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  • genetics
  • Previous studies hinted that genetics might influence an individual's risk of a cancer spreading, so to try to identify specific genes involved, Hunter and his team interbred mice predisposed to develop a particularly aggressive form of metastatic breast cancer with those at low risk of metastasis. (newscientist.com)
  • Genetics: From Genes to Genomes. (wikipedia.org)
  • disorder
  • A case in point is the mouse sodium channel modifier 1 (SCNM1), a gene that can turn a chronic disorder into a lethal disease. (alzforum.org)
  • and University of Trieste (Trieste, Italy) and Charles University (Prague, Czech Republic), present details of the adeno-associated virus (AAV)-mediated gene therapy approach they used to correct the metabolic disorder that causes hyperbilirubinemia in CNS1. (eurekalert.org)
  • proteins
  • We can try to find associated genes, proteins and other partners that are involved in this complex, as well as some of the mechanisms involved. (rxpgnews.com)
  • But one did infect the lungs, and it carried the RNA polymerase genes from the 1918 virus that allowed the virus to make the key step of synthesizing its proteins. (infectioncontroltoday.com)
  • He nd his colleagues suspected that glioblastomas might be addicted to proteins produced by gene fusions. (tbilaw.com)
  • quantitative
  • In this study, we conducted biochemical measurements (RT-qPCR of select genes and targeted, quantitative metabolomic profiling) on N. triangulifer mature larvae reared at temperatures associated with excellent survival and fitness (22-24°C), compromised survival and fitness (28°C), and chronic lethality (30°C -larvae survived for a few weeks but failed to emerge to adulthood). (stroudcenter.org)
  • researchers
  • By mixing and matching a contemporary flu virus with the "Spanish flu" - a virus that killed between 20 and 50 million people 90 years ago in history's most devastating outbreak of infectious disease - researchers have identified a set of three genes that helped underpin the extraordinary virulence of the 1918 virus. (infectioncontroltoday.com)
  • copies
  • If two cystic fibrosis carriers have children, they have a 25 percent chance of producing offspring having two copies of the lethal allele, eventually resulting in the death of the child. (wikipedia.org)
  • mice
  • Shift workers are more prone to cancer, and now a study in mice has found that changes to a gene that regulates the circadian clock seem to increase the likelihood of breast cancer spreading and becoming deadly. (newscientist.com)
  • The team then used gene-editing to alter its activity in cancer cells, and injected these into cancer-free mice. (newscientist.com)
  • Loss of a gene related to Arnt12 does seem to be associated with an increase in lung cancer , an effect that is enhanced when lung cancer mice are put on a sleep schedule resembling jet lag, says Chi Van Dang , director of the Abramson Cancer Centre in Pennsylvania. (newscientist.com)
  • In 2004, Kawaoka and his team identified another key gene from the 1918 virus that enhanced the pathogen's virulence in mice. (infectioncontroltoday.com)
  • Lethal alleles were first discovered by Lucien Cuénot in 1905 while studying the inheritance of coat colour in mice. (wikipedia.org)
  • The agouti gene in mice is largely responsible for determining coat colour. (wikipedia.org)
  • prognosis
  • A recent study suggested that Arntl2 can raise the activity of a set of genes associated with metastasis and a poor prognosis in lung adenocarcinoma, says Simon Archer at the University of Surrey in Guildford, UK. (newscientist.com)
  • single
  • For the most part, substituting single genes from the 1918 virus onto the template of a much more benign contemporary virus yielded agents that could only replicate in the upper respiratory tract. (infectioncontroltoday.com)
  • Several common single-gene alterations have been observed in glioblastomas. (tbilaw.com)
  • Although each gene plays a specific role in the cell, sometimes errors in the DNA cause two ordinary genes to fuse into a single entity, with novel characteristics that can lead to a tumor," said co-senior author Raul Rabadan, assistant professor in the department of Biomedical Informatics and the Center for Computational Biology and Bioinformatics, Columbia Initiative in Systems Biology. (tbilaw.com)
  • Vivo
  • Adenovirus-Mediated Transfer of a Rcombinant .alpha.1-Antitrypsin Gene to the Lung Epithelium in Vivo," Science 252: 431-434, 1991. (patentgenius.com)
  • CNS1 is an outstanding model for in vivo gene therapy with easily measured and clinically relevant metabolic endpoints," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy , and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia. (eurekalert.org)
  • CNS1 is an outstanding model for in vivo gene therapy with easily mea. (bio-medicine.org)
  • molecular
  • While Dr. Ho, assistant professor of biochemistry and molecular biology at Jefferson Medical College of Thomas Jefferson University and Jefferson s Kimmel Cancer Center in Philadelphia, and former Jefferson colleague Steven Farber, Ph.D., and Michael Pack, Ph.D., reported the findings in Science in 2001, one huge obstacle remained: identifying a gene behind the condition. (rxpgnews.com)
  • Cloning of the Complete Gene for Carcinoembryonic Antigen: Analysis of Its Promotor Indicates a Region Conveying Cell Type-Specific Expression," Molecular and Cellular Biology 10(6): 2738-2748, 1990. (patentgenius.com)
  • cell
  • Reporting in the April issue of the journal Cell Metabolism, the team explains that disrupting the gene interferes with the ability to absorb lipids through the intestine. (rxpgnews.com)
  • casein gene promoter constructs in a mammary epithelial cell line," Proc. (patentgenius.com)
  • Human Gene Therapy , the Official Journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German. (eurekalert.org)
  • Human Gene Therapy , the Official Journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German Society of Gene Therapy, and five other gene therapy societies, is an authoritative peer-reviewed journal published monthly in print and online. (eurekalert.org)
  • It's unlikely that we will find a gene fusion responsible for most glioblastomas," said co-senior author Dr. Anna Lasorella, associate professor of pathology and pediatrics at CUMC and a member of the Columbia Stem Cell Initiative and the HICCC. (tbilaw.com)
  • amino
  • This highest range of Replikin Counts (number of Replikins per 100 gene amino acids) was found elsewhere only in disorders with the highest five-year mortality rates. (biospace.com)
  • Rapid replication has been found to be associated with a newly found family of strictly specified gene peptides, named Replikins, characterized by gene peptides 7 to 50 amino acids long, containing a minimum of two lysine groups, 6 to 10 amino acids apart, a minimum of 1 histidine group, and a minimum concentration of 6% lysines. (biospace.com)
  • Replikin Count = number of gene Replikins per 100 amino acids). (biospace.com)
  • cells
  • The gene seems to be some sort of regulator that affects trafficking of lipids of cells through the gut, says Dr. Farber. (rxpgnews.com)
  • Hormonal Regulation of Chimeric Genes Containing the Phosphoenolpyruvate Carboxykinase Promoter Regulatory Region in Hepatoma Cells Infected by Murine Retroviruses," Journal of Biological Chemistry 263(33): 17798-17808, 1988. (patentgenius.com)
  • Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or other components of the homologous recombination pathway. (sigmaaldrich.com)
  • found
  • Now, Dr. Ho, Dr. Farber, now at the Carnegie Institution of Washington, and Dr. Pack at the University of Pennsylvania School of Medicine, have found a gene, which they dubbed fat free. (rxpgnews.com)
  • They found that the gene shares 75 percent of its sequence with a human gene called ANG2 (Another New Gene 2), and also shares parts of its sequence with a gene called COG8, which is known to affect the Golgi apparatus. (rxpgnews.com)
  • lung
  • Writing in the Proceedings of the National Academy of Sciences, a team led by University of Wisconsin-Madison virologists Yoshihiro Kawaoka and Tokiko Watanabe identifies genes that gave the 1918 virus the capacity to reproduce in lung tissue, a hallmark of the pathogen that claimed more lives than all the battles of World War I combined. (infectioncontroltoday.com)
  • In the late 1990s, scientists were able to recover genes from the 1918 virus by looking in the preserved lung tissue of some of the pandemic's victims. (infectioncontroltoday.com)
  • growth
  • The most common fusion they observed involved the genes FGFR (fibroblast growth factor receptor) and TACC (transforming acidic coiled-coil). (tbilaw.com)
  • specific
  • But we may be able to discover a number of other gene fusions, each accounting for a small percentage of tumors, and each with its own specific therapy. (tbilaw.com)
  • Science
  • The findings of the study, "Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma," were published last week today in the online edition of the journal Science. (tbilaw.com)
  • approach
  • A new gene therapy approach to correcting this metabolic error achieved significant, long-lasting reductions in bilirubin levels in a mouse model of CNS1 and is described in an Open Access article in Human Gene Therapy , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (eurekalert.org)
  • provides
  • Joint work* on advance detection provides time and gene structures for pre-outbreak countermeasures. (biospace.com)
  • study
  • Additionally, primers for genes associated with energy: INSULIN RECEPTOR (IR), mechanistic TARGET OF RAPAMYCIN (mTOR) and TREHALOSE 6 PHOSPHATE SYNTHASE (T6PS) were developed for this study. (stroudcenter.org)
  • ability
  • Scientists assumed that the ability of the virus to take over the lungs is associated with the pathogen's high level of virulence, but the genes that conferred that ability were unknown. (infectioncontroltoday.com)
  • makes
  • The gene is well conserved across species and no one has discovered its function as yet, which makes it very exciting. (rxpgnews.com)