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  • mutations
  • Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D. (wikipedia.org)
  • We searched for mutations in the EGFR gene in primary tumors from patients with non-small-cell lung cancer who had a response to gefitinib, those who did not have a response, and those who had not been exposed to gefitinib. (nih.gov)
  • A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib. (nih.gov)
  • Evolution of the initial tumour cell may occur by two methods: Sequentially ordered mutations accumulate in driver genes, tumour suppressor genes, and DNA repair enzymes, resulting in clonal expansion of tumour cells. (wikipedia.org)
  • Mutations in this gene have been associated with cancer. (wikipedia.org)
  • Since Neuregulin 1 promotes myelination and is decreased in schizophrenic patients, along with the finding that schizophrenic patients experience white matter deficits, mutations within Neuregulin 1 may underlie cognitive deficits associated with lower white matter integrity, especially within frontotemporal connections. (wikipedia.org)
  • Ligand
  • Its name originates from the viral homolog v - erbB which was isolated from an avian erythroblastosis virus ( AEV) where it was contained as a fragment of the chicken c - ErbB- 1 gene lacking the amino - terminal ligand- binding domain . (dictionary.net)
  • The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2. (wikipedia.org)
  • Expression
  • Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. (semanticscholar.org)
  • This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (wikipedia.org)
  • Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. (wikipedia.org)
  • Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single vector, allowing the medical intervention and control of expression of multiple genes and the initiation of an elaborate cascade of events. (wikipedia.org)
  • Also, it is possible to target a family of related genes by targeting and modulating the expression of the endogenous transcription factor(s) that control(s) them. (wikipedia.org)
  • By targeting the ZF-TF toward a specific DNA sequence and attaching the necessary effector domain, it is possible to downregulate or upregulate the expression of the gene(s) in question while using the same DNA-binding domain. (wikipedia.org)
  • The expression of a gene can also be downregulated by blocking elongation by RNA polymerase (without the need for an effector domain) in the coding region or alternatively, RNA itself can also be targeted. (wikipedia.org)
  • Engineering zinc finger protein transcription factors: the therapeutic relevance of switching endogenous gene expression on or off at command" (PDF). (wikipedia.org)
  • ErbB2
  • ErbB2 cannot directly bind NRG-1, but it is the favored partner for heterodimerization. (ahajournals.org)
  • The ErbB2-ErbB3 dimer is considered the most active of the possible ErbB dimers, in part because ErbB2 is the preferred dimerization partner of all the ErbB family members, and ErbB3 is the preferred partner of ErbB2. (wikipedia.org)
  • Genome
  • Human CIC genome location and CIC gene details page in the UCSC Genome Browser. (wikipedia.org)
  • As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (wikipedia.org)
  • transcription factor
  • In this respect, it is also possible to target a sequence that is common to multiple (usually functionally related) genes in order to control the transcription of all these genes with a single transcription factor. (wikipedia.org)
  • Artificial transcription factor, of which the ZF-TF is a type Gene therapy Zinc finger proteins Zinc finger chimera Zinc finger nuclease Gommans WM, Haisma HJ, Rots MG (2005). (wikipedia.org)
  • cell proliferation
  • Cyclin D1 also binds to histone acetylases and histone deacetylases to regulate cell proliferation and cell differentiation genes in the early to mid-G1 phase. (wikipedia.org)
  • Antigen
  • Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). (wikipedia.org)
  • Ki-67 and MIB-1 monoclonal antibodies are directed against different epitopes of the same proliferation-related antigen. (wikipedia.org)
  • genetics
  • More recently modern genetics techniques, primarily using transgenic mice, have been used to identify genes that are specifically expressed or highly enriched in the intestinal stem cells. (wikipedia.org)
  • variants
  • 5 NRG-1 biology is complicated by the fact that multiple splice variants are produced from the NRG-1 gene (for review, see elsewhere 6 ). (ahajournals.org)