AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceGeographicals
Enterobacter cloacaeEnterobacterEnterobacteriaceae InfectionsEnterobacteriaceaeEnterobacter aerogenesCloacabeta-LactamasesMicrobial Sensitivity TestsCephalosporinsCronobacter sakazakiiAnti-Bacterial Agentsbeta-LactamsCephalosporinaseGram-Negative BacteriaCitrobacter freundiiCephalosporin ResistanceKlebsiellaDrug Resistance, MicrobialCeftazidimePythiumBacteriaKlebsiella pneumoniaeSerratiaDNA, BacterialCitrobacterCefotaximeSerratia marcescensbeta-Lactam ResistancePlasmidsEscherichiaDrug Resistance, BacterialImipenemCarbapenemsNitroreductasesBacterial ProteinsEscherichia coliGenes, BacterialCross InfectionGram-Positive BacteriaSequence Analysis, DNAQuinolonesCefoperazoneCeftizoximeMolecular Sequence DataPenicillanic AcidAztreonamSerratia InfectionsMonobactamsLactamsCefoxitinCucumis sativusThienamycinsProteusTrinitrotolueneGram-Negative Bacterial InfectionsIsoelectric FocusingKlebsiella oxytocaElectrophoresis, Gel, Pulsed-FieldParabensSulfacetamideConjugation, GeneticAlgeriaDrug Resistance, Multiple, BacterialIntegronsBacterial InfectionsCephalexinCefmenoximeBacterial Typing TechniquesAntibiosisPiperacillinCiprofloxacinPenicillinsCefotiamPenicillinaseAnti-Infective AgentsAmpicillinCephaloridineBacteriological Techniques
EscherichiaKlebsiellaIsolatesAerogenesStrainsBACTERIAESBLMultidrug-resistantSubspEnterobacteriaceaeBacterialPneumoniaePathogensAmpCVirulenceStrainPseudomonasAntibioticGenomeBlaNDMPlasmid-borne resistancePredominantSpeciesProvidenciaAntimicrobial resistanceQuinolone resistance determDisseminationClinically significantCharacterizationComplexEpidemiologicalPolymerase chain reResistance GeneBlaIMPQnrBColistinOutbreakStaphylococcusEffluxClonalBlaKPC-2 foiResistantClustersPlasmidsEnzymesCarbapenemase gene
Escherichia15
Klebsiella8
  • Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States. (cdc.gov)
  • Role of IncHI2 plasmids harbouring blaVIM-1, blaCTX-M-9, aac(6')-Ib and qnrA genes in the spread of pneumoniae multiresistant Enterobacter cloacae and Klebsiella strains in different units at Hospital Vall d'Hebron, Barcelona, Spain. (edu.iq)
  • cloacae DSM 30054), Koxy ( Klebsiella oxytoca DSM 4798) and Ediss ( Enterobacter cloacae subsp. (biomedcentral.com)
  • This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. (biomedcentral.com)
  • Here we describe the first detection in Italy of the mcr-10 gene, carried by strains of Klebsiella quasipneumoniae . (biomedcentral.com)
  • Here we report the disrupted transmission of maternal Bacteroides strains, and high-level colonization by opportunistic pathogens associated with the hospital environment (including Enterococcus , Enterobacter and Klebsiella species), in babies delivered by caesarean section. (nature.com)
  • The drug sensitivity levels could also be increased in a clinical isolate of Enterobacter cloacae and to a lesser extent in Klebsiella variicola, both of which harboured also the blaCTX-M gene. (rwth-aachen.de)
  • When changing target to the blaKPC gene, resistance reduction to the intermediate level of imipenem was achieved in 63% of the retrieved clones of Klebsiella oxytoca clinical isolate. (rwth-aachen.de)
Isolates38
  • This study was aimed to detect the prevalence of blaVIM and blaNDM genes among Enterobacter cloacae isolates that were isolated from Iraqi patients. (edu.iq)
  • The antibiotic susceptibility for E.cloacae isolates was determined using the disk diffusion (Kirby Bauer) method and the results showed that these bacteria were showed resistance to Cefepime and Meropenem antibiotics in percentage (50%), (40%) respectively. (edu.iq)
  • EDTA combined disc test was used to detect the ability of E. cloacae isolates to produce carbapenemase and the results were showed that only 8 isolates were gave positive results , While the prevalence of blaVIM and blaNDM was determined using the conventional Polymerase chain reaction technique. (edu.iq)
  • Prevalence of extended-spectrum beta-lactamases in isolates of the Enterobacter cloacae complex from German hospitals. (edu.iq)
  • 3) evaluate the clonal relation among ESBL or KPC producers, in a collection of Enterobacter isolates cultivated from cases of healthcare associated infections in patients from hospitals located in the city of São Paulo. (usp.br)
  • METHODS: A total of 141 Enterobacter isolates were studied concerning ESBL production using the method from Jarlier and colleagues, minimum inhibitory concentrations for cefotaxime, ceftazidime and cefepime by agar dilution method, inhibition zone for ertapenem by by Kirby-Bauer method and the presence of genes coding for ESBLs or KPCs, by PCR. (usp.br)
  • Molecular typing using repetitive sequenced-based PCR (rep-PCR) and hsp60 sequencing were applied to a collection of diverse Enterobacter cloacae complex isolates. (paijournal.com)
  • To determine the most practical method for reference laboratories, we analyzed 71 E. cloacae complex isolates from sporadic and outbreak occurrences originating from 4 geographic areas. (paijournal.com)
  • Chlorhexidine MICs were determined for 535 isolates including 129 S. aureus, 156 E. coli, 142 K. pneumoniae, and 108 E. cloacae complex isolates. (cdc.gov)
  • A limited number of isolates also carried bla NDM-1 (n = 2) and bla OXA-48 (n = 1) carbapenemase genes. (ox.ac.uk)
  • In China, the presence of the qnr gene in the clinical isolates of Enterobacteriaceae has been reported, but this transmissible quinolone resistance gene has not been detected in strains isolated singly from pediatric patients. (biomedcentral.com)
  • This study therefore aimed to investigate the presence of the qnr gene in clinical isolates of E. coli and K. pneumoniae from pediatric patients in China. (biomedcentral.com)
  • The isolates were screened for the plasmid-mediated quinolone resistance genes of qnrA , qnrB , and qnrS by PCR. (biomedcentral.com)
  • The study found that 19 ciprofloxacin-resistant clinical isolates of E. coli and K. pneumoniae were positive for the qnr gene, and most of the qnr positive strains were ESBL producers. (biomedcentral.com)
  • Array analysis revealed 18 isolates with ESBL genes and one isolate with solely non-ESBL beta-lactamase genes. (afpm.org.my)
  • Ceftazidime-resistant (CAZ res ) isolates with a positive double-disc synergy test were screened for the presence of extended-spectrum β-lactamase-encoding genes. (advbiores.net)
  • Although the isolates were phenotypically susceptible to colistin, the emergence of mcr-10 is concerning due to the highly variable expression of the gene and the potential for horizontal transfer to other species. (biomedcentral.com)
  • genes and the susceptibility patterns in ESBL producing clinical isolates of Gram-negative bacilli in Jimma University Specialized Hospital (JUSH), southwest Ethiopia. (omicsdi.org)
  • Of the total 112 (50.0%) isolates screen positive for ESBLs, 63.4% (71/112) tested positive for ESBL encoding genes by Check-MDR array, which corresponds to 91.8% (67/73) of the total Enterobacteriaceae and 10.3% (4/39) of nonfermenting Gram-negative bacilli. (omicsdi.org)
  • genes among ESBL-producing isolates. (omicsdi.org)
  • On phylogenetic analysis there were three genetic clusters of E. cloacae containing both clinical and environmental isolates, and an additional four clusters restricted to either reservoir. (ox.ac.uk)
  • Two clinical isolates of E. cloacae, previously identified as representatives of two dominant hospital clones from the period 2014-2017, were included in the study for comparison. (bvsalud.org)
  • The blaKPC was identified also in the two isolates of K. oxytoca and blaVIM in all E. cloacae complex isolates. (bvsalud.org)
  • The two CR isolates of E. coli possessed blaKPC and blaOXA-48 genes. (bvsalud.org)
  • Among the 45 isolates, 38 harbored at least one carbapenemase-encoding gene. (ncku.edu.tw)
  • Of these, the bla GES (bla GES-5 , bla GES-6 , and bla GES-24 ) genes were found in 29 isolates. (ncku.edu.tw)
  • The genes were situated in novel class 1 integrons, but the integron structures were different between the Japanese (In1439 with bla GES-24 and In1440 with bla GES-5 ) and Taiwanese (In1441 with bla GES-5 and In1442 with bla GES-6 ) isolates. (ncku.edu.tw)
  • Other carbapenemase-encoding genes (bla VIM-1 , bla NDM-5 , bla IMP-8 , bla IMP-19 , and bla KPC-2 ) were found in one to three isolates. (ncku.edu.tw)
  • 100 copies/cell) and by directly tackling the blaTEM-1-and blaKPC genes from clinical isolates, both prevalent in multidrug-resistant bacteria. (rwth-aachen.de)
  • Despite the versatile challenges imposed by clinical isolates, the interference with the resistance gene led after all from minor to clear resistance reductions. (rwth-aachen.de)
  • The present study aimed to characterize the ESBL and carbapenemase genes among Enterobacter isolates from an Iranian inpatient population. (ac.ir)
  • A total of 96 Enterobacter isolates obtained from inpatients between June 2016 and March 2017, were identified by the conventional microbiological methods and diagnostic kits. (ac.ir)
  • Of the 96 Enterobacter isolates, 35 (36.5%) and 28 (29.2%) were phenotypically ESBL-positive and non-susceptible carbapenem, respectively. (ac.ir)
  • in our region, strict hygiene rules will be needed to control the quick spread of ESBL and carbapenemase-producing Enterobacter isolates in healthcare facilities of developing countries. (ac.ir)
  • An estimated 11 and 22% of the E. coli isolates carried virulence marker genes stx -2 and eae , respectively. (biomedcentral.com)
  • The bla CTX-M gene was the most predominant bla gene followed by the bla OXA gene which was detected in 53/55 (96.36%) of the isolates. (scienggj.org)
  • On the other hand, 44/55 (80%) of the isolates possessed the bla SHV gene while 38/55 (69.1%) carried the bla TEM gene. (scienggj.org)
  • Interestingly, bla genes were also detected even for isolates that were negative for the PCDDT indicating that these genes might be present but the β-lactamase enzyme might not have been actively expressed by the bacteria. (scienggj.org)
Aerogenes3
  • Enterobacter aerogenes, Pseudomonas sp. (afpm.org.my)
  • As espécies mais resistentes foram E. aerogenes, E. cloacae, C. freundii e K. oxytoca. (fiocruz.br)
  • 11. Qin X, Yang Y, Hu F, Zhu D. Hospital clonal dissemination of Enterobacter aerogenes producing carbapenemase KPC-2 in a Chinese teaching hospital. (ac.ir)
Strains11
  • Biocontrol strains from the genera Enterobacter and Pseudomonas and two chitinolytic enzymes from Trichoderma harzianum isolate P1 were combined and tested for antifungal activity in bioassays. (apsnet.org)
  • Eleven strains were identified via 16S rRNA gene sequencing as Pseudomonas aeruginosa, Bacillus spp. (bvsalud.org)
  • This report on transferable fluoroquinolone resistance due to the qnr gene among E. coli and K. pneumoniae strains indicated that plasmid-mediated quinolone resistance has emerged in pediatric patients in China. (biomedcentral.com)
  • Mutants of ceftazidime-susceptible strains were not sequenced, but phenotypes suggested altered drug accumulation or, for Enterobacter cloacae only, AmpC derepression. (uea.ac.uk)
  • In addition, the strains also carried an extended-spectrum β-lactamase gene and were phenotypically resistant to several beta-lactams. (biomedcentral.com)
  • This study investigates the contribution of efflux mechanism to carbapenem resistance in 61 acquired blaCHDL-genes-carrying A. baumannii clinical strains isolated in Warsaw, Poland. (bvsalud.org)
  • Prevalence and characterization of extended spectrum beta-lactamase-producing Enterobacter cloacae strains in Algeria. (ac.ir)
  • however, individual strains vary in their virulence potential due to the presence of mobile accessory genes. (biomedcentral.com)
  • Subsequent work showed that among ca. 500 strains of Enterobacteriaceae recovered from these animals the Hg and antibiotic resistance genes are physically associated (i.e. genetically linked) on transferrable plasmids (Wireman et al. (evidence-of-harm.com)
  • while 8, 17.5 and 6% of the strains carried tetracycline resistance-related genes tet A, tet B, and tet D, respectively. (biomedcentral.com)
  • Ten (18.18%) of the strains possessed three of the β-lactamase genes and another 10 harboured at least two genes. (scienggj.org)
BACTERIA12
  • The Imd pathway was first discovered in 1995 using Drosophila fruit flies by Bruno Lemaitre and colleagues, who also later discovered that the Drosophila Toll gene regulated defence against Gram-positive bacteria and fungi. (wikipedia.org)
  • The results of this study suggest that transgenic bacteria, capable of binding to fungal cell walls and expressing fungal genes encoding cell wall-degrading enzymes, may be powerful biocontrol agents. (apsnet.org)
  • The bacteria designated by the acronym SERMOR-PROVENF (SER = Serratia, MOR = Morganella, PROV = Providencia, EN = Enterobacter, F = freundii for Citrobacter freundii ) have similar, although not identical, chromosomal beta-lactamase genes that are inducible. (medscape.com)
  • The antimicrobial resistance (AMR) and/or virulence determinants possessed by the associated bacteria are generally found on mobile genetic elements (MGEs) that transmit between K . pneumoniae cells via horizontal gene transfer (HGT) [ 4 ]. (biomedcentral.com)
  • Many such people were significantly (0.001, chi-square) more likely also to have bacteria with a multiple antibiotic resistance genes. (evidence-of-harm.com)
  • So, beginning in 1989, my group in collaboration with investigators at the University of Calgary, specifically tested two hypotheses: that Hg is released from amalgam dental restorations in amounts sufficient to select for Hg resistant bacteria in the commensal microbiota and that the Hg resistance loci thus selected would be linked to antibiotic resistance genes and borne by bacterial plasmids (Summers et al. (evidence-of-harm.com)
  • Majority of the MDR gut bacteria harbored large plasmids [e.g., 140 MDa (43%), 105 MDa (30%), 90 MDa (14%)] carrying invasion and related antibiotic resistance marker genes. (biomedcentral.com)
  • Our results suggest gut of young Bangladeshi children to be an important reservoir for multi-drug resistant pathogenic bacteria carrying ESBL related genes. (biomedcentral.com)
  • This paper reports the presence of extended-spectrum β-lactamase (ESBL)-producing bacteria exhibiting multiple bla genes from sputum, endotracheal aspartate, urine, corneal specimen, wound discharge, breastmilk, and abscess from infected patients of Ospital ng Maynila Memorial Medical Center. (scienggj.org)
  • In other particular aspects, the bacterial cell is an Enterobacter or Serratia bacteria. (justia.com)
  • Few studies have investigated occurrence of Antibiotic Resistance Genes (ARGs) among bacteria including Aminoglycoside Modifying Genes (AMGs) from Drinking Water Distribution Systems (DWDS) in Nigeria. (bvsalud.org)
  • Combination of aph(3")c and ant (3")b in a single bacteria was observed as the highest (14, 7.73%) among the detected gene combination. (bvsalud.org)
ESBL11
  • 3) avaliar a relação clonal entre isolados produtores de ESBL ou KPC, uma coleção de isolados do gênero Enterobacter cultivadas de casos de infecções relacionadas aos cuidados com a saúde diagnosticadas em pacientes atendidos em hospitais da cidade de São Paulo. (usp.br)
  • MÉTODOS: Foram estudadas 141 isolados do gênero Enterobacter quanto à produção de ESBL pelo método de Jarlier e colaboradores, concentrações inibitórias mínimas para cefotaxima, cefepima e ceftazidima pelo método da diluição em ágar, halo de inibição para ertapenem pelo método de Kirby-Bauer e presença de genes que codificam ESBL ou KPC, por PCR. (usp.br)
  • Os genes que codificam cefotaximases foram detectados em 34,4% dos isolados com teste fenotípico positivo para ESBL, e houve predomínio do grupo da CTX-M-8, enquanto os genes que codificam variantes SHV foram detectados em 18,7% dos produtores de ESBL. (usp.br)
  • O gene blaKPC-2 foi detectado em três dos 15 isolados produtores de ESBL e resistentes ao ertapenem. (usp.br)
  • Antimicrobial susceptibility testing, molecular typing, characterization of ESBL-encoding genes and the genetic environment, conjugation experiments and plasmid analysis were carried out. (who.int)
  • those of ESBL producers mostly had genetic modifications outside β-lactamase genes, commonly affecting uptake, efflux, or β-lactamase quantity. (uea.ac.uk)
  • Analysis included identification by MALDI-TOF mass spectrometry, susceptibility testing, XbaI-PFGE, microarray, PCR and sequencing of specific ESBL genes, PCR based replicon typing (PBRT) of plasmids and Southern blot hybridization. (afpm.org.my)
  • In almost all cases ESBL and quinolone resistance genes were located on the same plasmid. (afpm.org.my)
  • From November 2021 to May 2022, a total of 62 human 24 h composite samples of raw sewage (1 L each) were collected weekly from two lines of a wastewater treatment plant located in Northern Italy (Ferrara province, 44°50′07.07″N 11°37′11.51″E). The sampling was part of a larger research project on antibiotic resistance surveillance, mainly focussed on the detection of extended-spectrum β-lactamase (ESBL) genes. (biomedcentral.com)
  • The ESBL and carbapenemase genes were screened using polymerase chain reaction (PCR). (ac.ir)
  • The type of β-lactamase genes carried by these ESBL-producers was also determined by amplification of the bla CTX-M , bla OXA , bla SHV , and bla TEM genes by Polymerase Chain Reaction. (scienggj.org)
Multidrug-resistant2
  • Leverstein-van Hall MA , Blok HE , Paauw A , Fluit AC , Troelstra A , Mascini EM , Extensive hospital-wide spread of a multidrug-resistant Enterobacter cloacae clone, with late detection due to a variable antibiogram and frequent patient transfer. (cdc.gov)
  • During the COVID-19 pandemic intrahospital dissemination of CR K. pneumoniae, producing carbapenemases of different molecular classes, as well as continuing circulation of dominant hospital clones of multidrug-resistant E. cloacae complex was documented. (bvsalud.org)
Subsp3
Enterobacteriaceae3
  • Quinolone resistance in Enterobacteriaceae results mainly from mutations in type II DNA topoisomerase genes and/or changes in the expression of outer membrane and efflux pumps. (biomedcentral.com)
  • With rare exceptions, E cloacae complex species are resistant to the narrow-spectrum penicillins that traditionally have good activity against other Enterobacteriaceae such as E coli (eg, ampicillin, amoxicillin) and to first-generation and second-generation cephalosporins (eg, cefazolin, cefuroxime). (medscape.com)
  • Dessa forma, este estudo demonstrou a disseminação do gene blaKPC-2 em 9 Enterobacteriaceae de diferentes regiões do Brasil, incluindo espécies nas quais o gene não havia sido previamente descrito, como P. agglomerans e P. Stuartii. (fiocruz.br)
Bacterial3
  • Chitinolytic enzyme activity in the presence of chitinous substrates enhanced the growth of E. cloacae and readily restored the ability of bacterial cells to bind to hyphae of the pathogens despite high concentrations of d-glucose or sucrose in the medium. (apsnet.org)
  • The recent emergence and global spread of plasmid-borne mobile colistin resistance ( mcr ) genes are therefore concerning, even because of their potential to spread rapidly among different bacterial species by horizontal transfer [ 1 ]. (biomedcentral.com)
  • In further aspects, the bacterial cell is an Enterobacter cloacae or Serratia marcescens bacterial cell. (justia.com)
Pneumoniae1
  • In particular, gene clusters encoding the biosynthesis of siderophores aerobactin ( iuc ) and salmochelin ( iro ) are associated with invasive disease and are common amongst hypervirulent K . pneumoniae clones that cause severe community-associated infections such as liver abscess and pneumonia. (biomedcentral.com)
Pathogens2
  • This observation suggests that ECC are emerging pathogens, requiring for detailed understanding on their genomic epidemiology including transmission dynamics and antimicrobial resistance profiles.Patients and methodsWe performed WGS on 79 Enterobacter spp. (ox.ac.uk)
  • Emerging strategies to combat and treat ESKAPE pathogens including Enterobacter include consideration for combination antibiotics, phage therapy, antimicrobial peptides, silver nanoparticles and photodynamic light therapy. (medscape.com)
AmpC2
  • Clonal relation and antimicrobial resistance pattern of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Enterobacter spp. (edu.iq)
  • With Enterobacter, the expression of the gene AmpC is repressed, but derepression can be induced by beta-lactams. (medscape.com)
Virulence2
  • Genomic epidemiology, antimicrobial resistance and virulence factors of Enterobacter cloacae complex causing potential community-onset bloodstream infections in a tertiary care hospital of Nepal. (ox.ac.uk)
  • Involvement of the AcrAB-TolC efflux pump in the resistance, fitness, and virulence of Enterobacter cloacae. (ac.ir)
Strain5
  • cloacae type strain ATCC 13047. (genome.jp)
  • E. cloacae strain WCHECl-1060 was recovered from a blood sample of a leukemia patient, who was not previously exposed to colistin. (medscape.com)
  • Multilocus sequence typing (MLST) is a strain-typing system that focuses strictly on conserved housekeeping genes. (advbiores.net)
  • However, even though plasmid integrity could be detected, sequence alterations in the blaTEM-1 gene were observed, resulting in a dysfunction of the gene product and, therefore, in an antibiotic sensitive strain. (rwth-aachen.de)
  • The presence of multiple bla genes within the same strain with 35 out of 55 (63.6%) possessing all the four genes tested were also observed. (scienggj.org)
Pseudomonas1
  • Inhibitory effects on spore germination and germ tube elongation of Botrytis cinerea, Fusarium solani, and Uncinula necator were synergistically increased by mixing fungal enzymes and cells of Enterobacter cloacae but not of Pseudomonas spp. (apsnet.org)
Antibiotic2
  • Antibiotic disks were purchased gene. (who.int)
  • The results indicate that CPE with various carbapenemase-encoding genes in different genetic contexts were present in biologically treated wastewater, highlighting the need to monitor for antibiotic resistance in wastewater. (ncku.edu.tw)
Genome2
  • Its genome encodes 4,827 genes, 86 tRNAs and 25 rRNAs. (idilbiotech.com)
  • Studies were conducted using phenotypic (susceptibility testing to carbapenems ± efflux pump inhibitors (EPIs)) and molecular (determining expression levels of efflux operon with regulatory-gene and whole genome sequencing (WGS)) methods. (bvsalud.org)
BlaNDM1
  • Multiplex PCR was used for detection of genes encoding carbapenemases from different classes (blaKPC, blaIMP, blaVIM, blaNDM, blaOXA-48). (bvsalud.org)
Plasmid-borne resistance1
  • The antimicrobial resistance (AMR) crisis urgently requires countermeasures for reducing the dissemination of plasmid-borne resistance genes. (rwth-aachen.de)
Predominant1
  • Enterobacter cloacae was the predominant organism, with 12 other species mainly found in either the environment or patients, some persisting despite several cleaning methods. (ox.ac.uk)
Species2
  • ObjectivesCommunity-onset bloodstream infections (BSIs) caused by carbapenemase-producing Enterobacter cloacae complex (ECC) species are increasing internationally. (ox.ac.uk)
  • Because most Enterobacter species are either very resistant to many agents or can develop resistance during antimicrobial therapy, the choice of appropriate antimicrobial agents is complicated. (medscape.com)
Providencia1
Antimicrobial resistance1
  • Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. (edu.iq)
Quinolone resistance determ2
  • In addition, the quinolone resistance genotype was characterized by screening for plasmid mediated quinolone resistance (PMQR) genes and mutations in the quinolone resistance determining region (QRDR) of gyrA and parC. (afpm.org.my)
  • Our study revealed considerable serovar diversity and a high prevalence of the co-occurrence of MDR determinants, including CTX-M-type ESBLs, quinolone resistance-determining region (QRDR) mutations, and PMQR genes. (omicsdi.org)
Dissemination1
  • 1 The ease of β-lactamase encoding genes ( bla NDM-1 ) dissemination has become apparent with the worldwide detection of NDM-1 producers. (who.int)
Clinically significant1
  • Enterobacter cloacae is a clinically significant Gram-negative, facultatively-anaerobic, rod-shaped bacterium. (idilbiotech.com)
Characterization1
  • Characterization of carbapenemases, extended spectrum β-lactamases and molecular epidemiology of carbapenem-non- susceptible Enterobacter cloacae in a Chinese hospital in Chongqing. (edu.iq)
Complex2
  • 4. Stumpf AN, Roggenkamp A, Hoffmann H. Specificity of enterobacterial repetitive intergenic consensus and repetitive extragenic palindromic polymerase chain reaction for the detection of clonality within the Enterobacter cloacae complex. (paijournal.com)
  • With few exceptions, the major classes of antibiotics used to manage infections with the E cloacae complex include the beta-lactams, carbapenems, the fluoroquinolones, the aminoglycosides, and TMP-SMZ. (medscape.com)
Epidemiological2
  • 3. Haertl R, Bandlow G. Epidemiological fingerprinting of Enterobacter cloacae by small-fragment restriction endonuclease analysis and pulsed-field gel electrophoresis of genomic restriction fragments. (paijournal.com)
  • The Team QEM "Quantitative Evolutionary Microbiology" , directed by Olivier Tenaillon and Mathilde Lescat , unraveled the dynamics of adaptation by combining theoretical and mechanistic models applied to quasi-exhaustive libraries of mutants at the gene or operon level, experimental evolution in vitro and in vivo, as well as inferences from phylogenetic and epidemiological data. (iame-research.center)
Polymerase chain re1
  • Polymerase chain reaction (PCR) assays and sequencing was used to determine the presence of β-lactamase encoding genes (bla) including bla NDM-1 and plasmid-mediated quinolone and aminoglycoside resistance determinants. (who.int)
Resistance Gene3
  • qnrA is the plasmid-mediated quinolone resistance gene encoding a 218 amino acid protein of the pentapeptide family that protects DNA gyrase from quinolone inhibition[ 4 ]. (biomedcentral.com)
  • Wastewater-based surveillance enabled the first detection of the mobile colistin resistance gene mcr-10 in Italy. (biomedcentral.com)
  • During this thesis, this system was further exploited by targeting the blaTEM-1 resistance gene located on a high copy plasmid (i.e. (rwth-aachen.de)
BlaIMP2
  • mapping and recombination-adjusted phylogenies), perform in silico typing (MLST, resistance genes and plasmid replicons) and reconstruct a subset of blaIMP plasmids for comparative plasmid genomics. (ox.ac.uk)
  • All blaIMP-4-positive organisms contained five or more other resistance genes. (ox.ac.uk)
QnrB1
  • PMQR genes (including aac(6')-1b-cr, qnrB and qnrS) were also frequently detected. (afpm.org.my)
Colistin2
  • A bla IMI -carrying Enterobacter cloacae , which was also resistant to colistin, is reported here. (medscape.com)
  • To our knowledge, this is the first report of an IMI-1 carbapenemase-producing colistin-resistant E. cloacae in China. (medscape.com)
Outbreak1
  • During the 2018 Lassa fever outbreak in Nigeria, samples from patients with suspected Lassa fever but negative Lassa virus PCR results were processed through custom gene expression array cards and metagenomic sequencing. (cdc.gov)
Staphylococcus1
  • This increase poses several problems, including a) the lack of available antimicrobials for therapy of infections caused by VRE, because most VRE are also resistant to multiple other drugs (e.g., aminoglycosides and ampicillin) previously used for the treatment of infections due to these organisms, and b) the possibility that the vancomycin resistance genes present in VRE may be transferred to other gram-positive microorganisms such as Staphylococcus aureus. (cdc.gov)
Efflux1
  • Clonality, outer-membrane proteins profile and efflux pump in KPC- producing Enterobacter sp. (ac.ir)
Clonal1
BlaKPC-2 foi1
  • A associação de KPC com outras beta-lactamases foi encontrada em 53% das amostras (45,8% produtoras de TEM, 6% produtoras de SHV e 22,9% produtoras de CTX-M). O gene blaKPC-2 foi encontrado associado a uma estrutura parcial do transposon Tn4401 com diferentes isoformas. (fiocruz.br)
Resistant2
  • Interestingly, both still resistant and intermediate sensitive clones had the plasmid copy number and the blaKPC gene expression reduced. (rwth-aachen.de)
  • This increase poses important problems, including a) the lack of available antimicrobial therapy for VRE infections, because most VRE are also resistant to drugs previously used to treat such infections (e.g., aminoglycosides and ampicillin), and b) the possibility that the vancomycin-resistant genes present in VRE can be transferred to other gram-positive microorganisms (e.g. (cdc.gov)
Clusters2
  • We identified several SM-encoding biosynthetic gene clusters (BGCs) from the metagenomic data of lean and obese individuals and found significant association between some BGCs, including those that produce hitherto unknown SM, and obesity. (hindawi.com)
  • The biosynthesis of SMs is controlled by enzymes encoded by biosynthetic gene clusters (BGCs). (hindawi.com)
Plasmids1
  • The bla NDM-1 gene was encoded on plasmids that were easily transferable. (who.int)
Enzymes1
  • Most microbial BGCs that have been identified so far contain genes encoding core biosynthetic enzymes such as polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS). (hindawi.com)
Carbapenemase gene1
  • bla IMI is a carbapenemase gene mediating resistance to carbapenems but has not been commonly found. (medscape.com)