Genes gene expression. Medical search. Frequent questions

The two expression profile datasets were integrated and we found out coexpression of differentially expressed genes (DEGs) using bioinformatics methods. (hindawi.com)
With the development of the gene expression profile, comparisons of differentially expressed genes that participate in the regulation of pathophysiological conditions in pathological tissue and normal tissue were available and convenient, and mRNAs gene expression profiles have been carried out in many diseases including TAD [ 6 ]. (hindawi.com)
Then we downloaded another microarray dataset GSE52093 [ 9 ] and screened out the coexpression of differentially expressed genes (DEGs) between TAD patients and non-TAD patients. (hindawi.com)
DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. (pharmiweb.com)
After identifying Differentially Expressed Genes (DEGs), we delve deeper into their functional significance. (pharmiweb.com)
Because of the recent development of new methods (especially microarrays) for identifying differentially expressed genes, a burst of research on caste differentiation is predicted. (europa.eu)
The mHTT and wtHTT groups showed the highest number of differentially expressed genes compared to the BACHD mouse model. (lu.se)
In BACHD mice, few hypothalamic genes were differentially expressed compared to age-matched WT controls. (lu.se)

Regulation of gene expression gives control over the timing, location, and amount of a given gene product (protein or ncRNA) present in a cell and can have a profound effect on the cellular structure and function. (wikipedia.org)
Regulation of gene expression is the basis for cellular differentiation, development, morphogenesis and the versatility and adaptability of any organism. (wikipedia.org)
Gene regulation may therefore serve as a substrate for evolutionary change. (wikipedia.org)
Gene regulation can occur at any point in gene expression, from the start of the transcription phase to the translation phase. (nature.com)
Due to the complexity of gene regulation, unveiling the complete mechanism of gene regulation has been a long-standing quest. (nature.com)
To elucidate the complex mechanism of gene regulation in living cellular systems, it is necessary to closely investigate each phase of gene expression and also to shed light on the cooperative effects between transcription and translation. (nature.com)
The aforementioned complex factors have made it difficult to investigate the impact of the DNA length on gene regulation, which has been an unexplored topic. (nature.com)
The molecular basis for this proposed regulation has now been investigated by adding oncotically active macromolecules to the circulation of normal or genetically albumin-deficient Nagase analbuminemic rats (NAR) and analyzing the hepatic expression of genes, including albumin after 24 h. (jci.org)
Feedback regulation of albumin gene expression by serum colloids may serve as a specific homeostatic mechanism to maintain the steady-state level of total protein in the circulation. (jci.org)
These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
In this review we discuss the current understanding of the signaling mechanisms used by TGF-beta to elicit its effects on target genes, focusing primarily on Smad proteins and their role in the transcriptional regulation of ECM gene expression. (nih.gov)
Transforming growth factor-beta (TGF-beta) plays a critical role in the regulation of extracellular matrix gene expression. (nih.gov)
Changes in expression with maze task occurred in 789 genes: up-regulation in 96 genes and down-regulation in 208 genes. (umich.edu)
In our proposed project, you would investigate expression regulation in clinically significant bacterium non-typeable Haemophilus influenzae (NTHi). (lu.se)
2022 ) Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. (lu.se)
Recent studies support a role for biotin in cell proliferation, DNA repair, epigenetic gene regulation as well as normal immune function. (medscape.com)

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype. (wikipedia.org)
These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. (wikipedia.org)
Gene expression in living cells is strictly self-regulated to ensure that the correct amounts of proteins are made at the most appropriate timing and location for maintaining cellular homeostasis. (nature.com)
Similarly, while your genes are "fixed", the expression of those genes - the amount of proteins they cause to be made, whether or not they are even switched on or off at all - depends on the "environment," the circumstances surrounding those genes . (marksdailyapple.com)
Analysis of the pattern of proteins or messenger RNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics.This typically involves the visualization of a few proteins or expressed genes at a time. (lu.se)
Applying the same criterium to the process of gene expression, which also involves many 'intermediate steps', would lead us to the conclusion that no genetic information is transmitted from genes to proteins, which is no less difficult to defend. (cyclingforums.com)
In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules. (pharmiweb.com)
Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. (nih.gov)
Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)

How to Do Differential Gene Expression Analysis? (pharmiweb.com)
Differential Gene Expression analysis is a fundamental tool for identifying genes whose expression levels significantly differ between experimental conditions or biological samples. (pharmiweb.com)
Various statistical tests, such as the negative binomial, edgeR, or DESeq2, are commonly used to assess differential gene expression. (pharmiweb.com)
We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)

Thoracic aortic dissection (TAD) is a catastrophic disease worldwide, but the pathogenic genes and pathways are largely unclear. (hindawi.com)
This study aims at integrating two gene expression profile datasets and verifying hub genes and pathways involved in TAD as well as exploring potential molecular mechanisms. (hindawi.com)
Traditional bioinformatics methods including gene ontology (GO) and pathways enrichment analyses of DEGs combined protein-protein interaction (PPI) network and cytohubber calculating software as well as Molecular Complex Detection (MCODE) analysis were used to analyze the key gene and pathway. (hindawi.com)
It is not the external stimulus per se , but the chemical output (=information) generated by processing of the stimulusin the neural circuit that via the respective signal transduction pathways reaches the genes responsible for the synthesis of melatonin, which is intelligible to (i.e. contains informatio for) activating those genes. (cyclingforums.com)
By subjecting DEGs to gene ontology enrichment analysis, pathway analysis, or functional annotation, we gain insights into the biological processes, molecular functions, and pathways associated with the observed gene expression changes. (pharmiweb.com)
In AAV groups, from the combined limma with GSEA using ClusterProfiler, we found both shared and unique gene sets and pathways for mice with wtHTT overexpression compared to mice with mHTT overexpression. (lu.se)
Multiple biosynthetic pathways such as sterol synthesis were among the top shared processes, where both unique and shared genes constituted leading-edge subsets. (lu.se)
The goal of our search was to identify publications describing the role of specific genes, gene signatures, or molecular pathways and their effects in response to environmental exposures. (cdc.gov)

In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p (cdc.gov)
In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. (cdc.gov)
Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. (cdc.gov)

With this study, we've seen thousands and thousands of genes change how they are turned on and turned off. (upi.com)
By analyzing the expression levels of thousands of genes simultaneously, researchers can identify genes that are upregulated (higher expression) or downregulated (lower expression) in one condition compared to another. (pharmiweb.com)

RNAseq of the dorsolateral prefrontal cortex and the nucleus accumbens, two brain areas strongly associated with addiction pathophysiology, showed that certain genes were expressed differently in people with OUD compared to controls. (eurekalert.org)
For example, if a disease increased the activity of certain genes, the program tried to match it with one or more drugs that decreased the activity of those genes. (sciencedaily.com)

0.05), and these candidate genes could be used as potential diagnostic biomarkers and therapeutic targets of TAD. (hindawi.com)
We picked up 12 candidate genes in conjunction with the memory. (umich.edu)

They created a computer program to search through the thousands of possible drug-disease combinations to find drugs and diseases whose gene expression patterns essentially cancelled each other out. (sciencedaily.com)
Using samples from 1,856 meningioma patients at 12 medical centers in the U.S., Europe and Hong Kong, Raleigh's team came up with a set of 34 genes whose gene expression patterns had the potential to predict whether a tumor would return. (ucsf.edu)

Spatial transcriptomics provides quantitative gene expression data and visualization of the distribution of mRNAs within tissue sections and enables novel types of bioinformatics analyses, valuable in research and diagnostics. (lu.se)
We will combine our mRNAs expression profile (6 TAD tissues versus 6 non-TAD tissues) and GSE52093 downloaded from the Gene Expression Omnibus (GEO) database. (hindawi.com)
The two mRNAs expression profiles contained 13 TAD aortic tissues and 11 non-TAD tissues. (hindawi.com)
They can bind to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs) in order to regulate gene expression post-transcriptionally with no sequence specificity but by potential electrostatic interactions with the phosphate backbone of RNA 2 , 3 . (nature.com)
and reduced expression of mRNAs encoding major coho odorant receptors (ORs). (cdc.gov)

In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, i.e. observable trait. (wikipedia.org)
Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast. (broadinstitute.org)

Intravenous infusion of albumin into normal rats also decreased transcriptional activity of the albumin gene by 50-60%, and this decrease correlated with changes in serum colloid osmotic pressure after albumin infusion. (jci.org)
In this study, we investigated whether hypothalamic HTT expression causes transcriptional changes. (lu.se)

To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
Within a quantitative genetic framework, we sequenced RNA from Drosophila melanogaster at different developmental stages to examine sex-biased gene expression and how selection acts upon it. (biorxiv.org)
We found evidence that gene expression is constrained by both univariate and multivariate shared genetic variation between genes, sexes and developmental stages, but may be resolved by differential splicing. (biorxiv.org)
Genomic imprinting is the differential expression of genetic material depending on whether it has been inherited from the father or mother. (msdmanuals.com)
WGCNA was utilized to establish a genetic network and categorize genes into diverse modules. (bvsalud.org)
More than half (23 of 39) of the articles represent epidemiologic studies including candidate gene and genome-wide association studies (GWAS) examining genetic effect modification on disease risk. (cdc.gov)

Many studies have investigated the determining factors that affect gene expression. (nature.com)
Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
Many factors can affect gene expression (and thus phenotypes). (msdmanuals.com)

The gene ontology and pathway enrichment of DEGs were performed by DAVID and Kyoto Encyclopedia of Genes and Genomes online analyses, respectively. (hindawi.com)

The scientists drew their data from the NIH National Center for Biotechnology Information Gene Expression Omnibus, a publicly available database that contains the results of thousands of genomic studies on a wide range of topics, submitted by researchers across the globe. (sciencedaily.com)
The micro-array data of 13 inflamed pulp and 11 normal pulp were acquired from Gene Expression Omnibus (GEO). (bvsalud.org)

Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
The early findings suggest space travel boosts methylation, the process of switching genes on and off. (upi.com)

To identify differing patterns of gene expression, they used RNA sequencing (RNAseq), a technique that reflects how strongly genes are being expressed in a given tissue. (eurekalert.org)
Identifying caste-specific patterns of gene expression thus offers a special opportunity to study the generation of adaptive morphological variation by a fundamental biological process, and is the key to profound understanding of the evolution of sociality. (europa.eu)
Now, researchers at UC San Francisco and Northwestern Medicine, in collaboration with 10 other medical centers, have found a highly accurate way to predict the best treatment for patients based on patterns of gene expression - which genes are turned on and off - in their tumors. (ucsf.edu)

This alignment process enables the determination of the origin of each read, allowing us to associate it with specific genes or genomic regions. (pharmiweb.com)

With RNA-seq , we can capture and quantify the abundance of transcripts, revealing the dynamic landscape of gene expression within a cell or tissue. (pharmiweb.com)
By comparing gene expression patterns during embryogenesis or tissue differentiation, we unravel the molecular events that shape organisms, advancing our understanding of developmental biology. (pharmiweb.com)

Gene-expression tests like this, that analyze a small number of genes at a time, are widely available for breast, prostate and some other cancers, and they've proven to be a very accurate and inexpensive alternative to other types of tests," said Chen. (ucsf.edu)
To analyze microarray datasets (34760 variables) and obtain functional implications of differential expression patterns, we used Linear Models for Microarray Data (limma) followed by Gene Set Enrichment Analysis (GSEA) using ClusterProfiler. (lu.se)
Future studies should be clear about methods used to analyze PTSD status, as phenotypes based on PTSD symptom dimensions may yield different gene sets than combined CAPS score analysis. (cdc.gov)

Two groups of scientists, including researchers at the Max Planck Institute of Molecular Genetics in Dresden and the Max Planck Institute for Evolutionary Biology in Plön, have now succeeded in demonstrating, for the first time, that parallels exist between individual development and phylogeny on the level of gene expression. (news-medical.net)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)

assay as gene expression input. (github.com)

The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)

Research in gene expression is exploding right now and is examining both the impact of environmental factors and the promise of epigenetic therapies. (marksdailyapple.com)
Similarly, the neural circuits 'translate' the external stimulus, which is 'senseless' to genes, into a specific epigenetic information for their activation/inactivation. (cyclingforums.com)

Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. (wikipedia.org)
There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)

When studying gene expression, researchers often compare gene expression profiles between different biological samples or experimental conditions, such as healthy and diseased tissues, treated and untreated cells, or different developmental stages. (pharmiweb.com)
A similar decline in apoptotic susceptibility associated with downregulation of Apaf-1 expression as a function of developmental age was also found in cultured primary rat cortical neurons. (jneurosci.org)

The process of gene expression is used by all known life-eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses-to generate the macromolecular machinery for life. (wikipedia.org)

The external stimulus per se is neutral to any known pathway in metazoans, it can't activate any specific gene. (cyclingforums.com)
Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)

In the present study, we use mRNA microarray to acquire differential expression profiles in human TAD tissues and non-TAD tissues. (hindawi.com)
I propose to study caste-specific gene expression in the fire ant, Solenopsis invicta, with a large ( and gt;20,000 clones) spotted cDNA microarray that was recently developed, sequenced, and annotated at the prospective host institute, the group of Prof. L. Keller at the University of Lausanne. (europa.eu)
In order to identify the memory-related gene expression by behavioral test, we performed DNA microarray analysis to investigate the changes in gene expression in the hippocampus. (umich.edu)
Validation analysis was similar to the results of the microarray and the expression of Trh and Tnxa increased to about 4 and 3 times, respectively. (umich.edu)

BACHD mice with ubiquitous expression of full-length mutant HTT (mHTT) and wild-type mice with targeted hypothalamic overexpression of either wild-type HTT (wtHTT) or mHTT fragments. (lu.se)
Gene Set Enrichment Analysis (GSEA) with leading-edge analysis showed that suppressed sterol- and cholesterol metabolism were shared between hypothalamic wtHTT and mHTT overexpression. (lu.se)

In a paper appearing Nov. 9, 2023 in Nature Medicine , the team concluded that just 1 in 5 patients with low-grade tumors (those less likely to regrow) may need radiation, while around 2 in 5 with higher-grade tumors may be better off without radiation, based on the results of the new gene-expression test. (ucsf.edu)
Raleigh, along with Magill and lead author William Chen , MD, decided to look at classifying tumors according to which of their genes are turned on and off, thereby offering clues to how aggressive they might be. (ucsf.edu)

The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)
The resource catalogs changes in gene activity under various conditions, such as in diseased tissues or in response to medications. (sciencedaily.com)
Hence, this study was conducted to examine the changes in PAL activity and gene expression patterns in relation to texture in the edible branchlet tissues during early postharvest handling. (scialert.net)

Analysis of gene expression from these individuals can help in identifying biomarkers of PTSD. (cdc.gov)

This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)

This method enables the measurement of the phylogenetic age of active genes. (news-medical.net)
Based on phylogenetic and synteny analyses, this study reveals that nanos1 gene has undergone multiple duplications and gene copies losses in Vertebrates. (nature.com)

Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
In mice, the suppression of Nanos3 expression in PGC resulted in the complete loss of germ cells in both sexes 9 . (nature.com)

When you change to a diet low in sugars and rich in healthy fats, those or other genes are directed to reduce inflammatory expression, down-regulate insulin-producing metabolic machinery, up-regulate insulin receptors and rebuild cell membranes to reflect the presence of better building materials (omega 3 fatty acids, etc. (marksdailyapple.com)

Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
This analysis enables us to pinpoint genes that play pivotal roles in phenotypic variation, disease development, or response to treatments. (pharmiweb.com)

Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington's disease (HD), a neurodegenerative disorder caused by an expanded cytosine-adenine-guanine (CAG) repeat in the huntingtin (HTT) gene. (lu.se)
In contrast, the ubiquitous expression of full-length mHTT in the BACHD hypothalamus moderately affects the transcriptomic profile. (lu.se)

1 % of alleles, expression is possible only from the paternal or maternal allele. (msdmanuals.com)

Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. (broadinstitute.org)

Objectives: It has been reported that spatial learning and memory was impaired by loss of teeth, but the effect of teeth loss on the changes in gene expression was not clarified yet. (umich.edu)

AFM observation of the DNA conformation indicates that longer DNA takes shrunken conformation with a higher segment density in the reaction mixture for gene expression, in contrast to the stiff conformation of shorter DNA. (nature.com)
In contrast, Teleosts have lost nanos1A but duplicated nanos1B leading to the emergence of two ohnologs ( nanos1Ba/1Bb ), whereas Tetrapods have lost nanos1B gene. (nature.com)
In contrast, nanos1B was detected in testis with the highest expression in the germinative zone. (nature.com)

Moreover, the scientists also observed that the expression pattern of key genes reflects the hourglass model most faithfully. (news-medical.net)

Eat a diet that is high in sugar, and gene expression moves in a direction that produces more insulin, that shuts off insulin receptors, that down-regulates lipase and other enzymes involved in fat-burning, that increases pro-inflammatory cytokines, etc. (marksdailyapple.com)
Synaptic transmitter binding to receptors on melatonin secreting cells in the pineal activate genes in the cell nucleus, but that involves a whole series of intermediate steps. (cyclingforums.com)
Cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile coho salmon (Oncorhynchus kisutch). (cdc.gov)

Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)

RNA polymerase I is responsible for transcription of ribosomal RNA (rRNA) genes. (wikipedia.org)
RNA polymerase II (Pol II) transcribes all protein-coding genes but also some non-coding RNAs (e.g., snRNAs, snoRNAs or long non-coding RNAs). (wikipedia.org)
RNA polymerase III transcribes 5S rRNA, transfer RNA (tRNA) genes, and some small non-coding RNAs (e.g., 7SK). (wikipedia.org)
We propose an underlying mechanism for the favorable effect of longer DNA on gene expression in terms of the enhancement of access of RNA polymerase to the shrunken conformation. (nature.com)
Reverse transcription -quantitative polymerase chain reaction (RT-qPCR) was used for validation of hub genes . (bvsalud.org)

Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
In silico analysis of available array data showed that a large number of genes traditionally classified as PEP dependent genes are transcribed during early embryo development from the pre-globular stage to the mature-green-stage. (frontiersin.org)
The study aimed to identify pulpits related key genes by integrating micro-array data analysis and systems biology network-based methods such as weighted gene co-expression network analysis (WGCNA). (bvsalud.org)

For example, expression of the gene for insulin -like growth factor 2 is normally expressed only from the paternal allele. (msdmanuals.com)

The integrated advanced bioinformatics methods may provide a way to solve the disadvantages and identify the hub genes involved in TAD. (hindawi.com)
Statistical methods are employed to identify genes that exhibit significant changes in expression between experimental conditions. (pharmiweb.com)
Hub genes in the most associated module to pulpitis were screened out using high module group members (MM) methods . (bvsalud.org)

It is expected that the enhancement of gene expression efficiency with a shrunken DNA conformation would also be a rather general mechanism in living cellular environments. (nature.com)

RT-qPCR proved the differences in expression levels of HMOX1, LOX, ACTG1, STAT3, GNB5 in inflamed dental pulp . (bvsalud.org)
Pulp capping reversed the expression level of HMOX1, LOX, ACTG1. (bvsalud.org)

While transcription of prokaryotic protein-coding genes creates messenger RNA (mRNA) that is ready for translation into protein, transcription of eukaryotic genes leaves a primary transcript of RNA (pre-RNA), which first has to undergo a series of modifications to become a mature RNA. (wikipedia.org)
This can be achieved by counting the number of reads that align to each gene or by estimating transcript abundance using sophisticated algorithms. (pharmiweb.com)

In Vertebrates, Nanos paralogous genes were associated to partial redundancies and specific functional evolutions. (nature.com)
Pulp capping using iRoot BP plus could reverse partial hub genes . (bvsalud.org)

Light entering the eye causes genes to be expressed in specific cells. (cyclingforums.com)
DGE analysis facilitates the identification of genes responsive to specific drug treatments. (pharmiweb.com)
In teleostean fish, two nanos1 genes were generated, probably during the Teleost specific whole genome duplication (3R). (nature.com)
Injury-induced cytochrome c -specific cleavage of caspase-9 followed by activation of caspase-3 in mature brain correlated with marked increases in Apaf-1 and caspase-3 mRNA and protein expression. (jneurosci.org)
These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
assigns single-cell RNA-seq expression to cancer clones by probabilistically mapping RNA-seq to clone-specific copy number profiles using reparametrization gradient variational inference . (github.com)

Sex-limited inheritance, perhaps more correctly called sex-influenced inheritance, refers to special cases in which sex hormones and other physiologic differences between males and females alter the expressivity and penetrance of a gene. (msdmanuals.com)

Salmon OR array analysis indicated that Cd preferentially impacted expression of OST and OR markers for ciliated olfactory sensory neurons (OSNs) relative to microvillus OSNs, suggesting a differential sensitivity of these two major OSN populations. (cdc.gov)

Using bulk RNA-sequencing from whole blood, we examined the association between gene expression and WTC-related PTSD symptom severity on (i) highest lifetime Clinician-Administered PTSD Scale (CAPS) score, (ii) past-month CAPS score, and (iii) PTSD symptom dimensions using a 5-factor model of re-experiencing, avoidance, emotional numbing, dysphoric arousal and anxious arousal symptoms. (cdc.gov)

Diet, exercise, exposure to toxic chemicals (or fresh air), medicines, even the thoughts you think (which generate actual chemical signals) all influence gene expression - positively and/or negatively, depending on the choice. (marksdailyapple.com)
To explore work on gene-environment interaction (GxE) at the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR), we examined the CDC-Authored Genomics and Precision Health Publications Database (CDC-Authored GPHPD) , which includes articles published by CDC/ATSDR authors since 2011. (cdc.gov)

Anatomy26

Organisms16

Diseases4

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes101

Disciplines and Occupations4

Information Science8

Health Care3

Differentially expressed8

Regulation16

Proteins9

Differential gene expression4

Pathways8

Significantly4

Thousands of genes2

Certain genes2

Candidate genes2

Whose gene expression patterns2

MRNAs5

Genotype2

Transcriptional2

Genetic6

Affect gene expression3

Ontology1

Omnibus2

Methylation2

Patterns of gene expression3

Genomic1

Tissue2

Analyze3

Genetics2

Assay1

Phenotypes1

Epigenetic2

Molecular2

Developmental2

Process of gene expression1

Pathway3

Microarray4

WtHTT2

Tumors2

Tissues3

Biomarkers1

Dataset1

Phylogenetic2

Mice2

Machinery1

Enables2

Hypothalamus2

Maternal1

Signatures1

Changes in gene1

Contrast3

Reflects1

Receptors3

Sequence1

Polymerase5

Data3

Insulin1

Methods3

Cellular1

HMOX12

Transcript2

Partial2

Specific6

Differences1

Olfactory1

Symptoms1

Toxic2