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  • apoptosis
  • Endothelin-1 (ET-1) is a potent survival factor that protects cardiac myocytes from apoptosis. (ahajournals.org)
  • 1 ET-1 acts not only as a vasoconstrictive and growth-promoting peptide but also as a survival factor against apoptosis in smooth muscle cells, 2 fibroblasts, 3 and cardiac myocytes. (ahajournals.org)
  • 5,8 The calcineurin/NFATc pathway not only mediates changes in gene expression during cardiac hypertrophy 9 but also is required for ET-1- and phenylephrine-mediated protection against myocardial cell apoptosis. (ahajournals.org)
  • 1 In a seminal paper Kerr, Wyllie, and Currie 2 later coined the word apoptosis to describe this form of death and went on to show that it was a widespread process in nature, occurring both during normal physiological development and in many pathological conditions. (bmj.com)
  • 4 The elimination of cell debris occurs in the absence of an inflammatory response, and this quiet, rapid, and efficient removal of apoptotic cells means that apoptosis can be difficult to detect in tissue: although as many as 50% of the cells in a developing organ may undergo apoptosis, less than 1% of cells are apoptotic at any one time. (bmj.com)
  • A number of agents have been developed as logical targets for induction of apoptosis and will be addressed below, also highlighted in tables 1 and ​ and2 2 . (pubmedcentralcanada.ca)
  • Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. (mdc-berlin.de)
  • ANT-1 expression led to all features of apoptosis, such as phenotypic alterations, collapse of the mitochondrial membrane potential, cytochrome c release, caspase activation, and DNA degradation. (mdc-berlin.de)
  • In apoptosis induced by γ-irradiation and cisplatin, two antitumor treatments that are cell-cycle phase-nonspecific agents, both Bcl-XL and Bcl-2 conferred similar protection against γ-irradiation, but Bcl-XL provided better protection than Bcl-2 against cisplatin. (bloodjournal.org)
  • Initial studies suggested that Bcl-XL protected better than Bcl-2 against apoptosis induced by the immunosuppressant drugs cyclosporin A, FK-506, and rapamycin. (bloodjournal.org)
  • However, the differential ability of Bcl-XL and Bcl-2 against chemotherapy-induced apoptosis was not universal and appeared to be dependent on the molecular mechanism or cellular target of the drug rather than its cell-cycle phase specificity. (bloodjournal.org)
  • Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. (biomedsearch.com)
  • Apoptosis is programed cell death characterized by certain cellular changes and regulated by various gene products including Bcl-2 and caspase-1. (biomedsearch.com)
  • Because cannabinoids have also been reported to induce apoptosis and because the release of IL-1 and suppression of lymphoproliferation are related to apoptosis, we tested for the induction of apoptosis by THC in murine immune cell cultures. (biomedsearch.com)
  • These data suggest that THC treatment of cultured immune cells induces apoptosis through the regulation of Bcl-2 and caspase activity. (biomedsearch.com)
  • phenotype
  • Results show that several genes are differentially expressed between fibroblasts of normal and adhesion peritoneum and that the peritoneal fibroblast may acquire a different phenotype during adhesion formation. (biomedcentral.com)
  • cellular
  • A cellular target of adenovirus early region 1A (E1A) oncoprotein, p300 also activates bcl-2 transcription in cardiac myocytes and is required for their survival. (ahajournals.org)
  • neoplasms
  • 1 , 2 Although aberrant expression of CyD1 is seen in almost 100% of MCL and a subset of other B-cell neoplasms, including 40% of multiple myelomas and hairy cell leukemias due to various mechanisms, 3 , 4 the precise role of CyD1 overexpression in lymphomagenesis is still elusive. (haematologica.org)
  • markedly
  • We show here that p300 markedly potentiates the binding of NFATc1 to the bcl-2 NFAT element by interacting with NFATc1 in an E1A-dependent manner. (ahajournals.org)
  • findings
  • These findings prompted us to investigate the role of NFATc in ET-1-dependent and p300-dependent bcl-2 transcription in cardiac myocytes. (ahajournals.org)
  • These findings suggest that ET-1-dependent NFATc signaling associates with p300 in the transactivation of bcl-2 gene in cardiac myocytes. (ahajournals.org)
  • Mammographic findings consisted of a noncalcified high density mass (Figure 1 ) and breast ultrasonography revealed a hypoechogenic nodule of irregular shape with partially defined limits measuring 17 × 13 × 11 mm in the right breast. (biomedcentral.com)
  • specific
  • Contributions of TGF-beta1 and hypoxia in the altered expression of specific genes were also examined using a semiquantitative RT-PCR technique. (biomedcentral.com)
  • Using four M-phase specific chemotherapeutic agents, Bcl-XL and Bcl-2 provided similar protection against vincristine and vinblastine whereas Bcl-XL afforded as much as 50% greater cell viability than Bcl-2 against etoposide and teniposide-induced cell death. (bloodjournal.org)
  • In addition, Bcl-XL provided significantly greater cell viability than Bcl-2 against methotrexate, fluorouracil, and hydroxyurea, three S-phase specific agents. (bloodjournal.org)
  • vascular
  • Endothelin-1 (ET-1) is a 21-residue peptide originally isolated from supernatants of vascular endothelial cells. (ahajournals.org)
  • family
  • In normal B cell activation, initial antigen binding activates the SRC-family kinase LYN as depicted in figure 1 . (pubmedcentralcanada.ca)
  • analysis
  • All aspirates were triaged through a uniform program including cell-size analysis, B- and T-cell clonality studies, flow cytometric immunophenotyping, and bcl-1 and bcl-2 gene rearrangements by PCR and FISH. (duke.edu)
  • activity
  • In primary cardiac myocytes prepared from neonatal rats, mutation of 2 NFAT sites within the bcl-2 promoter completely abolished the ET-1- and p300-induced increases in the activity of this promoter. (ahajournals.org)
  • For most men, the recommended dose is 50 mg. taken, as needed, approximately 1 hour before sexual activity. (matteomalagoli.it)
  • studies
  • 11 However, these studies were inconclusive in that levels of Bcl-2 and Bcl-XL could not be directly compared as they were determined using different antibodies. (bloodjournal.org)
  • However
  • 5 However, the precise mechanisms by which ET-1-dependent signaling transactivates the bcl-2 gene in cardiac myocytes are unknown. (ahajournals.org)
  • breast cancer
  • Whole-cell uptake and nuclear localization of 1,25-dihydroxy-cholecalciferol by breast cancer cells (T-47D) in culture. (xiangbio.com)
  • Male breast cancer accounts for 1% of all breast cancer cases, and men tend to be diagnosed at an older age than women (mean age is about 67 years). (biomedcentral.com)
  • cancer
  • The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene. (google.com)
  • treatment
  • The purpose of this study is to find out what effects, good and/or bad, the treatment including 1) Lenalidomide-RCHOP, 2) R-HIDAC, and 3) Lenalidomide-Rituximab maintenance has on the part. (bioportfolio.com)
  • study
  • To achieve a better understanding of the immunotoxicity of AhR agonists and their associated health risks, we have used computer simulations to study the behavior of the gene regulatory network underlying B cell terminal differentiation. (pubmedcentralcanada.ca)
  • The aim of this study was to evaluate the prognostic value of BCL-2 and BAX-1 gene expression in the tissue of non-muscle invasive superficial urothelial carcinoma. (prolekare.cz)
  • composition
  • 1. A pharmaceutical composition comprising an oligonucleotide consisting of SEQ ID NO:1439. (google.com)
  • shown
  • 2 Subsequently, Bcl-2 has been shown to repress cell death triggered by a diverse array of stimuli including chemotherapy and γ-irradiation. (bloodjournal.org)
  • changes
  • Our data substantiate that adhesion formation is a multigenic phenomenon and not all changes in gene expression pattern between normal and adhesion fibroblasts are the function of TGF-beta1 and hypoxia that are known to influence adhesion formation. (biomedcentral.com)
  • drug
  • and the remaining 1% are composed of cystine or ammonium acid urate or are diagnosed as drug-related stones. (jci.org)
  • protection
  • 6 Bcl-XL a functional and structural homologue of Bcl-2, also provides protection against a wide variety of chemotherapeutic agents. (bloodjournal.org)