Genes encoding proteins myod protein. Medical search. Frequent questions

Separately, E2a is necessary to drive transcription of Smad2 /3 target genes, including critical regulators of dorsal cell fate and morphogenesis. (xenbase.org)
In earlier reports, PRMTs promoted active transcription of target genes by mediating asymmetric dimethylation of arginine residues on histones, resulting in increased acetylation and the subsequent activation of transcription. (e-enm.org)
25 The downstream target genes of MAPK signaling cascades comprise of the differentiation related transcription aspects Jun ATF2/AP1, C/EBPB and Egr one, which are known to get necessary for myeloid differentiation. (chk1inhibitor.com)
26 29 Yet, in spite of a lot of reviews for the function of important MAPK cascade kinases and their target genes in hematopoiesis,thirty it is not clear what reg ulates the MAPK cascades in VDD induced cell differentiation. (chk1inhibitor.com)

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. (wikipedia.org)
Regulatory proteins, namely the Transcription Factors (TFs), bind in a sequence-specific manner to TFBSs to activate or suppress gene transcription (gene expression). (biomedcentral.com)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
Fasting signals are relayed by various intracellular enzymes, such as kinases, phosphatases, acetyltransferases, and deacetylases, which affect the transcriptional activity of transcription factors and transcriptional coactivators for gluconeogenic genes. (e-enm.org)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)

Changes in genes and regulatory elements are associated with exceptional mammalian traits, such as hibernation, that could inform therapeutic development. (bvsalud.org)
Many molecules have been reported to associate with desmin, such as other IF proteins (including members of the membrane dystroglycan complex), nebulin, the actin and tubulin binding protein plectin, the molecular motor dynein, the gene regulatory protein MyoD, DNA, the chaperone alphaB-crystallin, and proteases such as calpain and caspase. (biologicalworld.com)
3) Which of the following is a protein produced by a regulatory gene? (easynotecards.com)
7) A mutation that inactivates the regulatory gene of a repressible operon in an E. coli cell would result in A) continuous transcription of the structural gene controlled by that regulator. (easynotecards.com)

Among these, EZH2 that mediates repressive histone H3 lysine 27 trimethylation (H3K27me3) is upregulated and binds to muscle specific genes in ERMS. (elifesciences.org)

We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

Expression levels of mouse Akt2 mRNA and Akt2 protein varied among tissues, with the highest levels in skeletal muscle. (nih.gov)
The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation. (nih.gov)
We established at mRNA level the expression of 84 genes partici pating inside the MAPK signaling network and cell cycle regulation employing Human MAP kinase RT2 Profile PCR Array. (chk1inhibitor.com)

The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. (wikipedia.org)
Transcriptional regulation of the 11p15 mucin genes. (imrpress.com)
Previously, we reported ephrinA5 to trigger transcriptional changes of lncRNAs and protein-coding genes in cerebellar granule cells, a cell model for medulloblastoma. (biomedcentral.com)

We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)

This protein may play a role in cell growth, senescence, and differentiation. (wikipedia.org)
Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)
Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role of the major heterochromatin proteins in pluripotency is unknown. (biomedcentral.com)
Here we identify Heterochromatin Protein 1β (HP1β) as an essential protein for proper differentiation, and, unexpectedly, for the maintenance of pluripotency in ESCs. (biomedcentral.com)

explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
The human genome encodes seven sirtuins, with representatives from classes I-IV (Table 1 ) [ 17 ]. (biomedcentral.com)
A comparison of immune associated genes amid insect species On this review, the genome and transcriptome broad ana lysis revealed an intact innate immune network current ing in N. lugens. (cox2-inhibitors.com)
Defensins will be the distinctive antibacterial peptide genes out there within the N. lugens genome. (cox2-inhibitors.com)
The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene ( MyoD2 ) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained both MyoD paralogues. (mdpi.com)

Two transcript variants encoding different isoforms have been found for this gene. (wikipedia.org)
The two DUX4‐fl isoforms produce the same protein sequence and differ only in the splicing of the 3′UTR. (comprehensivephysiology.com)

FSHD candidate genes on chromosome 4q35. (comprehensivephysiology.com)
Locations of the candidate genes and the DME1 and DME2 myogenic transcription enhancers (92) are shown. (comprehensivephysiology.com)

E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism. (wikipedia.org)
Hey2 mit den bHLH-Proteinen E2-2, E2-5, MyoD und c-hairy1 nachgewiesen werden. (uni-wuerzburg.de)
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. (novusbio.com)
This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. (novusbio.com)

We report our analysis of MyoD1 and MyoD2 protein sequences from 54 teleost species, and show that O. alcalica , along with some other teleosts, include a polyserine repeat between the amino terminal transactivation domains (TAD) and the cysteine-histidine rich region (H/C) in MyoD1. (mdpi.com)
DUX4 protein sequences beginning at the ATG start codon, with the stop codon indicated, and the 3′UTRs shown in orange. (comprehensivephysiology.com)

states'' or gene expression patterns. (lu.se)
A number of immune re sponsive effector genes exhibited distinctive expression patterns. (chk1inhibitor.com)
Here we reveal the expression patterns of the two MyoD genes in Oreochromis ( Alcolapia) alcalica using in situ hybridisation. (mdpi.com)

Here, we investigate how perturbation of the cofactor E2a affects global patterns of Smad2 /3 binding and gene expression during gastrulation. (xenbase.org)
E2a Is Required for Subsets of Smad2/3 Binding and for Global Patterns of Smad2/3 Target Gene Expression (A) Smad2/3 targets 1,027 distinct genomic regions in control stage 10.5 embryos (yellow) and 1,671 regions in E2a -depleted embryos (blue). (xenbase.org)
12) Altering patterns of gene expression in prokaryotes would most likely serve the organism's survival in which of the following ways? (easynotecards.com)

Fluorescence in situ hybridization of the mouse cDNA to rodent metaphase spreads demonstrated that the Akt2 gene maps to mouse chromosome band 7B1 and rat chromosome 1q22. (nih.gov)
This analysis revealed significant associations at the CDKN2A/B gene locus on canine chromosome 11, mirroring previous findings in other dog breeds, such as the greyhound, that also show an elevated risk for OSA. (bvsalud.org)

Identification of transcription factor binding sites (TFBSs) is a central problem in Bioinformatics on gene regulation. (biomedcentral.com)
Therefore, TFBSs are a critical component in gene regulation, and identification of TFBSs is a central problem for understanding gene regulation in molecular biology. (biomedcentral.com)
Motif discovery provides significant insights into the understanding of the mechanisms of gene regulation. (biomedcentral.com)
The genomic organization and regulation of the murine and human resistin genes are divergent and may explain these discrepant findings ( 13 ). (diabetesjournals.org)
Here, we investigate a lncRNA-mediated targeting of DNMT1 to specific gene loci by the combined power of in silico modeling of RNA/DNA interactions and wet lab approaches, in the context of the clinically relevant use case of ephrinA5-dependent regulation of cellular motility of cerebellar granule cells. (biomedcentral.com)

and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)

These studies focus on the degradation of specific disease related proteins and the general status of the UPS under conditions of an excess of aberrant or misfolded proteins. (5dok.org)
To evaluate the capacity of the UPS to degrade disease related proteins, polyglutamine (polyGln) proteins were targeted for proteasomal degradation. (5dok.org)
However, aggregation of the aggregation- prone polyGln proteins prevented proteasomal degradation. (5dok.org)
Thus the formation of aggregates renders these toxic proteins resistant to proteasomal degradation and initiates the accumulation of polyGln proteins and polyGln-interacting proteins. (5dok.org)
A mutant form of Ub, UBB +1 is another protein that can resist proteasomal degradation. (5dok.org)
Since the UPS is also responsible for the degradation of ER proteins we investigated the effect of ER stress on the functionality of the UPS. (5dok.org)
However, in these diseases the UPS is compromised and some proteins might resist degradation. (5dok.org)
degradation of polyglutamine proteins. (5dok.org)
DUX4‐fl transcription factor misexpression in skeletal muscle leads to disrupted RNA splicing, nonsense mediated decay (NMD), and protein degradation, possibly causing damaged associated molecular pattern (DAMP) release, which may elicit an immune response to targeted damaged muscles. (comprehensivephysiology.com)

The evolutionary history of MyoD1 and MyoD2 is compared to the presence of this polyserine region using phylogenetics, and its functional relevance is tested using overexpression in a heterologous system to investigate subcellular localisation, stability, and activity of MyoD proteins that include and do not include the polyserine region. (mdpi.com)

One is, how, and to what extent, does the nervous system control protein expression in skeletal muscle fibers? (ucla.edu)

A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)

Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. (novusbio.com)

Protein arginine methyltransferases (PRMTs) comprise a group of enzymes that catalyze the transfer of methyl groups to the amino acid arginine or the arginine residues of proteins in eukaryotic species. (e-enm.org)
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. (lookformedical.com)

In particular, ESRR alpha (ESRRa) and ESRR gamma (ESRRg) are key metabolic regulators of energy homeostasis and abnormal functions of these proteins are linked to metabolic syndromes including diabetes and fatty liver disease 5 . (nature.com)

Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
Similarly, N. lugens CLIP genes also had substantially high expression levels in male grownups when when compared with the female adults. (chk1inhibitor.com)

N. lugens PGRP and GRP genes showed much higher expression levels in male adults than in female grownups. (chk1inhibitor.com)

While all three types of PRMTs are capable of catalyzing monomethylation of arginine residues, type I PRMTs can transfer a second methyl group to the monomethylated nitrogen atom of the guanidino group of monomethyl arginine, resulting in the formation of proteins containing one or more asymmetric dimethylarginine residues. (e-enm.org)
Type II PRMTs transfer a methyl group to the unmodified nitrogen atom of the guanidine group of monomethyl arginine to form proteins with symmetric dimethylarginine residues. (e-enm.org)
Post-translational modification of proteins at lysine residues by reversible acetylation is catalyzed by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which act on both histone and non-histone substrates despite their names. (biomedcentral.com)

Brix domain-containing proteins, such as Peter Pan (PPan), are essential for eukaryotic ribosome biogenesis. (silverchair.com)

Loss of PPan, but not interference with rRNA processing, led to an early downregulation of specific marker genes of the eye, including Rx1 and Pax6 , and of NCCs, such as Twist, Slug and FoxD3 . (silverchair.com)

Desmin: molecular interactions and putative functions of the muscle intermediate filament protein. (biologicalworld.com)
Molecular techniques including RNA-sequencing allowed to map and identify the LRMD causal mutation, consisting in a 2.2-Mb inversion disrupting the DMD gene within its intron 20, and involving TMEM47 gene. (researchsquare.com)

Also, other DUX4‐fl protein interactions may affect muscle function. (comprehensivephysiology.com)

Loss of function analysis shows that knockdown of esrra impairs expression of genes including sox9, col2a1, sox5, sox6, runx2 and col10a1 thus induces abnormally formed cartilage in pharyngeal arches. (nature.com)
However, whether and how DNMT targets specific gene loci, and induces transcriptionally relevant changes in DNA methylation signatures that elicit physiological responses, is not fully understood. (biomedcentral.com)

B) complete inhibition of transcription of the structural gene controlled by that regulator. (easynotecards.com)
These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)

Die Hey-(hairy and E(spl) related with YRPW motif)-Gene kodieren drei hairy/E(spl)/Hes-verwandte basische Helix-Loop-Helix-Transkriptionsfaktoren, die durch eine Orange-Domäne und einen charakteristischen Carboxyterminus gekennzeichnet sind. (uni-wuerzburg.de)

For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
D) bind to the repressor protein and inactivate it. (easynotecards.com)
D) The repressor protein and allolactose bind to RNA polymerase. (easynotecards.com)
Proteins which bind to DNA. (lookformedical.com)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)

A common feature in many of these diseases is the presence of aggregated proteins that are covalently linked to ubiquitin (Ub). (5dok.org)

Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)
B) Allolactose binds to the repressor protein. (easynotecards.com)
C) Allolactose binds to the regulator gene. (easynotecards.com)

Akt2 expression was low in a multipotent fibroblast cell line, but it was upregulated when these cells were transformed with Myod and induced to differentiate into myocytes. (nih.gov)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
The ubiquitin-proteasome system (UPS) is the main pathway in the cell for the elimination of aberrant or misfolded proteins. (5dok.org)
Nevertheless, in neurodegenerative diseases these proteins accumulate with disastrous consequences for neurons, eventually leading to cell death. (5dok.org)
In parallel to this active clinical research that has substantially increased the lifespan but also the quality of life of the DMD patients, innovative therapies including gene, cell and pharmacological therapies have been and are developed with the aim to cure or alleviate DMD. (researchsquare.com)
Antibody reactivity against recominant protein and cell lysate for WB. (novusbio.com)
Even though the physiological relevance of Eph/ephrin signaling has been well-proven for developmental and cancer-related processes, whether and how the ligand-mediated activation of Eph receptors triggers changes in gene expression that underlie discrete cell physiological responses is greatly unknown. (biomedcentral.com)
These analyses consist of enzyme activities of single muscle or neural cells, cell morphology, the kinds of proteins synthesized, the modulations of the mRNA's of specific myonuclei as well as the physiological properties of the nerve and muscle cells. (ucla.edu)
Proteins that control the CELL DIVISION CYCLE. (lookformedical.com)
Proteins found in the nucleus of a cell. (lookformedical.com)

Desmin was purified in 1977, the desmin gene was characterized in 1989, and knock-out animals were generated in 1996. (biologicalworld.com)

Signaling through the p38 mitogen-activated protein kinases (MAPKs) is essential for cartilage formation in primary cultures of limb mesenchyme. (biologists.com)
Gene expression analysis indicates that esrra is expressed in developing pharyngeal arches where genes necessary for cartilage development are also expressed. (nature.com)
Expression of esrra is colocalised with genes necessary for cartilage development in pharyngeal arches during zebrafish embryogenesis. (nature.com)

In other words, expression of specific genes might have relevance to pathogenesis of diseases. (intechopen.com)

Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. (e-enm.org)

Die Hey-(hairy and E(spl) related with YRPW motif)-Gene kodieren drei hairy/E(spl)/Hes-verwandte basische Die Entwicklung eines vielzelligen Organismus aus einer befruchteten Eizelle ist nur durch komplexe zelluläre Regulationsmechanismen möglich. (uni-wuerzburg.de)

The hormone resistin is a member of a novel family of cysteine-rich secreted proteins associated with pulmonary inflammation (FIZZ3) and expressed in the murine small bowel and adipose tissue ( 1 ). (diabetesjournals.org)

Sequence analysis revealed that, like its human homolog, Akt2 encodes a protein-serine/threonine kinase containing a pleckstrin homology domain at its amino terminus. (nih.gov)
The 1,25D delicate HL60 cells had been compared with 1,25D resistant 40AF cells, and this recognized, for the first time, hematopoietic progenitor kinase one as the most upregulated MAPK gene within the one,25D resistant cells. (chk1inhibitor.com)

The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)

The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)

E and F) Significant overlap exists between genes that are Smad2/3 targets and genes that are downregulated in E2a -depleted embryos. (xenbase.org)

This network included the abundant pattern recognition proteins, signal transduction compo nents involved with Toll, Imd and JAK/STAT pathways, modulation molecules in proPO activating cascade and immune responsive effectors. (cox2-inhibitors.com)
In this review, we centered on some immune linked genes and analyzed their expressions while in the different developmental phases and sexes. (chk1inhibitor.com)

ID1 has been shown to interact weakly with MyoD but very tightly with ubiquitously expressed E proteins. (wikipedia.org)
The possibility that intermediate filaments interact directly with peripheral membrane proteins and membrane lipids will also be addressed. (biologicalworld.com)

D) Genes that retain Smad2/3 binding at the same genomic coordinates in E2a -depleted embryos (red box in B) are more likely to be downregulated by 2-fold or more in E2a -depleted embryos. (xenbase.org)

The reeler gene showed a distinct expression pattern, together with the maximum transcript amounts staying detected from the 5th instar nymphs followed through the 2nd instar nymphs. (chk1inhibitor.com)

Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. (nih.gov)

These studies have shown that although the nervous system has a significant influence on the kind and amount of specific proteins synthesized, there are factors intrinsic to individual fibers that also define these properties. (ucla.edu)
Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)

A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)

Gene, 1998 Mar 16. (nih.gov)

Quality control test: Antibody Reactive Against Recombinant Protein. (novusbio.com)
TCF12 (NP_996919, 364 a.a. ~ 453 a.a) partial recombinant protein with GST tag. (novusbio.com)

At the genic level, single nucleotide polymorphisms (SNPs) in noncoding regions of the human resistin gene were either not significantly associated with insulin resistance ( 4 , 5 ) or associated with an insulin sensitivity index in the case of a different promoter SNP from the one that we present in this article ( 6 ). (diabetesjournals.org)

Anatomy1

Chemicals and Drugs2

Phenomena and Processes2

Target genes4

Transcription factors5

Regulatory4

Muscle specific genes1

Mammalian2

MRNA3

Transcriptional3

Regulates1

Differentiation4

Genome5

Isoforms2

Candidate genes2

BHLH4

Sequences2

Expression patterns3

Patterns3

Chromosome2

Regulation5

Chromosomal2

Degradation9

Subcellular1

Skeletal1

Polypeptides1

Transcript variants1

Species2

Regulators1

Similarly2

Lugens1

Residues3

Eukaryotic1

Downregulation1

Molecular2

Interactions1

Induces2

Structural3

Helix-loop-1

Bind5

Organism1

Presence1

Binds3

Cell11

19891

Cartilage3

Diseases1

Enzymes1

Motif1

Murine1

Kinase2

Subunit3

Sequence-specific1

Targets1

Immune2

Interact2

Genomic1

Distinct1

Inhibition1

Specific2

Chaperone1

19981

Recombinant2

Polymorphisms1