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  • genome
  • On an average, 17% of predicted protein-coding genes of any particular Prevotella genome represent the conserved core genes, while the remaining 83% contribute to the flexible and singletons. (nih.gov)
  • single nucleotide po
  • P. Farnia, J. Ghanavi, P. Tabasri, S. Saif, and A. A. Velayati, "The importance of single nucleotide polymorphisms in interferon gamma receptor-1 gene in pulmonary patients infected with rapid grower mycobacterium," International Journal of Mycobacteriology , vol. 5, Supplement 1, pp. (hindawi.com)
  • Frequencies of single-nucleotide polymorphisms of SLCO1A2, SLCO1B3 and SLCO2B1 genes in a Finnish population. (nih.gov)
  • The aim of the study was to investigate the frequencies of single-nucleotide polymorphisms (SNP) of SLCO1A2, SLCO1B3 and SLCO2B1 in a Finnish population. (nih.gov)
  • genotype
  • This Demonstration allows you to adjust the values of the fitness coefficients (drag their sliders to the right to improve the fitness of a genotype), and to adjust the initial frequency of the A allele in the gene pool (vertical slider). (wolfram.com)
  • When the sampling strategy favoured a particular genotype, unsurprisingly the estimate of gene frequency was biased towards the allele favoured. (unl.edu)
  • Frequency of Factor V Leiden G/A genotype in patients with DVT 7 (11.6%) had a significant association for DVT χ2 (OR = 5.1, P = 0.03). (deepdyve.com)
  • strains
  • The restriction map of the gvpA gene region in class I mutants is unchanged but the gene copy number is reduced compared to the Vac + strains. (pnas.org)
  • The main goal of this study was to identify virulence genes of ETEC, verotoxigenic (VTEC) and PEPEC in intestinal strains responsible for swine diseases, by molecular typing using PCR in newborn piglets from an intensive farm system. (engormix.com)
  • Of all E. coli strains studied, 19.51 % carried at least one virulence gene. (engormix.com)
  • The objective of this study was to identify genes encoding virulence factors causing intestinal disease in swine, in possible ETEC, VTEC and PEPEC strains by molecular typing using PCR in newborn piglets in an Argentine intensive farm system. (engormix.com)
  • The horizontal axis shows the percentage frequency of genes involved in respective pathways, while the strains are located on vertical axis. (nih.gov)
  • recessive
  • The article presents a case series of eight patients with autosomal recessive Parkinson's disease (PD), in whom Parkin gene mutation carriers were observed with isolated limb dystonia as the feature of their disorder that lasted for years before the development of symptoms. (ebscohost.com)
  • genetic
  • In the following pages you will examine other ways a population might change through gene flow, genetic drift, the founder effect and genetic bottlenecks. (docplayer.net)
  • Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis," Gene , vol. 543, no. 1, pp. 140-144, 2014. (hindawi.com)
  • Susceptibility to pulmonary tuberculosis: host genetic deficiency in tumor necrosis factor alpha (TNF-α) gene and tumor necrosis factor receptor 2 (TNFR2)," International Journal of Mycobacteriology , vol. 5, Supplement 1, pp. (hindawi.com)
  • We show that gene copy-number changes are a common class of adaptive genetic change. (biomedcentral.com)
  • Ohno [ 1 ] theorized that newly duplicated genes were freed from the constraints of natural selection, implicating a dominant role of genetic drift in their early evolutionary dynamics. (biomedcentral.com)
  • It is indisputable that normal infants of any genetic makeup can learn the language(s) they are exposed to in the first years of life, so we can assume with considerable confidence that there are no "genes for Chinese. (pnas.org)
  • Distribution of various functional COG categories differs significantly among the habitat-specific genes.Prevotella genomes derived from different body sites differ appreciably in gene repertoire, suggesting that these microbiome components might have developed distinct genetic strategies for niche adaptation within the host.Each individual microbe might also have a component of its own genetic machinery for host adaptation, as appeared from the huge number of singletons. (nih.gov)
  • Prevotella genomes derived from different body sites differ appreciably in gene repertoire, suggesting that these microbiome components might have developed distinct genetic strategies for niche adaptation within the host. (nih.gov)
  • mutation
  • A mutation is caused by a unexpected change in the gene frequency. (glogster.com)
  • Chromosomal instability and mutation of the K- ras proto-oncogene and the p53 suppressor gene are common. (aacrjournals.org)
  • Western diet characterized by high calories, fat, refined carbohydrates, and animal proteins is associated with p53 mutation and overexpression of the gene product ( 13 , 16 , 17 ). (aacrjournals.org)
  • To investigate the mechanism of this mutation, we recently cloned a plasmid-encoded gas vesicle protein gene, gvpA , from H. halobium . (pnas.org)
  • To investigate the intrinsic mutation frequency and substitution bias of SHMs at the amino acid level, we analyzed functional human antibody repertoires and developed mGSSP (method for gene-specific substitution profile), a method to construct amino acid substitution profiles from next-generation sequencing-determined B cell transcripts. (frontiersin.org)
  • High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. (bioinformatics.org)
  • protein
  • Recently, large scale gene expression profiling identified candidate alcohol responsive genes in human brains [ 6 - 10 ], including genes that encode proteins involved in myelination, neurodegeneration, protein trafficking as well as calcium, cAMP, and thyroid signaling pathways. (biomedcentral.com)
  • 1 The LIM-only gene LMO2 encodes a protein that participates in a transcription factor complex, which includes E2A, GATA1 , and LDB1 , TAL1. (haematologica.org)
  • High
  • We observed that wild-type C. glabrata exposed to fluconazole in a medium containing the drug at 50 μg/ml developed resistance to this agent and other azoles at a surprisingly high frequency (2 × 10 −4 to 4 × 10 −4 ). (asm.org)
  • We show here that this high-frequency azole resistance (HFAR) acquired in vitro was due, at least in part, to the upregulation of CgCDR1 . (asm.org)
  • High-frequency representation of a single VH gene in the expressed human B cell repertoire. (rupress.org)
  • The high frequency of VH18/2 expression in the B cell repertoire was confirmed by sequencing randomly picked JH+ plaques. (rupress.org)
  • Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. (edu.au)
  • In conclusion, non-synonymous sequence variations of SLCO1A2, SLCO1B3 and SLCO2B1 occur at high frequencies in the Finnish population. (nih.gov)
  • The purpose of this study is to clarify the biologic actions of extremely low-frequency (ELF) alternate-current (AC) high magnetic fields, especially their effects on gene functions including DNA replication, repair and transcription. (nii.ac.jp)
  • hereditary
  • Ibrahim, Ibrahim M 2017-05-10 00:00:00 AbstractThrombophilia may be anticipated by single or combined hereditary defects in encoding genes factor V, Prothrombin, and MTHFR. (deepdyve.com)
  • significantly
  • Distribution of various functional COG categories differs significantly among the habitat-specific genes. (nih.gov)
  • expression
  • Using time-lapse microscopy, we found that Crz1 exhibited short bursts of nuclear localization (~2 minutes) that occurred stochastically in individual cells and propagated to the expression of downstream genes. (pubmedcentralcanada.ca)
  • Using an analytic model, we found that this frequency modulation (FM) of bursts ensures proportional expression of multiple target genes across a wide dynamic range of expression levels, independent of promoter characteristics. (pubmedcentralcanada.ca)
  • Cells sense extracellular signals and respond by regulating the expression of target genes 1 , 2 , 3 . (pubmedcentralcanada.ca)
  • Second, transcription factors activate the expression of downstream genes that will implement cellular responses 1 , 2 , 3 . (pubmedcentralcanada.ca)
  • But it is not known in general how the expression levels of target genes are coordinated, allowing them to be regulated together, despite diverse promoter architectures 3 . (pubmedcentralcanada.ca)
  • We find that Crz1 dynamics connect the encoding of signals and the coordination of target gene expression. (pubmedcentralcanada.ca)
  • 14q11) loci with a variety of oncogenic transcription factors, such as LIM-only domain ( LMO ) genes, LMO1 and LMO2 resulting in their aberrant expression. (haematologica.org)
  • Caenorhabditis
  • Publications] Ogawa, H.: 'Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin'J. (nii.ac.jp)
  • resistance
  • Deletion of CgCDR1 in C. glabrata rendered the null mutant hypersusceptible to azole derivatives and showed the importance of this gene in mediating azole resistance. (asm.org)
  • Deletion of both CgCDR1 and CgCDR2 suppressed the development of HFAR in a medium containing fluconazole at 5 μg/ml, showing that both genes are important mediators of resistance to azole derivatives in C. glabrata . (asm.org)
  • population
  • Predicting population gene frequency from sample data" by R. M. Lewis, B. Grundy et al. (unl.edu)
  • Those strategies in part depend on the frequency of a favoured allele in a population. (unl.edu)
  • Since comprehensive genotyping of a population is seldom possible, we investigate the consequences of sampling strategies on the reliability of the gene frequency estimate for a bi-allelic locus. (unl.edu)
  • With random sampling, even when a small proportion of a line was genotyped (0·10), the gene frequency of the population was well estimated from the across-line mean. (unl.edu)
  • In using probable genotypes the bias was lessened but the estimate of gene frequency still reflected the sampling strategy rather than the true population frequency. (unl.edu)
  • When sampling was confined to a few clustered years, the estimation of gene frequency was biased for those generations preceding the sampling event, particularly when the presumed starting gene frequency differed from the true population gene frequency. (unl.edu)
  • The stock of different genes in an interbreeding population. (glogster.com)
  • Drastic drops in population can lead to random changes in a species gene pool. (glogster.com)
  • change in the gene frequency population attributable to chance alone. (coursehero.com)
  • changes
  • This suggests the types and frequencies, or mutational space, of a majority of amino acid changes sampled by the SHM machinery to be well captured by GSSPs. (frontiersin.org)
  • repertoire
  • These results show that VH18/2 is overrepresented in the B cell repertoire of normal subjects and suggest that the immune repertoire may be dominated by relatively few V genes. (rupress.org)
  • Divergences in gene repertoire among the reference Prevotella genomes derived from distinct body sites of human. (nih.gov)
  • The present report aims to explore, as a case study, the variations in gene repertoire of 28 Prevotella reference genomes derived from different body-sites of human, as reported earlier by the Human Microbiome Consortium. (nih.gov)
  • studies
  • Studies of such correlations usually consider allele frequencies and linguistic groupings (dialects, languages, linguistic families or phyla), sometimes controlling for geographic, topographic, or ecological factors. (pnas.org)
  • interactions
  • Also, the residual sums of squares, due to deviations from the linear trend, were significant for some crosses due to frequency-dependent selection and genotypic interactions. (csic.es)
  • stable
  • And in the case of heterozygous advantage (when the Aa fitness coefficient is 100% and the others are less), a stable limiting value for the frequency of A will manifest itself (Snapshot 3). (wolfram.com)
  • This is a repelling (rather than attracting) stable value for the allele frequencies. (wolfram.com)
  • Class III mutants are stable Vac - derivatives of either the wild-type or class I mutants and have no detectable copies of the gvpA gene. (pnas.org)
  • selection
  • The latter is expected if larger CNVs are more likely to encompass genes under selection for a change in gene dosage. (biomedcentral.com)
  • GSSPs can also be used for predicting the amino acid mutational space available for antigen-driven selection and for understanding factors modulating the maturation pathways of antibody lineages in a gene-specific context. (frontiersin.org)
  • Specifically, we focus on the derived haplogroups of the brain growth and development-related genes ASPM and Microcephalin , which show signs of natural selection and a marked geographic structure, and on linguistic tone, the use of voice pitch to convey lexical or grammatical distinctions. (pnas.org)
  • clinical
  • We recently showed that the ATP-binding-cassette (ABC) transporter gene CgCDR1 was upregulated in C. glabrata clinical isolates resistant to azole antifungal agents (D. Sanglard, F. Ischer, D. Calabrese, P. A. Majcherczyk, and J. Bille, Antimicrob. (asm.org)
  • vitro
  • Butters JT, Figueroa XA, Butters BM (2014) Non-thermal radio frequency stimulation of tubulin polymerization in vitro: a potential therapy for cancer treatment. (springer.com)