Loading...
  • planarian
  • To identify genes that are differentially expressed during early stages of planarian head regeneration, we generated a de novo transcriptome assembly from more than 300 million paired-end reads from planarian fragments regenerating the head at 16 different time points. (biomedcentral.com)
  • intermediate mesoderm
  • In the mouse, nephrons are the basic functional units of kidneys and develop from the intermediate mesoderm, and numerous genes involved in their development have been characterized ( Dressler, 2009 ). (biologists.org)
  • The most common in disease generally associated with long wave far red detection is being routinely relocated within the intermediate mesoderm into nephron epithelia later in this book in the recovery room should have a better indicator of the vhl tumor suppressor gene v c and kaplan gincidence of renal and gonadal dysgenesis or normal genital development in mammals is however clear that the higher the potency of the. (nationalnewstoday.com)
  • knockdown
  • Finally, the TALE (three amino acid loop extension) class homeodomain transcription factor prep is required for promoting anterior fates, with knockdown leading to a lack of anterior structures in the anterior blastema but without conversion to posterior fates ( Felix and Aboobaker, 2010 ). (biologists.org)
  • fibroblasts
  • Each individual bony ray consists of two concave hemirays that enclose a mesenchymal compartment composed of blood vessels, nerves, pigment cells, fibroblasts, and osteoblasts. (biomedcentral.com)
  • Fibroblasts are essential for salamander regeneration, but the mechanisms underlying their role in the formation of a regeneration blastema remain unclear. (jcancer.org)
  • Although other cell types contribute to blastema formation, fibroblasts appear to play a central role [ 5 , 6 ]. (jcancer.org)
  • Blood vessels, nerves, pigment cells, and fibroblasts are in the mesenchymal compartment between rays, as well as in the intraray space. (biologists.org)
  • lineage
  • Transgenic animals also had elevated levels of cells coexpressing markers of SC lineage and myogenic commitment at sites of muscle damage. (pnas.org)
  • Characterization of stem cell lineage potential can be accomplished with clonal assays that interrogate stem cell output at the single-cell level. (springer.com)
  • However, very few molecular tools exist for studying crucial cell lineage relationships over regeneration or for robust and sustained misexpression of genetic elements to test their function. (biologists.org)
  • neoblasts
  • Together with their immediate progeny, neoblasts account for ≈15-25% of all parenchymal cells ( 4 ). (pnas.org)
  • regenerate
  • Neural cells, for example, express growth-associated proteins, such as GAP-43 , tubulin , actin , an array of novel neuropeptides , and cytokines that induce a cellular physiological response to regenerate from the damage. (wikipedia.org)
  • salamander
  • Although infiltrating immune cells play a major role in determining the variable outcome of mammalian wound repair, little is known about the modulation of immune cell signaling in efficiently regenerating species such as the salamander, which can regrow complete body structures as adults. (pnas.org)
  • Genic Regions of a Large Salamander Genome Contain Long Introns and Novel Genes. (uci.edu)
  • genetic
  • Moreover, recent genetic analyses on several families identified several different chromosomal loci that are associated with CAKUT ( 18 , 19 , 20 ), although no specific gene involved has been identified from these studies. (asnjournals.org)
  • To investigate a genetic interaction between the p53 gene and the wt1 gene, we have crossed their respective knockout mice. (aacrjournals.org)
  • As a consequence of genetic sex determination, the indifferent gonadal blastema normally becomes either a testis or an ovary. (royalsocietypublishing.org)
  • Pattern formation in the morphogenesis of an animal is regulated by genetic induction factors that put cells to work after damage has occurred. (wikipedia.org)
  • Unlike many previous assumptions that there is a magic bullet for regeneration, like the presence of a specific gene, the group's comprehensive genetic analysis shows that it is a complex trait. (labmanager.com)
  • receptor
  • These viruses, when modified by changing their coat protein, can infect axolotl cells only when they have been experimentally manipulated to express the receptor for that coat protein, thus allowing for the possibility of targeting specific cell types. (biologists.org)
  • Viral gene transfer is an attractive alternative, as it can provide stable gene expression and can, in principle, be targeted to specific cell types based on the availability of a receptor. (biologists.org)
  • When these retroviruses are pseudotyped with ASLV-A envelope glycoprotein that mediates infection specifically through the avian TVA receptor, they are capable of infecting only axolotl cells that have been made to express the receptor. (biologists.org)
  • cytokines
  • Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48-96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast migration, and replication ( 17 ). (pnas.org)
  • organs
  • In view of the extremely high penetrance rate (autosomal dominant) of this anomaly within the same family and the uniform involvement of other organs, the PAX2 gene mutation appears to represent a special subgroup of CAKUT. (asnjournals.org)
  • Fresh cell therapy is mainly the use of live animal embryo organs cells which are injected into the patient with the purpose of achieving a revitalizing effect. (wikipedia.org)
  • It remains to be seen whether Dll and the Dlx genes have similar roles during the development of these organs. (biologists.org)