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  • Mammals
  • The data generated from these phylogenetically informative species are consistent with the evolution of imprinting about 150 million years ago in a common ancestor to Therian mammals (i.e. (wikipedia.org)
  • embryos
  • Publications] T.KANEKO-ISHINO el al: 'Genes differentially expressed between fertilized and parthenogenetic embryos in the mouse. (nii.ac.jp)
  • Right after fertilization, embryos at the earliest stages of development tell their genes: "Forget what it was like in the sperm or egg where you came from. (phys.org)
  • traits
  • Membro dell'Advisory Board del Centro di Eccellenza "Center of Excellence in Genomic and Biotechnology for Improving Functional Traits in Farm Animals and Theirs Products" dell'Accademia delle Scienze Polacca, (VI programma quadro dalla Comunit√† Europea). (unite.it)
  • Intralocus sexual conflict occurs because many phenotypic traits are determined by a common set of genes which are found in both male and female individuals. (wikipedia.org)
  • In other words, sex-limited genes cause the two sexes to show different traits or phenotypes, despite having the same genotype. (wikipedia.org)
  • genome
  • Ferguson-Smith, A.C. Epigenetic Control of the Genome-Lessons from Genomic Imprinting. (mdpi.com)
  • These discoveries have completely changed the classical view of the central dogma of molecular biology, as we now understand that protein coding genes account for less than 2 % of human genome, however, the vast majority of the genome is transcribed (Clark et al. (springer.com)
  • Human ASCL2 genome location and ASCL2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Jirtle has contributed to the better understanding of these human conditions by identifying novel imprinted genes, either by biochemical analysis of individual genes or by genome-wide studies that used machine learning-based approaches to predict candidate imprinted genes, followed by biochemical examination of these candidates. (wikipedia.org)
  • Candidate genes and susceptibility alleles for autism are identified using a combination of techniques, including genome-wide and targeted analyses of allele sharing in sib-pairs, using association studies and transmission disequilibrium testing (TDT) of functional and/or positional candidate genes and examination of novel and recurrent cytogenetic aberrations. (wikipedia.org)
  • genomes
  • Now, 48 years later, advancements in genomic technologies have enabled scientists to study genomes, transcriptomes, and proteomes, on an unprecedented and high-throughput scale, and even at the single cell resolution. (springer.com)
  • regulation
  • Thus, differentiation of ESCs recapitulates the earliest stages of human development, and understanding the gene regulatory networks in these cells will enhance our knowledge of the regulation of the earliest stages of development. (biomedcentral.com)
  • The insulin-like growth factor-1 is a growth hormone whose fetal form is encoded by a gene with a rather interesting regulation. (neatorama.com)
  • This paper is classified as a 'Highly Cited Paper' in Essential Science Indicators from Thomson Reuters, and was one of the key papers in ScienceWatch's Special Topics Research Front Map on Epigenetic Gene Regulation (2009). (wikipedia.org)
  • phenotypic
  • Sex-limited genes are responsible for sexual dimorphism, which is a phenotypic (directly observable) difference between males and females of the same species. (wikipedia.org)
  • mice
  • These mice have functioning KDM1A later on in development, because they inherit a good copy of the gene from their fathers," Macfarlan says. (phys.org)
  • Studies in mice suggest that disruption of the RTL1 concentration, whether increasing or decreasing the amount of this protein coding gene, can lead to serious errors in the conservation of placental fetal capillaries. (wikipedia.org)
  • single gene
  • Much of the amazing variation in size of different breeds of domestic dogs stems from tiny differences in a single gene, say researchers. (neatorama.com)
  • mouse
  • Publications] F.ISHINO et al: 'Screening of imprinting in the mouse. (nii.ac.jp)
  • Publications] F.Ishino et al: 'Screening of imprinting genes in the mouse' Abstracts in The Eighth International Conference of the International Society of Differentiation Hiroshima. (nii.ac.jp)
  • They teamed up with Todd MacFarlan, PhD, previously at the Salk Institute and now at the National Institute of Child Health and Human Development, to examine several mouse strains with alterations in the KDM1A gene. (phys.org)
  • Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth. (wikipedia.org)
  • Jirtle is noted for his research on genomic imprinting, and for his use of the Agouti mouse model to investigate the effect of environmental agents on the mammalian epigenome and disease susceptibility. (wikipedia.org)
  • protein
  • Menin, the product of the MEN1 gene, is a nuclear protein. (springer.com)
  • Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis protein nm23. (springer.com)
  • This false receptor is encoded by a gene that is indistinguishable from a sugar binding protein. (neatorama.com)
  • The function of this nonprotein-coding RNA (or noncoding RNA) is mostly obscure, despite a larger number of noncoding genes than protein-coding genes. (jci.org)
  • The SDHD gene produces a 17 kDa protein composed of 159 amino acids. (wikipedia.org)
  • The SDHD gene variants associated with Cowden syndrome and Cowden-like syndrome change single amino acids in the SDHD protein, which likely alters the function of the SDH enzyme. (wikipedia.org)
  • maternally
  • Conversely, when the false receptor is inherited from the father, it is inactive, while the maternally-inherited gene is active. (neatorama.com)
  • The Grb10 gene is expressed from the maternally-inherited copy in most fetal tissues outside of the central nervous system and we have shown that it acts to inhibit growth of both the embryo and placenta. (bath.ac.uk)
  • parental
  • The identification of parental fibroblast cells and produced iPSCs was TNF-alpha verified by high res HLA keying in (Supplementary Desk S2) and the current presence of the three-base set deletion in exon 4 from the gene in AS_?3 iPSCs was verified by sequencing (Supplementary Fig. S1). (researchreportone.com)
  • Imprinted genes behave unusually in that they are expressed predominantly, if not exclusively, from only one of their two parental copies. (bath.ac.uk)