Genes encode proteins. Medical search. Frequent questions

Seven genetic loci (USH1A-G) have been implicated in this disease to date, and four of the corresponding genes have been identified: USH1B, C, D and F. We carried out fine mapping of USH1G (chromosome 17q24-25), restricting the location of this gene to an interval of 2.6 Mb and then screened genes present within this interval for mutations. (nih.gov)
In two consanguineous USH1G-affected families, we detected two different frameshift mutations in the SANS gene. (nih.gov)
Mutations within the X linked MECP2 gene have been identified in patients with Rett syndrome (RTT), a neurodevelopmental disorder which affects females almost exclusively and which shares phenotypic overlap with AS. (bmj.com)
Finally, around 5% of patients have loss of function mutations in the UBE3A gene, a gene encoding E6-AP, a ubiquitin protein ligase. (bmj.com)
Mutations in the gene encoding the neuronal transmembrane protein stargazin bring about recessively inherited epilepsy and ataxia in "stargazer" mice. (healthcarecoremeasures.com)
Gain-of-function alleles of the Drosophila gene Bearded ( Brd ) cause sensory organ multiplication and loss pheno-types indistinguishable at the cellular level from those caused by loss-of-function mutations in the genes of the Notch pathway (Leviten, M. W. and Posakony, J. W. (1996). (biologists.com)
Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein. (ox.ac.uk)
Inherited mutations in the HSD17B10 gene encoding MRPP2 protein lead to a childhood disorder characterised by progressive neurodegeneration, cardiomyopathy or both. (ox.ac.uk)
The in vitro and in vivo analysis of the ribonuclease E-deficient (rne - ) and the altered mRNA stability protein-deficient (ams - ) strains of Escherichia coli has demonstrated that they carry mutations in the same structural gene. (psu.edu)
Mutations of the BRAF gene can cause certain inherited diseases and birth defects. (news-medical.net)
Mutations in the SH3BP2 gene have been identified in about 80 percent of people with cherubism. (medlineplus.gov)
Mutations in the SH3BP2 gene lead to production of an abnormal protein that does not get broken down when it is no longer needed. (medlineplus.gov)
Certain gene mutations are one culprit in this toxic accumulation. (medscape.com)
Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
Currently, manufacturers are focusing on and targeting assays to mutations in the S gene. (who.int)
MEN-1 is due to mutations in the tumor suppressor gene MEN1, located on chromosome 11q13. (medscape.com)

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
ZIP4 is a ZMM protein involved in homologous recombination and may act as a hub through physical interactions with components of the chromosome axis and other ZMMs 19 . (nature.com)
The genes encoding the red- and green-color-detecting proteins of the human eye are located next to one another on the X chromosome and probably evolved from a common ancestral pigment gene. (quizlet.com)
In mice, the Sry gene is located on the Y chromosome very close to one of the pseudoautosomal regions that pairs with the X chromosome during male meiosis. (quizlet.com)
It is linked to the TBCE gene on chromosome 1q42-43 which encodes for the tubulin-specific chaperone E protein [2-4]. (who.int)

The genomic distribution of the nsLTP genes in the rice genome differs from that in wheat. (korea.ac.kr)
The expansion of protein families through gene and whole genome duplication provides raw material for adaptive evolution via mutation and selection and is considered a driving force in the development of biological novelty and complexity (28-30). (healthcarecoremeasures.com)
E proteins made by the viral genome promote the activation of host DNA replication mechanisms that can then be used by the virus during its own replication. (medscape.com)
It is encoded from the highly diverse gene family consisting of approximately 60 variable genes per haploid genome of the parasite. (research-in-field.com)
Genome-Wide Identification and Analysis of the Genes Encoding Q-Type C2H2 Zinc Finger Proteins in Grapevine. (bvsalud.org)
Therefore, in this study, we conducted a genome -wide identification of ZFP genes in three species of grapevine, namely Vitis vinifera , Vitis riparia, and Vitis amurensis, based on the sequence databases and phylogenetic and their conserved domains. (bvsalud.org)
The human genome contains about 20,000 protein-coding genes and about 5,000 genes that specify functional RNAs. (blogspot.com)
I hope it's just sloppy thinking when they say that their 1800 essential "genes" represent 9.2% of all genes in the genome (Wang et al. (blogspot.com)
Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)

Crop wild relatives provide a valuable source of genes and allelic variants for abiotic stress tolerance, disease resistance and quality traits that are important for breeding, particularly in the context of human population growth and a changing climate. (nature.com)
In rare cases, Sarc− HCM cases may be caused by pathogenic variants in non-sarcomeric genes. (mdpi.com)
Nonetheless, the association signal primarily arises from de novo protein-truncating variants, as opposed to the more common missense variants. (springer.com)
We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
Utilizing our previous interactome perturbation predictor, we identify a set of missense variants that are likely disruptive to protein-protein interactions. (springer.com)
Extending earlier work, we show that de novo missense variants that disrupt protein interactions are enriched in individuals with ASD, often affecting hub proteins and disrupting hub interactions. (springer.com)
The evidence, however, largely comes from protein-truncating variants (PTVs) as opposed to de novo missense (dnMis) variants. (springer.com)
[6] [13] About half of these genetic cases are due to disease-causing variants in one of four specific genes . (wikipedia.org)
Six different variants of asp genes were found (denoted asp1-6). (lu.se)

The clustered gene analysis showed that the motif distribution was similar and the sequence of genes was highly conserved. (bvsalud.org)
They are among the most highly conserved genes in all of biology and they are essential. (blogspot.com)

Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display. (nih.gov)
Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (nih.gov)
Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling. (nih.gov)
Here we report the characterization of two benzene-regulated genes. (cdc.gov)

HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins. (mdpi.com)
The B-Raf gene has two hotspots for mutation. (news-medical.net)
A new mutation in the SH3BP2 gene showing reduced penetrance in a family affected with cherubism. (medlineplus.gov)

The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)
Immunohistochemistry (IHC) was used to detect expression of the S100A8 protein in 74 tissue samples of endometrial cancer and 22 normal endometrial tissue samples. (medscimonit.com)
The effects of expression of the S100A8 gene by endometrial cancer cells was investigated by the MTT assay, cell cycle and apoptotic assays, qRT-PCR, and Western blotting. (medscimonit.com)
The genes encoding non-specific lipid transfer proteins (nsLTPs), members of a small multigene family, show a complex pattern of expressional regulation, suggesting that some diversification may have resulted from changes in their expression after duplication. (korea.ac.kr)
Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene. (nih.gov)
Acts upstream of or within regulation of gene expression and toll-like receptor signaling pathway. (nih.gov)
Unexpectedly the mechanism of inhibition in this case appeared to be a reduction of α1 subunit protein expression by γ7 rather than modulation of existing channels (25). (healthcarecoremeasures.com)
The latency-related (LR) RNA is abundantly expressed during latency, and expression of a LR encoded protein is necessary for dexamethasone-induced reactivation from latency in cattle. (nebraska.edu)
The ORF-E peptide-specific antiserum also recognizes a protein when mouse neuroblastoma cells (neuro-2A) are transfected with an ORF-E expression construct. (nebraska.edu)
A gene encoding the rice 16.9-kDa class I low-molecular-mass (LMM) heat- shock protein (HSP), Oshsp16.9, was introduced into Escherichia coli using the pGEX-2T expression vector to analyze the possible function of this LMM HSP under heat stress. (ncu.edu.tw)
Finally, the expression of VvZFP genes was determined using real- time quantitative PCR , which confirmed that the identified genes were involved in response to methyl jasmonate (MeJA), abscisic acid (ABA), salicylic acid (SA), and low- temperature (4 °C) stress. (bvsalud.org)
VvZFP10-GFP and VvZFP46-GFP fusion proteins were localized in the nucleus of tobacco cells , and VvZFP10 is the most responsive gene among all VvZFPs with the highest relative expression level to MeJA, ABA, SA and low- temperature (4 °C) stress. (bvsalud.org)
For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
Their gene expression during brain development and within cell types highlights how they relate to ASD. (springer.com)
Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
Previous work showed that two wheat genes whose expression is stimulated when wheat flowers are treated with DON, likely encode transporter proteins that might remove DON from the wheat cells. (usda.gov)
This hypothesis was tested using a virus-induced gene silencing system which can turn-off expression of chosen wheat genes. (usda.gov)
Previously, a fragment of a wheat ABC transporter gene was shown to be associated with the DON resistance at the gene expression level. (usda.gov)
Virus-induced gene silencing of the expression of both TaABCC3 genes (using two independent gene-specific constructs) demonstrated that the respective encoded wheat ABCC proteins contribute to wheat resistance to DON. (usda.gov)
P). Gene expression studies indicate that TaABCC3.1 is part of the early host response to DON and that activation of TaABCC3.1 expression is not just a secondary effect of the toxins primary mode of action (i.e. inhibition of the elongation step in protein synthesis). (usda.gov)
Real-time quantitative PCR (RT-qPCR) analysis and sfGFP (superfolder green fluorescent protein) analysis reveal that AmtR directly and negatively regulates the transcription and expression of crn A, cre T, csh A, and hyu B. A growth test shows that C. glutamicum ATCC 14067 can use creatine or creatinine as a sole nitrogen source. (frontiersin.org)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. (cdc.gov)
To analyze benzene-caused aberrant gene expression, we examined differential gene expression by microarray analysis of peripheral mononuclear blood cells from seven workers diagnosed with benzene poisoning and seven matched controls. (cdc.gov)
Disruption of E1 and E2 allows for dysregulated downstream genes and the expression of E6 and E7 proteins, which are selectively maintained in virally induced tumors. (medscape.com)

At the primary sequence level, the two telomerase proteins share only limited homologies with other polymerases and polymerase accessory factors. (jhu.edu)
In addition to the information found in the GenBank records, which includes properties such as sequence, position, length and description about introns, exons and protein-coding regions, Xpro provides annotations on the splice sites and intron phases. (edu.au)
We have cloned the oho31 gene of Drosophila melanogaster and determined its nucleotide sequence. (rupress.org)
In comparison to Ph1 , the causative gene sequence for Ph2 is yet to be determined. (nature.com)
Amino acid sequences deduced from the four isolated genes contain characteristic repeated regions, which consist of repeated units whose consensus sequence is similar to that of RD22. (biu.ac.il)
Based on chromosomal location, sequence and promoter sequence, the genes are separated into three major organizations (A, B, and C) [4]. (research-in-field.com)
In this study, sequence and motif variability of genes with emphasis on the DBL1 and DBL2-C2 domains from field isolates collected in two different malaria endemic areas in Indonesia are reported. (research-in-field.com)
Moreover, the 3′ UTRs of Brd and of the m4 transcription unit of the Enhancer of split gene complex [E(spl)-C] exhibit an unusually high degree of sequence identity that includes not only Brd box sequences but also a second motif we refer to as the 'GY box' (GTCTTCC). (biologists.com)
There are 4 major subfamilies of emm genes, which are defined by sequence differences within the 3' end, encoding the peptidoglycan-spanning domain. (medscape.com)
It phosphorylates a specific sequence on protein targets. (news-medical.net)
These proteins had a signal sequence in the amino-terminal end and a cell. (lu.se)
These proteins had a signal sequence in the amino-terminal end and a cell wall-sorting region in the carboxy-terminal end, which contained an LPATG-motif, a hydrophobic domain and a positively charged tail. (lu.se)

Xpro is a relational database that contains all the eukaryotic protein-encoding DNA sequences contained in GenBank with associated data required for the analysis of eukaryotic gene architecture. (edu.au)
The two proteins demonstrate 76 percent homology in their amino acid sequences. (quizlet.com)
The DBL1 cys2 type was observed in all indicated sequences gene domains with a larger sample size are required to confirm with statistical significance observed associations with severe malaria in Indonesian samples. (research-in-field.com)
By using in silico tools, LipJG3 was related to the transporter protein sequences. (ugm.ac.id)
Within LR promoter sequences, a small open reading frame (ORF) was identified (ORF-E) that is antisense to the LR-RNA, and downstream of the bICP0 gene. (nebraska.edu)
The phylogenetic tree analysis of the amino acid sequences of VvZFP, VaZFP, VrZFP, and AtZFP proteins showed that they were closely related and were divided into six subgroups. (bvsalud.org)

Essential is a word that should always be used with caution because such thing does not exist in phage genomes (unlike ribosomal genes and tRNA synthetases in bacteria for example). (edu.au)
Q-type C2H2 zinc finger proteins (ZFPs), the largest family of transcription factors , have been extensively studied in plant genomes . (bvsalud.org)
However, the genes encoding this transcription factor family have not been explored in grapevine genomes . (bvsalud.org)
The aims of this study were to describe the surface proteome of A. urinae and to analyse A. urinae genomes in search for genes encoding surface proteins. (lu.se)
The 25 genomes had in median 13 genes encoding LPXTG-proteins (range 6-24). (lu.se)

MRPP2 also moonlights in a complex with the MRPP1 (also known as TRMT10C) protein for N1-methylation of purines at position 9 of mitochondrial tRNA, and in a complex with MRPP1 and MRPP3 (also known as PRORP) proteins for 5'-end processing of mitochondrial precursor tRNA. (ox.ac.uk)
Homo sapiens uracil-DNA glycosylase (UNG), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. (lu.se)

We describe the purification of telomerase and the cloning of cDNAs encoding two protein subunits from the ciliate Tetrahymena. (jhu.edu)
Additional experiments proven that γ2 coimmunoprecipitates with GluR1 -2 and -4 AMPAR subunits indicated in heterologous COS cells which the postsynaptic denseness proteins PSD-95 must translocate the γ2-AMPAR complicated to neuronal postsynaptic membranes (10). (healthcarecoremeasures.com)
Some of them are the protein-coding genes for RNA polymerase subunits, ribosomal proteins, enzymes of lipid metabolism, and many other enzymes. (blogspot.com)
If the membrane-anchor is missing or defective, Fp and Ip subunits accumulate as soluble proteins in the cytoplasm. (lu.se)

It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)
Rask classified the PfEMP1 protein in 628 homology blocks [6]. (research-in-field.com)

S100A8 mRNA and S100A8 protein levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. (medscimonit.com)
Hansen (26) showed that coexpression of γ6 significantly decreased currents through recombinant T-type Ca2+ channels (CaV3.1) in HEK-293 cells and native T-type Ca2+ channels in atrial HL-1 cells and that this effect did not accompany any decrease in the level of CaV3.1 mRNA or protein. (healthcarecoremeasures.com)
Strains encoding either thermolabile RNase E (rne-3071) or Ams protein (ams-1) are defective in both rRNA processing and mRNA turnover. (psu.edu)
Babitzke, P & Kushner, SR 1991, ' The Ams (altered mRNA stability) protein and ribonuclease E are encoded by the same structural gene of Escherichia coli ', Proceedings of the National Academy of Sciences of the United States of America , vol. 88, no. 1, pp. 1-5. (psu.edu)
moreover, CYP4F3A mRNA and protein were induced by benzene metabolite phenol in HL-60 and K562 cells as well as ex vivo in human peripheral neutrophils. (cdc.gov)
DNA-PKcs mRNA was found consistently increased in the patients and DNA-PKcs mRNA and protein were induced by hydroquinone in HL-60 cells. (cdc.gov)

This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
GAPDH transcript was used as an internal control to normalize gene manifestation levels. (gasyblog.com)

We cloned and characterized four independent genes encoding BURP domain-containing proteins from mangrove, Bruguiera gymnorrhiza, two as cDNA (BgBDC2 and BgBDC3) and the other two as genomic DNA (S2 and L3). (biu.ac.il)
To identify the photoreceptive molecule that regulates photoperiodic responses, in the present study, we have cloned and characterized the cDNA encoding an opsin gene expressed in the ayu brain, a putative site of the photoreceptor for photoperiodism. (bioone.org)

We showed, by means of co-transfection experiments, that SANS associates with harmonin, a PDZ domain-containing protein responsible for USH1C. (nih.gov)

Each group identified between 1500 and 2000 protein-coding genes that are essential in their chosen cell lines. (blogspot.com)
The respective genes encode proteins of 1500 and 1497aa, respectively, which shared 97% identity. (usda.gov)

All isolates had either one or two of these asp-genes located in a conserved locus, designated Locus encoding Aerococcal Surface Proteins (LASP). (lu.se)
For other Gram-positive bacteria, cell wall-anchored surface proteins with an LPXTG-motif play a key role for virulence. (lu.se)
The virus' surface proteins, hemagglutinin (HA) and neuraminidase (NA), were highlighted in light and dark blue, respectively. (cdc.gov)
Three of these RNP segments encode the virus' surface proteins, i.e., the HA, NA and M proteins. (cdc.gov)

The gene encodes a phosphoprotein of 522 amino acids made of three domains: a central hydrophobic domain of eight repeats of 42-44 amino acids each, displaying similarity to the arm motif found in junctional and nucleopore complex proteins, and flanked by two hydrophilic NH2- and COOH-terminal domains. (rupress.org)

Here, we describe the cloning and functional characterisation of this gene, TaABCC3.1, as well as of its homolog (TaABCC3.2). (usda.gov)

Polymerase chain reactions (PCRs) were setup in 10-μl reaction mixtures using TaqMan Gene Manifestation Assays (SHANK1: Mm01206737_m1 SHANK2: Mm01163731_m1 SHANK3: Mm00498775_m1 PV: Mm00443100_m1 Slc17a7 (VGluT1): Mm00812886_m1 GAPDH: Mm99999915_g1 Applied Biosystems). (gasyblog.com)
Genomic polymerase chain reaction (PCR) demonstrated that the ayu rhodopsin gene is intron-less. (bioone.org)

MEN1 encodes a transcriptional regulator protein, menin. (medscape.com)

The genomic distribution pattern of nsLTP genes in the Poaceae family points to the existence of some differences among cereal nsLTP genes, all of which diverged from an ancient gene. (korea.ac.kr)

We compared the survivability of E. coli XL1-Blue cells transformed with a recombinant plasmid containing a glutathione S-transferase (GST)-Oshsp16.9 fusion protein (pGST-FL cells) with the control E. coli cells transformed with the pGEX-2T vector (pGST cells) under heat-shock (HS) after isopropyl β-D-thiogalactopyranoside induction. (ncu.edu.tw)
Recombinant mutant proteins were expressed and characterised biochemically to investigate their effects towards the functions of MRPP2 and associated complexes in vitro. (ox.ac.uk)
Recombinant Lucia Luciferase Protein is a positive control for luciferase reporter assays. (invivogen.com)
A dilution series of the recombinant Lucia luciferase protein can also be used to determine the linear range of the assay. (invivogen.com)
Activity of recombinant Lucia luciferase protein determined by measuring Relative Light Units (RLU) in a luminometer using QUANTI-Luc™ . (invivogen.com)
The presence of these proteins on the surface was also shown using ELISA with serum from rabbits immunized with the recombinant Asp. (lu.se)

DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene. (wikipedia.org)

Some of these genes are the genes for ribosomal RNA, tRNAs, the RNAs involved in splicing, and many other types of RNA. (blogspot.com)

The database currently contains information for 493 983 genes - 351 918 introncontaining genes and 142 065 intron-less genes. (edu.au)

The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. (imperial.ac.uk)
Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)

The human cellular prion protein (PrP C ) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. (mdpi.com)
B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
Cellular proteins encoded by the c-mos genes (GENES, MOS). (bvsalud.org)

This may be described if loss of γ2 is functionally rescued by compensating proteins or alternatively if γ2 is not required as a Ca2+ channel subunit and (18-20). (healthcarecoremeasures.com)
DNA-dependent protein kinase catalytic subunit (DNAPKcs) regulates non-homologous end joining (NHEJ) in DNA double strand break (DSB) repair. (cdc.gov)

Based on the known interaction between USH1B (myosin VIIa), USH1C (harmonin) and USH1D (cadherin 23) proteins and the results obtained in this study, we suggest that a functional network formed by the USH1B, C, D and G proteins is responsible for the correct cohesion of the hair bundle. (nih.gov)
Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. (nature.com)
We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)

This may be attributed to gene migration, chromosomal rearrangement, and/or differential gene loss. (korea.ac.kr)
The chromosomal arrangement of emm subfamily genes reveals 5 major emm patterns, designated as emm patterns A through E. An example of the usefulness of emm typing is described by McGregor et al. (medscape.com)

The mature protein has an approximate molecular weight of 24 kDa. (invivogen.com)
The HSP70 gene family encodes the major heat shock protein of molecular weight 70,000. (blogspot.com)
In a normal brain, a protein called beta-amyloid is cleared away through our lymphatic system by microglia as molecular junk. (medscape.com)
Thus, it will be of great interest to explore the function of the Asp proteins of A. urinae to establish a better understanding of the molecular mechanisms by which A. urinae cause disease. (lu.se)

The SANS protein contains three ankyrin domains and a sterile alpha motif, and its C-terminal tripeptide presents a class I PDZ-binding motif. (nih.gov)

Some pharmaceutical companies are developing inhibitors of B-Raf protein as anticancer therapies. (news-medical.net)

The proteins encoded by genes in Human Leukocyte Antigen (HLA) complex regulate the innate and adaptive arms of human immune responsiveness through antigen recognition, and presentation, inflammation regulation, and the complement system, and the impact of this region is well documented in solid organ and hematopoietic stem cell transplantation, and in various immune-mediated conditions. (frontiersin.org)
E1 protein has helicase activity for replication, and E2 encodes DNA-binding protein for regulation of transcription. (medscape.com)

The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)

The Shank genes (SHANK1 2 3 encode scaffold proteins highly enriched in postsynaptic densities where they regulate synaptic structure in spiny neurons. (gasyblog.com)

During the interphase of early embryonic cell cycles, the OHO31 protein is present in the cytoplasm and massively accumulates in the nucleus at the onset of mitosis in late interphase and prophase. (rupress.org)

consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)

Each Mouse monoclonal to CD10 gene potentially encodes between two to seven Duffy-binding like (DBL), and cysteine-rich interdomain areas (CIDR). (research-in-field.com)

RNA samples extracted from hippocampal CA1 PV+ and pyramidal neurons were reverse-transcribed into cDNA using TaqMan Gene Manifestation Cells-to-CT Kit (Ambion). (gasyblog.com)

gene, PfEMP1, ICAM-1 Background During the erythrocytic cycle, expresses a protein which is definitely exported from your parasite to the surface of the infected erythrocyte (IE) approximately 18?hours post invasion, called erythrocyte membrane protein 1 (PfEMP1). (research-in-field.com)
We recently isolated the tumor-associated membrane protein gene, Tmp, from a c- myc-induced mouse brain tumor. (huji.ac.il)

These studies suggest that a protein encoded by ORF-E has the potential to alter the physiology or metabolism of neuronal cell types, which may be important for long-term latency. (nebraska.edu)
Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)

At Last, the Details of How Proteins Evolve? (evolutionnews.org)

RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)

The protein belongs to the short-chain dehydrogenase/reductases (SDR) family and is involved in the catabolism of isoleucine in vivo and steroid metabolism in vitro. (ox.ac.uk)
What they should detect is all of the genes required in core metabolism. (blogspot.com)

We show here that constructs containing the Tmp regulatory region fused to a reporter gene are activated by c-Myc through this CACGTG element and that the c-Myc-Max protein complex can bind to this element. (huji.ac.il)

These four genes are highly homologous to the dehydration-responsive RD22 gene from Arabidopsis thaliana. (biu.ac.il)

Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. (nih.gov)
They won't detect any of the genes required for spermatogenesis or embryonic development. (blogspot.com)

Moreover, an inducible form of c-Myc, the MycER fusion protein, can activate the endogenous Tmp gene. (huji.ac.il)
We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). (nature.com)
We show that radiation-induced migration/invasion occurs through the stabilization and nuclear accumulation of the transcription factor hypoxia-inducible factor 1 alpha (HIF1α), which drives the transcription of Junction-mediating and regulatory protein (JMY) 27 that stimulates GSC migration through its actin nucleation-promoting activity. (nature.com)
There are two inducible genes, HSPA1A and HSPA1B. (blogspot.com)

In this study, the evolution of nsLTP genes within the Poaceae family was characterized via a survey of the pseudogenes and unigenes encoding the nsLTP in rice pseudomolecules and the NCBI unigene database. (korea.ac.kr)

A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. (wikidata.org)
We have isolated the Tmp promoter region and identified a putative c-Myc binding element, CACGTG, located in the first intron of the gene. (huji.ac.il)

We report 8 patients from 7 Jordanian families, 6 of whom underwent genetic testing and were found to have a 12 bp (155-166 del) deletion within the tubulin-specific chaperone E (TBCE gene) in exon 3 at 1q42-43. (who.int)
Twenty-two genes were found up-regulated and 18 down-regulated in benzene patients compared with controls. (cdc.gov)

I looked first at the genes encoding the enzymes for gluconeogenesis and glycolysis. (blogspot.com)
The mechanisms for liberating this N are unclear as ectomycorrhizal fungi have lost many genes encoding lignocellulose-degrading enzymes present in their saprotrophic ancestors. (lu.se)

Both mutant proteins showed significant reduction in the dehydrogenase, methyltransferase and tRNA processing activities compared to wildtype, associated with reduced stability for protein with p.V12L, whereas the protein carrying p.V176M showed impaired kinetics and complex formation. (ox.ac.uk)

MRPP2 (also known as HSD10/SDR5C1) is a multifunctional protein that harbours both catalytic and non-catalytic functions. (ox.ac.uk)
Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)

It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)

Mutations16

Chromosome5

Genome9

Variants9

Highly conserved2

Characterization4

Mutation3

Expression27

Sequence12

Sequences6

Genomes5

Mitochondrial2

Subunits4

Homology3

MRNA6

Transcript2

Cloned and characterized2

Domain-contain1

15002

Surface proteins4

Complex proteins1

Homolog1

Polymerase2

Transcriptional1

Genomic1

Recombinant6

Humans1

Ribosomal1

Intron-less1

Effector2

Cellular3

Subunit2

Functional3

Chromosomal2

Molecular4

Motif1

Anticancer1

Regulation2

Accumulating in the nucleus1

Postsynaptic1

Cytoplasm1

Inhibition1

Monoclonal1

CDNA1

Membrane2

Neuronal3

Evolve1

Downstream1

Metabolism2

Constructs1

Homologous1

Embryonic2

Inducible4

Pseudogenes1

Putative2

Patients2

Enzymes2

TRNA1

Catalytic2

Phosphorylation1