• Like group A Streptococcus, many pathogenic bacteria have completely sequenced genomes, but we don't know what most of the genes are doing. (scienceblog.com)
  • By using a specialist bioinformatics infrastructure and expertise to develop, manage and interpret these data the GENOBOX consortium aims to predict the functional properties of bacterial strains based solely on their genomic sequencing and will compare the data with hundreds of genomes of micro-organisms available in the public domain. (nutraingredients.com)
  • For most commercial applications gene-editing's appeal is simplicity and precision: it alters genomes at precise sites and without inserting foreign DNA. (greenmedinfo.com)
  • My high-density genome data visualization approach relies on interactive visual queries to transform large data volumes into high-resolution comparative genomic maps, that use pre-attentive visual cues to address analytic tasks for comparative gene neighborhood investigations across large volumes of complete bacterial genomes. (uic.edu)
  • describes BGDM Docker - a tool specifically designed to evaluate bacterial pan-genomes. (peerj.com)
  • Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. (mdpi.com)
  • The final result of conjugation, transduction, and/or transformation is the production of genetic recombinants, individuals that carry not only the genes they inherited from their parent cells but also the genes introduced to their genomes by conjugation, transduction, and/or transformation. (wikipedia.org)
  • In this study, we analyzed all genes from sequenced plastid genomes to unearth any neglected cases of HGT and to obtain a measure of the overall extent of HGT to the plastid. (biomedcentral.com)
  • Here we show evidence for the presence of photosystem I (PSI) genes in the genomes of viruses that infect these marine cyanobacteria, using pre-existing metagenomic data from the global ocean sampling expedition as well as from viral biomes. (nih.gov)
  • The seven cyanobacterial core PSI genes identified in this study, psaA, B, C, D, E, K and a unique J and F fusion, form a cluster in cyanophage genomes, suggestive of selection for a distinct function in the virus life cycle. (nih.gov)
  • A protein secreted by bacteria to kill other microbes has been re-engineered to tweak DNA inaccessible to other gene editors, scientists report online July 8 in Nature . (sciencenews.org)
  • We hypothesized that there must be genes in the bacteria important for invading soft tissues and surviving under the skin. (scienceblog.com)
  • These genes would be good targets for a vaccine or treatment because the bacteria missing these genes did not flourish in the infection site. (scienceblog.com)
  • This is a prime location for gene products involved in infection because many dangerous bacteria secrete toxins or proteins through the membrane to attack the host. (scienceblog.com)
  • By analyzing the genes of bacteria, University of Florida researchers have moved a step closer to pinpointing how two brain disorders common in small-breed dogs occur. (ufl.edu)
  • The researchers are continuing to analyze the effects of bacterial infection on immune system cells known as macrophages to determine how the bacteria could breach the blood-brain barrier. (ufl.edu)
  • As central microbiota functions are determined by bacterial community networks, it is important to gain insight into the principles that govern bacteria-bacteria interactions. (nature.com)
  • Bacterial recombination is a type of genetic recombination in bacteria characterized by DNA transfer from one organism called donor to another organism as recipient. (wikipedia.org)
  • In contrast, bacteria also import genes in a process called homologous recombination, first discovered by the observation of mosaic genes at loci encoding antibiotic resistance. (wikipedia.org)
  • AMR, through acquired genes located on transposons or conjugative plasmids, is the horizontal transmission of genes required for a given bacteria to withstand antibiotics. (mdpi.com)
  • By contrast, metagenomic sequencing was a "single diagnostic test with precise and clear quantitative detection of clinically important species and antibiotic-resistance genes of MDR bacteria relative to the abundance of all other species and antibiotic-resistance genes within the gut microbiota. (genomeweb.com)
  • Because sea ice has only been extensive on Earth since the mid-Eocene, it has been hypothesized that bacteria highly adapted to inhabit sea ice have traits that have been acquired through horizontal gene transfer (HGT). (edu.au)
  • XDR Shigella strains can spread antimicrobial resistance genes to other enteric bacteria. (cdc.gov)
  • Bacterial meningitis can be caused by several types of bacteria including Streptococcus pneumonia or Neisseria meningitidis ( N.meningitidis ). (biomedcentral.com)
  • Each of Recombinetics' calves possessed two antibiotic resistance genes, along with other segments of superfluous bacterial DNA. (greenmedinfo.com)
  • For example, bacterial recombination has been shown to promote the transfer of multi drug resistance genes via homologous recombination that goes beyond levels purely obtained by mutation. (wikipedia.org)
  • Agrilife24.com: Researchers from the International Rice Research Institute and Oklahoma State University reported a gene (B5) that could provide cotton plants with broad-spectrum resistance to bacterial blight. (agrilife24.com)
  • An analysis of the results indicated that there was little overlap between the three groups, "indicating distinct species and antibiotic resistance gene composition between all groups," the authors wrote. (genomeweb.com)
  • Looking at antibiotic resistance genes, they identified 60 that best classified the samples, although there was no difference in the abundance of drug-resistance genes between groups. (genomeweb.com)
  • The inpatient and outpatient cohorts had a somewhat surprisingly similar proportion of antibiotic-resistance genes. (genomeweb.com)
  • In particular, the authors were "surprised to find a relatively high prevalence of clinically important bacterial species and antibiotic-resistance genes" in outpatient samples, despite not being on antibiotics at the time. (genomeweb.com)
  • The researchers did identify differences between the inpatient and outpatient groups when looking at specific types of antibiotic-resistance genes. (genomeweb.com)
  • For instance, two inpatient samples, or 24 percent, had the vancomycin regulatory resistance gene, while none had that gene in the outpatient group. (genomeweb.com)
  • Meanwhile, more than half of the outpatient cohort had an AmpC resistance gene, while 24 percent of inpatient samples had that gene. (genomeweb.com)
  • When comparing the sequencing method to culture, the researchers found that the culture missed several drug-resistance genes and was "cumbersome and required additional testing given the growth of isolates not intended to be selected on all types of screening media. (genomeweb.com)
  • The researchers noted that their next step would be to develop prediction models in order to better stratify patients according to their risk of developing a multi-drug resistance bacterial based on their metagenomic sequencing profile. (genomeweb.com)
  • We found that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively expressed in guard cells and modulates stomatal dynamics during bacterial invasion We analyzed tissue expression patterns of AtJAZ genes and measured stomata opening and pathogen resistance in loss- and gain-of-function mutants. (nih.gov)
  • One approach made use of the temperature sensitive gene replacement vector pKO3 that contains genes for chloramphenicol resistance and levansucrase, which is lethal to E. coli in the presence of sucrose. (ucl.ac.uk)
  • Here, we report a new strain with chromosomally integrated ethanologenic pathway under the control of a constitutive promoter, without recombinant plasmids and resistance genes. (biomedcentral.com)
  • Mutations in all six genes cause resistance to the bacterial pathogen Microbacterium nematophilum, and most of these mutations also affect bacterial adhesion and biofilm formation by Yersinia species, demonstrating that both infection and biofilm formation depend on interaction with complex surface carbohydrates. (ox.ac.uk)
  • data are preliminary and based on broth microdilution susceptibility testing and/or presence of resistance genes and mutations found in whole genome sequences of bacterial DNA. (cdc.gov)
  • Only one position, 91 (83 in E.coli gyrA gene), was linked to CIP resistance. (biomedcentral.com)
  • The evolution of gyrA gene of CC4821 N.meningitidis strains is not dependent on CC4821 evolution or on CIP resistance phenotype. (biomedcentral.com)
  • Analyzing the evolution of gyrA gene within CC4821 strains is critical to monitor the CIP resistance phenotype and the acquisition of new resistance markers. (biomedcentral.com)
  • Cefoxitin (30g) was used as surrogate to determine phenotypic methicillin resistance in staphylococcus isolates, and the methicillin resistance ( mec A) gene was detected by conventional PCR assay. (who.int)
  • 24. Yet another alarming signal was China's detection last year, in animal and human samples, of a mechanism of drug resistance, involving the mcr-1 gene, that is easily transferred from one bacterial strain to others, including some with epidemic potential. (who.int)
  • The GENOBOX platform will allow industry to determine specific functional benefits of bacterial species in a fast, cheap, and reproducible way, according to NIZO Food Research - who coordinate the consortium behind the platform. (nutraingredients.com)
  • To enable nanopore sequencing for broad methylation discovery, they generated a training dataset from an assortment of bacterial species and develop a technique that combines the identification and fine mapping of the three forms of methylation into a multi-label classification framework. (genomeweb.com)
  • Cd resistant genera Massilia, Burkholderia , Streptomyces and Methylobacterium were essential to bacterial interactions via building connections with non-resistant species. (bvsalud.org)
  • The ability to undergo natural transformation is present in at least 67 bacterial species. (wikipedia.org)
  • Natural transformation is common among pathogenic bacterial species. (wikipedia.org)
  • Metagenomic profiling revealed 8302 bacterial, 395 archaeal, 744 fungal, 524 protist and 1103 viral species in classroom dust. (biomedcentral.com)
  • Most, if not all of these transfers seem to be the result of a gene being transferred from the mitochondrial genome of one species to that of another. (biomedcentral.com)
  • While they identified over 2,000 distinct bacterial species, further analysis revealed that 79 species tended to classify samples into their respective cohorts. (genomeweb.com)
  • The complete sequence of gyrA gene from 77 strains are reported in this study and analyzed in the context of publicly available sequences from N. meningitidis of other CCs as well as other Neisseria species. (biomedcentral.com)
  • Specifically, RP2 aims to develop host-directed therapeutics that harness innate intracellular defense mechanisms through induction of autophagy for the treatment of bacterial pathogens including S. Typhimurium, L. monocytogenes, S. aureus, multiple-drug-resistant strains thereof, and additional priority pathogens with RP1, RP3, and RP4. (grantome.com)
  • The isolation of bacterial pathogens resistant to the commonly prescribed antibiotics from pregnant women symptomatic and asymptomatic for UTI calls for early screening of all pregnant women for UTI during antenatal care service delivery. (who.int)
  • In conclusion, a three-tiered experimental system successfully spanned the lab-to-field gap and identified beneficial and deleterious bacterial strains for sorghum under drought. (nature.com)
  • The current study aimed to use Coagulase gene polymorphism to identify methicillin-resistant Staphylococcus aureus (MRSA) subtypes isolated from nasal carriers in Minia governorate, Egypt, evaluate the efficiency of these methods in discriminating variable strains, and compare these subtypes with antibiotypes. (hindawi.com)
  • The aim of this study was to use coa gene polymorphism to identify MRSA subtypes isolated from nasal carriers in Minia governorate, Upper Egypt, evaluate the efficiency of these typing methods in discriminating variable strains, and compare these subtypes with antibiotypes. (hindawi.com)
  • The aim of this study was to assess the evolution of the DNA gyrase A ( gyrA ) gene from N.meningitidis CC4821 strains collected in China between 1978 and 2016. (biomedcentral.com)
  • Furthermore, the strains that are sharing the sequence of 4 or more genes (identified as a number for convenience) among the 7 genes used to determine STs could be classified into the same clonal complex (CC) [ 3 ]. (biomedcentral.com)
  • The identified isolates were tested by Coagulase gene RFLP typing. (hindawi.com)
  • This study was aimed at determining the urinary bacterial isolates and their susceptibility to selected antibiotics among pregnant women attending antenatal clinics of selected Hospitals in Ilorin, Nigeria. (who.int)
  • Four of the 9 (44.4%) CoNS isolates were cefoxitin resistant and all the 4 (100%) carried mec A gene. (who.int)
  • Transposons, also known as jumping genes, are short sequences of DNA that physically move within a genome, mutating genes by jumping into them. (scienceblog.com)
  • Based on patterns in their DNA sequences, these genes likely encode proteins in the bacterial membrane. (scienceblog.com)
  • In this thesis, I present Bacterial Gene Neighborhood Investigation Environment, or BactoGeNIE, a new comparative gene neighborhood visualization designed to address large volumes of bacterial genome sequences and explore the design decisions that best take advantage of large, high-resolution environments. (uic.edu)
  • Based on the results of phylogenetic similarity of 16SrDNA gene sequences, strain DB17 was identified to be Pseudomonas putida. (omicsonline.org)
  • 80% of all rRNA gene sequences originated from proteobacteria. (edu.au)
  • A box plot showing the different gene clusters ranked according to average pair-wise bit score of the protein sequences (BitScore) normalised against alignment length (AliLen). (biomedcentral.com)
  • Our search relied primarily on phylogenetic analyses, but also involved scrutiny of each potential case (including generation of new gene sequences from phylogenetically relevant taxa) to rule out artifacts and various types of homoplasy. (biomedcentral.com)
  • DNA sequence analysis of the 3′-end of the Coagulase ( coa ) gene revealed heterogeneity in the 81 bp tandem repeats region that encoding repeated 27-amino-acid sequences in the C-terminal region. (hindawi.com)
  • The patterns of 16S rRNA sequences found in phage metagenomes did not follow changes in the total bacterial community. (qub.ac.uk)
  • These frameshift mutations in probably inactivated genes are indicators of an incipient genome erosion in Streptomyces philanthi . (mpg.de)
  • At least 20 RPSA gene mutations have been identified in individuals with isolated congenital asplenia. (medlineplus.gov)
  • RPSA gene mutations are thought to reduce the amount of functional ribosomal protein SA. (medlineplus.gov)
  • It is unclear why RPSA gene mutations solely affect the development of the spleen. (medlineplus.gov)
  • Gain-of-function mutations in JAZ2 prevent stomatal reopening by COR and are highly resistant to bacterial penetration. (nih.gov)
  • In some cases, the DNA repair capability provided by recombination during transformation facilitates survival of the infecting bacterial pathogen. (wikipedia.org)
  • In this thesis, I present a novel genome data visualization targeting an important area of genomics research: comparative bacterial gene neighborhood analysis. (uic.edu)
  • MLST revisited: the gene-by-gene approach to bacterial genomics. (ox.ac.uk)
  • The researchers identified 273 scf genes as potentially involved in establishing infection under the skin, but two genes stood out: scfA and scfB. (scienceblog.com)
  • However, some patients may have bacterial infection despite negative urine cultures. (medscape.com)
  • Additionally, gene expression of AtVPS34 was increased upon infection by Pst DC3000 ( avrRpt2 ), and SA upregulated AtVPS34 gene expression in this process. (frontiersin.org)
  • Our results demonstrate the existence of a COI1-JAZ2-MYC2,3,4-ANAC19,55,72 module responsible for the regulation of stomatal aperture that is hijacked by bacterial COR to promote infection. (nih.gov)
  • Shigellosis is an acute enteric infection that is an important cause of domestically acquired and travel-associated bacterial diarrhea in the United States. (cdc.gov)
  • In a new study, McIver's laboratory and researchers at the University of Maryland School of Medicine identified two genes important for invasive group A Streptococcus infections in mice. (scienceblog.com)
  • The genes, subcutaneous fitness genes A (scfA) and B (scfB), may prove to be promising clinical targets in the fight against these infections, as there are no vaccines against group A Streptococcus or effective treatments for invasive infections. (scienceblog.com)
  • Without this organ, affected individuals are highly susceptible to bacterial infections, which can be life-threatening. (medlineplus.gov)
  • One of the most common chronic bacterial oral infections, periodontitis, affects the supporting structures of the teeth. (medscape.com)
  • However, because the functional potential of such micro-organisms are largely determined by its genomic sequence that encodes enzymes and proteins, it is theoretically possible to reveal functionalities from sequencing the genes alone. (nutraingredients.com)
  • The RPSA gene provides instructions for making a protein called ribosomal protein SA, which is one of approximately 80 different ribosomal proteins. (medlineplus.gov)
  • Recently, core photosystem II (PSII) genes were identified in cyanophages and proposed to function in photosynthesis and in increasing viral fitness by supplementing the host production of these proteins. (nih.gov)
  • Potentially, the seven proteins encoded by the viral genes are sufficient to form an intact monomeric PSI complex. (nih.gov)
  • We show here that six genes (bus-2, bus-4, and bus-12, together with the previously cloned srf-3, bus-8, and bus-17) encode proteins predicted to act in surface glycosylation, thereby affecting disease susceptibility, locomotory competence, and sexual recognition. (ox.ac.uk)
  • Genetic features that can be linked to the psychrophilic and sea ice-specific lifestyle of P. torquis include genes for exopolysaccharide (EPS) and polyunsaturated fatty acid (PUFA) biosynthesis, numerous specific modes of nutrient acquisition, and proteins putatively associated with ice-binding, light-sensing (bacteriophytochromes), and programmed cell death (metacaspases). (edu.au)
  • It is the strongest of the bacterial promoters that we provide and this high level of expression can cause expression problems with some proteins with poor solubility. (sigmaaldrich.com)
  • It is the strongest bacterial promoter we sell and this can cause solubility and expression problems with some proteins. (sigmaaldrich.com)
  • Chronic bacterial prostatitis (CBP) is most often caused by Escherichia coli or other gram-negative Enterobacteriaceae, and typically affects men 36 to 50 years of age. (medscape.com)
  • INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
  • We further assessed differences in the total bacterial community at the single sample level by clustering the EU and BF samples according to their bacterial genera as found by the RDP classifier (Ribosomal Database Project v. 2.1). (harvard.edu)
  • Ribosomal genes are not included. (biomedcentral.com)
  • In serotype 4b, gtcA appears to be the first member of a bicistronic operon which includes a gene with homology to Bacillus subtilis rpmE , encoding ribosomal protein L31. (asm.org)
  • The cells undergo horizontal gene transfer in which the genetic material is transferred. (wikipedia.org)
  • Among their findings are new genes and pathways related to inflammatory bowel disease, hundreds of genes that appear to control different traits through effects in different cell types, and a role for the mitochondrial metabolism-related gene PPIF in tuning mitochondrial function in macrophages. (genomeweb.com)
  • Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
  • A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
  • Although several genes gave strongly supported conflicting trees under certain conditions, we are confident of HGT in only a single case beyond the rubisco HGT already reported. (biomedcentral.com)
  • Proteomic analysis showed that several genes associated with these traits are highly translated, especially those involved with EPS and PUFA production. (edu.au)
  • However, there is still limited research into spatial and temporal variation patterns of bacterial community assemblages in mangrove soils. (frontiersin.org)
  • An increased understanding of the spatial and temporal variation of bacterial communities is critical when assessing delivery of ecosystem services and their role in soil biogeochemical processes. (frontiersin.org)
  • Today, in the whole-genome era of microbiology, the need for systematic, standardized descriptions of bacterial genotypic variation remains a priority. (ox.ac.uk)
  • We wondered whether the long-term association with the host has resulted in changes in the symbiont's genome or shaped gene regulation and metabolic interactions between the beewolf and its bacterial partners," explains Mario Sandoval-Calderón, one of the first authors of the study, the motivation for this study. (mpg.de)
  • Here, we focused on the growth and metabolic interactions of the Oligo-Mouse-Microbiota (OMM 12 ) synthetic bacterial community, which is increasingly used as a model system in gut microbiome research. (nature.com)
  • Metabolic network reconstruction in combination with metabolomics analysis of bacterial culture supernatants provided insights into the metabolic potential and activity of the individual community members. (nature.com)
  • The scientists believe that B5 could be used to develop new varieties of cotton that are resistant to bacterial blight. (agrilife24.com)
  • Expression of genes for the osteoclast markers calcitonin receptor (CTR), cathepsin K (CTSK) and tartrate-resistant acid phosphatase (TRAP) was also increased by B. pseudomallei-infected, but not by B. thailandensis-infected cells. (edu.au)
  • With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
  • A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
  • Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)
  • If the mutation causes an interesting effect, scientists can identify the mutated gene by locating the transposon, sequencing the DNA surrounding the transposon and mapping its location in the genome. (scienceblog.com)
  • Mutation of lfpA significantly reduced expression of the tested host genes, relative to the response to wild-type B. pseudomallei. (edu.au)
  • Furthermore, heteroplasmic cells plated in the absence of kanamycin resumed WT growth rate and colony morphology indicating that the presence of the disrupted gene was deleterious and/or that the gene product is required in stoichiometric amounts. (ucl.ac.uk)
  • Our gene-based typing approach using online platforms such as the Bacterial Isolate Genome Sequence Database (BIGSdb) allows the scalable organization and analysis of whole-genome sequence data. (ox.ac.uk)
  • Using this assay in concert with other in vitro and in vivo tests, more than 50 native bacterial NTRs of diverse sequence and origin were assessed for their ability to reduce a panel of clinically attractive nitroaromatic prodrugs. (wgtn.ac.nz)
  • An ST is characterized by a different sequence nucleotide for at least one of the 7 reference genes. (biomedcentral.com)
  • A new bacterial interaction, involving locomotory inhibition by a strain of Bacillus pumilus, reveals diversity in the surface properties of these mutants. (ox.ac.uk)
  • Understanding the presence of plasmid vectors requires an appreciation of the basics of gene-editing, which, confusingly, are considerably distinct from what the word 'editing' means in ordinary English. (greenmedinfo.com)
  • The phylogenetic analysis of CC4821 gyrA gene reveals at least 5 distinct genetic clusters. (biomedcentral.com)
  • The plasmid contains a constitutive promoter (OXB20) derived from the region upstream of the E. coli RecA gene. (sigmaaldrich.com)
  • This plasmid contains a constitutive bacterial promoter that does not require induction. (sigmaaldrich.com)
  • Shifts in bacterial diversity, interactions and microbial elemental cycling genes under cadmium contamination in paddy soil: Implications for altered ecological function. (bvsalud.org)
  • They imply, at the very least, the need for strong measures to prevent contamination by stray DNA, along with thorough scrutiny of gene-edited cells and gene-edited organisms. (greenmedinfo.com)
  • Bacterial contamination of organ preservation solution used in transplant surgery. (cdc.gov)
  • This study investigated the response of bacterial community and microbial ecological functions to Cd contamination in paddy soil of East China . (bvsalud.org)
  • Bacterial diversity and community structure significantly changed under Cd contamination . (bvsalud.org)
  • In the case of the lac operon of E. coli, a well-studied system for whether a gene is regulated. (lu.se)
  • The discovery of homologous recombination has made an impact on the understanding of bacterial evolution. (wikipedia.org)
  • The importance of evolution in bacterial recombination is its adaptivity. (wikipedia.org)
  • Bacterial recombination undergoes various different processes. (wikipedia.org)
  • In the second step of bacterial recombination, branch migration. (wikipedia.org)
  • This suggests that gene replacement somehow occurred by recombination at the very ends of rpl36 , without the level and length of similarity normally expected to support recombination. (biomedcentral.com)
  • These differences in nirK-gene abundance show that there is greater potential for denitrification in soil water under sugarcane, leading to low concentrations of nitrate in the underlying groundwater. (edu.au)
  • The overall elemental cycling genes abundance was negatively correlated to soil Cd content. (bvsalud.org)
  • Actinobacteria (mean relative abundance 49.7%), Gammaproteobacteria (18.4%) and Alphaproteobacteria (10.0%) were the most abundant bacterial classes. (biomedcentral.com)
  • S. aureus isolated from nasal swabs were assessed for antibiotic susceptibility, spa type and absence of the scn gene. (cdc.gov)
  • Further genetic analyses provided hints that the metabolism of the bacterial symbionts is mainly directed towards the production of antibiotic substances necessary for the protection of the beewolves' offspring. (mpg.de)
  • Coagulase gene PCR-RFLPs exhibited 10 patterns that ranged from 1 to 8 fragments with AluI digestion. (hindawi.com)
  • Newly created genome-wide maps of more than 6 million enhancer-gene connections and their use in interpreting the functions of disease-related genetic variants are reported in Nature this week . (genomeweb.com)
  • In the paper, a team led by Broad Institute scientists use their activity-by-contact model, which predicts which enhancers regulate which genes, to create enhancer-gene maps in 131 human cell types and tissues, then apply the maps to analyze fine-mapped genetic variants associated with 72 diseases and complex traits. (genomeweb.com)
  • Today, genetic exchange, or gene transfer is viewed as a major driving force in the evolution of prokaryotes. (wikipedia.org)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
  • validation of novel anti-infective candidates generated by RP1-RP5 as inducers of anti-bacterial autophagy using in vitro and in vivo models. (grantome.com)
  • The results suggest that these two genes are involved in the invasion process and may be potential targets for therapeutics. (scienceblog.com)
  • BGDM Docker integrates a software for genome annotation (Prokka), a software for pan-genome analysis and classification (PanX) and a software dedicated to identify clusters of biosynthetic genes, along with the metabolites that can be produced from such clusters (anti-SMASH). (peerj.com)
  • This knowledge can be used towards development of soil and land-use management practices promoting bacterial denitrification in groundwater to lessen the undesirable ecological consequences where groundwater discharges lower in the GBR catchment zones. (edu.au)
  • Collectively, these results unraveled a novel and broad role of PI3K in plant immunity which promoted stomatal closure and PR gene expression possibly via regulating ROS production. (frontiersin.org)
  • But FDA's findings are potentially trivial besides another recent discovery about gene-editing: that foreign DNA from surprising sources can routinely find its way into the genome of edited animals. (greenmedinfo.com)
  • The genomic islands are rich in pseudogenes, insertional elements, and addiction modules, suggesting that gene acquisition is being followed by a process of genome reduction potentially indicative of evolving ecosystem specialism. (edu.au)
  • Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)
  • Copy numbers of both genes were greater in soil water samples than groundwater (P = 0.05), with the difference in nirK being greater under sugarcane than banana. (edu.au)
  • 1) BactoGeNIE is a novel visualization design that is the first scalable visualization for comparative analysis of hundreds to thousands of gene neighborhoods. (uic.edu)
  • ABSTRACT This study aimed to evaluate the association of plasma MIF level and -173 G/C single nucleotide polymorphism of the MIF gene with the occurrence, severity and mortality of sepsis patients. (who.int)
  • High MIF levels and MIF -173G/C gene polymorphism are powerful predictors of the severity of sepsis and its outcome. (who.int)