Genes encoding transcription. Medical search. Frequent questions

Light effects on the expression of nuclear genes for plastid proteins and for the 18S, 5.8S and 25S ribosomal RNAs are discussed, together with some recent information concerning the expression of chloroplast genes in developing plastids. (ncsu.edu)
Here we show that the AN gene encodes a C-terminal binding proteins/brefeldin A ADP-ribosylated substrates (CtBP/BARS) related protein. (nih.gov)
Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. (ox.ac.uk)
Differences in promoter structure may thus result in differences in the response to different Brn-3 factors, thus allowing these factors to produce diverse activation patterns of neuronally expressed genes, such as those encoding different synaptic proteins. (ox.ac.uk)
Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. (origene.com)
Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. (origene.com)
This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. (novusbio.com)
Confocal micrograph showing the expression of different fluorescent proteins in the stem of a thale cress seedling (Arabidopsis thaliana) used to study in vivo gene expression. (cellimagelibrary.org)
Histone deacetylases (HDACs) are a family of epigenetic enzymes that suppress gene transcription by removing acetyl groups from histone proteins ( Kouzarides, 2007 ). (jneurosci.org)
Transcription factor Nrf2 is a key regulator of genes encoding phase II detoxification enzymes and antioxidant proteins in response to environmental chemical insults. (cdc.gov)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
This gene provides instructions for making a protein that attaches (binds) to other proteins and then binds to specific regions of DNA to help control the activity of many other genes. (medlineplus.gov)
A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. (bvsalud.org)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

Mutations in the human ATRX gene, encoding a putative transcription regulator, cause diverse changes in the pattern of DNA methylation. (ox.ac.uk)
The cause of this disorder is mutations in the autoimmune regulator (AIRE) gene. (europa.eu)
Mutations within the X linked MECP2 gene have been identified in patients with Rett syndrome (RTT), a neurodevelopmental disorder which affects females almost exclusively and which shares phenotypic overlap with AS. (bmj.com)
Finally, around 5% of patients have loss of function mutations in the UBE3A gene, a gene encoding E6-AP, a ubiquitin protein ligase. (bmj.com)
We isolated novel mutations affecting condensin, as well as mutations in four genes not previously implicated in mitotic chromosome condensation in fission yeast. (ens-lyon.fr)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
Mutations in the TCF4 gene cause Pitt-Hopkins syndrome. (medlineplus.gov)
TCF4 gene mutations disrupt the protein's ability to bind to DNA and control the activity of certain genes. (medlineplus.gov)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
The emm43.4/PBP2x-T553K variant, comprised of two isolates, displayed the most significant phenotype (ampicillin MIC 0.25 g/ml) and harbored missense mutations within 3 non-PBP genes with known involvement in antibiotic efflux, membrane insertion of PBP2x, and peptidoglycan remodeling. (cdc.gov)

This study indicates that chloroplast genes are often grouped into multigene transcriptional units which can be cotranscribed, and that light-stimulated plastid development involves changes in the relative abundance of the overlapping RNAs of different length that result from transcription of these genes or gene clusters. (ncsu.edu)
Emphasis is given to the diversity of different responses observed with different genes and evidence for light effects at both transcriptional and post‐transcriptional levels. (ncsu.edu)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
In contrast to the SNAP-25 gene, the gene encoding the synaptic vesicle protein synapsin 1 is activated by all the Brn-3 factors, the first gene for which this activation pattern has been reported Interestingly, however, similar activation by all three Brn-3 factors can be observed if the SNAP-25 promoter is truncated by removal of sequences from -2200 to -288 relative to the transcriptional start site. (ox.ac.uk)
SUPERMAN (SUP) and SUPERMAN-like genes such as APETALA2 work as a protein complex regulators with other corepressors known as TOPLESS (TPL) and a Histone Deacetylase 19 (HD19) in order to repress transcriptional functions in plants Superman has been found to undergo to epigenetic modifications. (wikipedia.org)
The lack of understanding of post-transcriptional regulation implies we still do not have a complete picture of how genes are regulated. (tum.de)
The encoded protein acts as a transcriptional activator. (novusbio.com)

The genome of the geminivirus tomato golden mosaic virus (TGMV) consists of two circular DNA molecules designated as components A and B. The A component contains the only virally-encoded function required for autonomous replication in infected plant cells. (ncsu.edu)
A transcription map of the pea chloroplast genome. (ncsu.edu)
A set of 53 cloned pea chloroplast DNA fragments representing approximately 90% of the chloroplast genome was used to probe Northern blots of total pea RNA, resulting in a nearly complete chloroplast transcription map. (ncsu.edu)
For many regions of the genome, we have detected multiple overlapping transcripts including both small, gene-sized RNAs and large transcripts covering entire gene clusters. (ncsu.edu)
The gradual conversion from endosymbiont to organelle during the course of evolution has clearly been accompanied by a dramatic reduction in genome size as the chloroplasts lost most of their genes to the nucleus. (frontiersin.org)
High transformation efficiency of citrus is of great importance for large scale characterization of gene functions and also cultivar development via transgenic and genome editing technologies. (springer.com)
As we all know, the genome encodes the instructions to regulate gene activity. (tum.de)
Recent genome-wide binding studies showingthat in most species condensin is enriched near highly expressed genes suggest aconserved link between condensin occupancy and high transcription rates. (ens-lyon.fr)
Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
The effect of Buchnera genome evolution on gene expression levels has also been analysed in order to assess the constraints imposed by the obligate symbiosis with aphids, underlining the importance of some gene sets for the survival of the two partners. (biomedcentral.com)
Despite an important reduction in its genome size and an apparent decay of its capacity for regulating transcription, this work reveals a significant correlation between mRNA abundances and chromosomal organization of the aphid-symbiont Buchnera . (biomedcentral.com)
Employing the DNA blot analysis only one COMT-encoding gene was found in the rat genome. (lu.se)

Gene ID: 5925, OMIM 614041 ) gene, which encodes a tumor suppressor protein. (molvis.org)
This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)
The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)

This gene encodes a putative transcription factor in medullary thymic epithelial cells. (europa.eu)

The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. (yeastgenome.org)
It is one of many regulators of FLO11 , but seems to play a central role as it is absolutely required for FLO11 transcription. (yeastgenome.org)
Hox genes encode crucial developmental regulators that specify segmental identities along the Antero-Posterior (A-P) body axis in the developing embryo of bilaterian species. (biorxiv.org)
Regulators of Transcription with epigenetic changes in a (TaRGET) Program particular type of tissue. (medlineplus.gov)

It encodes a transcription factor (specifically a C2H2 type zinc finger protein). (wikipedia.org)
Superman encodes a transcription factor. (wikipedia.org)
The PITX gene encode the paired-like homeodomain transcription factor family. (nature.com)
BRC1 encodes a transcription factor that can inhibit branching. (europa.eu)
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. (nih.gov)
Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. (nih.gov)
The maize homeobox gene knotted1 ( kn1 ) encodes an AP2/ERF transcription factor (Hake et al. (springer.com)
MSS11 encodes a transcription factor that lacks overall similarity to known transcription regulator families, although it has similarity to Flo8p . (yeastgenome.org)
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
Transcription factor STAT3 (which stands for signal transducer and activator of transcription 3) has been found to play a key role in the growth brain tumors, such as glioblastoma multiforme (GBM). (azbigmedia.com)
A transcription factor is a protein that binds to specific DNA sequences and controls the rate of the transcription of genetic information from DNA to messenger RNA. (azbigmedia.com)
STAT3 is a type of transcription factor. (azbigmedia.com)
The transcription factor STAT3 (signal transducer and activator of transcription 3) plays a key role in the development and progression of high-grade malignant gliomas, the most common and aggressive brain tumors. (azbigmedia.com)
The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
On the basis of its DNA binding and gene controlling activities, the TCF4 protein is known as a transcription factor. (medlineplus.gov)
The second strongest association was for the transcription factor IRX1 . (medscape.com)
The CEBPE gene encodes a transcription factor, which is expressed primarily during granulocytic differentiation. (lu.se)

Superman is a plant gene in Arabidopsis thaliana, that plays a role in controlling the boundary between stamen and carpel development in a flower. (wikipedia.org)
Homologous genes are known in the petunia and snapdragon, which are also involved in flower development, although in both cases there are important differences from the functioning in Arabidopsis. (wikipedia.org)
This protein binds to the DNA through a zinc finger binding motif acts as a regulator of floral homeotic genes, controlling the development of the flowers of Arabidopsis thaliana plants. (wikipedia.org)
The EnCoDe project used the model plant Arabidopsis to elucidate how this process is regulated and to understand its significance in natural populations. (europa.eu)
In Arabidopsis thaliana we use the spatial data to identify differences in expression levels of 141 genes and 189 pathways in eight inflorescence tissue domains. (nature.com)
These 77 genes were then divided into eleven subfamilies according to their homology with Arabidopsis thaliana . (biomedcentral.com)

a plastid-encoded bacterial-type RNA polymerase (PEP) and a nuclear-encoded phage-type RNA polymerase (NEP), which recognize distinct types of promoters. (frontiersin.org)
Steven Hahn (Fred Hutchinson Cancer Research Center, Seattle): "TFIID is one of the essential components in the machinery necessary to initiate transcription by RNA polymerase II. (the-scientist.com)
S100A8 mRNA and S100A8 protein levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. (medscimonit.com)
Indeed, bacterial genomes carry, on average, from 78% (for genomes containing the polymerase PolC) to 58% (for the other genomes) of their genes on the leading strand [ 3 ]. (biomedcentral.com)

Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)
WRN protein is thought to be involved in optimization of various aspects of DNA metabolism, including DNA repair, recombination, replication, and transcription. (amrita.edu)

Nuclear and cytoplasmic mRNAs for several phytochrome-regulated genes were examined in Pisum seedlings in order to investigate possible light effects on mRNA partitioning between the nucleus and cytoplasm. (ncsu.edu)
Transcripts from each of five light-regulated genes exhibited different responses to a variety of light treatments, but for each transcript we observed a characteristic linear relationship between nuclear and cytoplasmic levels over a wide range of total transcript abundance. (ncsu.edu)
It is caused by pathogenic variants in the WRN gene, which encodes a multifunctional nuclear protein with exonuclease and helicase activities. (amrita.edu)

ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. (aacrjournals.org)

Even in wild-type “Chinese Spring”, the NOR on chromosome 1B is partially dominant to that on chromosome 6B, since the 1B locus is more active in spite of having fewer genes. (ncsu.edu)
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
Our results therefore provide strong additional evidence for a functional connection between chromosome condensation and transcription. (ens-lyon.fr)
In D. melanogaster , the eight Hox genes are organized in two separate clusters on chromosome 3R: the Antennapedia cluster (ANT-C) and the Bithorax cluster (BX-C). The 350 kb BX-C contains the Ubx, abd-A and Abd-B genes, which specify the identity of the more posterior embryonic parasegments 5 to 14 (PS5 to PS14). (biorxiv.org)
Past genomic studies have comprehensively described the organization of the bacterial chromosome, for example in terms of gene localization, order and orientation. (biomedcentral.com)
Gene organization in the bacterial chromosome has very well known effects on transcription and a standard example is the organization of genes into operons, which allows for a sophisticated regulation of gene expression [ 9 ]. (biomedcentral.com)
It has also been shown that neighbouring genes in a bacterial chromosome tend to be co-expressed, even if they are not in the same operon [ 10 ], suggesting the existence of a "supra-operonic" organization [ 11 ]. (biomedcentral.com)

One CCGG site 164 base-pairs upstream from the start of transcription is preferentially unmethylated in some genes. (ncsu.edu)
Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
Predicted to act upstream of or within gene silencing by RNA and regulation of translation. (nih.gov)
The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)
Primer extension analysis showed that the transcription start point of the rat liver COMT mRNA was 450 bp upstream from the. (lu.se)

The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)

mRNA steady state levels of the chlorophyll a/b-binding protein of photosystem II, ferredoxin I, the small and large subunits of ribulose 1,5-bisphosphate carboxylase, and pEA214 and pEA207, two other light-responsive genes, were determined during chlorophyll photooxidation. (ncsu.edu)
Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic transcription reactions. (mdpi.com)
The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was enabled with previous innovations in nucleoside modifications during in vitro transcription and lipid nanoparticle delivery materials of mRNA. (mdpi.com)
First, there is the transcription of genes to mRNA which is largely regulated by the promoter sequence. (tum.de)
Our analysis showed that mRNA abundances, gene organization (operon) and gene essentiality are correlated in Buchnera (i.e., the most expressed genes are essential genes organized in operons) whereas no link between mRNA abundances and gene strand bias was found. (biomedcentral.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)

Studies on the developmental onset of the teleost circadian clock have been carried out in zebrafish and, recently, in rainbow trout and Senegalese sole, where rhythms of clock gene expression entrained by light-dark (LD) cycles have been reported from the first days post fertilization. (researchgate.net)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)

Cytosine methylation has been studied in wheat rRNA genes at nucleolar organizers displaying different activities. (ncsu.edu)
The methylation pattern within a specific multigene locus is influenced by the number and type of rRNA genes in other rDNA loci in the cell. (ncsu.edu)
It is concluded that cytosine methylation in rDNA is regulated and that the methylation pattern correlates with the transcription potential of an rRNA gene. (ncsu.edu)
This methylation brings about the Clark Kent (clk) epialleles, which are a set of altered versions of the Superman gene lacking function. (wikipedia.org)
Whereas most cases of cytosine methylation in plants tend to happen in the Promoter of transcription, the cytosine methylation of Superman happens within the gene, just after the promoter. (wikipedia.org)
Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)

We show that the promoter of the gene encoding the presynaptic nerve terminal protein SNAP-25 resembles previously characterised target genes in being activated by Brn-3a and Brn-3c, but being repressed by Brn-3b. (ox.ac.uk)
Unlike other target genes, however, the SNAP-25 promoter can be activated by either the N- or C-terminal activation domains of Brn-3a. (ox.ac.uk)
Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)

The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
In an attempt to address these issues with a genetic intervention, scientists reprogrammed neurons in mouse eyes to regrow after inducing glaucoma or crushing the optic nerve, and restored visual acuity in healthy, middle-aged mice to that of younger mice by expressing a set of genes known to revert cells to a pluripotent state, according to a study published in Nature Wednesday (December 2). (the-scientist.com)
The effects of a maize knotted1 ( kn1) gene under the control of the cauliflower mosaic virus 35S promoter on genetic transformation efficiencies of six citrus genotypes were tested. (springer.com)
With all six genotypes of citrus tested including Eureka lemon, a cultivar difficult to be transformed, our results demonstrate that the kn1 gene may provide an effective molecular tool to enhance genetic transformation efficiencies of various citrus varieties. (springer.com)
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)
Cloning of the gene opened up a whole series of biochemical and molecular genetic approaches for studying the mechanism of transcription. (the-scientist.com)
These include the recent cloning of the TFIID genes from other eukaryotes, genetic screens to identify other. (the-scientist.com)
Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)

Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes. (yeastgenome.org)

HPV-negative tumors contained novel co-amplifications of 11q13 and 11q22, an event that likely promotes the interaction of BIRC2 and FADD , genes that together work to inhibit cell death. (cancer.gov)

Researchers at Harvard Medical School report in the April 23, 2006 issue of Nature that they have identified neurons that encode the values that subjects assign to different items. (harvard.edu)
Researchers repaired what is otherwise irreversible damage in the animals' ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells. (the-scientist.com)
ABOVE: A mouse's crushed optic nerve, composed of retinal ganglion cell axons (bright streaks), regenerates after researchers injected a virus into the eye that contains genes whose activity dedifferentiates cells into a more youthful state, allowing them to regrow. (the-scientist.com)
To test whether adult mice can regain this ability, the researchers crushed the optic nerves of some mice and induced glaucoma in another set of mice by inserting tiny beads into their eyes, then injected the virus encoding the three transcription factors into all the mice's eyes. (the-scientist.com)
Researchers have identified two genes that may contribute to Raynaud phenomenon, a condition where blood vessels in the extremities constrict and limit blood flow. (medscape.com)
The researchers identified two genes that are likely involved with Raynaud. (medscape.com)
Researchers can use ENCODE data-- are associated with epigenetic changes that may lead to which has been combined with other data, such as cancer, cardiovascular diseases, autoimmune diseases, environmental information--to better understand diseases and neurological disorders. (medlineplus.gov)

The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)

The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). (bvsalud.org)

YAP and TAZ are fused to other genes that code for transcription factors that activate YAP and TAZ constitutively. (oist.jp)

Our process includes high-throughput spatial transcriptome profiling followed by spatial gene and pathway analyses. (nature.com)

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)

Dominant, very active loci have a higher proportion of rRNA genes with unmethylated cytosine residues in comparison with recessive and inactive loci. (ncsu.edu)

Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. (genome.gov)
By contrast, an autosomal recessive disorder requires two copies of the mutated gene (one from each parent) to cause the disorder. (genome.gov)
By contrast, an autosomal dominant disorder requires only a single copy of the mutated gene from one parent to cause the disorder. (genome.gov)

The sequence of the four nucleotide bases encodes DNA's information. (genome.gov)
A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Deciphering the language in which genomes are written, that is knowing the words and grammar and instructions made of A, C, G, and Ts encoding how cells should react to environmental changes, is a long-standing goal of biology. (tum.de)
However, this analysis requires accurate reference genomes to identify the specific genes from which RNA reads originate. (osti.gov)
Sample-specific meta-genomic assembled genomes (MAGs) were used as reference genomes to accurately identify the origin of RNA reads, and transcript ratios of genes with opposite transcription responses were compared to eliminate biases related to differences in organismal abundance, an approach hereafter named the "diametric ratio" method. (osti.gov)

Hox genes encode transcription factors that specify segmental identities along the Antero-Posterior body axis. (biorxiv.org)

The three members of the Brn-3 subfamily of POU transcription factors have distinct effects on target gene expression. (ox.ac.uk)
The mouse Pitx2 gene encodes three distinct protein isoforms (Pitx2a, b, c), and Pitx2c plays a determinant role in left-right atrium signaling from early somitogenesis onward 5 . (nature.com)
Two transcript variants encoding distinct isoforms have been identified for this gene. (novusbio.com)

Patterns of phytochrome-induced gene expression in etiolated pea buds. (ncsu.edu)
tures and gene expression patterns. (lu.se)
RESULTS: We identified substantial inter-patient heterogeneity in the composition of cell types (including malignant, mesothelial and immune cell populations), in expression of subtype-specific gene signatures and in copy number aberration patterns, that captured variability across breast cancer cell populations. (bvsalud.org)

Several transcript variants have been described for this gene. (nih.gov)

We investigated the expression of genes of interest using quantitative reverse transcription PCR. (molvis.org)

The second ben/cat operon was located in a 92-kb scaffold along with (i) an operon ( opp ) comprising genes for the transformation of OPP to BA and 2-hydroxypenta-2,4-dienoate (and genes for its transformation) and (ii) an incomplete biphenyl catabolic operon ( bph ). (nature.com)

The bacterial genes encoding chloramphenicol acetyltransferase (CAT) and beta-glucuronidase (GUS) were transiently expressed in leaf discs from the AR1 promoter in TGMV A. The levels of AR1 and GUS RNAs were similar in leaf discs after adjusting for viral DNA copy number, while CAT RNA was less abundant. (ncsu.edu)

Genomic analysis identified two orthologous operons encoding the ortho -cleavage of benzoic acid (BA) ( ben/cat ). (nature.com)
A unique feature of Hox genes in most species is that they are organized in clusters, with their relative genomic position corresponding to their order of expression along the A-P axis ( McGinnis and Krumlauf, 1992 ). (biorxiv.org)
Genomic studies on bacteria have clearly shown the existence of chromosomal organization as regards, for example, to gene localization, order and orientation. (biomedcentral.com)
Using an oligonucleotide-based microarray, we normalized the transcriptomic data by genomic DNA signals in order to have access to inter-gene comparison data. (biomedcentral.com)
We analysed the genomic sequences to identify serotypes and penicillin-binding protein (PBP) genes 1A, 2B and 2X, and other resistance determinants, to predict minimum inhibitory concentrations (MICs) against penicillin, erythromycin, clindamycin, co-trimoxazole and tetracycline. (cdc.gov)

The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)

We reported here that Cd induces cytoprotective genes NAD(P)H-quinone oxidoreductase I (Nq01) and heme oxygenase I (Ho-1) via the Nrf2/Keap1 pathway. (cdc.gov)

Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

This gene encodes a member of the p53 family of transcription factors. (origene.com)

First, they regulate the expression of the BRC1 gene in buds. (europa.eu)

S. Hahn, S. Buratowski, P.A. Sharp, L. Guarente, "Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions," Cell, 58, 1173-81, 22 September 1989. (the-scientist.com)

A rare sarcoma of soft tissues, known as the EHE - Epithelial Hemangio-Endothelioma is driven by the mutated versions of YAP or TAZ genes. (oist.jp)
Functional aspects such as growth, development, biochemistry and physiology ultimately derive from underlying gene expression programmes that are actively regulated in different organs and tissues. (nature.com)
Another challenge to using transgenic plant technology in citrus is the long juvenile phase of immature tissues that ranges from 5 to 20 years, which greatly delays analysis of the effects of candidate genes. (springer.com)
We reviewed published microarray and RNA sequencing studies in which gene expression profiles were compared between human RB and normal retina tissues. (molvis.org)

Synthesis of AR1 RNA was dependent on T-DNA transfer and TGMV DNA replication, demonstrating that it is a plant transcription product. (ncsu.edu)
Chromatin structure and expression of plant ribosomal RNA genes. (ncsu.edu)

6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
In Drosophila , the BX-C cluster contains the three most posterior Hox genes, where their collinear activation incorporates progressive replacement of histone modifications, reorganization of 3D chromatin architecture and sequential activation of boundary elements and cis -regulatory regions. (biorxiv.org)

ABSTRACT This study aimed to evaluate the association of plasma MIF level and -173 G/C single nucleotide polymorphism of the MIF gene with the occurrence, severity and mortality of sepsis patients. (who.int)

the gene expression profile during B lymphoid differentiation. (lu.se)

Ribosomal RNA genes at different nucleolar organizer (NOR) loci in hexaploid wheat are expressed at different levels. (ncsu.edu)
Here, we show that rRNA genes at dominant loci are organized in a chromatin conformation that renders them more sensitive to DNase I digestion than other rRNA genes. (ncsu.edu)

Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)

Previous studies in zebrafish and rainbow trout have shown that circadian oscillation of clock genes represents one of the earliest detectable rhythms in the develo. (researchgate.net)

Although these techniques can provide spatially resolved or cell-type-specific gene expression data, they each have inherent limitations. (nature.com)
Higher transcription levels of IP-10, IL-1β, IL-6, IL-10, IL-12 cytokines, and NF-κB translocation to the nucleus were more often documented for type II strains than type I strains. (springer.com)

The neurons we have identified encode the value individuals assign to the available items when they make choices based on subjective preferences, a behavior called 'economic choice. (harvard.edu)
The next challenge: to see if these transcription factors could successfully revert old and injured neurons back to a more youthful and healthy state. (the-scientist.com)

These genes are organized in clusters, where their order corresponds to their activity along the body axis, an evolutionary conserved feature known as collinearity. (biorxiv.org)

Anatomy15

Organisms9

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes84

Disciplines and Occupations1

Information Science3

Proteins15

Mutations11

Transcriptional7

Genome12

Tumor5

Protein encoded by this gene2

Putative transcription1

Regulators4

Factor19

Arabidopsis6

Polymerase4

Metabolism2

Nuclear3

Regulator1

Chromosome7

Upstream5

Phenotypes2

MRNA5

Pathways2

Developmental2

Methylation7

Target genes3

Genetic9

Locus1

Inhibit1

Researchers7

Embryonic1

Trinucleotide1

Factors that activate1

Transcriptome1

Molecular1

Residues1

Autosomal3

Sequence2

Datasets1

Genomes3

Segmental1

Distinct3

Patterns3

Variants1

Quantitative reverse1

Operon1

Bacterial1

Genomic5

Apoptosis1

Induces1

Surrogate1

Family of transcription factors1

Buds1

Suppressor1

Tissues4

Plant2

Cluster2

Abstract1

Differentiation1

Loci2

Cardiac1

Circadian1

Type2

Neurons2

Clusters1