• Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. (wikipedia.org)
  • alpha1AC is an acute phase protein that is induced during inflammation. (qedbio.com)
  • were able to identify a set of genes (known as "biomarkers") that are associated with inflammation in animals. (elifesciences.org)
  • Description: Description of target: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. (chipab.com)
  • The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. (chipab.com)
  • The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. (chipab.com)
  • Our study identified key genes differentially methylated already in primary infection and in tissues that could contribute to the persisting metabolic disorders and inflammation in HIV-infected individuals despite effective treatment. (biomedcentral.com)
  • The purpose of this study was to determine whether acute systemic inflammation after lipopolysaccharide injection induces hepatic immediate-early genes that are induced by partial hepatectomy. (usuhs.edu)
  • A recent study identified the ability of this periodontal pathogen to alter the expression of protein encoding genes, increasing inflammation and aetherosclerosis in the coronary arteries (the vessels that supply blood to the heart) (3) . (dentaid.com)
  • Besides, IL-11 can increase the production of proteins in the liver during acute inflammation, and inhibit the formation of fat cells. (creative-proteomics.com)
  • The identification of further pleiotropic genes could provide insight into the biological mechanisms that link chronic inflammation to lipids. (biomedcentral.com)
  • We identified multiple overlapping genetic variants between CRP and lipids and confirmed novel genes implicated in the biology of chronic inflammation. (biomedcentral.com)
  • Over the last two decades, studies based on genome-wide gene expression and functional profiling have revealed the great diversity of transcriptional alterations occurring in liver carcinogenesis. (aging-us.com)
  • Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)
  • Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
  • Thus, MRs comprise typically a small number of TF-encoding genes (and their products) that control a disproportionate level of gene expression, giving rise to distinct molecular phenotypes associated with a particular disease. (aging-us.com)
  • Since the expression of genes defining discrete phenotypes is highly coordinated, application of reverse engineering algorithms to transcriptome datasets allows interpreting transcriptional networks by defining MRs and their associated regulons and gene circuits. (aging-us.com)
  • Furthermore, the NPC tumors with this particular SAA1.5/1.5 genotype showed higher levels of SAA1 gene expression, and SAA1.1 and 1.3 alleles were preferentially inactivated in tumor tissues that were examined. (hku.hk)
  • Here we present evidence that induction of metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product. (cnrs.fr)
  • However, in Toll-deficient;imd double mutants, metchnikowin gene expression can no longer be detected after immune challenge. (cnrs.fr)
  • Establishment of transgenic fly lines in which the GFP reporter gene was placed under the control of 1.5 kb of metchnikowin gene upstream sequences indicates that this fragment is able to confer full immune inducibility and tissue specificity of expression on the transgene. (cnrs.fr)
  • Compared to WT macrophages, p58IPK deficient cells demonstrated significantly stronger activation of PKR, NF-κB, and JNK and higher expression of pro-inflammatory genes TNF-α and IL-1β. (docksci.com)
  • STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. (thermofisher.com)
  • The protein expression of several transcriptionally enriched markers identified by scRNA-seq was validated by immunostaining. (nature.com)
  • Early changes included higher expression of heat shock proteins in dehydrated animals than in controls. (nature.com)
  • Dehydration also increased the expression of genes linked to cell volume regulation. (nature.com)
  • In contrast to reports on the response of epithelial cells, in mRECs hyperosmolarity reduced the expression of S lc12a2 , which encodes a Na + -K + -Cl - cotransporter. (nature.com)
  • Nutrigenomics investigations represent innovative approaches in understanding the relation between diet effect and gene expression related to the animal performance. (biomedcentral.com)
  • Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses. (biomedcentral.com)
  • Our aim is to use the potential of RNA-Sequencing data in order to evaluate the effect of an EO supplementary diet on gene expression in both lamb liver and muscle. (biomedcentral.com)
  • Our study reveals a sex-dependent effect of EO diet in both tissues, and an influence on the expression of genes mainly involved in immune, inflammatory and stress pathway. (biomedcentral.com)
  • Out of these, 4 SNPs from 3′ UTR were found to play role in miRNA binding, 7 SNPs from 5′ near and intronic region were predicted to involve in transcription factor binding and expression of MBL2 gene. (springeropen.com)
  • One nsSNP Gly54Asp (rs1800450) was found to be deleterious and damaging by both SIFT and Polyphen-2 servers and thus affecting MBL2 protein stability and expression. (springeropen.com)
  • Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. (neuromics.com)
  • Gene profiling analysis allowed to identify a set of about 50 genes whose expression might account for the proliferative activity of CCN2 in these cells. (neuromics.com)
  • Blockade of trans-signaling in the brain of the GFAP-IL6 mice significantly attenuated Serpina3n but not SOCS3 gene expression, whereas vascular changes including angiogenesis and blood-brain barrier leakage as well as gliosis were also reduced significantly. (jneurosci.org)
  • Now, importantly, we have identified a lead compound that binds to ApoE4 protein, obviating its interactions with CLEAR DNA and restoring the expression of three autophagy genes, that encode for production of p62, LC3B, and LAMP2 proteins. (hhs.gov)
  • The hepatic acute-phase response is the result of reprogramming of gene expression in the liver. (usuhs.edu)
  • Similar acute-phase responses occur in regenerating liver after partial hepatectomy and are preceded by increases in the expression of a set of transcriptional regulatory proteins that are encoded by 'immediate-early' genes. (usuhs.edu)
  • These transcription factors likely have important roles in the reprogramming of gene expression that leads to the acute-phase response. (usuhs.edu)
  • Immunization with rTcSSP4 protein makes mice more susceptible to trypomastigote infection, with high mortality rates, whereas mice immunized with a eukaryotic expression plasmid containing the TcSSP4 cDNA were able to control the acute phase of infection. (ijbs.com)
  • IL-11 can regulate the expression of plasma protein genes in hepatocytes and induce acute phase protein production. (creative-proteomics.com)
  • Annotating the effect of replicated CRP SNPs to the expression of nearby genes, we observed an effect of rs10435719 on gene expression of FDFT1 , and an effect of rs7621025 on PCCB . (biomedcentral.com)
  • These hormones act on cells in virtually every body tissue by combining with nuclear receptors and altering expression of a wide range of gene products. (msdmanuals.com)
  • 3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)
  • Other research successes include novel immunovirotherapy approaches and receiving approval of investigational new drug applications after the launch of clinical trials testing first-in-human intravenous administration of vesicular stomatitis virus strains in patients with endometrial cancer or hematologic malignancies (multiple myeloma, acute myeloid leukemia and T-cell lymphoma). (mayo.edu)
  • 2423}. Whole-genome sequencing has ing has shown that more than half of all shown that more than half of all cases cases of MDS-MLD carry mutations in of MDS-MLD carry mutations in genes genes that are also mutated in MDS with that are also mutated in MDS with excess excess blasts and acute myeloid leukae- blasts and acute myeloid leukaemia. (who.int)
  • Humans with variants of pro- and anti-inflammatory cytokine genes show increased susceptibility to alcoholic liver disease[ 2 ]. (wjgnet.com)
  • One of the cytokine proteins is interleukin-6 (IL-6), which performs many functions. (lab24.pl)
  • We established the pluripotent interleukin-1ß (IL-1 ß) cytokine as a significant player in the pathogenesis of Alzheimer's disease as it sets in motion a self-amplifying positive-feedback cycle in which neuronal stress induces synthesis of the neuron's acute phase protein ß APP and release of its fragments sAPPa and Aß. (hhs.gov)
  • The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)
  • Upon engagement, these receptors activate a series of signaling pathways resulting in upregulation of genes encoding pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα ), interleukin 1β (IL-1β ), and interleukin 6 (IL-6). (docksci.com)
  • Some of the main mREC transcriptional changes in response to dehydration-induced hyperosmotic stress were associated with cell metabolism, including the upregulation of genes linked to glycolysis but also oxidative phosphorylation (OXPHOS)-associated genes - this result was unexpected since endothelial cells are glycolysis-addicted and use glycolysis to produce most of their ATP," observes Carmeliet. (nature.com)
  • In humans, the STAT3 gene is located on the q arm of chromosome 17. (thermofisher.com)
  • 1998 ). The MBL2 gene is composed of 7461 bases and lies between the regions 52765380 to 52772841 bp of chromosome no. 10 (NCBI reference sequence number NC_000010.11). (springeropen.com)
  • Introduction: KIF1A-associated-neurological-disorder (KAND) encephalopathy is a group of progressive neurodegenerative pathologies of varying severity caused by mutations in the KIF1A gene (Kinesin family member 1A) located on chromosome 2q37.3. (bvsalud.org)
  • The CRP gene is located on chromosome 1. (medscape.com)
  • SAP is closely related to the acute-phase reactant C-reactive protein (CRP) and has been shown to be an elastase inhibitor. (medscape.com)
  • One such way would be that used by mediators that travel from the periodontal lesion through the body, causing damage at a distance, and inducing formation of acute-phase reactant compounds in the liver, such as C-reactive protein. (dentaid.com)
  • Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. (qedbio.com)
  • In addition, mice in which the receptor gene for TNFα has been knocked out are resistant to alcohol-induced liver injury[ 5 ]. (wjgnet.com)
  • Using a treatment and sex interaction model, 13 and 4 differentially expressed genes were identified in liver and muscle respectively. (biomedcentral.com)
  • Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. (springeropen.com)
  • Mannose binding lectin (MBL) is a liver derived acute phase protein. (springeropen.com)
  • Different mutations in the SERPINA1 gene result in alpha-1 antitrypsin (AAT) deficiency and in an increased risk for the development of liver diseases. (isciii.es)
  • [ 2 ] It is a member of pentraxin family of proteins and is synthesized by liver. (medscape.com)
  • CCN2 was seen in a higher proportion of mononuclear cells of patients with acute lymphoblastic leukemia. (neuromics.com)
  • In contrast, nonpathogenic SIVagm infection induced DNA methylation in genes coding for regulatory proteins such as LAG-3, arginase-2, interleukin-21 and interleukin-31. (biomedcentral.com)
  • Lesion reference to AHA types V and VI was discarded, because it failed to account for the 3 different morphologies (rupture, erosion, and calcified nodule) that give rise to acute coronary thrombosis. (medscape.com)
  • In patients with acute coronary disease, CRP level predicts mortality and cardiac complications. (medscape.com)
  • [ 3 ] High CRP levels augur a worse prognosis in patients with acute coronary syndromes. (medscape.com)
  • hs-CRP can be ordered for patients with some established risk factors of coronary heart disease to determine strategy for prevention of cardiovascular events and for follow-up of patients with acute coronary syndromes. (medscape.com)
  • CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. (thermofisher.com)
  • CRP -- an acute phase serum protein - is a surrogate for the pro-inflammatory interleukin IL-6. (medscape.com)
  • Mannose binding lectin gene 2 ( MBL2 ) polymorphisms are reported to be associated with various diseases. (springeropen.com)
  • Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
  • Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. (aging-us.com)
  • p58IPK is a molecular chaperone that regulates protein homeostasis through inhibiting eIF-2α kinases including double-stranded RNA-dependent protein kinase (PKR), which has been recently implicated in inflammasome activation. (docksci.com)
  • The responses are initiated when pathogen-associated or damage-associated molecular patterns are recognized by specific cell surface receptors such as Toll-like receptors (TLRs) and C-type lectin receptors or cytoplasmic proteins including the retinoic acid-inducible gene (RIG)-I-like receptors and NOD-like receptors (NLRs)1. (docksci.com)
  • p58IPK is a multifunctional molecular chaperone that regulates protein homeostasis. (docksci.com)
  • Our advanced molecular and histological approaches will be applied to confirm predictions of protein-protein interactions derived from proteomics approaches, particularly those involving GFAP. (hhs.gov)
  • [ 5 ] CRP is a 224-residue protein with a molecular weight of 25106 Da. (medscape.com)
  • It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
  • Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
  • It encodes a 248 amino acid residue transmembrane protein, MBL (NCBI accession number XP_011538118.1) which is encoded via a 3570 bp long mRNA (NCBI accession number NM_000242.21). (springeropen.com)
  • Transgene-encoded IL-6 mRNA levels were similar in the brain of GFAP-IL6 and GFAP-IL6/sgp130 mice. (jneurosci.org)
  • Cloning of the metchnikowin gene revealed the presence in the 5' flanking region of several putative cis-regulatory motifs characterized in the promoters of insect immune genes: namely, Rel sites, GATA motifs, interferon consensus response elements and NF-IL6 response elements. (cnrs.fr)
  • These molecules orchestrate the inflammatory response and play critical roles in inducing acute-phase proteins, modifying endothelial function and permeability, recruiting immune cells to injury site, and regulating survival and cell death. (docksci.com)
  • Initiation of ART during acute HIV-1 infection leads to a better control of immune activation than initiation in chronic infection [ 10 ]. (biomedcentral.com)
  • Genetic studies have exhibited multiple HLA- em DRB1 /em alleles encoding a conserved sequence at amino acid positions 70C74 are associated with susceptibility and severity of RA. (exposed-skin-care.net)
  • It is the leasts conserved one of the four domains at the level of nucleotide sequence, but it appears to be critical for several of the biological functions attributed to the CCN proteins. (neuromics.com)
  • The deduced amino acid sequence of PPS1p shows similarity with protein-tyrosine phosphatases (PTPases) and is most closely related to a subfamily of PTPases that are capable of dephosphorylating phosphoseryl and phosphothreonyl residues as well as phosphotyrosyl residues. (embl.de)
  • Analysis of the predicted amino acid sequence suggests that the protein consists of an active phosphatase domain, an inactive phosphatase-like domain, and an NH2-terminal extension. (embl.de)
  • The IL-11 gene contains a 7 kb gene sequence, with 5 exons and 4 introns, located on chromosomes 19q13.3-19q13.4. (creative-proteomics.com)
  • Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
  • Our investigators have pioneered first-in-human testing of different viral platforms that they developed as oncolytic agents, including measles virus strains encoding the sodium iodide symporter gene, vesicular stomatitis virus strains encoding the human interferon beta and NIS genes, and measles virus strains encoding the TLR-2 agonist neutrophil activating protein. (mayo.edu)
  • Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. (thermofisher.com)
  • The region of DNA in the gene regulatory region of this gene at position -597, in which the substitution of guanine (G) for adenine (A) occurs, is called the genetic marker G (-597) A. The IL6 gene can exist in the form of two allelic variants, which include both G-allele and A-allele. (lab24.pl)
  • Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. (thermofisher.com)
  • Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. (wikipedia.org)
  • In humans, it is encoded by the SERPINA3 gene. (qedbio.com)
  • [ 4 ] In humans, about 23 different unrelated proteins are known to form amyloid fibrils in vivo. (medscape.com)
  • Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogeneic amyloid proteins in the skin without systemic involvement. (medscape.com)
  • These proteins either arise from proteins expressed by cells at the deposition site (localized), or they precipitate systemically after production at a local site (systemic). (medscape.com)
  • Sex-specific differentially expressed (DE) genes were identified in both sexes. (biomedcentral.com)
  • Between 15 and 18% of genes with DNA methylation changes were differentially expressed in CD4 + T cells in vivo. (biomedcentral.com)
  • CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)
  • In healthy women, carriers of the G allele on the marker G (-597) A and the allele G on another marker of the IL-6 gene - the marker G (-174) C, higher levels of circulating IL-6 and basal cortisol, 11-deoxycortisol and 17-hydroxyprogesterone, in comparison with carriers of alleles A and c according to these genetic markers. (lab24.pl)
  • Several genetic mutations, broadly categorized as defects in 2 subunits of the propionyl-CoA carboxylase gene ( PCCA and PCCB ), may give rise to varying levels of functioning propionyl-CoA carboxylase. (medscape.com)
  • Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. (thermofisher.com)
  • Transcriptional changes seemed to occur in two stages - an early adaptation phase (12-24 h) and a late response (36-48 h). (nature.com)
  • We have demonstrated that ApoE4 competes with Transcriptional Factor EB (TFEB) for binding to the CLEAR DNA motifs, thus, hindering the transcription of three proteins crucial for lysosomal autophagy. (hhs.gov)
  • The secreted SAA1.1 and SAA1.3 proteins can block cell adhesion and induce apoptosis in the vascular endothelial cells. (hku.hk)
  • Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. (caslab.com)
  • It is a negative acute-phase protein with normal circulating levels in adults (300-600 μg/mL), which fall significantly (30-50%) during injury and infection (5). (rndsystems.com)
  • Differentially methylated genes in pathogenic SIV infection were enriched for Th1-signaling (e.g. (biomedcentral.com)
  • Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
  • Heart tissue of gene-vaccinated animals did not show myocarditis and tissue damage at 365 days following infection, as compared with control animals. (ijbs.com)
  • As for instance, in a patient with a monoclonal protein without any evidence of infection, ESR may be high (in 100) but CRP will be normal. (medscape.com)
  • nsSNPs may affect the protein function by reducing protein solubility or by destabilizing protein structure (Chasman and Adams 2001 ). (springeropen.com)
  • STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. (thermofisher.com)
  • The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). (thermofisher.com)
  • A previous functional complementation approach and the subsequent cDNA microarray analysis have identified that serum amyloid A1 (SAA1) is an NPC candidate tumor suppressor gene. (hku.hk)
  • Collectively, this homozygous SAA1.5/1.5 genotype appears to be a recessive susceptibility gene, which has lost the antiangiogenic function, whereas SAA1.1 and SAA1.3 are the dominant alleles of the tumor suppressor phenotype. (hku.hk)
  • Harnessing genes and viruses to infect and kill tumor cells offers a promising step forward in cancer treatment. (mayo.edu)
  • Our investigators also successfully completed a phase I clinical trial that tested the first-in-human delivery of an oncolytic virus employing mesenchymal stem cells, a strategy intended to protect the virus from neutralization and to optimize tumor homing. (mayo.edu)
  • Specifically, GFAP-binding chemical agents were shown to inhibit protein aggregation. (hhs.gov)
  • Through the action of our specific drug candidates to inhibit the ApoE4 protein we will, therefore, restore the lysosomal autophagy necessary for efficient clearance of large aggregates, which, as we reported, is repressed in the brains of those who inherit one or both APOE4 genes. (hhs.gov)
  • Amyloidosis is a generic term that signifies the abnormal extracellular tissue deposition of one of a family of biochemically unrelated proteins that share certain characteristic staining properties, including apple-green birefringence of Congo red-stained preparations viewed under polarizing light. (medscape.com)
  • Innate factors of protection are proteins-cytokines, which are produced by blood and tissue cells (monocytes, macrophages, granulocytes, lymphocytes) and transmit signals between cells. (lab24.pl)
  • The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
  • Thyroid hormone is required for normal brain and somatic tissue development in the fetus and neonate, and, in people of all ages, thyroid hormone regulates protein, carbohydrate, and fat metabolism. (msdmanuals.com)
  • The proteins c-Jun and Jun-B are detected in the AP-1 complex after administration of lipopolysaccharide. (usuhs.edu)
  • The induction of hepatic immediate-early genes after lipopolysaccharide is similar to that that follows partial hepatectomy. (usuhs.edu)
  • It is a major plasma protein and a member of the cystatin superfamily of protease inhibitors (2, 3). (rndsystems.com)
  • Mice were immunized with the recombinant protein rTcSSP4 and with cDNA for Tc SSP4 , and challenged with bloodstream trypomastigotes. (ijbs.com)
  • Triggered by the secretion signal, the matured granules immediately release the stored hormones into the bloodstream, creating an acute export beyond the biosynthetic capacity 10 . (nature.com)
  • Free T3 and T4 are then released into the bloodstream, where they are bound to serum proteins for transport. (msdmanuals.com)
  • Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. (neuromics.com)
  • The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (abcam.com)
  • Complexes of LPS and LBP (LPS-Binding Protein) bind with high affinity to monocytes through the surface CD14. (thermofisher.com)
  • The primary transport protein is thyroxine-binding globulin (TBG), which has high affinity but low capacity for T3 and T4. (msdmanuals.com)
  • These results indicate a distinct separation between proteins in the washable surface liquid and the mucus fraction. (biomedcentral.com)
  • Samples collected from newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglets revealed that distinct proteins were bound to the mucus as opposed to the ones easily washed off and associated with the airway liquid. (biomedcentral.com)
  • Many mechanisms of protein function contribute to amyloidogenesis, including "nonphysiologic proteolysis, defective or absent physiologic proteolysis, mutations involving changes in thermodynamic or kinetic properties, and pathways that are yet to be defined. (medscape.com)
  • The experiments show that the responses of genes in the blood and lymph cells of the mice are connected to those in the muscle cells. (elifesciences.org)
  • Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage. (thermofisher.com)
  • 2006 ). Mice have two homologous genes of MBL i.e. (springeropen.com)
  • MBL1 and MBL2 , but in human the first of them is pseudogene leaving one functional gene MBL2 (Guo et al. (springeropen.com)
  • The PPS1 protein was expressed in Escherichia coli, and the protein was shown to catalyze the hydrolysis of p-nitrophenyl phosphate, dephosphorylate phosphotyrosyl, and phosphothreonyl residues in synthetic diphosphorylated peptides and to inactivate the human ERK1 protein. (embl.de)
  • The chromosomal localization of genes was improved, and Human Genome Variation Society (HGVS) notation was used throughout for translocations, insertions, and other gene alterations. (who.int)
  • Alternatively, increased levels of these proteins could indicate altered lung development in the CF piglets. (biomedcentral.com)
  • Each hormone peptide has its own class B type G-protein coupled receptor 19 , 21 functioning along identical receptor activating schemes (Fig. 1c ). (nature.com)
  • This gene encodes a key acute phase plasma protein. (wikipedia.org)
  • Circulating Angiopoietin-like Protein 8 Is Independently Associated With Fasting Plasma Glucose and Type 2 Diabetes Mellitus. (phoenixpeptide.com)
  • Amyloid deposits contain (in addition to the fibrillar component) a nonfibrillar protein referred to as amyloid-P (Am-P). This protein is identical to normal plasma globulin, known as serum amyloid-P (SAP). (medscape.com)
  • Mutation of the catalytic cysteinyl residue in the active phosphatase domain reduced the in vitro activity of the mutant protein to less than 0.5% of wild type activity, while mutation of the corresponding cysteinyl residue of the inactive phosphatase-like domain had no effect on in vitro activity. (embl.de)
  • We used mass-spectrometry based proteomic analysis of unstimulated and carbachol stimulated newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglet airways to study proteins in the airway surface liquid and mucus, to investigate if levels of MUC5AC and MUC5B were affected by carbachol stimulation and whether the proteins clustered according to function. (biomedcentral.com)
  • The protein encoded by this gene belongs to the pentaxin family. (caslab.com)
  • SAA1 belongs to a family of acute-phase proteins that are encoded by five polymorphic coding alleles. (hku.hk)
  • The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. (thermofisher.com)
  • Proteins in the first four extracted fractions clustered together and the fifth fraction contained the mucus cluster, mucins and other proteins known to associate with mucins, whereas the traditional airway surface liquid proteins clustered to fraction 1-4 and were absent from the mucus fraction. (biomedcentral.com)
  • In fractions 1-4 from newborn CF piglets an additional cluster containing acute phase proteins was observed, suggesting an early inflammatory response in CF piglets. (biomedcentral.com)
  • The presence of RA associated antibodies (ACCP or RF) and/or the SE genes are indicative for any poorer radiological end result and higher grade of activity. (exposed-skin-care.net)
  • The present study is usually a cross-sectional analysis aimed to evaluate the significance of the presence of SE genes, defined as em DRB1*01 /em or em DRB1*04 /em , in relation to anti-CCP antibodies, antikeratin antibody (AKA) and RF in individuals who developed RA. (exposed-skin-care.net)
  • Luminex uses fluorescently encoded microspheres with specific antibodies to different target molecules. (creative-proteomics.com)
  • Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)