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  • extracellular
  • Material and methods: The short hairpin RNA interference cassette targeting COX2 mRNA, containing the mouse RNA promoter U6, was amplified and cloned into the Eco72I site of pVAX-ratECTM (RRT), a vector carrying the extracellular and transmembrane domains of rat ErbB-2, and into pVAXI, to obtain respectively RRT-COX2 and pVAXCOX2. (unicam.it)
  • This mediates recruitment of growth factor receptor binding protein 2/son of sevenless homologue complexes ( 2 - 5 ) and Gab-family adaptors ( 2 , 6 - 8 ) leading to Ras/RAF/extracellular signal-regulated kinase (ERK) and PI3K/AKT signaling ( 9 - 11 ). (aacrjournals.org)
  • inhibition
  • Three concepts are of particular importance: (1) formation of free radicals, (2) assumed inhibition of tyrosine kinases, and (3) binding to and interference with the function of members of the Hsp90 family of proteins. (pubmedcentralcanada.ca)
  • Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells. (springer.com)
  • antigen
  • In order to investigate COX2 as a potential target for the prevention and treatment of cancer, we propose a novel immunotherapeutic approach for the prevention of ErbB-2 positive breast carcinomas, based on DNA vaccination against a specific antigen (ErbB-2) in combination with the silencing of COX2. (unicam.it)
  • Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). (wikipedia.org)
  • tumour
  • β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
  • gastric
  • HER-2 is over-expressed in approximately 7-34% of patients with gastric cancer and in 30% of salivary duct carcinomas. (wikipedia.org)
  • EGFR
  • A single child displaying multi-organ epithelial inflammation was found to have a homozygous loss of function mutation in the EGFR gene. (wikipedia.org)
  • homologous
  • 2 It is thought that telomeres have multiple roles, including protection against degeneration, reconstruction, fusion and loss, 3 as well as contributing to pairing of homologous chromosomes. (wiley.com)
  • breast
  • Use of 70-gene signature to predict prognosis of patients with node-negative breast cancer: a prospective community-based feasibility study (RASTER). (springer.com)