• The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein. (lu.se)
  • Treatment of leukemic K562 cells with cytarabine upregulated IRF8 protein and mRNA, which was correlated to increased expression of ZNF224. (lu.se)
  • Knock down of ZNF224 with shRNA suppressed both basal and cytarabine-induced IRF8 expression. (lu.se)
  • Some miRNAs modulate expression of known oncogenes or tumour suppressor genes whereas others function as so called onco-miRs or tumour-suppressor-miRs. (uni-luebeck.de)
  • These characteristics are caused by altered gene expression, as a result of genetic mutations that inactivate tumour suppressor genes and / or activate oncogenes. (savedelicious.com)
  • And indeed, different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1. (uni-luebeck.de)
  • Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
  • The present invention relates to methods, kits and systems for predicting the benefit from inclusion of taxane in a chemotherapy regimen based on the measurements of gene expression levels in tumor samples of breast cancer patients. (justia.com)
  • More over, since most tumor specimens Decitabine Antimetabolites inhibitor and tumor derived cell lines utilized in these investigations have now been ovarian SACs, the position of mTOR in CCC remains largely as yet not known. (deubiquitinase.com)
  • Just like the well-known tumor suppressor gene Phosphatase and Tensin Homolog (PTEN) it hydrolyses phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3). (oncotarget.com)
  • The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. (lu.se)
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • However, this expression depends on a preliminary DNA replication that occurs normally between 21 h and 31 h following activation at 18°C. Thus, the gene for DNA-ligase I is overtly expressed at the 1-cell stage. (silverchair.com)
  • In the same cytoplasmic environment, and following egg activation and DNA replication, the gene for DNA-ligase I introduced by the male pronucleus is unable to direct any production of the corresponding enzyme. (silverchair.com)
  • CCC may be a good candidate for therapy with a mTOR inhibitor, as it is well known that loss of PTEN expression and consequent activation of AKT signaling end in hypersensitivity to mTOR inhibition. (deubiquitinase.com)
  • Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
  • They regulate gene expression at the post-transcriptional level and control thereby cellular mechanisms including developmental transitions, organ morphology, apoptosis and cell proliferation. (uni-luebeck.de)
  • Another cellular enzyme, RNAse L-also induced by interferon action-destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. (wikipedia.org)
  • Defining the GR-cistrome identified Gc regulation of motility genes. (ox.ac.uk)
  • The heterodimer binds to vitamin D response element in target genes and leads to gene transcription regulation ( 1 ). (jcancer.org)
  • In addition, calcitriol has rapid effects that are independent of gene transcription regulation, which are defined as non-genomic effects and not mediated directly through steroid receptor-ligand-DNA interaction. (jcancer.org)
  • On the other hand, non-genomic actions may indirectly affect gene transcription via the regulation of intracellular signaling pathways that target transcription factors ( 3 ). (jcancer.org)
  • Multidrug resistance, generally, results from over expression of ATP-dependent efflux pumps [5]. (savedelicious.com)
  • Lack of sequence information makes harnessing the diversity of disease resistance (R) genes in wild crops highly challenging. (plantae.org)
  • report AgRenSeq, a reference genome-free technique, for rapid cloning of nucleotide binding/Leucine-rich repeat (NLR) resistance genes from wild crops. (plantae.org)
  • Then, the prognostic model and the expression levels of the three genes were validated using the dataset from GEO. (biomedcentral.com)
  • We applied our proprietary RADR® platform to an NCI-60 discovery dataset encompassing LP-184 IC50s and publicly available gene expression data. (biomedcentral.com)
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells. (wikipedia.org)
  • Dr. Ho did her PhD work in herpesvirus pathogenesis and postdoctoral research in CNS gene therapy with viral vectors at Stanford University. (stanford.edu)
  • A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
  • it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
  • The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. (lu.se)
  • More than twenty distinct IFN genes and proteins have been identified in animals, including humans. (wikipedia.org)
  • Two distinct subtypes of LIHC were identified based on cuproptosis-related genes, with different prognosis and immune characteristics. (biomedcentral.com)
  • Using R gene enrichment sequencing, the authors captured thousands of NLR-specific contigs from 151 distinct accessions of Aegilops taushii , a wild relative of bread wheat. (plantae.org)
  • However, emerging evidence suggests that the lipid phosphatase SH2-domain-containing 5 inositol phosphatase (SHIP2), encoded by the INPPL1 gene, may act as an oncogene. (oncotarget.com)
  • Oncogene: A gene with the potential to cause cancer. (pvpharma.com)
  • Proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression. (pvpharma.com)
  • In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
  • It has been noted that lack of PTEN expression is widespread in CCC of the ovary. (deubiquitinase.com)
  • Gene technology-based antimetabolite design: The use of an in vitro protein expression system to facilitate antimetabolite design for virally-induced human diseases and malignant conditions. (ntu.ac.uk)
  • Together, these data indicate that SHIP2 expression contributes to the malignant potential of colorectal cancer, providing a possible target in the fight against this devastating disease. (oncotarget.com)
  • An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
  • Once released, type I interferons bind to specific receptors on target cells, which leads to expression of proteins that will prevent the virus from producing and replicating its RNA and DNA. (wikipedia.org)
  • GR enhanced differentiation of a newly defined proliferative mesenchymal progenitor cell (PMP) into matrix fibroblasts (MFBs), in part by directly activating extracellular matrix-associated target genes, including Fn1, Col16a4, and Eln and by modulating VEGF, JAK-STAT, and WNT signaling. (stanford.edu)
  • During aging, a subset of AT2 cells expressing the canonical Wnt target gene, Axin2, function as stem cells, renewing themselves while generating new AT1 and AT2 cells. (stanford.edu)
  • Precision Health Diagnostic and Surveillance Network uses S Gene Target Failure (SGTF) combined with sequencing technologies to identify emerging SARS-CoV-2 variants. (cdc.gov)
  • There is increasing interest in an association between miRNA expression in tumours and chemo- and radiosensitivity, both with regards to predicting or modulating sensitivity. (uni-luebeck.de)
  • Spheroids were studied morphologically, electron microscopically and by qRT-PCR for selected matrix genes, related factors and miRNA. (biomedcentral.com)
  • Features associated to the 3D cell model are increased expression of matrix proteins and miRNA as well as stromal markers such as PPP1R1B and SNED1. (biomedcentral.com)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. (lookformedical.com)
  • We then extracted the expression of cuproptosis-related genes and established a prognostic model by lasso cox regression analysis. (biomedcentral.com)
  • Using lasso cox regression analysis, we developed a prognostic risk model based on three cuproptosis-related genes (GCSH, LIPT1 and CDKN2A). (biomedcentral.com)
  • We used multiple feature selection layers followed by the XGBoost regression model and reduced the complexity of 20,000 gene expression values to generate a 16-gene signature leading to the identification of a set of predictive candidate biomarkers which form an LP-184 response gene signature. (biomedcentral.com)
  • We found that SHIP2 and INPPL1 expression is increased in colorectal cancer tissue in comparison to adjacent normal tissue, and this is correlated with decreased patient survival. (oncotarget.com)
  • IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages, and they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (MHC) antigens. (wikipedia.org)
  • Poor humoral response was persistently associated with use of antimetabolite immunosuppression. (cdc.gov)
  • Machine learning can be used to reduce the complexity of whole genome gene expression patterns to derive manageable signatures of response. (biomedcentral.com)
  • It leads to decreased expression of IL-3, IL-4, IL-5, and TNFα, and it inhibits mast cell and neutrophil activation. (medscape.com)
  • The paper highlights the untapped potential of scRNA-seq to provide gene expression at single cell resolution which could be applied to other species and plant organs (Summary by Alex Bowles ) Plant Physiology 10.1104/pp.18.01482 . (plantae.org)
  • Deletion of the glucocorticoid receptor gene (Nr3c1) from fetal pulmonary mesenchymal cells phenocopied defects caused by global Nr3c1 deletion, while lung epithelial- or endothelial-specific Nr3c1 deletion did not impair lung function at birth. (stanford.edu)
  • Open data on the gene expression of the NCI-60 cell lines, provides a unique opportunity to add another dimension to the preclinical development of such drugs by interrogating correlations with gene expression patterns. (biomedcentral.com)
  • Haploid androgenetic axolotl embryos develop devoid of the 8S DNA-ligase characteristic of control embryos ( Fig. 1A,B ). The paternal gene for DNA-ligase I is in a repressed state. (silverchair.com)
  • We integrated genome-wide gene expression profiling, ATAC-seq, and single cell RNA-seq data in mice in which GR was deleted or activated to identify the cellular and molecular mechanisms by which glucocorticoids control prenatal lung maturation. (stanford.edu)
  • Consequently, the protected colons showed lower IL-12, IL-1β expression, and decreased interferon-γ levels. (nature.com)
  • Analysis of single cell transcriptomic profiles reveals that gene expression from all root tissues are identified improving insights into cell-type differentiation. (plantae.org)
  • From a functional genomics perspective, the sequence information provides direct access to the genes responsible for the trait-of-interest, which could be used in developing transgenics. (plantae.org)
  • It functions as a transcriptional activator for the INTERFERON TYPE I genes. (lookformedical.com)
  • Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress. (cdc.gov)