• His own work with a similar technique has shown promise in chronic lymphocytic leukemia and in ALL in children. (911families.org)
  • Gene therapy is under development for the treatment of acute leukaemia such as relapsed and refractory acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML) after allogeneic hematopoietic stem cell transplantation. (globaldata.com)
  • Recent evidence suggests that the prognostic impact of gene mutations in patients with chronic lymphocytic leukemia (CLL) may differ depending on the immunoglobulin heavy variable (IGHV) gene somatic hypermutation (SHM) status. (soton.ac.uk)
  • Broadly, there are two types of leukemia- chronic leukaemia develops over months to years, whereas acute leukaemia progresses rapidly. (asianscientist.com)
  • OBJECTIVE: To investigate the expression and regulation mechanism of mismatch repair (MMR) genes in chronic myeloid leukemia (CML). (hku.hk)
  • A gene expression signature of primary resistance to imatinib in chronic myeloid leukemia. (crcm-marseille.fr)
  • Using gene expression profiling we show that the expression of 105-probe sets in mononuclear cells collected from chronic myeloid leukemia (CML) chronic phase (CP) patients with raised leukocyte counts who subsequently achieved complete cytogenetic response after 12 months on imatinib, differed substantially from that of patients who failed to achieve any degree of cytogenetic response. (crcm-marseille.fr)
  • Translocations and other types of mutations involving the RUNX1 gene have been associated with different types of leukemia and related blood disorders, including acute lymphoblastic leukemia (ALL), chronic myelomonocytic leukemia (CMML), familial platelet disorder with predisposition to acute myeloid leukemia, and myelodysplastic syndromes (MDS). (medlineplus.gov)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • Imatinib has a 95% response rate in patients with chronic myeloid leukemia (caused by a chromosomal rearrangement called the Philadelphia chromosome) and extends quality-adjusted life . (cdc.gov)
  • Venetoclax has an 80% response rate in patients with chronic lymphocytic leukemia who have a 17p deletion. (cdc.gov)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
  • Acute lymphocytic leukemia (ALL) in children is a clonal disease of bone marrow hematopoietic stem cells. (medscimonit.com)
  • Cytogenetically normal acute myeloid leukemia (CN-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. (medlineplus.gov)
  • The contribution of the bone marrow (BM) immune microenvironment (TME) to acute myeloid leukemia (AML) development is well-known, but its prognostic significance is still elusive. (ntu.ac.uk)
  • Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow . (bvsalud.org)
  • A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
  • Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood. (frontiersin.org)
  • Patients with acute myelogenous leukemia (AML) present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)
  • Acute myelogenous leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
  • In a recent study, researchers around Irmela Jeremias, Head of the Research Unit "Apoptosis in Hematopoietic Stem Cells" (AHS) at Helmholtz Munich, identified two genes that can be effectively used in precision medicine of acute myeloid leukemia. (helmholtz-munich.de)
  • Akin to the normal hematopoietic system, leukemias are sustained by a small number of leukemia stem-like cells (LSC), which can be distinct from the normal hematopoietic stem cells (HSC) but also exhibit functional characteristics of self-renewal and (abnormal or hindered) differentiation, and are often quiescent ( 2 - 4 ). (frontiersin.org)
  • Hox genes modulate the properties of hematopoietic stem cells (HSCs) and reacquired Hox expression in progenitors contributes to leukemogenesis. (nih.gov)
  • the most commonly affected genes are NPM1 , FLT3 , DNMT3A , CEBPA , IDH1 , and IDH2 . (medlineplus.gov)
  • The proteins produced from the CEBPA and DNMT3A genes regulate gene activity and help to control when cells divide and how they mature. (medlineplus.gov)
  • We could show for the first time that the genes WT1 or DNMT3A harbor an essential function in leukemia stem cells of individual patients, although the literature did not suggest it," state Maryam Ghalandary and Yuyiao Gao. (helmholtz-munich.de)
  • WT1 and DNMT3A can be used as targets for leukemia therapy in certain patients to eliminate their tumor cells via precision oncology. (helmholtz-munich.de)
  • Acute myeloid leukemia patients with DNMT3A mutations exhibit DERARE hypomethylation, elevated HOXB expression, and adverse outcomes. (nih.gov)
  • A Chinese group have just published a paper in the journal Leukemia and Lymphoma , claiming that a genetic polymorphism in the XRCC1 gene, which has been previously linked to various cancers, raises the risk of electromagnetic field (EMF)-related leukemia. (discovermagazine.com)
  • Under the assumption that genotype is not correlated with environment in the general population (a reasonable assumption, and they did test this in a control sample), this indicates a G x E interaction for leukemia / lymphoma risk, with p below 0.01. (discovermagazine.com)
  • Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. (ac.be)
  • For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • Patients with Burkitt leukemia/lymphoma are treated with regimens specific for this diagnosis. (medscape.com)
  • Recent studies have shown that pyroptosis-related genes are associated with the prognosis of cancer patients. (nature.com)
  • Researchers reported fresh evidence Wednesday that using gene therapy to manipulate the immune system is emerging as a promising new strategy in the fight against cancer. (911families.org)
  • Pretreatment blood samples from 84 cytogenetically normal AML patients aged less than 60 years, who were characterized for BAALC expression, FLT3 internal tandem duplication (ITD), and MLL partial tandem duplication (PTD) and uniformly treated on Cancer and Leukemia Group B 9621 protocol, were analyzed for ERG expression by real-time reverse transcriptase polymerase chain reaction. (nih.gov)
  • Researchers from the Pusan National University in South Korea have found that a gene called SURF4 can help regulate progression of leukemia, a type of blood cancer. (asianscientist.com)
  • Leukemia is also the leading cause of cancer-related mortality in children younger than five years old , placing an enormous strain on individuals and families, globally. (asianscientist.com)
  • For instance, an amino acid protein called Stimulator of Interferon genes (STING) plays a critical role in modulating anti-cancer response. (asianscientist.com)
  • Leukemia, or blood cancer, is a common tumor in children and occurs in many different genetic variations, thus complicating treatment. (helmholtz-munich.de)
  • Scholars@Duke publication: Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. (duke.edu)
  • A rearrangement (translocation) of genetic material involving the RUNX1 gene is found in approximately 7 percent of individuals with a form of blood cancer known as acute myeloid leukemia (AML). (medlineplus.gov)
  • Acute lymphoblastic leukemia is the most common cancer in children, and precursor B-cell acute lymphoblastic leukemia accounts for approximately 75-80% of newly diagnosed pediatric ALL cases. (bjbms.org)
  • Gene Therapy Turns Several Leukemia Patients Cancer Free. (singularityhub.com)
  • Conclusions: Given the decreased expression levels of sestrin 2, adiponectin, and AMPK genes as tumor inhibitors and the increased expression level of the mTOR gene as an oncogene in the patients with AML in our study, it is thought that disruption of this pathway may be involved in leukemogenesis and can be considered as an effective factor in the progression of cancer. (ijbiotech.com)
  • Congratulations to the international group of researchers led by HemaSphere Editor-in-Chief Prof. Jan Cools of the VIB-KU Leuven Center for Cancer Biology who have made a breakthrough in understanding the development of acute lymphoblastic leukemia, an aggressive cancer of the blood. (ehaweb.org)
  • ALL is the most common type of cancer and leukemia in children in the United States. (medscape.com)
  • Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • In addition, the use of gene expression profiling in breast cancer management has matured in the past few years propelled by the results of a prospective clinical trial . (cdc.gov)
  • The American Cancer Society estimates that in the United States in 2023 there will be about 20,000 new cases of acute myeloid leukemia (AML) and about 11,300 deaths , almost all in adults. (msdmanuals.com)
  • High-density oligonucleotide arrays were used to identify genes differentially expressed between high and low ERG expressers. (nih.gov)
  • The top differentially expressed genes between IDO1low and IDO-1high and between PLXNC1low and PLXNC1 high cases further improved the prognostic value of IDO1 providing a 7 and 10-gene immune signature, highly predictive of survival and correlating with AML mutational status at diagnosis. (ntu.ac.uk)
  • Previous studies have shown that fusion genes are the most important cause of pediatric B-cell acute lymphoblastic leukemia, and the prognosis of different fusion genes is significantly different. (bjbms.org)
  • Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis? (frontiersin.org)
  • Acute myeloid leukemia has a number of subtypes and precursor neoplasms that are distinguished from each other by morphology, immunophenotype, cytochemistry, and genetic abnormalities (see also The 2016 World Health Organization [WHO] Classification of myeloid neoplasms ) all of which have important implications for prognosis and treatment. (msdmanuals.com)
  • Cases of malignant lymphomas and leukemias were not described in gibbons until the 1960s, when several cases of haematopoietic neoplasia were reported in a single colony of white-handed gibbons housed at the SEATO research facility in Bangkok, Thailand. (wikipedia.org)
  • 18 years with advanced leukemias, lymphomas, and solid tumors. (cardiff.ac.uk)
  • Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. (medlineplus.gov)
  • While t(8;21) is important for leukemia development, a mutation in one or more additional genes is typically needed for the myeloid blasts to develop into cancerous leukemia cells. (medlineplus.gov)
  • For example, people with an NPM1 gene mutation frequently also have a mutation in the FLT3 gene, both of which are likely involved in the cancer's development. (medlineplus.gov)
  • Transcription factors - proteins that regulate gene expression - play critical roles in cell fate decisions and are frequent targets of mutation in a variety of human cancers. (vumc.org)
  • Depending on the type of mutation, these conditions can be related to impaired regulation of gene activity or loss of normal gene function. (medlineplus.gov)
  • My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. (globalgenes.org)
  • Just carrying a particular mutation doesn't mean that a leukemia is guaranteed, however. (blogspot.com)
  • Having two copies of the MTHFR gene mutation may raise your risk for certain health conditions, though more research is needed. (healthline.com)
  • About 30 to 40 percent of the American population may have a mutation at gene position C677T. (healthline.com)
  • The risk is possibly increased if a person has two gene variants or is homozygous for the MTHFR mutation. (healthline.com)
  • The proteins produced from these genes have different functions in the cell. (medlineplus.gov)
  • Although the proteins produced from two other genes involved in CN-AML, IDH1 and IDH2 , are not normally involved in proliferation, differentiation, or survival of cells, mutations in these genes lead to the production of proteins with a new function. (medlineplus.gov)
  • This study aimed to explore the associations between MTHFR or TS genetic polymorphisms and susceptibility to acute lymphocytic leukemia (ALL) in children. (medscimonit.com)
  • After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
  • Which genetic alterations represent powerful anchors for targeted leukemia therapy? (helmholtz-munich.de)
  • The translocation, written as t(8;21), combines genetic information from chromosome 21 and chromosome 8, fusing the RUNX1 gene on chromosome 21 with a gene on chromosome 8 called RUNX1T1 (also known as ETO ). (medlineplus.gov)
  • A rare genetic polymalformative syndrome characterized by a Noonan-like phenotype associated with increased risk of developing juvenile myelomonocytic leukemia (JMML). (globalgenes.org)
  • Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and is characterized by recurring structural genetic alterations. (lu.se)
  • We found that the different genetic subtypes of ALL are characterized by distinct DNA methylation signatures that exhibit significant correlation with gene expression profiles. (lu.se)
  • THURSDAY, Feb. 26, 2015 (HealthDay News) -- For many people, an increase in genetic mutations that could trigger leukemia seems to be an inevitable part of aging, a new study finds. (blogspot.com)
  • Widespread genetic testing for Parkinson's disease is feasible, according to results from an initial phase of the PD GENEration (PD GENE) clinical trial. (genomeweb.com)
  • PD GENE was launched in 2019 and provides free genetic counseling and testing for people with Parkinson's disease, with the first phase of the study focusing on the feasibility of testing as well as interest in such testing. (genomeweb.com)
  • Emergence of LSC is dependent on individual or combined genetic mutations that broadly determine the cellular affiliation of the leukemia, and permit or impose ectopic self-renewal and a restricted differentiation potential into what constitutes the proliferative bulk of the leukemia ( 5 , 6 ). (frontiersin.org)
  • The mechanism of this arrest is under study, but in many cases, it involves the activation of abnormal genes through chromosomal translocations and other genetic abnormalities. (medscape.com)
  • acute myeloid leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)
  • The authors took 123 childhood leukemia patients living near Shanghai. (discovermagazine.com)
  • or = 30 kg/m2) frequently follow treatment for childhood acute lymphoblastic leukemia (ALL). (duke.edu)
  • Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL. (duke.edu)
  • We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases using microarray analysis of DNA copy number alterations and gene expression, and genome-wide cytosine methylation profiling using the HpaII tiny fragment enrichment by ligation-mediated PCR (HELP) assay. (lu.se)
  • See the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
  • AML comprises about 25% of childhood leukemias, often developing in infancy. (msdmanuals.com)
  • In this retrospective multi-cohort study, we investigated whether combining pyroptosis- and immune-related genes improves prognostic classification of AML patients. (nature.com)
  • Using a robust gene pairing approach, which effectively eliminates batch effects across heterogeneous patient cohorts and transcriptomic data, we developed an immunity and pyroptosis-related prognostic (IPRP) signature that consists of 15 genes. (nature.com)
  • found that pyroptosis-related genes can be used for prognostic prediction of skin cutaneous melanoma and lung adenocarcinoma, respectively. (nature.com)
  • Inconsistent data formats and batch effects between different profiling platforms often challenge the development and application of prognostic gene signatures. (nature.com)
  • To make the gene signature and risk cutoff widely applicable, we developed a novel analytic approach based on mRNA expression levels of gene-pairs to construct a robust prognostic model, and show how one-hot binary encoding of the gene-pairs effectively eliminates the influence of batch effects. (nature.com)
  • To test the prognostic significance of ETS-related gene (ERG) expression in cytogenetically normal primary acute myeloid leukemia (AML). (nih.gov)
  • With the aim to develop a prognostic IDO1-based immune gene signature, biological and clinical data of 732 patients with newly diagnosed, non-promyelocytic AML were retrieved from public datasets and analyzed using established computational pipelines. (ntu.ac.uk)
  • PLXNC1, a semaphorin receptor involved in inflammation and immune response, was the IDO1-interacting gene retaining the strongest prognostic value. (ntu.ac.uk)
  • We discuss the value of lncRNAs as putative diagnostic, prognostic and therapeutic targets in myeloid leukemias and indicate novel directions in this exciting research field. (frontiersin.org)
  • To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
  • We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)
  • Cytogenetically normal refers to the fact that this form of acute myeloid leukemia is not associated with large chromosomal abnormalities. (medlineplus.gov)
  • Older patients with newly diagnosed acute myeloid leukemia (AML) in the phase 3 AZA-AML-001 study were evaluated at entry for cytogenetic abnormalities, and a subgroup of patients was assessed for gene mutations. (ox.ac.uk)
  • Overall survival (OS) was assessed for patients with common (occurring in ≥10% of patients) cytogenetic abnormalities and karyotypes, and for patients with recurring gene mutations. (ox.ac.uk)
  • This arrest is caused by an abnormal expression of genes, often as a result of chromosomal translocations or abnormalities of chromosome number. (medscape.com)
  • Specific fusion genes play important roles as risk factors for strategic treatment. (bjbms.org)
  • However, not all patients are positive for fusion genes. (bjbms.org)
  • Therefore, we tried to assess the outcomes of and risk factors for pediatric B-cell acute lymphoblastic leukemia without specific fusion genes in three Chinese institutes, and then we used the next-generation sequencing in relapsed patients to try to reveal more risk gene mutations in pediatric B-cell acute lymphoblastic leukemia. (bjbms.org)
  • Zou P, Zhou M, Wen J, Liao X, Shen Y, Liu H, Song L, Xiao J. The long-term outcome and risk factors for precursor B cell acute lymphoblastic leukemia without specific fusion genes in Chinese children: experiences from multiple centers. (bjbms.org)
  • In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
  • This change in gene activity blocks the maturation (differentiation) of blood cells and leads to the production of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)
  • In this application we are proposing studies in mice and leukemic cells to test the role of BIM inhibition as a target for leukemia, and to test RAS inhibitors as candidate therapies for these leukemias. (alexslemonade.org)
  • Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
  • Gibbon-ape leukemia virus (GaLV) is an oncogenic, type C retrovirus that has been isolated from primate neoplasms, including the white-handed gibbon and woolly monkey. (wikipedia.org)
  • The virus was identified as the etiological agent of hematopoietic neoplasms, leukemias, and immune deficiencies within gibbons in 1971, during the epidemic of the late 1960s and early 1970s. (wikipedia.org)
  • Researchers have known that a gene called surfeit 4 ( SURF4 ) produces its protein, SURF4, in higher quantities in such cancers. (asianscientist.com)
  • Germline mutations in the gene AML1 ( RUNX1, CBFA2 ) occur in the familial platelet disorder with predisposition for AML, an autosomal dominant disorder characterized by moderate thrombocytopenia, a defect in platelet function, and propensity to develop AML. (medscape.com)
  • Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
  • For example, the protein produced from the FLT3 gene stimulates the proliferation and survival of cells. (medlineplus.gov)
  • Acute myeloid leukemia FLT3 Gene profiling Histone deacetylases Methylation Integrated data obtained from. (karger.com)
  • Understanding how transcription factors contribute to disease requires the identification of their direct gene targets, but traditional methods are time-consuming and m ake it difficult to distinguish direct from secondary changes. (vumc.org)
  • Objective: In this study, expression of mTOR genes and three upstream targets (5' adenosine monophosphate-activated protein kinase (AMPK, adiponectin, and sestrin 2) involved in mTOR signaling was investigated. (ijbiotech.com)
  • abstract = "K- sam bek, N- sam flg and FGFR3 sam3 establish gene family of the receptors for heparin-binding growth factors (HBGFs) or FGFs. (elsevierpure.com)
  • The NPM1 gene provides instructions for a protein that is likely involved in the regulation of cell growth and division. (medlineplus.gov)
  • Here, our transcriptome and DNA methylome analyses revealed that Hoxb cluster and retinoid signaling genes are predominantly enriched in LT-HSCs, and this coordinate regulation of Hoxb expression is mediated by a retinoid-dependent cis-regulatory element, distal element RARE (DERARE). (nih.gov)
  • Collectively, these findings demonstrate pivotal roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes. (nih.gov)
  • But when the researchers injected SURF4 -suppressed cells in the tumors of lab rodents, the tumour growth was arrested, suggesting that suppressing levels of SURF4 protein can regulate leukemia progression. (asianscientist.com)
  • Finally, we identified aberrant methylation in multiple genes also targeted by recurring DNA copy number alterations in ALL, suggesting that these genes are inactivated far more frequently than suggested by structural genomic analyses alone. (lu.se)
  • Methylation is one of the main physiological processes to induce silencing of gene expression. (karger.com)
  • Acute myeloid leukemia results from the accumulation of mutations that deregulate survival and differentiation of hematopoietic cells, and drive leukemia. (alexslemonade.org)
  • Leukemia can be the only clinical manifestation of the syndrome. (globalgenes.org)
  • We retrospectively analyzed clinical and laboratory findings, treatment responses and outcomes in 283 B-cell acute lymphoblastic leukemia patients. (bjbms.org)
  • As a leading global developer of innovative cell-based technologies and therapeutics and laboratory testing provider, Avalon GloboCare Corp. (Nasdaq: ALBT) announced it has deployed a breakthrough fusion gene map technology to be used for the goal of developing companion diagnostic kits and devices to enhance personalized clinical management of leukemia patients. (stockresearchtoday.com)
  • Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (nih.gov)
  • In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
  • Occasionally, patients have skin rashes due to infiltration of the skin with leukemic cells (leukemia cutis). (medscape.com)
  • The thesis work would focus on identification of genes that are essential for the optimal functioning of the ubiquitin-proteasomal system in leukemic cells. (lu.se)
  • Expression of bcr-abl mRNA and MMR genes mRNA were detected by RT-PCR in 26 CML patients with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) and 4 CML patients on imatinib treatment. (hku.hk)
  • CONCLUSION: Expressions of hMSH2, hMSH3 and hMLH1 mRNA were down-regulated by bcr-abl fusion gene. (hku.hk)
  • The patients, who ranged in age from 23 to 66, were diagnosed with acute lymphoblastic leukemia, or ALL, and had previously relapsed after standard chemotherapy. (911families.org)
  • The incorporation of PLXNC1 into the 2-gene IDO1-BIN1 score gave rise to a powerful immune gene signature predicting survival, especially in patients receiving chemotherapy. (ntu.ac.uk)
  • Scholars@Duke publication: Expression of multiple chemokine genes by a human mast cell leukemia. (duke.edu)
  • Five patients with a lethal leukemia achieved complete and rapid remissions after the treatment, in which cells from their own immune systems were genetically altered to specifically attack the disease. (911families.org)
  • Taken together, our data indicate that IDO1 is pivotal for the construction of an immune gene signature predictive of survival in AML patients. (ntu.ac.uk)
  • BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
  • Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
  • Although various treatment options have been used for different types of leukemia , understanding the molecular pathways involved in the development and progression of leukemia is necessary. (bvsalud.org)
  • Here we report on a combined analysis by molecular genetics and in situ hybridization of these two patients, in which we wanted to determine whether the PML gene has alternative fusion partners or whether cryptic rearrangement of the RARA locus has occurred instead. (lu.se)
  • After transplanting tumor cells in mice, the researchers systematically knocked out several genes with so-called "gene scissors" to assess their function in the tumor. (helmholtz-munich.de)
  • Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog , and STAT3. (bvsalud.org)
  • The results indicate an absolute requirement for the rearrangement of the RARA gene in the pathogenesis of APL and underline the importance of RARA during normal myeloid differentiation. (lu.se)
  • The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
  • FAB M3) is a reciprocal translocation, t(15;17)(q22;q12), which serves to fuse the PML gene on chromosome 15 to the retinoic acid receptor alpha (RARA) gene on chromosome 17. (lu.se)
  • Two APL patients with simple variants of this translocation, t(3;15)(q21;q22) and t(X;15)(p11;q22), have previously been reported who lack cytogenetic involvement of chromosome 17, although their breakpoint positions on chromosome 15 still suggest the involvement of the PML gene. (lu.se)
  • The engineered cells are then infused back into the patient, primed to hunt down the leukemia cells. (911families.org)
  • The therapy comprises of T-cells genetically modified by lentiviral transduction to express TCR targeting the leukemia-associated minor H antigen, HA-1 and is administered as an intravenous infusion. (globaldata.com)
  • We compared the effects of anti-inflammatory glucocorticoids on the expression of chemokine genes in HMC-1 to their effects in activated T-cells. (duke.edu)
  • They found that up to 20 percent of people aged 50 to 60, and more than 70 percent of people older than 90, have blood cells with the same gene changes seen in leukemia. (blogspot.com)
  • Leukemia results from the gradual accumulation of DNA mutations in blood stem cells, in a process that can take decades," McKerrell explained. (blogspot.com)
  • Signaling pathways governing the behaviors of leukemia stem cells. (bvsalud.org)
  • These mRNAs were detected in human leukemia cells, CMK, K562 and HEL, which have megakaryocytic phenotype or the potency to differentiate into megakaryocytic lineage. (elsevierpure.com)
  • We used microarray to analyze differential gene expression in the white blood cells (WBC) from 7 patients diagnosed with occupational benzene poisoning compared with 7 matched controls. (cdc.gov)
  • CYP4F3 was also induced in cultured promyolocytic leukemia cells (HL-60) by a benzene metabolite, phenol , similarly to all-trans retinoic acid (ATRA). (cdc.gov)
  • Multiple-gated acquisition (MUGA) scans or echocardiograms are needed when the diagnosis of ALL is confirmed, because almost all treatment regimens for acute leukemia include anthracyclines (eg, daunorubicin, doxorubicin), which are potentially cardiotoxic. (medscape.com)
  • Dr. Zhu Chen, Dr. Anne Dejean and Dr. Hugues de Thé will be awarded the Sjöberg Prize 2018 for their work on how acute promyelocytic leukemia (APL) could be cured based on arsenic and retinoic acid. (ehaweb.org)
  • Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care. (ox.ac.uk)
  • They defined a small core network of about 60 direct AML1-ETO-regulated genes , including mediators of myeloid differentiation and cell fate decisions. (vumc.org)