to Fluarix , time point 28D. (gsea-msigdb.org)
  • After infection, IL-18 and IL-34 gene expression was measured to assess epithelial cell immune responses, and lactate dehydrogenase (LDH) activity was measured as an indicator of cell damage. (bvsalud.org)
  • These data show that transient inhibition of LH-stimulated MAPK3/1 activity abrogates ovulation in mice. (phytid.org)
  • Finally, the data of GSE23561 (validated set) were used to validate the diagnostic potential of these hub genes. (qxmd.com)
  • This infrastructure integrates highly curated data from databases (Bind, IntAct, etc.), literature (PubMed), and gene expression resources (such as GEO and ArrayExpress). (biomedcentral.com)
  • The second most important role of BPC 157 is the activation of a mechanism for gene expression. (theironden.com)
  • The receiver operating characteristic (ROC) curve analysis was constructed to examine the role of hub genes in CAD diagnosis. (qxmd.com)
  • Bioinformatics analysis technology was used to identify 10 hub DEIOGs that might play a crucial role in CAD progression, and five special hub genes (Fos, Il6, Jun, Mapk3, and Mmp9) could be regarded as potential biomarkers for CAD diagnosis. (qxmd.com)
  • Among the 13 prioritized candidate genes, we identified MIF to be a potential emerging candidate due to its role as a pro-inflammatory cytokine. (biomedcentral.com)
  • To assess gene signatures related to humoral response among healthy older subjects following seasonal influenza vaccination, we studied 94 healthy adults (50-74 years old) who received one documented dose of licensed trivalent influenza vaccine containing the A/California/7/2009 (H1N1)-like virus strain. (gsea-msigdb.org)
  • The disease is associated with single amino acid changes (A7V, A9V or A33P) in myofibrillogenesis regulator 1 (MR-1) on chromosome 2q35 which is the causative gene of PNKD [ 6 - 10 ]. (jneuropsychiatry.org)
  • S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (cancerindex.org)
  • A recently available research using granulosa-specific knockout (KO) mice [5] supplied proof for the need for Mapk3/1 signaling in LH signaling during ovulation. (phytid.org)
  • As a result, PD0325901 treatment is a superb alterative solution to inhibit Mapk3/1 activity at specific time-points during follicular advancement. (phytid.org)
  • However, further studies are required to verify the functions of these hub genes. (qxmd.com)
  • We have previously reported the first large Chinese PNKD pedigree, and found a novel mutation of A7V on exon 1 of the PNKD/ MR-1 gene [ 11 ]. (jneuropsychiatry.org)