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  • HOXA1
  • HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) is a myeloid-specific lncRNA, which is transcribed between the HOXA1 and HOXA2 genes. (biomedcentral.com)
  • Targets
  • 1,200 medulloblastoma genomes has shown that medulloblastoma subgroups exhibit distinct genomics, and implicated novel actionable genes within the subgroups that may serve as attractive targets for future therapy. (aacrjournals.org)
  • As it turned out, Pfizer already had a drug that targets CDK6 and in a follow-up study published in the Journal of NeuroOncology, when Vibhakar and colleagues tested the drug in medulloblastoma cells, they found reduced cancer cell survival. (bio-medicine.org)
  • Genomics
  • The application of high-resolution genomics to the study of medulloblastoma has recently led to a significant enhancement in our understanding of its pathogenesis, implicating new genes and gene families, previously uncharacterized molecular processes, and the existence of distinct biological subgroups: WNT, SHH, Group 3, and Group 4. (aacrjournals.org)
  • receptor
  • Southern blot analysis revealed rearranged bands on both heavy- and lambda light-chain genes, in contrast to germline configuration on T cell antigen receptor (beta, gamma and delta) genes. (biomedsearch.com)
  • LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. (cancerindex.org)
  • sequence
  • The CDK6 3′UTR sequence with the binding site for miR-25 was cloned into the pMIR-REPORT luciferase construct (Ambion Life Technologies, Carlsbad, CA, USA). (spandidos-publications.com)
  • commonly
  • These DNA primer pairs were designed by prioritizing the gene regions most commonly found in transcript variants. (bio-rad.com)
  • To streamline reference gene selection, we offer PCR primers for a set of commonly used reference genes that can be used individually, easily screened using our preplated 96-well and 384-well reference panels or added to custom-designed plates. (bio-rad.com)
  • synthesis
  • The antiestrogen tamoxifen also suppressed MCF7 cell DNA synthesis but had no effect on CDK6 expression, while a combination of I3C and tamoxifen inhibited MCF7 cell growth more stringently than either agent alone. (wellnessresources.com)
  • studies
  • By identifying and characterizing the genes repressed by p53 and HIF through JARID1B during hypoxia, our studies should clarify some of the complex regulatory mechanisms activated in the hypoxic microenvironment. (grantome.com)
  • Also interesting is the fact that studies of microRNA are leading us to genes implicated in cancer that we may not have discovered otherwise," Vibhakar says. (bio-medicine.org)
  • analysis
  • Single-cell gene expression analysis reveals CML stem cell heterogeneity and changes imposed by TKI therapy. (bloodjournal.org)
  • Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to define the heterogeneity within the LSC population in chronic phase chronic myeloid leukemia (CML) patients at diagnosis and following conventional tyrosine kinase inhibitor (TKI) treatment. (bloodjournal.org)