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  • homeotic
  • During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. (bmj.com)
  • Cdx2
  • This study provides the first experimental evidence that Cdx2 is a tumour suppressor gene involved in cancer progression in the distal colon. (bmj.com)
  • Knockout mice for the Cdx2 gene undergo compaction, but lose the TE epithelial integrity during the late blastocyst stage. (wikipedia.org)
  • roles
  • It remains to be seen whether Dll and the Dlx genes have similar roles during the development of these organs. (biologists.org)
  • 1 2 Homeobox genes exist in a wide variety of metazoan genomes and encode sequence-specific DNA binding transcription factors that play fundamental roles in the temporal and spatial pattern formation or in the commitment of cells to specific developmental pathways. (ahajournals.org)
  • 1994 ) Roles of the GLABROUS1 and TRANSPARENT TESTA GLABRA genes in Arabidopsis trichome development. (biologists.org)
  • Gene expression and functional data lends tentative support to this hypothesis, although in many animals the roles of the genes have changed in evolution, notably the Gsx gene family which plays a role in brain (not foregut) development in vertebrates. (wikipedia.org)
  • adult
  • Amplification of each isoform by reverse transcriptase-polymerase chain reaction revealed that all of the three isoforms are expressed in fetal and adult hearts and that the homeobox-containing isoform CSX1a is most abundant. (ahajournals.org)
  • Based on recent advances in our understanding of Crx in the rodent pineal gland, we here suggest that homeobox genes play a role in adult pineal physiology both by ensuring pineal-specific Aanat expression and by facilitating cAMP response element-based circadian melatonin production. (hindawi.com)
  • amphioxus
  • The analysis reveals not only the repertoire of amphioxus homeobox genes but also gives insight into the evolution of chordate homeobox genes. (springer.com)
  • These genes were first shown to be arranged into a physically-linked chromosomal cluster in amphioxus, an invertebrate with a single member of each of the three gene families. (wikipedia.org)
  • processes
  • The cardiovascular system undergoes extensive remodeling during embryogenesis and disease states such as atherosclerosis and tumor-induced angiogenesis, and homeobox genes may play an important role in regulating these processes. (ahajournals.org)
  • Recently, homeobox genes have been detected in both vascular smooth muscle and endothelial cells, and they are implicated in pathological processes such as arterial restenosis after balloon angioplasty and tumor-induced angiogenesis. (ahajournals.org)
  • Homeobox genes encode a large group of transcription factors involved in developmental processes throughout the animal kingdom [ 1 ]. (hindawi.com)
  • In the pineal gland, a number of homeobox genes control developmental processes. (hindawi.com)
  • HOX gene dysregulation can also affect biological processes such as apoptosis, proliferation, and signal transduction during oncogenesis. (qiagen.com)
  • murine
  • The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. (sciencemag.org)
  • common ancestor
  • The actual function of these genes can be very different in diverse animals, reflecting divergent evolution from the proposed common ancestor to extant species. (biologists.org)