Genes dominant. Medical search. Frequent questions

Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
To analyze the pathogenic genes and clinical phenotypes of a Chinese Han family with autosomal dominant retinitis pigmentosa (ADRP). (cjeo-journal.org)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

Taking a more scientific approach, we can explain this by considering that many genes come in different versions, also called alleles. (familyeducation.com)
Alleles can be dominant (strong) or recessive (weak). (familyeducation.com)
Dominant white (W) is a group of genetically related coat color alleles on the KIT gene of the horse, best known for producing an all-white coat, but also able to produce various forms of white spotting, as well as bold white markings. (wikipedia.org)
However, most of the currently-known alleles can be linked to a documented spontaneous mutation that began with a single ancestor born of non-dominant white parents. (wikipedia.org)
Other researchers suggest the term "dominant white" be used only for the W alleles thought to be embryonic lethal when homozygous. (wikipedia.org)
Each person has two alleles for each gene, one from each parent. (cdc.gov)
If the alleles of a gene are the same, the person is homozygous for the gene. (cdc.gov)
If the alleles are different, the person is heterozygous for the gene. (cdc.gov)
It can also refer to the alleles that a person has for a specific gene. (cdc.gov)
The pod color gene has green and yellow versions, or alleles. (livescience.com)
Mendel's green pod alleles are dominant, and the yellow pod alleles are recessive. (livescience.com)

Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal genetic disease-;about a half million people in the United States alone suffer from the condition. (news-medical.net)
Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16. (ox.ac.uk)
The major site for mutations leading to autosomal dominant polycystic kidney disease (ADPKD) is at the PKD1 locus, previously mapped to 16p13. (ox.ac.uk)
In an attempt to isolate candidate genes for autosomal dominant polycystic kidney disease, a number of CpG-rich islands have been identified from a region defined genetically as the site of disease mutations. (johnshopkins.edu)

However, alternatively compounded patterns of human protein-coding gene transcripts would complicate gene expression data processing and interpretation. (nature.com)
In order to investigate representative mRNA transcript isoforms to be utilized as transcriptome analysis references, we utilized GTEx data to establish a top-ranked transcript isoform expression data resource for human protein-coding genes. (nature.com)
Distinctive tissue specific expression profiles and modulations could be observed for individual top-ranked transcripts of protein-coding genes. (nature.com)
Protein-coding transcripts or genes do occupy much higher expression fraction in transcriptome data. (nature.com)
These studies provided us more information on the spliced transcript isoforms of protein-coding genes as well as more understanding on their expression profiles and translated protein products in human tissues and diseases. (nature.com)
This is not surprising given the strong evidence for interaction between myelin and axon gene expression in development and after experimental nerve lesions. (medscape.com)
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. (nih.gov)
Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
A phenotypically dominant regulatory mechanism suppresses major histocompatibility complex class II gene expression in a murine plasmacytoma. (ox.ac.uk)
Thus, our results suggest that the NS1 plasmacytoma suppresses MHC class II expression by a phenotypically dominant regulatory mechanism. (ox.ac.uk)
The co-expression of MHC class I protein and I-A and I-E region gene transcripts provides strong evidence that the MHC gene cluster is structurally intact, and that lack of class II expression is due to a genetic regulatory mechanism. (ox.ac.uk)
Gene expression refers to the process of making proteins using the instructions from genes. (cdc.gov)
Changes in gene expression can affect how much of a protein is made, as well as when the protein is made. (cdc.gov)
We found that the runaway expression of a single gene, white , which we used as a "utility tool" in our experiments, induces homosexual courtship among mature males. (nybooks.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
A brief introduction to high throughput technologies for measuring and analyzing gene expression is given. (lu.se)
The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. (lu.se)
Using such probes, one can obtain a fingerprint of the gene expression activity in a macroscopic sample. (lu.se)
Microarrays are one such tool that allows for the study of expression of thousands of genes simultaneously. (lu.se)
In what follows we limit ourselves to the analysis of gene expression measurements obtained using microarrays with small spots of DNA fixed to glass slides. (lu.se)
Levels of gene expression are measured using a preparation of fluorescently labeled tissue RNA (copies of DNA), together with reference RNA labeled with a different fluorochrome, hybridized onto the slides. (lu.se)

Our study suggested that the p.Ser178Leu mutation of TBC1D24 is a probable cause for dominant, nonsyndromic hearing impairment. (nih.gov)
HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins. (mdpi.com)
The c. 982delC variant in the RHO gene is a pathogenic mutation in this pedigree, and this variant is reported for the first time in a Chinese Han family. (cjeo-journal.org)
We select for phage encoding a dominant lethal version of gene 2.5, whose viability is recovered via second-site suppressor mutation(s). (neb.com)
Dominant diseases can be caused by only one copy of a gene with a DNA mutation. (cdc.gov)
For recessive diseases, both copies of a gene must have the DNA mutation for a person to have one of these diseases. (cdc.gov)
Mice homozygous for a dominant negative knock-in mutation in this gene exhibit partial prenatal lethality and abnormal afterhyperpolarization in the in the CA3 area of hippocampus. (jax.org)
Science currently knows of eight genes in which a mutation can cause the disorder. (bartleby.com)
Noonan Syndrome is an autosomal dominant disorder, which is inherited by the mutation from one affected parent. (bartleby.com)
This is because most cases of TS are caused by a new gene change (mutation) and are not inherited. (uhhospitals.org)
Thirty eight of the patients were found to have parasites with a specific K13 mutation, the C580Y mutation, which is also the dominant K13 mutation in Cambodia. (cdc.gov)

In a dominant family segregated with late-onset, progressive, nonsyndromic hearing impairment, linkage analysis revealed a 2.07 Mb candidate region on chromosome 16p13.3 that contains TBC1D24. (nih.gov)
Linkage of autosomal dominant hearing loss to the short arm of chromosome 1 in two families. (jamanetwork.com)
A chromosome contains a single, long piece of DNA with many different genes. (cdc.gov)
It's caused by changes in a gene on chromosome 17. (uhhospitals.org)
It affects about 1 in 25,000 babies in the U.S. The gene change that causes NF2 is on chromosome 22. (uhhospitals.org)
The unique caused by mutations in the lamin A/C gene localization of emerin in desmosomes and on chromosome 1 (1q11-q23) [ 3 ]. (who.int)
Mutations of the puratrophin-1 (PLEKHG4) gene on chromosome 16q22.1 are not a common genetic cause of cerebellar ataxia in a European population. (cdc.gov)

Our genetics experts explain how genes are passed from one generation to the next and why traits may skip a generation. (familyeducation.com)
as with a lot of things when it comes to genetics, in reality, eye color is more complicated than this as it is not inherited via a single gene but multiple ones that all interact with each other. (familyeducation.com)

A gene that almost always results in a specific physical characteristic, for example a disease, even though the patient's genome possesses only one copy. (dana.org)
This single cell will undergo cell division and multiply many, many times to form a baby, who will have a genome made up of a mixture of genes inherited from its mother and father. (familyeducation.com)
The Pl18 gene has been molecularly mapped to linkage group 2 of the sunflower genome and is different from all known DM resistance genes in sunflower. (usda.gov)
Pl18 has been mapped to linkage group 2 of the sunflower genome and is independent of all known identified DM resistance genes in sunflower. (usda.gov)
The number of genes in an organism's complete set of DNA, called a genome, varies from species to species. (livescience.com)
Plurality consensus sequences are returned in the main folder and are named after the virus genome or gene segment class label, see the IRMA output page for more details . (cdc.gov)

Knobloch syndrome is an autosomal recessive phenotype mainly characterized by retinal detachment and encephalocele caused by biallelic pathogenic variants in the COL18A1 gene. (nih.gov)
Gene signatures derived from the genes containing functionally germline variants significantly distinguished recurred and non-recurred patients in two ER+ breast cancer independent cohorts ( n = 200 and 295, P = 1.4 × 10 −3 ). (nature.com)
In addition, the inherited germline variants from these gene signatures were predominately enriched in T cell function, antigen presentation, and cytokine interactions, likely impairing the adaptive and innate immune response thus favoring a pro-tumorigenic environment. (nature.com)
In rare cases, Sarc− HCM cases may be caused by pathogenic variants in non-sarcomeric genes. (mdpi.com)
MHC class I and class II gene variants are associated with diisocyanate -induced asthma. (cdc.gov)
Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene. (bvsalud.org)

Even though half of a person's genes come from each parent, some traits are more likely to be inherited from the mother or father . (familyeducation.com)
The baby's parents, in turn, inherited half of their genes from each of their own parents so one-quarter of each person's genes, therefore, come from their grandparents. (familyeducation.com)
The idea of altering a person's genes to potentially cure a disease sounds like science fiction, but gene therapy has been used more and more in medicine in recent years. (wkbn.com)

AD-HIES is thought to be caused by mutations in other genes that have not been definitively linked to the condition. (medlineplus.gov)
This is caused by mutations in either the SMARCB1 or LZTR1 genes. (uhhospitals.org)

The condition occurs when a parent passes on an affected gene to their child that produces constantly active proteins, leading to a disruption in the process of normal cell division and growth. (bartleby.com)
Genes control everything from hair color to blood sugar by telling cells which proteins to make, how much, when, and where. (livescience.com)

Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state. (wakehealth.edu)
Reference: Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine. (neb.com)
Screening for suppressors of dominant lethal mutations of essential genes is challenging as the phenotype prevents propagation. (neb.com)
The suppressor mutations in gene 5 are necessary and sufficient to suppress the lethal phenotype of gp2.5 lacking the C-terminal phenylalanine. (neb.com)
Phenotype is how a person looks (on the outside and inside the body) due to his or her genes and the environment (for example, having a certain eye color, being a specific blood type, or being a certain height). (cdc.gov)
Huntington's disease-like phenotype due to trinucleotide repeat expansions in the TBP and JPH3 genes. (cdc.gov)

They are inherited as an autosomal dominant trait with an incidence of about 5% in the Caucasian population. (tag-challenge.com)

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. (jamanetwork.com)
Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. (jamanetwork.com)
Huizing EHvan den Wijngaart WSVerschuure J A follow-up study in a family with dominant progressive inner ear deafness. (jamanetwork.com)
however, discovery of dominant genes including deafness genes (DFNA) remains challenging. (bvsalud.org)

for instance, carriers of sickle-cell disease and thalassaemia genes may be protected from contracting malaria. (who.int)

The aim of this meta-analysis was to discover the effect of dominant and recessive genetic models of LSP1 gene rs3817198 polymorphism on breast cancer risk. (waocp.com)

Family history remains one of the major risk factors that contribute to cancer, and recent studies have identified several genes whose germline mutations are associated with cancer. (nature.com)
Extragenic suppressor mutations occur in several genes encoding enzymes of DNA metabolism. (neb.com)

When the STAT3 gene is involved, one altered copy of the gene is sufficient to cause the disorder (which is known as autosomal dominant inheritance). (medlineplus.gov)
Dominant means that only 1 copy of the gene is needed to have the condition. (uhhospitals.org)
This drug was chosen partly because genetic analysis of the parasites in the study showed that the parasites from all 46 patients had a single copy of the gene Pfmdr1 , confirming that all parasites were sensitive to mefloquine. (cdc.gov)

With a dominant gene , the chance of passing on the gene (and therefore the trait or disease) to children is 50-50 in each pregnancy. (dana.org)
With attached earlobes, however, this particular trait comes from a single gene. (tag-challenge.com)
and one gene can make instructions for more than trait. (livescience.com)

Scientists estimate that humans have around 25,000 genes. (livescience.com)

In contrast, when the ZNF341 gene is involved, both copies of the gene are altered (which is known as autosomal recessive inheritance). (medlineplus.gov)
Others, such as SB-1 and W20, are incomplete dominants, capable of producing viable offspring with two copies of the gene, and who generally have more white than horses with only one copy. (wikipedia.org)
A copy number variation (CNV) is when the number of copies of a gene or other section of DNA is different between people. (cdc.gov)
The recessive types of dystrophic epidermolysis bullosa (RDEB) result from mutations in both copies of the COL7A1 gene in each cell. (medlineplus.gov)
Individuals have two copies of each gene, one inherited from each parent. (livescience.com)

A new study shows that total RPE65 protein levels in mice with autosomal dominant retinitis pigmentosa were doubled following subretinal delivery of adeno-associated virus (AAV)-RPE65 gene supplementation. (news-medical.net)

Full of information, genes pass similar traits from one generation to the next. (livescience.com)

Linkage analysis using DNA polymorphisms in the DRPLA gene and the genes for gamma-aminobutyric acid (GABA) receptor subunits, GABAR beta 1, GABAR beta 3, and GABAR alpha 6, showed that these genes were not responsible for BAFME. (bmj.com)
After adjusting for potential confounders, single nucleotide polymorphisms (SNPs) mapping to HLA-E, HLA-B, HLA-DOA, HLA-DQA2, and HLA-DPB1 genes showed associations with altered risk of developing DA. (cdc.gov)

As the sequencing and gene annotation projects of entire genomes of many species are headed towards completion (see, e.g. [13] ), massive mapping efforts in biology are now focused on how the genes interact. (lu.se)

These conditions are described as genetic diseases because a defect in one or more genes or chromosomes leads to a pathological condition. (who.int)

[ 6 ] However, the gene mutations responsible for the different forms of CMT1 are clearly myelin genes. (medscape.com)
Most of the COL7A1 gene mutations responsible for RDEB-sev gen result in production of abnormally short pro-α1(VII) chains that cannot form type VII collagen. (medlineplus.gov)

Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
Based on the tumor purity and lung carcinoma gene matrix, we performed weighted gene coexpression network analysis (WGCNA), and the tumor purity-related module was identified. (hindawi.com)
Five coexpressed genes (CD4, CD53, EVI2B, PLEK, and SASH3) were identified as tumor purity coexpressed genes that negatively correlated with tumor purity. (hindawi.com)
Using GSEA analysis, we found that the antigen processing and presentation pathway were related to the five tumor coexpressed genes mentioned above. (hindawi.com)
In this study, we constructed a tumor purity coexpression network based on weighted gene coexpression network analysis (WGCNA) [ 8 ]. (hindawi.com)

Using eye color as our example, the brown allele can be seen as being dominant with blue eyes being recessive. (familyeducation.com)
An allele is the version of the gene that is present. (cdc.gov)
it will use the IUPAC code that combines the dominant and minority allele bases. (cdc.gov)

The molecular interactions of genes and gene products underlie fundamental questions of biology. (lu.se)

With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. (nature.com)

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. (nih.gov)
Leukocyte-specific protein 1 (LSP1) gene is located on 11p15.5 and encodes an F-actin binding protein. (waocp.com)

Scientists have recently discovered a dominant defective gene that is responsible for many diseases and conditions. (huntingtonssa.org)
If you are one of the people who carries this gene, it is important that you know about it and take action to prevent yourself from developing these diseases. (huntingtonssa.org)
Scientists have found a gene that is commonly responsible for many diseases and conditions. (huntingtonssa.org)
The Dominant Defective Gene is a cause of many different diseases and conditions. (huntingtonssa.org)
The Dominant Defective Gene is linked to many different diseases and conditions. (huntingtonssa.org)
The Dominant Defective Gene is a cause of many diseases and conditions, including heart disease, high blood pressure, stroke, diabetes, and cancer. (huntingtonssa.org)
Scientists are working hard to find new treatments for diseases and conditions that are caused by the Dominant Defective Gene. (huntingtonssa.org)
For example, genes affect what a person will look like and whether the person might have certain diseases. (cdc.gov)
Increased knowledge of genomics over the past two decades has made it apparent that the traditional category of genetic diseases represents only those conditions in which the genetic contribution is particularly marked, whereas in fact diseases can be arrayed along a spectrum representing the varied contribution of genes and the environment. (who.int)
Others can arise from the presence of an abnormal gene in any autosome: if the gene is dominant, it results always in what is called a dominant condition, whereas if it is recessive many of these diseases appear only when the gene is inherited from both parents (and are thus called recessive conditions). (who.int)

Genetic association studies underscored the importance of human leucocyte antigen (HLA) genes within major histocompatibility complex (MHC) as susceptibility loci for DA. (cdc.gov)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

In general, cancer recurrence and metastasis are the result of the interactions of multiple mutated genes. (nature.com)
When neoplasms arise, they are modulated by the interactions of multiple genes based on a great diversity of genetic alterations, which leads to high tumoral heterogeneity. (nature.com)

Intriguingly, some of the top-ranked transcripts are noncoding splicing isoforms, which imply diverse gene regulation mechanisms. (nature.com)
Therefore, information regarding reference annotated mRNA transcripts of respective human protein-coding genes would be beneficial for biomedical researches and pathological sequence variation analyses. (nature.com)
Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)

We report a new DFNA gene , ATP11A, in a Newfoundland family with a variable form of bilateral sensorineural hearing loss (SNHL). (bvsalud.org)

Benign adult familial myoclonus epilepsy (BAFME): an autosomal dominant form not linked to the dentatorubral pallidoluysian atrophy (DRPLA) gene. (bmj.com)
The genetic differences between two types of dominant inherited myoclonus epilepsy, dentatorubral pallidoluysian atrophy (DRPLA) and benign adult familial myoclonus epilepsy (BAFME), have been reported. (bmj.com)
Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. (nih.gov)

gene loci structures and their regulation. (nature.com)

We have examined CAG repeat expansion in the DRPLA gene in five BAFME families, and the abnormal CAG expansion was not observed in the affected subjects. (bmj.com)

The gene coding for the PRKAR1A protein is one of the causative genetic loci (type 1). (bvsalud.org)

The present results are consistent with the hypothesis that an immunological mechanism is involved in DA and that genetic variations within HLA genes play a role in DA risk. (cdc.gov)

Resistance is conditioned by a single dominant gene named Pl18. (usda.gov)
The DM resistance in HA-DM1 originated from wild H. argophyllus accession PI 494573 and is conditioned by a single dominant gene named designated Pl18. (usda.gov)

Mutations in the ZNF341 gene cause a disorder similar to AD-HIES but with a different pattern of inheritance. (medlineplus.gov)
A rare genetic hematologic disease characterized by increased levels of serum hemoglobin hematocrit and erythrocyte mass associated with elevated or inappropriately normal erythropoietin serum levels occurring in various members of a family and with autosomal dominant inheritance. (globalgenes.org)
ORs and their reported 95% confidence interval (CI) for dominant and recessive inheritance models were extracted from final retrieved studies. (waocp.com)
It is remarkable that white is one of the most studied genes in man's quest to understand genetic control and function in Drosophila (described in 1910 by Thomas Hunt Morgan as the first example of sex-linked inheritance in flies) and yet this phenomenon had not previously been reported. (nybooks.com)

Victoria Gray, the first sickle cell patient to undergo exa-cel, told the FDA's advisory committee on cellular, tissue, and gene therapies that the treatment freed her from constant hospital visits due to SCD-related pain events. (wkbn.com)

It is essential to exhaustively interrogate complex mRNA isoforms of protein-coding genes with an unified data resource. (nature.com)
We found that NS1 cells express correctly sized mRNA for the MHC class II genes A alpha, E alpha and the invariant chain. (ox.ac.uk)

The specific order, or sequence, of these bases determines the exact information carried in each gene (for example, instructions for making a specific protein). (cdc.gov)

A plurality rule was chosen over majority consensus because it is more inclusive for pattern matching purposes and does not assign strict thresholds for the dominant virus phase in the sample. (cdc.gov)

Mutations in the COL7A1 gene can also cause a rare condition called epidermolysis bullosa with congenital localized absence of skin (also known as Bart syndrome or aplasia cutis congenita type VI). (medlineplus.gov)

Genes, Dominant" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)

Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. (nih.gov)
Researchers report on the safety of a gene therapy to treat the common autosomal recessive hereditary disorder alpha 1-antitrypsin (AAT) deficiency in a new article in the peer-reviewed journal Human Gene Therapy. (news-medical.net)
Introduction Noonan syndrome, named eponymously for the pediatric cardiologist who ﬁrst described it, is an autosomal dominant disorder (Gelb and Tartaglia, 2006). (bartleby.com)
Tuberous sclerosis (TS) is an autosomal dominant disorder. (uhhospitals.org)
Neurofibromatosis Type 1 (NF1) occurs in about 1 in 3,000 to 4,000 babies in the U.S. NF1 is an autosomal dominant disorder. (uhhospitals.org)
Neurofibromatosis Type 2 (NF2) is less common, is also an autosomal dominant disorder. (uhhospitals.org)
FH is a disorder of cholesterol metabolism associated with mutations in the low-density lipoprotein (LDL) receptor and a few other genes. (cdc.gov)

The COL7A1 gene provides instructions for making a protein called pro-α1(VII) chain that is used to assemble a larger protein called type VII collagen. (medlineplus.gov)

More than 30 FDA-approved gene therapies are used to treat illnesses like cancers, hemophilia and certain degenerative disorders. (wkbn.com)

One major difficulty confronted is complex alternatively spliced transcript isoforms in human protein-coding genes. (nature.com)

Anatomy26

Organisms16

Diseases35

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology7

Phenomena and Processes88

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Health Care12

Geographicals1

Phenotypes5

Alleles11

Autosomal dominan4

Expression21

Mutation11

Chromosome7

Genetics2

Genome6

Variants6

Person's genes3

Caused by mutations2

Proteins2

PHENOTYPE6

Inherited as an autosomal1

Deafness4

Sickle cell di1

Recessive Genetic Models1

Several genes2

Copy of the gene3

Trait3

25,0001

Copies5

Retinitis pigmentosa1

Traits1

Polymorphisms2

Annotation1

Chromosomes1

Mutations responsible2

Tumor5

Allele3

Underlie1

Protein-codi1

Encodes2

Diseases10

Susceptibility2

Interactions2

Transcripts3

Newfoundland1

Familial3

Structures1

Abnormal1

Loci1

Genetic variations1

Single2

Inheritance4

Cellular1

MRNA2

Sequence1

Thresholds1

Congenital1

MeSH1

Disorder7

Collagen1

Cancers1

Transcript1