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  • diseases
  • Human milk components not only nourish the infant, they provide myriad bioactive compounds for the offspring that influence the growth, stimulation, and modulation of the immune system, cognitive development, protection from toxins and pathogenic diseases, and perhaps most remarkably, the establishment of the intestinal microbiota ( 1 ⇓ - 3 ). (pnas.org)
  • The Type B association may explain why many Jews, with high numbers of Type B blood, suffer these diseases more than others. (dadamo.com)
  • The virus grows slowly and without symptoms until twenty or more years after it has entered the system Type ABs are also at risk for these B-like diseases, since their bodies do not produce anti-B antibodies.Type O and Type A seem to be relatively immune by virtue of their strong anti-B antibodies. (dadamo.com)
  • One hypothesis to explain the steep rise in allergic diseases in recent years is the 'hygiene hypothesis': the excessive 'cleanliness' of the environment has led to a decline in the infectious stimuli that are necessary in the development of the immune system. (scielo.br)
  • Many candidate genes have been suggested in atopy and allergic diseases. (scielo.br)
  • Studies evaluating the relationship between ABO blood group status and atopic diseases have appeared in the literature since the late sixties. (scielo.br)
  • Mourant discovered the new blood group antigens of the Lewis, Henshaw, Kell, and Rhesus systems, and analyzed the association of blood groups and various other diseases. (wikipedia.org)
  • Such patients are very difficult to identify, but the MGH group has one of the largest groups in the world, developed through the efforts of co-authors Arthur Kim, MD, MGH Division of Infectious Diseases , and Lia Lewis-Ximenez, MD, at the Oswaldo Cruz Institute in Rio de Janeiro, Brazil. (eurekalert.org)
  • The blood donated by healthy persons is tested to ensure that the level of hemoglobin is satisfactory and that there is no risk of transmitting certain diseases, such as AIDS or hepatitis . (britannica.com)
  • populations
  • Blood group frequencies in multiple sclerosis populations in the United States. (dadamo.com)
  • BACKGROUND Studies in Western populations suggest that cagA, iceA, and vacA gene status in Helicobacter pylori isolates is associated with increased virulence and peptic ulcer disease. (bmj.com)
  • The A and B genes are co-dominant, so individuals can be phenotyped as A, B, AB or O. A common dimorphism in some populations leads to the division of blood group A into A 1 and A 2 , the latter showing weaker antigenicity. (biomedcentral.com)
  • In his book Genetics and the Races of Man (1950), Boyd categorized the world population into 13 distinct races, based on their different blood type profiles and his idea that human races are populations with differing alleles. (wikipedia.org)
  • The frequency of ABO blood group antigens varies in different populations. (medscape.com)
  • Studying patterns of gene expression in these two populations of chronic-HCV-associated T cells enabled the investigators to distinguish between expression changes related to T-cell receptor-mediated signaling and stimuli related to an inflammatory environment. (eurekalert.org)
  • allele
  • ABO blood grouping discrepancies were investigated serologically and by ABO genotyping [duplex polymerase-chain-reaction (PCR) - restriction-fragment-length-polymorphism (RFLP) and PCR - allele-specific-primer (ASP) across intron and DNA sequencing of the ABO gene and its proposed regulatory elements. (biomedcentral.com)
  • ABO allele nomenclature poses significant problems that are still under consideration by the International Society of Blood Transfusion (ISBT). (biomedcentral.com)
  • The ABO gene contains seven exons and a 1062 base pair (bp) sequence codes for a glycosyltransferase, of which the A 1 [Aallele (usually described as the consensus allele) product adds a monosaccharide ( N -acetyl-α-D-galactosamine) to a specific acceptor glycoconjugate. (biomedcentral.com)
  • transplantation
  • A short, updated textual content on blood teams, for individuals operating or education within the box of blood transfusion, transplantation, or human genetics, yet who're now not specialising within the box of blood teams, the third version of crucial advisor to Blood teams is a pocket-sized publication, containing complete color textual content including schematic figures and tables. (bitmicro.com)
  • clinical
  • A concise full-color evaluation of the mechanisms of blood ailments and issues - in line with a Harvard clinical college hematology course2015 Doody's center name! (bitmicro.com)
  • PathType is a searchable database of blood group and disease associations, clinical correlates and citations. (dadamo.com)
  • The ABO test may be part of a group of tests performed in various clinical settings. (medscape.com)
  • polymorphisms
  • The discovery of the human blood groups and, later, of the Major Histocom- patibility Complex (MHC) had a seminal effect on the field of human genetics, providing the first sound examples of mendel ian polymorphisms. (indigo.ca)
  • immune
  • 5 Mhc Genes, Immune Response, and Vaccines. (indigo.ca)
  • The virus cannot be combatted by the Type B immune system since it can't produce anti-B antibodies. (dadamo.com)
  • The disease, also known as hay fever or pollinosis, occurs in individuals with a sensitized immune system. (scielo.br)
  • Massachusetts General Hospital (MGH) investigators have identified differences in gene transcription within key immune cells that may distinguish those individuals infected with the hepatitis C virus (HCV) who develop chronic infection from those whose immune systems successfully clear the virus. (eurekalert.org)
  • While the adaptive immune system responds to HCV in individuals who develop chronic infection - producing CD8 and CD4 T cells specifically targeting the virus - the number of virus-specific T cells eventually diminishes, and those that remain lose their functionality, a phenomenon called T-cell exhaustion. (eurekalert.org)
  • Principal investigator Georg Lauer, MD, PhD, MGH Gastroenterology Unit, explains that the infection's unique property of naturally leading to two distinct outcomes - chronic infection versus complete viral clearance - inspired their investigation into the immune system factors leading to protection or viral persistence in human patients. (eurekalert.org)
  • An alternative to this medicinal chemistry approach is a systems biology based strategy that seeks to amplify selectively the anti-inflammatory activity of very low dose glucocorticoid in immune cells without modulating alternative cellular networks that mediate glucocorticoid toxicity. (springer.com)
  • The immune system will then kill or neutralize the antigen that is recognized as a foreign and potentially harmful invader. (absoluteastronomy.com)
  • enzyme
  • But a different thought just occurred to me: When the "Se" enzyme produces that H type 1 antigen, is that just the secreted blood type O molecule? (dadamo.com)
  • 3) This to-be-secreted "H" antigen is added upon by the Lewis enzyme to create the Lewis "B" antigen, which is also secreted. (dadamo.com)
  • 4) The original "Type I" compound (from "1)") can also be added upon by that same Lewis enzyme, to yield the Lewis "A" antigen, which is not secreted. (dadamo.com)
  • carbohydrates
  • infantis strains shows a bias toward genes required to use mammalian-derived carbohydrates by comparison with adult-borne bifidobacteria. (pnas.org)
  • The Helicobacter pylori adhesin BabA binds mucosal ABO/Le(b) blood group (bg) carbohydrates. (rcsb.org)
  • Rhesus
  • 4 The Rhesus System. (indigo.ca)
  • Thus, in addition to the ABO antigens and Rhesus antigens, many other antigens are expressed on the red blood cell surface membrane. (wikidoc.org)
  • This was accomplished by seeking statistical differences between heterosexuals and homosexuals for four traits that are known to be genetically determined: eye color, natural hair color, blood type, and the Rhesus factor. (springer.com)
  • amino
  • The A and B genes differ in a few single-base substitutions that change four amino-acid residues which may cause differences in A and B transferase specificity. (scielo.br)
  • A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of. (absoluteastronomy.com)
  • chromosomal
  • And if that's the case, is the non-secreted form, though identical, produced through the actions of a completely different gene at chromosomal site 9q34, rather than the secreted form, which is produced at either chromosome 11 or the other one? (dadamo.com)
  • Is it really the case that both the secreted and non-secreted forms of all the various blood type antigens are chemically indistinguishable from each other, even though they're produced at two different chromosomal sites? (dadamo.com)
  • peptic ulcer
  • AIM To investigate the relationship between peptic ulcer and expression of Lewis (Le) antigens as well as cagA, iceA, and vacA in H pylori isolates in Singapore. (bmj.com)
  • Vacuolating cytotoxin gene ( vacA ) s1a genotype and the cytotoxin associated gene ( cagA ) have been demonstrated to be related to the virulence of H pylori infection and the development of peptic ulcer. (bmj.com)
  • 13 Peptic ulcer disease has been suggested to be associated with H pylori expression of Le x /Le y , and an association between cagA gene and expression of Le x /Le y has also been reported. (bmj.com)
  • His work led him to discover that peptic ulcer was more dominant in blood group O, and that AB blood type mothers had a high male-to-female birth ratio. (wikipedia.org)
  • precursor
  • Most people have the antigen "H" encoded, because this is the precursor for antigen A or B. Thus, depending on whether the other genes are encoded, it will be determined if they will remain a type O or change to type A, B, or AB. (medscape.com)
  • linkage group
  • 2) Sherrington R, Curtis D, Brynjolfsson J, Moloney E, Rifkin L, Petursson H, Gurling H. A linkage study of affective disorder with DNA markers for the ABO-AK1-ORM linkage group near the dopamine beta hydroxylase gene. (dadamo.com)
  • interaction
  • Ex-vivo drug testing platform to map the biological complexity and inter- and intra-patient heterogeneity of blood tumours in the context of their interaction with the microenvironment. (embl.de)
  • incidence
  • ANSWER: There is some evidence that type O blood is associated with higher a higher incidence of bi-polar problems, sometimes also referred to a 'manic depressive disease. (dadamo.com)
  • The incidence of group O is much higher in Native American Indians, Africans and Australian aboriginals. (transfusion.ca)
  • individuals
  • This is not due to variation in ABO frequency, since the specimens from patients and normals are matched for ABO frequency, and it is not due to differences in secretor frequency, but represents a real dificit for Pp2 in patients with multiple sclerosis, particularly noticeable in group O individuals. (dadamo.com)
  • A2 has a frequency of 10% among group A individuals in Asia. (transfusion.ca)
  • Blood samples from five individuals living in Portugal, Switzerland, Sweden and the USA were analysed. (biomedcentral.com)
  • This was only possible because of the availability of a group of 43 individuals diagnosed with HCV soon after their initial infection who provided a total of 78 blood samples - one to three from each - that were taken within 36 weeks of infection. (eurekalert.org)
  • On the other hand, O group individuals lack both the A and the B antigen and thus have both anti-A and anti-B in their serum. (britannica.com)