In 1932, Paul and Bunnell discovered that serum from symptomatic patients had antibodies that agglutinate the red blood cells (RBCs) of unrelated species, the "heterophile antibodies. (medscape.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Species2
Antigens that exist in alternative (allelic) forms in a single species. (lookformedical.com)
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
A new histo-blood group system was discovered, based on the identification of Forssman glycolipid antigen on human red blood cells. (ashpublications.org)
Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
In analogy with histo-blood group A antigen, Forssman (Fs) antigen terminates with α3- N -acetylgalactosamine and can be used by pathogens as a host receptor in many mammals. (ashpublications.org)
Forms2
Some evidence confirms the paradoxical beneficial role of harmful antigens when used in highly diluted forms. (openaccesspub.org)
In this experiment, we observed cytokine gene expression changes in Gallus gallus embryo after challenge with Delta SARS-CoV-2 RBD spike protein antigen, from a concentration of 10 µg/mL to a series of highly diluted forms in ethanol, along with controls. (openaccesspub.org)
Individuals1
The Fs synthase gene, GBGT1 , in A pae individuals encoded an arginine to glutamine change at residue 296. (ashpublications.org)
Determinants1
It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. (lookformedical.com)
Hapten1
A measure of the binding strength between antibody and a simple hapten or antigen determinant. (lookformedical.com)
Antibody3
Antigen is a substances usually protein in nature and sometimes polysaccharide, that generates a specific immune response and induces the formation of a specific antibody or specially sensitized T cells or both. (microbiologyinfo.com)
It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes. (lookformedical.com)
the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. (lookformedical.com)
Protein1
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes. (lookformedical.com)
Specific2
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. (lookformedical.com)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). (lookformedical.com)
Foreign2
An antigen must be a foreign substances to the animal to elicit an immune response. (microbiologyinfo.com)
They are used for transporting foreign genes into recipient cells. (lookformedical.com)
Cells3
The differences between the strains are due to the altered sequence of viral genes expressed during latent infection, which differ in their ability to transform B cells. (medscape.com)
These antigens enters the body or system and start circulating in the body fluids and trapped by the APCs (Antigen processing cells such as macrophages, dendritic cells, etc. (microbiologyinfo.com)
The endogenous antigens are processed by the macrophages which are later accepted by the cytotoxic T - cells. (microbiologyinfo.com)