• Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
  • The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)
  • Transfective expression in undifferentiated myoblasts produced slow TnT mRNA but not a detectable amount of truncated or intact slow TnT proteins, indicating a muscle cell-specific proteolysis of TnT when it is not integrated into myofilaments. (clinicforspecialchildren.org)
  • These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
  • This family includes three members, Boule (or Boll ), Dazl (or Dazla ) and DAZ , encoding RNA binding proteins. (ijbs.com)
  • The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
  • These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and at least one characteristic sequence of 24 amino acids, which are termed as DAZ repeats [ 1 ]. (ijbs.com)
  • Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
  • The identification of pathogenic mutations within prion-like domains (PrLDs) of the RNA-binding proteins hnRNPA2B1 and hnRNPA1 add to our understanding of how mutations in these proteins lead to degenerative disease, and highlight the potential importance of PrLDs in degenerative diseases of the nervous system, muscle and bone. (natureasia.com)
  • Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster. (uchicago.edu)
  • Drosophila bearing the ocelliless mutation underproduce two major chorion proteins both of which map near this gene. (uchicago.edu)
  • Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. (lookformedical.com)
  • The single-stranded mature miRNA can then associate with an Argonaute protein, which mediates its function of mRNA regulation through direct mRNA target cleavage or interactions with associated RNA-induced silencing complex (RISC) proteins [ 24 ]. (biomedcentral.com)
  • Its molecular characterization, subcellular localization and antibody recognition by infected sheep. (obihiro.ac.jp)
  • They can bind to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs) in order to regulate gene expression post-transcriptionally with no sequence specificity but by potential electrostatic interactions with the phosphate backbone of RNA 2 , 3 . (nature.com)
  • 2, 3, 4, 5] The WT1 gene contains 10 exons that produce 4 different messenger RNAs (mRNAs) as a result of 2 alternative splicing sites in exons 5 and 9 that, in turn, encode 4 different isoforms of the WT1 protein. (medscape.com)
  • First identified in embryonic stem cells, SEs mediate pluripotent state maintenance by promoting the expression of pluripotent identity genes, including Oct4 , Sox2 , Nanog and Klf4 . (nature.com)
  • Gene expression decreased. (appliedbioinfo.com)
  • Luteinization of porcine preovulatory follicles leads to systematic changes in follicular gene expression. (appliedbioinfo.com)
  • Gene expression was measured by hybridization of fluorescently labeled cDNA (preovulatory estrogenic or -luteinized) to the microarray. (appliedbioinfo.com)
  • In this study, we tried to identify differentially expressed genes between largest (F1) and second-largest follicles (F2), and classify them by global gene expression profiling using a combination of microarray and quantitative real-time PCR (QPCR) analysis. (biomedcentral.com)
  • Global gene expression profiles of F1 (10.7 +/- 0.7 mm) and F2 (7.8 +/- 0.2 mm) were analyzed by hierarchical cluster analysis and expression profiles of 16 representative genes were confirmed by QPCR analysis. (biomedcentral.com)
  • Cluster A was composed of only F2 and was characterized by high expression of 31 genes including IGFBP5, whereas cluster B contained only F1 and predominantly expressed 45 genes including CYP19 and FSHR. (biomedcentral.com)
  • We demonstrated that global gene expression profiling of F1 and F2 clearly reflected a difference in their follicular status. (biomedcentral.com)
  • Expression of stage-specific genes in follicles may be closely associated with their growth or atresia. (biomedcentral.com)
  • It is well documented that increased expression of LH receptor (LHR) in granulosa cells (GC) and specific changes of intrafollicular factors such as the insulin-like growth factor (IGF) and inhibin-activin-follistatin systems play a critical role in E 2 production in the DF [ 6 , 7 ]. (biomedcentral.com)
  • Some studies compared the gene expression profiles between DF and SF around the time of follicular selection. (biomedcentral.com)
  • Infection of bovine leukocytes by the apicomplexan parasite Theileria annulata results in alteration of host cell gene expression and stimulation of host cell proliferation. (lookformedical.com)
  • To test this hypothesis, we analyzed expression of viral and cellular genes in brain-infiltrating immune cells. (biomedcentral.com)
  • Enhanced PCR-based methods were used to investigate expression of 75 immune-related genes and 6 EBV genes associated with latent and lytic infection. (biomedcentral.com)
  • EBV genes were detected in brain samples from 9 of 11 MS patients with expression patterns suggestive of in situ activation of latent infection and, less frequently, entry into the lytic cycle. (biomedcentral.com)
  • Comparison of data obtained in meningeal and white matter infiltrates revealed higher expression of genes related to interferonγ production, B cell differentiation, cell proliferation, lipid antigen presentation, and T cell and myeloid cell recruitment, as well as more widespread EBV infection in the meningeal samples. (biomedcentral.com)
  • Additionally, we showed the 4-fold over-expression of "ovochymase-2/similar to oviductin" (GeneID:769290), a vitelline membrane-specific protease. (biomedcentral.com)
  • To uncover potential regulators of sheep fecundity, RNA-seq was used to comparatively analyze miRNA expression profiles of endometrium between high prolificacy sheep (HP, litter size = 3) and low prolificacy sheep (LP, litter size = 1) with FecB genotype. (bvsalud.org)
  • A co-expression network of DE miRNAs and target genes has been constructed, and hub genes related litter size are included, such as DE miRNA unconservative_NC_019472.2_1229533 and unconservative_NC_019481.2_1637827 target to estrogen receptor α (ESR1) and unconservative_NC_019481.2_1637827 targets to transcription factor 7 (TCF7). (bvsalud.org)
  • The expression network of three candidate genes ( ARHGAP10, NR3C2, and EDNRA) regulating dose transcription was constructed by RNA sequencing. (bvsalud.org)
  • Results indicated that these genes were involved in the proliferation and differentiation of skeletal muscle satellite cells (SMSCs) and their overexpression significantly increased the expression of SAA3. (bvsalud.org)
  • The objective of this study was to identify the expression and distribution of EPHA4 and Ephrin A3 genes in the development and morphogenesis of hair follicles in fine-wool sheep. (bvsalud.org)
  • Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program. (genetex.com)
  • This chapter considers what is known about the process underlying the expression of the structural and functional organization of developing follicles and how they are controlled. (glowm.com)
  • Instead, the experiments suggest that Tao negatively regulates BMP signaling as reduction of Tao leads to an increase in pMad levels in motor neuron nuclei and an increase in BMP target gene expression. (sdbonline.org)
  • Gene and protein expression of steroidogenic enzymes were determined. (sciencegate.app)
  • Obese women showed a significantly higher expression of genes of the backdoor pathway and of CYP19 in visceral AT. (sciencegate.app)
  • Exons 1-6 of the WT1 gene encode the regulatory domain, which regulates expression of target genes, and exons 7-10 encode the 4 zinc fingers of the DNA-binding region of the WT1 protein. (medscape.com)
  • Composed of multiple constituent enhancers, super enhancers (SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. (nature.com)
  • Identification of regions interacting with ovoD mutations: potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. (uchicago.edu)
  • Drosophila embryonic neuroblasts in culture: autonomous differentiation of specific neurotransmitters. (uchicago.edu)
  • Genes related to T cell activation, cytotoxic cell-mediated (or type 1) immunity, B cell growth and differentiation, pathogen recognition, myeloid cell function, type I interferon pathway activation, and leukocyte recruitment were found expressed at different levels in most or all MS brain immune infiltrates. (biomedcentral.com)
  • MicroRNAs (miRNAs) are a large class of non-coding RNAs that play important roles in the proliferation and differentiation of adipocytes. (bvsalud.org)
  • The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)
  • Point mutations in the WT1 gene result in loss of its regulatory function, with the consequent abnormalities in glomerular formation and gonadal differentiation seen in Denys-Drash syndrome. (medscape.com)
  • Mutations that disrupt the second alternative splicing site of the WT1 gene alter the normal ratio of KTS-positive/negative isoforms from 2:1 to 1:2 and result in abnormalities in glomerular formation and gonadal differentiation seen in Frasier syndrome. (medscape.com)
  • Mature oocytes become fertilizable, and their meiosis is arrested again at a species-specific stage: metaphase of the first division (MetI, many invertebrates), metaphase of the second division (MetII, most vertebrates), or G1-phase (some echinoderms and coelenterates) until fertilization. (elifesciences.org)
  • In female mammals, primordial follicles consist of two types of cells, namely, oocytes and pregranulosa cells that surround the oocytes. (appliedbioinfo.com)
  • Oocytes were collected from aspirated porcine tertiary follicles. (biomedcentral.com)
  • Histology evaluation: Tiny ovaries with no growing oocytes or follicles (see 3). (jax.org)
  • Mammalian ovaries are endowed with a huge number of small oocytes (primordial oocytes) in primordial follicles. (go.jp)
  • Typically, the human ovaries produce a single dominant follicle that results in a single ovulation each menstrual cycle (Fig. 1). (glowm.com)
  • In any given cycle, the dominant follicle must complete all the steps in folliculogenesis in a timely manner. (glowm.com)
  • 1 , 2 , 3 In each menstrual cycle, the dominant follicle that ovulates its egg originates from a primordial follicle that was recruited to initiate growth almost 1 year earlier (Fig. 2). (glowm.com)
  • The dominant follicle of the cycle appears to be selected from a cohort of class five follicles, and it requires about 20 days to develop to the ovulatory stage. (glowm.com)
  • Folliculogenesis is the process in which a recruited primordial follicle grows and develops into a specialized graafian follicle with the potential to either ovulate its egg into the oviduct at mid-cycle to be fertilized or to die by atresia. (glowm.com)
  • HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
  • Recently, we found that primordial follicles in mature cows and prepubertal pigs took longer to initiate growth in xenografts compared with those in neonatal animals. (go.jp)
  • Although the DF continues to grow by transition of gonadotropin dependency from FSH to luteinizing hormone (LH) and secretes large quantities of estradiol (E 2 ), the remaining subordinate follicles (SFs) cease to grow, then undergo atresia [ 5 ]. (biomedcentral.com)
  • The LH surge initiates the luteinization of preovulatory follicles and causes hormonal and structural changes that ultimately lead to ovulation and the formation of corpora lutea. (appliedbioinfo.com)
  • A class 4 (1 to 2 mm) follicle, if selected, requires about 50 days to grow and develop to the preovulatory stage. (glowm.com)
  • RPAP2 transports RNA Pol II from the cytoplasm to the nucleus and guides Pol II to target ZBTB16 via recognition of the navigator BRD4 on SEs. (nature.com)
  • Neurotransmitter Transporter-Like: a male germline-specific SLC6 transporter required for Drosophila spermiogenesis. (uchicago.edu)
  • Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes. (uchicago.edu)
  • The ovo locus is required for sex-specific germ line maintenance in Drosophila. (uchicago.edu)
  • Molecular genetics of the Drosophila melanogaster ovo locus, a gene required for sex determination of germline cells. (uchicago.edu)
  • The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism. (uchicago.edu)
  • Within each tissue, downstream PCP effectors link the signal to tissue specific readouts such as stereocilia orientation in the inner ear and hair follicle orientation in vertebrates or the polarization of ommatidia and wing hairs in Drosophila melanogaster. (uni-wuerzburg.de)
  • The Drosophila follicle-cell epithelium provides an appropriate model system for studying the potential role of electrochemical signals, like intracellular pH (pH i ) and membrane potential (V mem ), during development. (biomedcentral.com)
  • Our data show that in the Drosophila follicle-cell epithelium stage-specific pH i - and V mem -gradients develop which result from the activity of several ion-transport mechanisms. (biomedcentral.com)
  • Mechanistically, SEs recruited bromodomain containing 4 (BRD4) at the site of ZBTB16 , which then bound to RNA polymerase II-associated protein 2 (RPAP2) that transported RNA polymerase II (POL II) into the nucleus. (nature.com)
  • This region contained 55 genes, including SLC17A5, the gene encoding the lysosomal N-acetylneuraminic acid transport protein. (clinicforspecialchildren.org)
  • The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. (appliedbioinfo.com)
  • PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
  • One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
  • In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
  • Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)
  • on the basis of nuclear protein-coding genes. (obihiro.ac.jp)
  • Thus, the maturing oocyte is reliant on processes such as post-transcriptional gene regulation (PTGR) to regulate the mRNA and protein repertoire. (biomedcentral.com)
  • Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. (nih.gov)
  • However, the four ADAMTS proteases show differences in the number and localization of predicted sites for posttranslational modifications, such as N-glycosylation ( http://www.cbs.dtu.dk/services/NetNGlyc/ ), O-fucosylation, and furin processing which could specify individual substrates, define protein-protein interactions, or govern autocatalytic properties that collectively distinguish these four ADAMTS proteases from each other. (encyclopedia.pub)
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. (genetex.com)
  • In human, an array of four DAZ genes ( DAZ 1-4) is located in two clusters on the Y chromosome and mutations of these genes cause severe oligospermia or azospermia [ 1 ]. (ijbs.com)
  • In summary, our results indicate that JAK signaling contributes to germline cyst breakdown and primordial follicle formation by regulating oocyte loss and pregranulosa cell proliferation in the fetal mouse ovary. (appliedbioinfo.com)
  • Only a few follicles in the human ovary survive to complete the cytodifferentiation process, with 99.9% dying by a programmed cell death mechanism called apoptosis. (glowm.com)
  • 2009 ). At a larger scale, DSB formation occurs in the context of a specific chromosome architecture that consists of chromatin loops anchored to a proteinaceous axis (Zickler and Kleckner 1999 ). (springer.com)
  • In all species, Boule and Dazl are located in single copy on autosomes, while multiple DAZ genes are located on the Y chromosome. (ijbs.com)
  • Denys-Drash syndrome is the result of mutations in the WT1 gene on chromosome band 11p13. (medscape.com)
  • Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
  • DAZ family genes are highly conserved. (ijbs.com)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • During the course of folliculogenesis, growth is achieved by cell proliferation and formation of follicular fluid, whereas development involves cytodifferentiation of all the cells and tissues in the follicle. (glowm.com)
  • We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. (cdc.gov)
  • We describe the detection and localization of SARS-CoV-2 in autopsy tissues from a 25-week neonate who died at 4 days of age with clinical history, laboratory, and pathologic findings consistent with severe COVID-19. (cdc.gov)
  • Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
  • Deletion or mutations of their encoding genes usually severely impair either oogenesis or spermatogenesis or both. (ijbs.com)
  • The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. (uchicago.edu)
  • JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice. (appliedbioinfo.com)
  • They showed that DF up-regulates genes regulating E 2 synthesis, anti-apoptosis, cell proliferation and gene transcription. (biomedcentral.com)
  • The results could lay a theoretical basis for understanding the molecular mechanism that regulates hair follicle development. (bvsalud.org)
  • In this study, we first examined the ovulation of Ciona intestinalis Type A by monitoring follicle rupture in vitro, identifying a novel mechanism of neuropeptidergic regulation of oocyte maturation and ovulation. (elifesciences.org)
  • These findings demonstrate that various neuropeptides are responsible for triggering oocyte maturation and ovulation in invertebrates, and suggest that oocyte maturation and ovulation and their underlying molecular mechanisms are regulated in both a species-specific and evolutionarily conserved fashion. (elifesciences.org)
  • Photomicrograph of ovulation shows the expanded egg-cumulus complex leaving the follicle through the stigma. (glowm.com)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • Recognition that only a few follicles become dominant beautifully demonstrates the fundamental principle that folliculogenesis in mammals is a highly selective process. (glowm.com)
  • Eight of the top ten over-expressed genes are known components of the egg yolk or perivitelline membrane. (biomedcentral.com)
  • The relatively narrow intercellular space of the primordial follicle allows ferritin and possibly other molecules of similar size to cross, whereas in the late stages of rapid follicular growth, the shape of granulosa cells must accommodate the increasing flow of egg yolk precursors that accumulate at the surface of the plasma membrane of the follicle [ 7 ]. (biomedcentral.com)
  • Schip1 is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1 . (sdbonline.org)
  • PlGF was localized in GC and in the theca layer (TL) of healthy follicles. (biomedcentral.com)
  • The production of estrogen and at a lower magnitude testosterone by the theca of the growing follicle increases 2 to 3 weeks before the production of the first egg and contributes to the development of reproductive organs and the synthesis of egg constituents [ 1 - 6 ]. (biomedcentral.com)
  • The remaining cells in the follicle wall ( i.e. granulosa, membrana and periantral, theca, the theca interna and externa) develop into the corpus luteum. (glowm.com)
  • Chondrichthyan species display two nanos1 genes (named nanos1A / 1B ), which were both retrieved in some Osteichthyes at basal positions in Sarcopterygii and Actinopterygii lineages. (nature.com)
  • A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. (lookformedical.com)
  • The size of the primordial follicle pool determines the reproductive ability of female mammals. (appliedbioinfo.com)
  • The overall goals of this program were to produce and distribute mutant models for infertility and to investigate underlying causes in order to identify new genes and pathways contributing to reproductive function. (jax.org)
  • In this study, we show that oocyte-derived Janus kinase (JAK) signaling is vital for germline cyst breakdown and primordial follicle formation in vitro JAK2 and JAK3 activity is increased while germline cysts are breaking down. (appliedbioinfo.com)
  • Alternatively, specific inhibition of JAK3 decreases pregranulosa cell proliferation by downregulating Notch2 signaling, implying that JAK3 acts on pregranulosa cells by controlling the extracellular secretion of oocyte-derived factors. (appliedbioinfo.com)
  • The inability to transcribe mRNA during this stage of development and the probable necessity for post-transcriptional gene regulation (PTGR) suggests an important role for non-coding RNA in the maturing oocyte. (biomedcentral.com)
  • Of particular interest is understanding the role of non-coding RNA in regulating meiotic checkpoints in the oocyte, particularly that of microRNA-21 (MIR21). (biomedcentral.com)
  • In Vertebrates, Nanos paralogous genes were associated to partial redundancies and specific functional evolutions. (nature.com)
  • Moreover, functional annotation analysis showed that the target genes (NRCAM and NEGR1) of the DE miRNAs were significantly enriched in cell adhesion molecules (CAMs) signaling pathway, which was related to uterine receptivity. (bvsalud.org)
  • MicroRNA (miRNA) are a class of functional small RNA that target mRNA to affect their abundance and translational efficiency. (biomedcentral.com)
  • Using functional imaging and behavioral analysis, loss of Tao-induced ectopic synapses with inappropriate partner neurons were shown to be functional and altered behavioral responses in a connection-specific manner. (sdbonline.org)
  • Transcription factor TFIID, composed of TBP and TAF(II) subunits, is a central component of the RNA polymerase II machinery. (appliedbioinfo.com)
  • The follicular status of F1 and F2 were further evaluated in terms of healthy and atretic conditions by investigating mRNA localization of identified genes. (biomedcentral.com)
  • The healthy or atretic condition of examined follicles was classified by progesterone and estradiol concentrations in follicular fluid. (biomedcentral.com)
  • IGFBP5 was detected in both GC and TL of atretic follicles. (biomedcentral.com)
  • GADD45A and TSP2 were localized in both GC and TL of atretic follicles, whereas healthy follicles expressed them only in GC. (biomedcentral.com)
  • It is believed that this local regulatory system plays an important role in the complex mechanisms governing the timing of folliculogenesis and whether a follicle becomes dominant or atretic. (glowm.com)
  • Based on phylogenetic and synteny analyses, this study reveals that nanos1 gene has undergone multiple duplications and gene copies losses in Vertebrates. (nature.com)
  • The two successive nanos gene duplications may result from the second and third whole genome duplication events at the basis of Vertebrates and Teleosts respectively. (nature.com)
  • In Vertebrates, three Nanos paralogous genes were described. (nature.com)
  • Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. (bvsalud.org)
  • In this capacity, it survives the negative events that operate to destroy the other follicles by atresia. (glowm.com)
  • Atresia can occur in preantral class 1, 2, and 3 follicles. (glowm.com)
  • However, the underlying mechanisms controlling primordial follicle assembly remain unclear. (appliedbioinfo.com)
  • Multivariate analysis grouped genes expressed in meningeal and white matter immune infiltrates into artificial factors that were characterized primarily by genes involved in type 1 immunity effector mechanisms and type I interferon pathway activation. (biomedcentral.com)
  • The mechanisms regulating follicle growth and development are under the control of changing concentrations of ligands ( i.e. hormones and growth factors). (glowm.com)
  • Therefore, we analysed stage-specific gradients of pH i and V mem as well as their dependence on specific ion-transport mechanisms. (biomedcentral.com)
  • Germline and somatic follicle cells mutant for dm exhibit a profound decrease in their ability to grow and to carry out endoreplication,a modified cell cycle in which DNA replication occurs in the absence of cell division. (biologists.com)
  • However, in cases in which the entire germline cyst or the whole follicular epithelium was mutant for dm , the growth of the entire follicle, including the wild-type cells, was delayed. (biologists.com)
  • Inhibition of either JAK2 or JAK3 prevents germline cyst breakdown and primordial follicle formation. (appliedbioinfo.com)
  • In testes, noa RNA is detected in the cyst cells during the postmeiotic phase of germ cell development. (biologists.com)
  • Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. (novusbio.com)
  • The ancillary domain, which mediates binding to ECM components and specific protease substrates, consists of a conserved central thrombospondin type 1 sequence repeat motif (TSR), a cysteine-rich domain and a spacer domain. (encyclopedia.pub)
  • With this method, the resolving power was less than 100 µm, but nonetheless he was able to localize the radioactivity to specific thyroid [follicles]. (wikipedia.org)
  • Thyroid-stimulating immunoglobulins (TSIs) bind to and activate thyroid-stimulating hormone (TSH) receptors, causing the thyroid gland to grow and the thyroid follicles to increase synthesis of thyroid hormone. (medscape.com)
  • Histology evaluation: Tiny ovaries with some follicle activity (see 3), hemorrhagic cysts present in some ovaries (see 4). (jax.org)
  • A nonsense mutation at codon Glu180 in exon 11 of slow skeletal muscle troponin T (TnT) gene (TNNT1) causes an autosomal-recessive inherited nemaline myopathy. (clinicforspecialchildren.org)
  • The HSV of the Boer goat contributed to superior skeletal muscle growth via the dose effects of overlapping genes. (bvsalud.org)
  • Surprisingly, despite their impaired ability to endoreplicate, dm mutant follicle cells appeared to carry out chorion gene amplification normally. (biologists.com)
  • Detection of G119S ace-1 (R) mutation in field-collected Anopheles gambiae mosquitoes using allele-specific loop-mediated isothermal amplification (AS-LAMP) method. (obihiro.ac.jp)
  • We further show that specific suppression of JAK2 delays germ cell loss through the downregulation of p53, but has no influence on pregranulosa cell proliferation. (appliedbioinfo.com)
  • Recently, we described the characterisation of a parasite gene (TashAT2), whose polypeptide product bears AT hook DNA-binding motifs and may be transported from the parasite to the host nucleus. (lookformedical.com)
  • T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
  • Studies in infectious disease models have provided a wealth of information regarding memory CD8 T cell generation and localization. (frontiersin.org)
  • Twenty-three postmortem snap-frozen brain tissue blocks from 11 patients with progressive MS were selected based on good RNA quality and prominent immune cell infiltration. (biomedcentral.com)
  • White matter perivascular and intrameningeal immune infiltrates, including B cell follicle-like structures, were isolated from brain sections using laser capture microdissection. (biomedcentral.com)
  • This is the autocrine/paracrine system of developing follicles. (glowm.com)
  • Hierarchical cluster analysis of microarray data classified the follicles into two clusters. (biomedcentral.com)
  • Here we discuss DAZ family genes in a phylogenic perspective, focusing on the common and distinct features of these genes, and their pivotal roles during gametogenesis evolved during evolution. (ijbs.com)
  • The development of preantral and antral follicles is gonadotropin independent and gonadotropin dependent, respectively. (glowm.com)
  • Female mice lacking this gene do not form a stable zona matrix and are sterile. (nih.gov)